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Contamination of Coagulation Factor Concentrates with Human Parvovirus Genotype 2 DNA is Less Frequent than Contamination with Genotype 1 (B19) DNA

  • Conference paper
34th Hemophilia Symposium

Conclusion

Human parvovirus genotype 1 (B19-like) DNA was frequently present in coagulation factor VIII concentrates used until the beginning of the eighties (contamination rate 81%). In concentrates presently used for replacement therapy, overall genotype 1 DNA contamination was about 42.5%. The level of viral load was similar in formerly used and presently used concentrates.

Genotype 2 DNA was detected much less frequently in coagulation factor concentrates than genotype 1 DNA. Overall, 2.5% of the lots proved to be contaminated. In the present study, all genotype 2 DNA-contaminated lots were also genotype 1-contaminated.

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Author information

Authors and Affiliations

  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin der Universitä, D-Bonn, Germany

    Dr. H. -H. Brackmann

  2. Institut für Medizinische Mikrobiologie und Immunologie, Universitätsklinikum Bonn, D-Bonn, Germany

    Frau Prof. Dr. A. M. Eis-Hübinger

Authors
  1. B. Schneider
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  2. M. Becker
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  3. U. Reber
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  4. Dr. H. -H. Brackmann
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  5. Frau Prof. Dr. A. M. Eis-Hübinger
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    I. Scharrer

  2. Dept. of Hemostaseology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    W. Schramm

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© 2005 Springer Medizin Verlag Heidelberg

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Schneider, B., Becker, M., Reber, U., Brackmann, H.H., Eis-Hübinger, A.M. (2005). Contamination of Coagulation Factor Concentrates with Human Parvovirus Genotype 2 DNA is Less Frequent than Contamination with Genotype 1 (B19) DNA. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_35

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  • DOI: https://doi.org/10.1007/3-540-27022-1_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22886-8

  • Online ISBN: 978-3-540-27022-5

  • eBook Packages: MedicineMedicine (R0)

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