Skip to main content
SpringerLink
Log in

Hepatic Sinusoidal Endothelial Cells

  • Chapter
Signaling Pathways in Liver Diseases

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selected Reading

  1. Wisse E, Braet F, Luo D et al. Structure and function of sinusoidal lining cells in the liver. Toxicol Pathol 1996;24:100–111. (This review summarizes the biology and function of HSEC and its neighboring cell types.)

    PubMed  Google Scholar 

  2. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003;125:917–936. (This review outlines approaches to protect the hepatic microcirculation from ischemic injury.)

    Article  PubMed  Google Scholar 

  3. Shah V. Cellular and molecular basis of portal hypertension. Clin Liver Dis 2001;5:629–644. (This review outlines mechanisms of endothelial cell pathobiology relevant to portal hypertension.)

    Article  PubMed  Google Scholar 

  4. Shah V, Kamath PS. Nitric oxide in liver transplantation: pathobiology and clinical implications. Liver Transplant 2003;9:1–11. (This review article outlines NO signaling as it relates to biologic processes relevant to liver transplantation.)

    Article  Google Scholar 

  5. Adams D. Leucocyte adhesion molecules and alcoholic liver disease. Alcohol Alcohol 1994;29:249–260.

    PubMed  Google Scholar 

  6. Anasagasti M, Alvarez A, Martin J et al. Sinusoidal endothelium release of hydrogen peroxide enhances very late antigen-4-mediated melanoma cell adherence and tumor cytotoxicity during interleukin-1 promotion of hepatic melanoma metastasis in mice. Hepatology 1997;25:840–846.

    Article  PubMed  Google Scholar 

  7. Arii S, Imamura M. Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J Hepatobiliary Pancreat Surg 2000;7:40–48.

    Article  PubMed  Google Scholar 

  8. Babbs C, Haboubi N, Mellor J et al. Endothelial cell transformation in primary biliary cirrhosis: a morphological and biochemical study. Hepatology 1990;11:723–729.

    PubMed  Google Scholar 

  9. Bauer M, Bauer I, Sonin N et al. Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver. Hepatology 2000;31:937–947.

    Article  PubMed  Google Scholar 

  10. Bird I, Spragg J, Ager A, Matthews N. Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO. Immunology 1993;80:553–560.

    PubMed  Google Scholar 

  11. Braet F, de Zanger R, Baekeland M et al. Structure and dynamics of the fenestrae-associated cytoskeleton of rat liver sinusoidal endothelial cells. Hepatology 1995;21:180–189.

    Article  PubMed  Google Scholar 

  12. Braet F, Luo D, Spector I et al. Endothelial and pit cells. In: Arias I, Boyer J, Chisari F et al, eds. The liver: biology and pathobiology (4th ed). Philadelphia: Lippincott Williams & Wilkins, 2001:438–453.

    Google Scholar 

  13. Braet F, Spector I, De Zanger R, Wisse E. A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide. Proc Natl Acad Sci USA 1998;95:13635–13640.

    Article  PubMed  Google Scholar 

  14. Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol 2002;23:1.

    Article  Google Scholar 

  15. Burt A, Le Bail B, Balabaud C, Bioulac-Sage P. Morphologic investigation of sinusoidal cells. Semin Liver Dis 1993;13:21–38.

    PubMed  Google Scholar 

  16. Caldwell-Kenkel J, Currin R, Tanaka Y et al. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991;13:83–95.

    Article  PubMed  Google Scholar 

  17. Caldwell-Kenkel J, Currin R, Tanaka Y et al. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989;10:292–299.

    PubMed  Google Scholar 

  18. Clark S, Angus H, Cook H et al. Defenestration of hepatic sinusoids as a cause of hyperlipidemia in alcoholics. Lancet 1988;2:1225–1227.

    Article  PubMed  Google Scholar 

  19. Clavien P. Sinusoidal endothelial cell injury during hepatic preservation and reperfusion. Hepatology 1998;28:281–285.

    Article  PubMed  Google Scholar 

  20. Cogger V, Mross P, Hosie M et al. The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacol Toxicol 2001;89:306–311.

    Article  PubMed  Google Scholar 

  21. Couvelard A, Scoazec J, Dauge M et al. Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans. Blood 1996;87:4568–4580.

    PubMed  Google Scholar 

  22. Couvelard A, Scoazec J, Feldmann G. Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver. Am J Pathol 1993;143:738–752.

    PubMed  Google Scholar 

  23. Deaciuc I, Spitzer J. Hepatic sinusoidal endothelial cell in alcoholemia and endotoxemia. Alcohol Clin Exp Res 1996;20:607–614.

    PubMed  Google Scholar 

  24. DeLeve L. Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther 1994;268:1261–1270.

    PubMed  Google Scholar 

  25. DeLeve L, Ito Y, Bethea N et al. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol 2003;284:G1045–G1052.

    Google Scholar 

  26. DeLeve L, McCuskey R, Wang X et al. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 1999;29:1779–1791.

    Article  PubMed  Google Scholar 

  27. DeLeve L, Shulman H, McDonald G. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 2002;22:27–41.

    Article  PubMed  Google Scholar 

  28. DeLeve L, Wang X, Huybrechts M. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology 1996;24:830–837.

    PubMed  Google Scholar 

  29. DeLeve L, Wang X, Kaplowitz N et al. Sinusoidal endothelial cells as a target for acetominophen toxicity. Biochem Pharmacol 1997;53:1339–1345.

    Article  PubMed  Google Scholar 

  30. DeLeve L, Wang X, Kuhlenkamp J, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology 1996;23:589–599.

    PubMed  Google Scholar 

  31. Dobbs B, Rogers W, Xing H, Fraser R. Endotoxin-induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis? Liver 1994;14:230–233.

    PubMed  Google Scholar 

  32. Enzan H, Hara H, Yamashita Y et al. Fine structure of hepatic sinusoids and their development in human embryos and fetuses. Acta Pathol Jpn 1983;33:447–466.

    PubMed  Google Scholar 

  33. Fraser R, Bowler L, Day W. Damage of rat liver sinusoidal endothelium by ethanol. Pathology 1980;12:371–376.

    PubMed  Google Scholar 

  34. Fraser R, Dobbs B, Rogers G. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology 1995;21:863–874.

    Article  PubMed  Google Scholar 

  35. Fulton D, Gratton J, Sessa W. Post-translational control of endothelial nitric oxide synthase: why isn’t calcium/calmodulin enough? J Pharmacol Exp Ther 2001;299:818–824.

    PubMed  Google Scholar 

  36. Gao W, Bentley R, Madden J, Clavien P. Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 1998;27:1652–1660.

    Article  PubMed  Google Scholar 

  37. Horn T, Christoffersen P, Henriksen J. Alcoholic liver injury: defenestration in noncirrhotic livers — a scanning electron microscopic study. Hepatology 1987;7:77–82.

    PubMed  Google Scholar 

  38. Jaeschke H. Chemokines, neutrophils, and inflammatory liver injury. Shock 1996;6:403–404.

    PubMed  Google Scholar 

  39. Kin M, Torimura T, Ueon T et al. Sinusoidal capillarization in small hepatocellular carcinoma. Pathol Int 1994;44:771–778.

    PubMed  Google Scholar 

  40. Knolle P, Germann T, Treichel U et al. Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. J Immunol 1999;162:1401–1407.

    PubMed  Google Scholar 

  41. Knolle P, Limmer A. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol 2001;22:432–437.

    Article  PubMed  Google Scholar 

  42. Knolle P, Schmitt E, Jin S et al. Induction of cytokine production in naive CD4+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Thl cells. Gastroenterology 1999;116:1428–1440.

    PubMed  Google Scholar 

  43. Knolle P, Uhrig A, Hegenbarth S et al. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clin Exp Immunol 1998;114:427–433.

    Article  PubMed  Google Scholar 

  44. Kohli V, Selzner M, Madden J et al. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 1999;67:1099–1105.

    Article  PubMed  Google Scholar 

  45. Lalor P, Adams D. Adhesion of lymphocytes to hepatic endothelium. J Clin Pathol: Mol Pathol 1999;52:214–219.

    Google Scholar 

  46. Laskin D, Gardner C, Price V, Jollow D. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology 1995;21:1045–1050.

    Article  PubMed  Google Scholar 

  47. Le Couteur D, Fraser R, Cogger V, McLean A. Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 2002;359:612–615.

    Google Scholar 

  48. Lohse A, Knoll P, Bilo K et al. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology 1996;110:1175–1181.

    Article  PubMed  Google Scholar 

  49. Magnusson S, Berg T. Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells. Biochem J 1989;257:651–656.

    PubMed  Google Scholar 

  50. McKeown C, Edwards V, Phillips M et al. Sinusoidal lining cell damage: the critical injury in cold preservation of liver allografts in the rat. Transplantation 1988;46:178–191.

    PubMed  Google Scholar 

  51. McNab G, Reeves J, Salmi M et al. Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium. Gastroenterology 1996;110: 522–528.

    Article  PubMed  Google Scholar 

  52. Mendoza L, Olaso E, Anasagasti M et al. Mannose receptor-mediated endothelial cell activation contributes to B16 melanoma cell adhesion and metastasis in liver. J Cell Physiol 1998;174:332–330.

    Article  Google Scholar 

  53. Mori T, Okanoue T, Sawa Y et al. Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis. Hepatology 1993;17:891–897.

    Article  PubMed  Google Scholar 

  54. Neubauer K, Wilfling T, Ritzel A, Ramadoria G. Platelet-endothelial cell adhesion molecule-1 gene expression in liver sinusoidal endothelial cells during liver injury and repair. J Hepatol 2000;32:921–932.

    Article  PubMed  Google Scholar 

  55. Okouchi Y, Sasaki K, Tamaki T. Ultrastructural changes in hepatocytes, sinusoidal endothelial cells and macrophages in hypothermic preservation of the rat liver with University of Wisconsin solution. Virchows Archiv 1994;424:477–484.

    Article  PubMed  Google Scholar 

  56. Rieder H, Armbrust T, Buschenfelde K, Ramadori G. Contribution of sinusoidal endothelial liver cells to liver fibrosis: expression of transforming growth factor-betal receptors and modulation of plasmin-generating enzymes by transforming growth factor-betal. Hepatology 1993;18:937–944.

    PubMed  Google Scholar 

  57. Rockey D, Chung J. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344–351.

    PubMed  Google Scholar 

  58. Rockey D, Chung J. Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis. Am J Physiol 1997;273:G124–G130.

    PubMed  Google Scholar 

  59. Rockey D, Chung J. Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am J Physiol 1996;271:G260–G267.

    PubMed  Google Scholar 

  60. Sakamoto S, Okanoue T, Itoh Y et al. Intercellular adhesion molecule-1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rats. Hepatology 1997;26:658–663.

    PubMed  Google Scholar 

  61. Sarphie T, D’Souza N, Deaciuc I. Kupffer cell inactivation prevents lipopolysaccharide-induced structural changes in the rat liver sinusoid: an electron-microscopic study. Hepatology 1996;23:788–796.

    PubMed  Google Scholar 

  62. Schulman H, Fisher L, Schoch H et al. Venoocclusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms. Hepatology 1994;19:1171–1180.

    Article  PubMed  Google Scholar 

  63. Shah V. Cellular and molecular basis of portal hypertension. Clin Liver Dis 2001;5:629–643.

    Article  PubMed  Google Scholar 

  64. Shah V. Hepatic circulation. In: Johnson LR, ed. Encyclopedia of gastroenterology. Elsevier, 2004:299–304.

    Google Scholar 

  65. Shah V, Cao S, Hendrickson H et al. Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats. Am J Physiol 2001;280:G1209–G1216.

    Google Scholar 

  66. Shah V, Haddad F, Garcia-Cardena G et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997;100:2923–2930.

    PubMed  Google Scholar 

  67. Shah V, Kamath P. Nitric oxide in liver transplantation: pathobiology and clinical implications. Liver Transplant 2003;9:1–11.

    Article  Google Scholar 

  68. Smedsrod B, Pertoft H, Eriksson S et al. Studies in vitro on the uptake and degradation of sodium hyaluronate in rat liver endothelial cells. Biochem J 1984;223:617–626.

    PubMed  Google Scholar 

  69. Steinberg P, Lafranconi W, Wolf R et al. Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver. Mol Pharmacol 1987;32:463–470.

    PubMed  Google Scholar 

  70. Steinberg P, Schlemper B, Molitor E et al. Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin Bl. Environ Health Perspect 1990;88:71–76.

    PubMed  Google Scholar 

  71. Steinhoff G, Behrend M, Schrader B et al. Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Am J Pathol 1993;142:481–488.

    PubMed  Google Scholar 

  72. Steinhoff G, Brandt M. Adhesion molecules in liver transplantation. Hepato-Gastroenterology 1996;43:1117–1123.

    PubMed  Google Scholar 

  73. Sun X, Kimura T, Kobayashi T et al. Viability of liver grafts from fasted donor rats: relationship to sinusoidal endothelial cell apoptosis. J Hepatobiliary Pancreat Surg 2001;8:268–273.

    Article  PubMed  Google Scholar 

  74. Thiele G, Miller J, Klassen L, Tuma D. Chronic ethanol consumption impairs receptor-mediated endocytosis of formaldehyde-treated albumin by isolated rat liver endothelial cells. Hepatology 1999;29:1511–1517.

    Article  PubMed  Google Scholar 

  75. Tsukamoto H, Lu S. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 2001;15:1335–1349.

    Article  PubMed  Google Scholar 

  76. Vidal-Vanaclocha F. The hepatic sinusoidal endothelium: functional aspects and phenotypic heterogeneity. In: Vidal-Vanaclocha F, ed. Functional heterogeneity of liver tissue. R.G. Landes Company, 1997:69–107.

    Google Scholar 

  77. Vidal-Vanaclocha F. Role of sinusoidal endothelium in the pathogenesis of liver disease. In: Vidal-Vanaclocha F, ed. Functional heterogeneity of liver tissue. R.G. Landes Company, 1997:109–132.

    Google Scholar 

  78. Vidal-Vanaclocha F, Alvarez A, Asumendi A et al. Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro. J Natl Cancer Inst 1996;88:198–204.

    PubMed  Google Scholar 

  79. Vidal-Vanaclocha F, Fantuzzi G, Mendoza L et al. IL-18 regulates IL-1 beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. PNAS 2000;97:734–739.

    Article  PubMed  Google Scholar 

  80. Wake K. Sinusoidal structure and dynamics. In: Vidal-Vanaclocha F, ed. Functional heterogeneity of liver tissue. R.G. Landes Company, 1997:57–67.

    Google Scholar 

  81. Wisse E. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrastructure Res 1970;31:125–150.

    Article  Google Scholar 

  82. Wisse E, Braet F, Luo D et al. Structure and function of sinusoidal lining cells in the liver. Toxicol Pathol 1996;24:100–111.

    PubMed  Google Scholar 

  83. Xu B, Broome U, Uzunel M et al. Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis. Am J Physiol 2003;163:1275–1289.

    Google Scholar 

  84. Yokoi Y, Nakamura S, Muro H, Baba S. Functional abnormalities of sinusoidal endothelial cells in rats with acute liver rejection. Transplantation 1994;57:27–31.

    PubMed  Google Scholar 

  85. Yoneda J, Saiki I, Kobayashi H etal. Inhibitory effect of recombinant fibronectin polypeptides on the adhesion of liver-metastatic lymphoma cells to hepatic sinusoidal endothelial cells and tumor invasion. Jpn J Cancer Res 1994;85:723–734.

    PubMed  Google Scholar 

Download references

Authors
  1. Roman E. Perri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vijay Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut Klinische Pharmakologie, Universität Bern, Murtenstrasse 35, 3010, Bern, Switzerland

    Jean-François Dufour

  2. Klinik für Viszeral- und Transplantationschirurgie, Universitätsspital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland

    Pierre-Alain Clavien

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Perri, R.E., Shah, V. (2005). Hepatic Sinusoidal Endothelial Cells. In: Dufour, JF., Clavien, PA., Trautwein, C., Graf, R. (eds) Signaling Pathways in Liver Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27194-5_5

Download citation

  • DOI: https://doi.org/10.1007/3-540-27194-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22934-6

  • Online ISBN: 978-3-540-27194-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation