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Evidence-Based Management of Patients with Respiratory Failure pp 79–97Cite as

Acute Exacerbation of Chronic Obstructive Pulmonary Diseases: What is the impact of bronchodilators, corticosteroids and antibiotics?

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References

  1. Balter M, Hyland R, Low D (1994) Recommendations on the management of chronic bronchitis: A practical guide for Canadian physicians. Can Med Assoc J 151(Suppl):7–33

    Google Scholar 

  2. Mannino DM, Homa DM, Akinbani LJ, Ford E, Redd SC (2000) Chronic Obstructive Pulmonary Disease Surveillance United States, 1971–2000. MMWR Surveill Summ 51:1–16

    Google Scholar 

  3. Snow S, Lascher S, Mottur-Pilson C for the Joint Expert Panel on Chronic Obstructive Pulmonary Disease of the ACCP and the ACP-ASIM (2001) Evidence base for management of acute exacerbation of chronic obstructive pulmonary disease. Ann Intern Med 134:595–599

    PubMed  CAS  Google Scholar 

  4. Oswald NC, Harold JT, Martin WJ (1953) Clinical pattern of chronic bronchitis. Lancet 2:693–743

    Google Scholar 

  5. Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106:196–204

    PubMed  CAS  Google Scholar 

  6. Seemungal TA, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA (2000) Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 161:1608–1613

    PubMed  CAS  Google Scholar 

  7. Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA (1998) Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 157 (5:Pt 1):1418–1422

    PubMed  CAS  Google Scholar 

  8. Mushlin AI, Black ER, Connolly CA, Buonaccorso KM, Eberly SW (1991) The necessary length of hospital stay for chronic pulmonary disease. JAMA 266:80–83

    Article  PubMed  CAS  Google Scholar 

  9. Connors AF, Dawson NV, Thomas C, et al (1996) Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med 154 (4:Pt 1):959–967

    PubMed  Google Scholar 

  10. Burk RH, George RB (1973) Acute respiratory failure in chronic obstructive pulmonary disease. Immediate and long-term prognosis. Arch Intern Med 132:865–868

    Article  PubMed  CAS  Google Scholar 

  11. Seneff MG, Wagner DP, Wagner RP, Zimmerman JE, Knaus WA (1995) Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA 274:1852–1857

    Article  PubMed  CAS  Google Scholar 

  12. Cydulka RK, McFadden ER Jr, Emerman CL, Sivinski LD, Pisanelli W, Rimm AA (1997) Patterns of hospitalization in elderly patients with asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 156:1807–1812

    PubMed  CAS  Google Scholar 

  13. Osman IM, Godden DJ, Friend JA, Legge JS, Douglas JG (1997) Quality of life and hospital re-admission in patients with chronic obstructive pulmonary disease. Thorax 52:67–71

    Article  PubMed  CAS  Google Scholar 

  14. Peach H, Pathy MS (1981) Follow-up study of disability among elderly patients discharged from hospital with exacerbations of chronic bronchitis. Thorax 36:585–589

    PubMed  CAS  Google Scholar 

  15. Hagedorn SD (1992) Acute exacerbations of COPD. How to evaluate severity and treat the underlying cause. Postgrad Med 91:105–107

    PubMed  CAS  Google Scholar 

  16. Seemungal T, Harper-Owen R, Bhowmik A, et al (2001) Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164:1618–23

    PubMed  CAS  Google Scholar 

  17. Emerman CL, Cydulka RK (1993) Evaluation of high-yield criteria for chest radiography in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med 22:680–684

    PubMed  CAS  Google Scholar 

  18. Tsai TW, Gallagher EJ, Lombardi G, Gennis P, Carter W (1993) Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. Ann Emerg Med 22:1854–1858

    PubMed  CAS  Google Scholar 

  19. Sherman S, Skoney JA, Ravikrishnan KP (1989) Routine chest radiographs in exacerbations of chronic obstructive pulmonary disease. Diagnostic value. Arch Intern Med 149:2493–2496

    Article  PubMed  CAS  Google Scholar 

  20. Jamal K, Cooney TP, Fleetham JA, Thurlbeck WM (1984) Chronic bronchitis. Correlation of morphologic findings to sputum production and flow rates. Am Rev Respir Dis 129:719–722

    PubMed  CAS  Google Scholar 

  21. Wolkove N, Dajczman E, Colacone A, Kreisman H (1989) The relationship between pulmonary function and dyspnea in obstructive lung disease. Chest 96:1247–1251

    PubMed  CAS  Google Scholar 

  22. Peto R, Speizer F, Cochrane A, et al (1983) The relevance in adults of air-flow obstruction but not of mucus hypersecretion, to morality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis 128:491–500

    PubMed  CAS  Google Scholar 

  23. Hodgkin JE (1990) Prognosis in chronic obstructive pulmonary disease. Clin Chest Med 11:555–569

    PubMed  CAS  Google Scholar 

  24. Vitacca M, Clini E, Porta R, Foglio K, Ambrosino N (1996) Acute exacerbations in patients with COPD: predictors of need for mechanical ventilation. Eur Respir J 9:1487–1493

    Article  PubMed  CAS  Google Scholar 

  25. Niewoehner D, Collins D, Erbland M (2000) Relation to FEV1 to clinical outcomes during exacerbations of chronic obstuctive pulmonary disease. The Department of Veterans Affairs Cooperative Study Group. Am J Respir Crit Care Med 161:1201–1205

    PubMed  CAS  Google Scholar 

  26. Mannino DM, Etzel RA, Flanders WD (1993) Dothe medical history and physical examination predict low lung function? Arch Intern Med 153:1892–1897

    Article  PubMed  CAS  Google Scholar 

  27. Kesten S, Chapman K (1993) Physician perceptions and management of COPD. Chest 104:254–258

    PubMed  CAS  Google Scholar 

  28. Renwick DS, Connolly MJ (1996) Prevalence and treatment of chronic airways obstruction in adults over the age of 45. Thorax 51:164–168

    PubMed  CAS  Google Scholar 

  29. Kuhl DA, Agiri OA, Mauro LS (1994) Beta-agonists in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Ann Pharmacother 28:1379–1388

    PubMed  CAS  Google Scholar 

  30. Emerman CL, Cydulka RK (1997) Effect of different albuterol dosing regimens in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med 29:474–478

    PubMed  CAS  Google Scholar 

  31. ODriscoll BR, Taylor RJ, Horsley MG, Chambers DK, Bernstein A (1989) Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction. Lancet 1:1418–1420

    CAS  Google Scholar 

  32. Backman R, Helstrom P (1985) Fenoterol and ipratropium bromid for treatment of patients with chronic bronchitis. Curr Ther Res 38:135–140

    Google Scholar 

  33. Karpel JP, Pesin J, Greenberg D, Gentry E (1990) A comparison of the effects of ipratropium bromide and metaproterenol sulfate in acute exacerbations of COPD. Chest 98:835–839

    PubMed  CAS  Google Scholar 

  34. Rebuck AS, Chapman KR, Abboud R, et al (1987) Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. Am J Med 82:59–64

    Article  PubMed  CAS  Google Scholar 

  35. Moayyedi P, Congleton J, Page RL, Pearson SB, Muers MF (1995) Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. Thorax 50:834–837

    PubMed  CAS  Google Scholar 

  36. Patrick DM, Dales RE, Stark RM, Laliberte G, Dickinson G (1990) Severe exacerbations of COPD and asthma. Incremental benefit of adding ipratropium to usual therapy. Chest 98:295–297

    PubMed  CAS  Google Scholar 

  37. Cydulka RK, Emerman CL (1995) Effects of combined treatment with glycopyrrolate and albuterol in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med 25:470–473

    PubMed  CAS  Google Scholar 

  38. Shrestha M, OBrien T, Haddox R, Gourlay HS, Reed G (1991) Decreased duration of emergency department treatment of chronic obstructive pulmonary disease exacerbations with the addition of ipratropium bromide to beta-agonist therapy. Ann Emerg Med 20:1206–1209

    PubMed  CAS  Google Scholar 

  39. Turner M, Patel A, Ginsburg S, FitzGerald J (1997) Bronchodilator delivery in acute airflow obstruction. A meta-analysis. Arch Intern Med 157:1736–1744

    Article  PubMed  CAS  Google Scholar 

  40. Rice KL, Leatherman JW, Duane PG, et al (1987) Aminophylline for acute exacerbations of chronic obstructive pulmonary disease. A controlled trial. Ann Intern Med 107:305–309

    PubMed  CAS  Google Scholar 

  41. Seidenfeld JJ, Jones WN, Moss RE, Tremper J (1984) Intravenous aminophylline in the treatment of acute bronchospastic exacerbations of chronic obstructive pulmonary disease. Ann Emerg Med 13:248–252

    PubMed  CAS  Google Scholar 

  42. Bullard M, Liaw S, Tsai Y, Min H (1996) Early corticosteroid use in acute exacerbations of chronic airflow obstruction. Am J Emerg Med 14:139–143

    Article  PubMed  CAS  Google Scholar 

  43. Emerman C, Connors A, Lukens T, May M, Effron D (1989) A randomized controlled trial of methylprednisolone in the emergency treatment of acute exacerbations of COPD. Chest 95:563–567

    PubMed  CAS  Google Scholar 

  44. Thompson W, Nielson C, Carvalho P, Charan N, Crowley J (1996) Controlled trial of oral prednisone in outpatients with acute COPD exacerbation. Am J Respir Crit Care Med 154:407–412

    PubMed  CAS  Google Scholar 

  45. Davies L, Angus R, Calverley P (1999) Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. Lancet 354:456–460

    PubMed  CAS  Google Scholar 

  46. Niewoehner D, Erbland M, Deupree R, et al (1999) Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N Engl J Med 340:1941–1947

    Article  PubMed  CAS  Google Scholar 

  47. Murata G, Gorby M, Chick T, Halperin A (1990) Intravenous and oral corticosteroids for the prevention of relapse after treatment for decompensated COPD: Effect on patients with a history of multiple relapses. Chest 98:845–849

    PubMed  CAS  Google Scholar 

  48. Sayiner A, Aytemur ZA, Cirit M, Unsal I (2001) Systemic glucorticoids in severe exacerbations of COPD. Chest 119:726–730

    Article  PubMed  CAS  Google Scholar 

  49. Decramer M, Gosselink R, Troosters T, Verschueren M, Evers G (1997) Muscle weakness is related to utilization of health care resources in COPD. Eur Respir J 10:417–423

    PubMed  CAS  Google Scholar 

  50. Woolhouse C, Hill S, Stockley R (2001) Symptom resolution assessed using a patient directed diary card during treatment of acute exacerbations of chronic bronchitis. Thorax 56:947–953

    Article  PubMed  CAS  Google Scholar 

  51. Maltais F, Ostinelli J, Bourbeau J, Tonnel A, Jacquemet N, Haddon J (2002) Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Am J Respir Crit Care Med 165:698–703

    PubMed  Google Scholar 

  52. Elmes P, Fletcher C, Dutton A (1957) Prophylactic use of oxytetracycline for exacerbations of chronic bronchitis. Br Med J 2:1272–1275

    Article  PubMed  CAS  Google Scholar 

  53. Berry D, Fry J, Hindley C, et al (1960) Exacerbations of chronic bronchitis treatment with oxytetracycline. Lancet 1:137–139

    PubMed  CAS  Google Scholar 

  54. Elmes P, King T, Langlands J, et al (1965) Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis. Br Med J 5467:904–908

    PubMed  CAS  Google Scholar 

  55. Peterson E, Esmann V, Honcke P, Munkner C (1967) A controlled study of the effect of treatment on chronic bronchitis: an evaluation using pulmonary function tests. Acta Med Scand 182:293–305

    Google Scholar 

  56. Pines A, Raafat H, Greenfield J, Linsell W, Solari M (1972) Antibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis. Br J Dis Chest 66:107–115

    PubMed  CAS  Google Scholar 

  57. Nicotra MB, Rivera M, Awe RJ (1982) Antibiotic therapy of acute exacerbations of chronic bronchitis. A controlled study using tetracycline. Ann Intern Med 97:18–21

    PubMed  CAS  Google Scholar 

  58. Allegre L, Grasi E, Pozzi E (1991) Puolo degli antibiotici nel trattamento delle riacutizza della bronchite cronica. Ital J Chest Dis 45:138–148

    Google Scholar 

  59. Nouira S, Marghli S, Belghith M, Besbes L, Elatrous S, Abroug F (2001) Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomized placebo-controlled trial. Lancet 358:2020–2035

    Article  PubMed  CAS  Google Scholar 

  60. Sachs A, Koeter G, Groenier K, Van Der Waaij D, Schiphuis J, Meyboom-de Jong B (1995) Changes in symptoms, peak expiratory flow, and sputum flora during treatment with antibiotics of exacerbations in patients with chronic obstructive pulmonary disease in general practice. Thorax 50:758–763

    PubMed  CAS  Google Scholar 

  61. Sethi S, Paluri R, Grant E, Murphy T (1999) Prediction models for the etiology of acute exacerbations of COPD. Am J Respir Crit Care Med 159:A819 (abst)

    Google Scholar 

  62. Stockley R, OBrien C, Pye A, Hill S (2000) Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest 117:1638–1645

    Article  PubMed  CAS  Google Scholar 

  63. Saint S, Bent S, Vittinghoff E, Grady D (1995) Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA 273:957–960

    Article  PubMed  CAS  Google Scholar 

  64. Ball P, Harris J, Lowson D, Tillotson G, Wilson R (1995) Acute infective exacerbations of chronic bronchitis. QJM 88:61–68

    PubMed  CAS  Google Scholar 

  65. Macfarlane JT, Colville A, Guion A, Macfarlane RM, Rose DH (1993) Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet 341:511–514

    PubMed  CAS  Google Scholar 

  66. Destache CJ, Dewan N, ODonohue WJ, Campbell JC, Angelillo VA (1999) Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother 43(Suppl A):107–113

    PubMed  CAS  Google Scholar 

  67. Doern GV, Brueggemann AB, Pierce G, Holley HP Jr, Rauch A (1997) Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of beta-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study. Antimicrob Agents Chemother 41:292–297

    PubMed  CAS  Google Scholar 

  68. Doern G, Pfaller M, Kugler K, Freeman J, Jones R (1998) Prevalence of antimicrobial resistance among respiratory tract isolates of Streptococcus pneumoniae in North America: 1997 results from the SENTRY Antimicrobial Surveillance Program. Clin Infect Dis 27:764–770

    PubMed  CAS  Google Scholar 

  69. Sportel JH, Koeter GH, van Altena R, Lowenberg A, Boersma WG (1995) Relation between beta-lactamase producing bacteria and patient characteristics in chronic obstructive pulmonary disease (COPD). Thorax 50:249–253

    PubMed  CAS  Google Scholar 

  70. Doern GV, Brueggemann A, Holley HP Jr, Rauch AM (1996) Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother 40:1208–1213

    PubMed  CAS  Google Scholar 

  71. Doern GV, Pfaller MA, Kugler K, Freeman J, Jones RN (1998) Prevalence of antimicrobial resistance among respiratory tract isolates of Streptococcus pneumoniae in North America: 1997 results from the SENTRY Antimicrobial Surveillance Program. Clin Infect Dis 27:764–770

    PubMed  CAS  Google Scholar 

  72. Thornsberry C, Ogilvie P, Kahn J, Mauriz Y (1997) Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996–1997 respiratory season. The Laboratory Investigator Group. Diagn Microbiol Infect Dis 29:249–257

    Article  PubMed  CAS  Google Scholar 

  73. Plant PK, Owen JL, Elliott MW (2000) Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet 355:1931–1935

    Article  PubMed  CAS  Google Scholar 

  74. Keenan SP, Kernerman PD, Cook DJ, Martin CM, McCormack D, Sibbald WJ (1997) Effect of noninvasive positive pressure ventilation on mortality in patients admitted with acute respiratory failure: a meta-analysis. Crit Care Med 25:1685–1692

    PubMed  CAS  Google Scholar 

  75. Mehta S, Hill NS (2001) Noninvasive ventilation. Am J Respir Crit Care Med 163:540–577

    PubMed  CAS  Google Scholar 

  76. Anton A, Guell R, Gomex J, et al (2000) Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitation. Chest 117:828–833

    Article  PubMed  CAS  Google Scholar 

  77. Ambrosino N, Foglio K, Rubini F, Clini E, Nava S, Vitacca M (1995) Non-invasive mechanical ventilation in acute respiratory failure due to chronic obstructive pulmonary disease: correlates for success. Thorax 50:755–757

    Article  PubMed  CAS  Google Scholar 

  78. Meduri G, Turner R, Abou-Shala N, Wunderink R, Tolley E (1996) Noninvasive positive pressure ventilation via face mask. First-line intervention in patients with hypercapnic and hypoxemic respiratory failure. Chest 109:179–193

    PubMed  CAS  Google Scholar 

  79. Anthonisen N, Connett J, Kiley J, et al (1994) Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: The Lung Health Study. JAMA 272:1497–1505

    Article  PubMed  CAS  Google Scholar 

  80. Higgins M, Enright P, Kronmal R, Schenker M, Anton-Culver H, Lyles M (1993) Smoking and lung function in elderly men and women. The cardiovascular health study. JAMA 269:2741–2748

    Article  PubMed  CAS  Google Scholar 

  81. Postma D, Sluiter H (1989) Prognosis of chronic obstructive pulmonary disease: the Dutch experience. Am Rev Respir Dis 140:S100–S105

    PubMed  CAS  Google Scholar 

  82. Wynder E, Kaufman P, Lesser R (1967) A short-term follow-up study on ex-cigarete smokers. With special emphasis on persistent cough and weight gain. Am Rev Respir Dis 96:645–655

    PubMed  CAS  Google Scholar 

  83. Rutger S, Postma D, ten Hacken N, et al (2000) Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax 55:12–18

    Google Scholar 

  84. Turato G, Di Stefano A, Maestrelli P, et al (1995) Effect of smoking cessation on airway inflammation in chronic bronchitis. Am J Respir Crit Care Med 152:1262–1267

    PubMed  CAS  Google Scholar 

  85. Kanner RE, Anthonisen NR, Connett JE, For the Lung Health STudy Research Group (2001) Lower respiratory illnesses promote FEV1 decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the Lung Health Study. Am J Respir Crit Care Med 164:358–364

    PubMed  CAS  Google Scholar 

  86. Fiore M (2000) US public health service clinical practice guidelines: treating tobacco use and dependence. Respir Care 45:1200–1262

    PubMed  CAS  Google Scholar 

  87. Jorenby D, Leischow S, Nides M, et al (1999) Acontrolled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340:685–691

    Article  PubMed  CAS  Google Scholar 

  88. Buscho R, Saxtan D, Shultz P, Finch E, Mufson M (1978) Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis 137:377–383

    PubMed  CAS  Google Scholar 

  89. Carilli A, Gohd R, Gordon W (1964) A virologic study of chronic bronchitis. N Engl J Med 270:123–127

    Article  PubMed  CAS  Google Scholar 

  90. Lamy M, Ponthier-Simon F, Debacker-Williame E (1973) Respiratory viral infections in hospital patients with chronic bronchitis. Chest 63:336–341

    PubMed  CAS  Google Scholar 

  91. Walsh E, Falsey A, Hennessey P (1999) Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med 160:791–795

    PubMed  CAS  Google Scholar 

  92. Smith C, Kanner R, Golden C, Klauber M, Renzetti AJ (1980) Effect of viral infection on pulmonary function in patients with chronic obstructive pulmonary disease. J Infect Dis 141:271–280

    PubMed  CAS  Google Scholar 

  93. Nichol K, Margolis K, Wuorenma J, Von Sternberg T (1994) The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med 331:778–784

    Article  PubMed  CAS  Google Scholar 

  94. Nichol K, Baken L, Nelson A (1999) Relation between influenza vaccination and outpatient visits, hospitalizations and mortality among elderly patients with chronic lung disease. Ann Intern Med 130:397–403

    PubMed  CAS  Google Scholar 

  95. Fine M, Smith M, Carson C, et al (1994) Efficacy of pneumococcal vaccination in adults. A meta-analysis of randomized controlled trials. Arch Intern Med 154:2666–2677

    PubMed  CAS  Google Scholar 

  96. Hutchison B, Oxman A, Shannon H, Lloyd S (1999) Clinical effectivenes of pneumococcal vaccines: Meta-analysis. Can Fam Physician 45:2381–2393

    PubMed  CAS  Google Scholar 

  97. Nichol K, Baken L, Wuorenma J, Nelson A (1999) The health and economic benefits associated with pneumococcal vaccination of elderly patients with chronic lung disease. Arch Intern Med 159:2437–2442

    Article  PubMed  CAS  Google Scholar 

  98. Butler J, Breiman R, Campbell J, Lipman H, Broome C, Facklam R (1993) Pneomococcal polysaccharide vaccine efficacy: an evaluation of current recommendations. JAMA 270:1826–1831

    Article  PubMed  CAS  Google Scholar 

  99. Advisory Committee on Immunization Practices (ACIP) (1997) Prevention of pneumococcal disease. MMWR Recomm Rep 46:1–24

    Google Scholar 

  100. Poole P, Black P (2000) Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2:CD001287

    Google Scholar 

  101. Stey C, Steurer J, Bachmann S, Medici T, Tramer N (2000) The effects of oral N-acetylcysteine in chronic bronchitis: a quantitative systemic review. Eur Respir J 16:253–262

    Article  PubMed  CAS  Google Scholar 

  102. Poole PJ, Black PN (2001) Oral mucolytic drugs for exacerbating of chronic obstructive pulmonary disease: a systemic review. Br Med J 322:1271–1274

    CAS  Google Scholar 

  103. Grandjean E, Berthet P, Ruffman R, Lenberger P (2000) Cost-effectiveness analysis of oral N-Acetylcysteine as a preventive treatment in chronic bronchitis. Pharmacol Res 42:39–50

    PubMed  CAS  Google Scholar 

  104. Abert R, Martin T, Lewis S (1980) Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med 92:753–758

    Google Scholar 

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  1. A. Anzueto
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Editors and Affiliations

  1. Intensive Care Service, Getafe University Hospital, Carretera de Toledo Km 12,500, 28905, Getafe Madrid, Spain

    Andrés Esteban M.D, Ph.D. (Chief) (Chief)

  2. St. Joseph’s Hospital, McMaster University, Hamilton, Ontario, L8N 325, Canada

    Deborah J. Cook M.D. (Academic Chair, Critical Care) (Academic Chair, Critical Care)

  3. Pulmonary/Critical Care Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA

    Antonio Anzueto M.D.

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Anzueto, A. (2005). Acute Exacerbation of Chronic Obstructive Pulmonary Diseases: What is the impact of bronchodilators, corticosteroids and antibiotics?. In: Esteban, A., Cook, D.J., Anzueto, A. (eds) Evidence-Based Management of Patients with Respiratory Failure. Update in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27314-X_11

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