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The Structure of Foot-and-Mouth Disease Virus

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Foot-and-Mouth Disease Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 288))

Abstract

Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.

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Authors and Affiliations

  1. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK

    E. E. Fry & D. I. Stuart

  2. School of Biochemistry and Microbiology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK

    D. J. Rowlands

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  1. Centers for Disease Control and Prevention, National Center for Infectious Diseases, Mailstop C 12, 1600 clifton road, Atlanta, GA, 30333, USA

    Brian W.J. Mahy

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Fry, E.E., Stuart, D.I., Rowlands, D.J. (2005). The Structure of Foot-and-Mouth Disease Virus. In: Mahy, B.W. (eds) Foot-and-Mouth Disease Virus. Current Topics in Microbiology and Immunology, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27109-0_4

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