Abstract
Entamoeba histolytica is a human intestinal parasite that causes amoebic colitis as well as liver abscesses. Host tissues are damaged through a three-step process involving adherence, contact-dependent cytolysis, and phagocytosis. These three processes all contribute to the pathogenicity of this parasite. Adherence is provided by the Gal/GalNAc adherence lectin. Host cells are lysed in a contact-dependent fashion. There is evidence that suggests that this contact-dependent killing involves the induction of the host cell’s apoptotic machinery. Phagocytosis can then occur, consistent with metazoan apoptotic clearance.
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Boettner, D.R., Petri, W.A. (2004). Entamoeba histolytica Activates Host Cell Caspases During Contact-Dependent Cell Killing. In: Griffin, D.E. (eds) Role of Apoptosis in Infection. Current Topics in Microbiology and Immunology, vol 289. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27320-4_8
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DOI: https://doi.org/10.1007/3-540-27320-4_8
Publisher Name: Springer, Berlin, Heidelberg
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