Entamoeba histolytica Activates Host Cell Caspases During Contact-Dependent Cell Killing

Boettner, D. R.; Petri, W. A.

doi:10.1007/3-540-27320-4_8

D. R. Boettner¹¹ &
W. A. Petri¹²

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 289))

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7 Citations

Abstract

Entamoeba histolytica is a human intestinal parasite that causes amoebic colitis as well as liver abscesses. Host tissues are damaged through a three-step process involving adherence, contact-dependent cytolysis, and phagocytosis. These three processes all contribute to the pathogenicity of this parasite. Adherence is provided by the Gal/GalNAc adherence lectin. Host cells are lysed in a contact-dependent fashion. There is evidence that suggests that this contact-dependent killing involves the induction of the host cell’s apoptotic machinery. Phagocytosis can then occur, consistent with metazoan apoptotic clearance.

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References

Bailey GB, Day DB, Nokkaew C, Harper CC (1987) Infect Immun 55:1848–1853
PubMed Google Scholar
Berninghausen O, Leippe M (1997a) Arch Med Res 28 Spec No:158–160
PubMed Google Scholar
Berninghausen O, Leippe M (1997b) Infect Immun 65:3615–3621
PubMed Google Scholar
Bracha R, Nuchamowitz Y, Leippe M, Mirelman D (1999) Mol Microbiol 34:463–472
Article PubMed Google Scholar
Brandt H, Tamayo RP (1970) Hum Pathol 1:351–385
PubMed Google Scholar
Bretscher MS (1972) Nat New Biol 236:11–12
PubMed Google Scholar
Chadee K, Petri WA Jr, Innes DJ, Ravdin JI (1987) J Clin Invest 80:1245–1254
PubMed Google Scholar
Cheng XJ, Tsukamoto H, Kaneda Y, Tachibana H (1998) Parasitol Res 84:632–639
Article PubMed Google Scholar
Fadok VA, Henson PM (2003) Curr Biol 13:R655–657
Article PubMed Google Scholar
Flynn R (1973) Parasites of Laboratory Animals. Iowa State University Press, Ames, IA
Google Scholar
Guerrant RL, Brush J, Ravdin JI, Sullivan JA, Mandell GL (1981) J Infect Dis 143:83–93
PubMed Google Scholar
Haque R, Huston CD, Hughes M, Houpt E, Petri WA Jr (2003) N Engl J Med 348:1565–1573
Article PubMed Google Scholar
Hudler H, Stemberger H, Scheiner O, Kollaritsch H, Wiedermann G (1983) Tropenmed Parasitol 34:248–252
PubMed Google Scholar
Huston CD, Boettner DR, Miller-Sims V, Petri WA Jr. (2003) Infect Immun 71:964–972
Article PubMed Google Scholar
Huston CD, Haupt ER, Mann BJ, Hahn CS, Petri WA (2000) Cell microbiol 2:617–625
Article PubMed Google Scholar
Kobiler D, Mirelman D (1981) J Infect Dis 144:539–546
PubMed Google Scholar
Leippe M, Andra J, Nickel R, Tannich E, Muller-Eberhard HJ (1994) Mol Microbiol 14:895–904
PubMed Google Scholar
Leippe M, Ebel S, Schoenberger OL, Horstmann RD, Muller-Eberhard HJ (1991) Proc Natl Acad Sci U S A 88:7659–7663
PubMed Google Scholar
Leippe M, Sievertsen HJ, Tannich E, Horstmann RD (1995) Parasitology 111 (Pt 5): 569–574
PubMed Google Scholar
Leroy A, Lauwaet T, De Bruyne G, Cornelissen M, Mareel M (2000) FASEB J 14:1139–1146
PubMed Google Scholar
Li E, Becker A, Stanley SL Jr. (1989) Infect Immun 57:8–12
PubMed Google Scholar
Li E, Stenson WF, Kunz-Jenkins C, Swanson PE, Duncan R, Stanley SL Jr (1994) Infect Immun 62:5112–5119
PubMed Google Scholar
Li E, Yang WG, Zhang T, Stanley SL Jr (1995) Infect Immun 63:4150–4153
PubMed Google Scholar
Mann BJ, Torian BE, Vedvick TS, Petri WA Jr (1991) Proc Natl Acad Sci U S A 88:3248–3252
PubMed Google Scholar
McCoy JJ, Mann BJ, Vedvick TS, Pak Y, Heimark DB, Petri WA Jr (1993) J Biol Chem 268:24223–24231
PubMed Google Scholar
McGinnis KM, Gnegy ME, Park YH, Mukerjee N, Wang KK (1999) Biochem Biophys Res Commun 263:94–99
Article PubMed Google Scholar
Orozco E, Guarneros G, Martinez-Palomo A, Sanchez T (1983) J Exp Med 158:1511–1521
Article PubMed Google Scholar
Petri WA Jr, Haque R, Mann BJ (2002) Annu Rev Microbiol 56:39–64
Article PubMed Google Scholar
Petri WA Jr, Smith RD, Schlesinger PH, Murphy CF, Ravdin JI (1987) J Clin Invest 80:1238–1244
PubMed Google Scholar
Porn-Ares MI, Samali A, Orrenius S (1998) Cell Death Differ 5:1028–1033
Article PubMed Google Scholar
Que X, Reed SL (2000) Clin Microbiol Rev 13:196–206
Article PubMed Google Scholar
Ragland BD, Ashley LS, Vaux DL, Petri WA Jr (1994) Exp Parasitol79:460–467
Article PubMed Google Scholar
Ravdin JI, Croft BY, Guerrant RL (1980) J Exp Med 152:377–390
Article PubMed Google Scholar
Ravdin JI, Guerrant RL (1981) J Clin Invest 68:1305–1313
PubMed Google Scholar
Ravdin JI, Moreau F, Sullivan JA, Petri WA Jr, Mandell GL (1988) Infect Immun 56:1505–1512
PubMed Google Scholar
Ravdin JI, Schlesinger PH, Murphy CF, Gluzman IY, Krogstad DJ (1986) J Protozool 33:478–486
PubMed Google Scholar
Ravdin JI, Sperelakis N, Guerrant RL (1982) J Infect Dis 146:335–340
PubMed Google Scholar
Ravichandran KS (2003) Cell 113:817–820
Article PubMed Google Scholar
Russell JH (1983) Immunol Rev 72:97–118
PubMed Google Scholar
Salata RA, Cox JG, Ravdin JI (1987) Parasite Immunol 9:249–261
PubMed Google Scholar
Schulte W, Scholze H (1989) J Protozool 36:538–543
PubMed Google Scholar
Seigneuret M, Devaux PF (1984) Proc Natl Acad Sci U S A 81:3751–3755
PubMed Google Scholar
Seydel KB, Stanley SL Jr (1998) Infect Immun 66:2980–2983
PubMed Google Scholar
Shamsuzzaman SM, Haque R, Hasin SK, Petri WA Jr, Hashiguchi Y (2000) Southeast Asian J Trop Med Public Health 31:399–404
PubMed Google Scholar
Tannich E, Ebert F, Horstmann RD (1991) Proc Natl Acad Sci U S A 88:1849–1853
PubMed Google Scholar
WHO (1997) Epidemiol Bull 18:13–14
Google Scholar
Williamson P, Kulick A, Zachowski A, Schlegel RA, Devaux PF (1992) Biochemistry 31:6355–6360
Article PubMed Google Scholar
Yan L, Stanley SL Jr (2001) Infect Immun 69:7911–7914
Article PubMed Google Scholar
Zhang X, Zhang Z, Alexander D, Bracha R, Mirelman D, Stanley SL Jr (2004) Infect Immun 72:678–683
Article PubMed Google Scholar

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Authors and Affiliations

Department of Microbiology, University of Virginia, MR4 Bldg. Room 2115, Lane Road, Charlottesville, VA, 22908-1340, USA
D. R. Boettner
Division of Infectious Diseases and International Health, University of Virginia, MR4 Bldg. Room 2115, Lane Road, Charlottesville, VA, 22908-1340, USA
W. A. Petri

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D. R. Boettner
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Bloomberg School of Public Health Department of Molecular Microbiology and Immunology, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD, 21205, USA
Diane E. Griffin MD, PhD

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Boettner, D.R., Petri, W.A. (2004). Entamoeba histolytica Activates Host Cell Caspases During Contact-Dependent Cell Killing. In: Griffin, D.E. (eds) Role of Apoptosis in Infection. Current Topics in Microbiology and Immunology, vol 289. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27320-4_8

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DOI: https://doi.org/10.1007/3-540-27320-4_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-23006-9
Online ISBN: 978-3-540-27320-2
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