The use of local agents: bone wax, gelatin, collagen, oxidized cellulose

  • Claudio Schonauer
  • Enrico Tessitore
  • Aldo Moraci
  • Giuseppe Barbagallo
  • Vincenzo Albanese


The use of local agents to achieve hemostasis is an old and complex subject in surgery. Their use is almost mandatory in spinal surgery. The development of new materials in chemical hemostasis is a continuous process that may potentially lead the surgeon to confusion. Moreover, the more commonly used materials have not changed in about 50 years. Using chemical agents to tamponade a hemorrhage is not free of risks. Complications are around the corner and can be due either to mechanical compression or to phlogistic effects secondary to the material used. This paper reviews about 20 animal and clinical published studies with regard to the chemical properties, mechanisms of action, use and complications of local agents.


Oxidized regenerated cellulose Bone wax Gelatin foam Collagen fleece Local hemostasis 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Claudio Schonauer
    • 1
    • 2
  • Enrico Tessitore
    • 1
  • Aldo Moraci
    • 1
  • Giuseppe Barbagallo
    • 3
  • Vincenzo Albanese
    • 3
  1. 1.Department of NeurosciencesSecond University of NaplesNaplesItaly
  2. 2.NaplesItaly
  3. 3.Section of Neurosurgery, Department of NeurosciencesUniversity of CataniaCataniaItaly

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