Conclusion
Comparing actual data to those of the previous surveys we got very consistent findings indicating good data quality. In addition our data is comparable to that of international large-scale prevalence studies and registry data. Despite mortality from HIV in patients with hemophilia is keeping on decreasing, HIV still remains an important factor as an HIV/HCV coinfection seems to increase the risk of progression of liver disease to cirrhosis and hepatocellular carcinoma [8, 11]. A relevant portion of patients reported dead of cancer might have died of primary hepatocellular carcinoma induced by chronic HCV. This hypothesis has to be proved in future surveys by discriminating type of cancer. Moreover we will have to investigate the cohort of chronic HCV-infected patients in order to be able to calculate cumulative risks of death from liver disease in patients with hemophilia infected between 1969 and 1985 with HCV-contaminated blood products. Therefore there might be evident arguments especially in HIV-coinfected patients for an early onset of an HCV-therapy in spite of a good liver capacity and plain immunological conditions [2, 5].
on behalf of the participating German Hemophilia Centers
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Krebs, H., Schramm, W. (2005). HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2002/2003 Survey). In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_1
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