Photoreceptor Degeneration in Aging and Age-Related Maculopathy

  • Gregory R. Jackson
  • Christine A. Curcio
  • Kenneth R. Sloan
  • Cynthia Owsley


Retinal Pigment Epithelium Dark Adaptation Macular Pigment Photoreceptor Degeneration Foveal Cone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Age-Related Eye Disease Study Research (AREDS) Group (2000) Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3. Ophthalmology 107: 2224–2232Google Scholar
  2. Age-Related Eye Disease Study Research AREDS Group (2001) Report No. 8: a randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Ophthalmol 119: 1417–1436Google Scholar
  3. Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP (2003) Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 48: 257–293PubMedGoogle Scholar
  4. Ball K, Owsley C, Stalvey B, Roenker DL, Graves M (1998) Driving avoidance and functional impairment in older drivers. Accident Anal Prevent 30: 313–322Google Scholar
  5. Barlow H (1972) Dark and light adaptation: psychophysics. In: Hurvich L (ed) Handbook of sensory physiology, vol VII. Springer, New York, pp 1–28Google Scholar
  6. Beatty S, Boulton M, Henson D, Koh H-H, Murray IJ (1999) Macular pigment and age-related macular degeneration. Br J Ophthalmol 83: 867–877PubMedGoogle Scholar
  7. Birch DG, Anderson JL, Fish GE, Jost BF (1992) Pattern-reversal electroretinographic acuity in untreated eyes with subfoveal neovascular membranes. Invest Ophthalmol Vis Sci 33: 2097–2104PubMedGoogle Scholar
  8. Bressler NM, Bressler SB (2000) Photodynamic therapy with verteporfin (Visudyne): impact on ophthalmology and visual sciences. Invest Ophthalmol Vis Sci 41: 624–628PubMedGoogle Scholar
  9. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR (1994) Clinicopathological correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina 14: 130–142PubMedGoogle Scholar
  10. Bridges C, Alvarez R, Fong S (1982) Vitamin A in human eyes: amount, distribution, and composition. Invest Ophthalmol Vis Sci 22: 706–714PubMedGoogle Scholar
  11. Brown B, Adams AJ, Coletta NJ, Haegerstrom-Portnoy G (1985) Dark adaptation in age-related maculopathy. Ophthalmol Physiol Opt 6: 81–84Google Scholar
  12. Brown B, Tobin C, Roche N, Wolanowski A (1986) Cone adaptation in age-related maculopathy. Am J Ophthalmol Physiol Opt 63: 450–454Google Scholar
  13. Campochiaro PA (2000) Retinal and choroidal neovascularization. J Cell Physiol 184: 301–310CrossRefPubMedGoogle Scholar
  14. Carter-Dawson L, Kuwabara T, O’Brien P, Bieri J (1979) Structural and biochemical changes in vitamin A-deficient rat retinas. Invest Ophthalmol Vis Sci 18: 437–446PubMedGoogle Scholar
  15. Chen JC, Fitzke FW, Pauleikhoff D, Bird AC (1992) Functional loss in age-related Bruch’s membrane change with choroidal perfusion defect. Invest Ophthalmol Vis Sci 33: 334–340PubMedGoogle Scholar
  16. Ciulla TA, Danis RP, Harris A (1998) Age-related macular degeneration: a review of experimental treatments. Surv Ophthalmol 43: 134–146PubMedGoogle Scholar
  17. Copp RP, Wisniewski T, Hentati F, Larnaout A, Ben Hamida M, Kayden HJ (1999) Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res 822: 80–87CrossRefPubMedGoogle Scholar
  18. Council NAE (1998) Vision research — a national plan: 1999–2003. Executive summary. National Institutes of Health, Bethesda, MDGoogle Scholar
  19. Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, Sakaguchi H, Kamei M, Hasan A, Yan L, Rayborn ME, Salomon RG, Hollyfield JG (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA 99: 14682–14687CrossRefPubMedGoogle Scholar
  20. Crabtree DV, Adler AJ, Snodderly DM (1996a) Radial distribution of tocopherols in rhesus monkey retina and retinal pigment epithelium-choroid. Invest Ophthalmol Vis Sci 37: 61–76PubMedGoogle Scholar
  21. Crabtree DV, Adler AJ, Snodderly DM (1996b) Vitamin E, retinyl palmitate, and protein in rhesus monkey retina and retinal pigment epithelium-choroid. Invest Ophthalmol Vis Sci 37: 47–60PubMedGoogle Scholar
  22. Crabtree D, Snodderly D, Adler A (1997) Retinyl palmitate in macaque retina-retinal pigment epithelium-choroid: distribution and correlation with age and vitamin E. Exp Eye Res 64: 455–463CrossRefPubMedGoogle Scholar
  23. Curcio CA (2001) Photoreceptor topography in ageing and age-related maculopathy. Eye 15: 376–383PubMedGoogle Scholar
  24. Curcio CA, Millican CL (1999) Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Opthalmol 117: 329–339Google Scholar
  25. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292: 497–523CrossRefPubMedGoogle Scholar
  26. Curcio CA, Millican CL, Allen KA, Kalina RE (1993) Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34: 3278–3296PubMedGoogle Scholar
  27. Curcio CA, Medeiros NE, Millican CL (1996) Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci 37: 1236–1249PubMedGoogle Scholar
  28. Curcio CA, Saunders PL, Younger PW, Malek G (2000) Peripapillary chorioretinal atrophy: Bruch’s membrane changes and photoreceptor loss. Ophthalmology 107: 334–343CrossRefPubMedGoogle Scholar
  29. Curcio CA, Millican CL, Bailey T, Kruth HS (2001) Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci 42: 265–274PubMedGoogle Scholar
  30. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36: 718–729PubMedGoogle Scholar
  31. Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey CK (2000) Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci 41: 496–504PubMedGoogle Scholar
  32. Del Priore LV, Kuo Y-H, Tezel TH (2002) Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci 43: 3312–3318PubMedGoogle Scholar
  33. Dowling J, Wald G (1958) Vitamin A deficiency and night blindness. Proc Natl Acad Sci USA 44: 648–661Google Scholar
  34. Dunaief JL, Dentchev T, Ying GS, Milam AH (2002) The role of apoptosis in age-related macular degeneration. Arch Opthalmol 120: 1435–1442Google Scholar
  35. Eisner A, Fleming SA, Klein ML, Mauldin WM (1987) Sensitivities in older eyes with good acuity: eyes whose fellow eye has exudative AMD. Invest Ophthalmol Vis Sci 28: 1832–1837PubMedGoogle Scholar
  36. Eldred GE (1998) Lipofuscin and other lysosomal storage deposits in the retinal pigment epithelium. In: Wolfensberger TJ (ed) The retinal pigment epithelium: function and disease. Oxford University Press, New York, pp 651–668Google Scholar
  37. Feeney-Burns L, Ellersieck MR (1985) Age-related changes in the ultrastructure of Bruch’s membrane. Am J Ophthalmol 100: 686–697PubMedGoogle Scholar
  38. Feeney-Burns L, Hilderbrand E, Eldridge S (1984) Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci 25: 195–200PubMedGoogle Scholar
  39. Feeney-Burns L, Burns RP, Gao C-L (1990) Age-related macular changes in humans over 90 years old. Am J Ophthalmol 109: 265–278PubMedGoogle Scholar
  40. Friedrichson T, Kalbach HL, Buck P, Kuijk FJGM van (1995) Vitamin E in macular and peripheral tissues of the human eye. Curr Eye Res 14: 693–701PubMedGoogle Scholar
  41. Gao H, Rayborn ME, Meyers KM, Hollyfield JG (1990) Differential loss of neurons during aging of human retina. Invest Ophthalmol Vis Sci 31: 357Google Scholar
  42. Gellermann W, Ermakov IV, Ermakova MR, McClane RW, Zhao DY, Bernstein PS (2002) In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina. J Opt Soc Am A Opt Image Sci Vis 19: 1172–1186PubMedGoogle Scholar
  43. Goldstein EB, Wolf BM (1973) Regeneration of the green-rod pigment in the isolated frog retina. Vision Res 13: 527–534PubMedGoogle Scholar
  44. Gotoda T, Arita M, Arai H, Inoue K, Yokota T, Fukuo Y, Yazaki Y, Yamada N (1995) Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein. N Engl J Med 333: 1313–1318CrossRefPubMedGoogle Scholar
  45. Green WR, Enger C (1993) Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture. Ophthalmology 100: 1519–1535PubMedGoogle Scholar
  46. Macular Photocoagulation Study Group (1991) Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the Macular Photocoagulation Study. Arch Ophthalmol 109: 1242–1257Google Scholar
  47. Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM (2001) The lipid composition of drusen, Bruch’s membrane, and sclera by hot stage polarizing microscopy. Invest Ophthalmol Vis Sci 42: 1592–1599PubMedGoogle Scholar
  48. Handa JT, Verzijl N, Matsunaga H, Aotaki-Keen A, Lutty GA, Koppele JM te, Miyata T, Hjelmeland LM (1999) Increase in the advanced glycation end product pentosidine in Bruch’s membrane with age. Invest Ophthalmol Vis Sci 40: 775–779PubMedGoogle Scholar
  49. Harman AM, Fleming PA, Hoskins RV, Moore SR (1997) Development and aging of cell topography in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci 38: 2016–2026PubMedGoogle Scholar
  50. Hayward C, Shu X, Cideciyan AV, Lennon A, Barran P, Zareparsi S, Sawyer L, Hendry G, Dhillon B, Milam AH, Luthert PJ, Swaroop A, Hastie ND, Jacobson SG, Wright AF (2003) Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration. Hum Mol Genet 12: 2657–2667CrossRefPubMedGoogle Scholar
  51. Hecht S, Mandelbaum J (1939) The relation between vitamin A and dark adaptation. J Am Med Assoc 112: 1910–1916Google Scholar
  52. Heckenlively JR (1988) Retinitis pigmentosa. Lippincott, PhiladelphiaGoogle Scholar
  53. Hoang Q, Linsenmeier RA, Chung C, Curcio CA (2002) Photoreceptor inner segments in monkey and human retina: mitochondrial density, optics, and regional variation. Vis Neurosci 19: 395–407CrossRefPubMedGoogle Scholar
  54. Hogan MJ (1972) Role of the retinal pigment epithelium in macular disease. Trans Am Acad Ophthalmol Otolaryngol 76: 64–80PubMedGoogle Scholar
  55. Holopigian K, Seiple W, Greenstein V, Kim D, Carr RE (1997) Relative effects of aging and age-related macular degeneration on peripheral visual function. Optom Vis Sci 74: 152–159PubMedGoogle Scholar
  56. Holz FG, Schütt F, Kopitz J, Eldred GE, Kruse FE, Völcker HE, Cantz M (1999) Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 40: 737–743PubMedGoogle Scholar
  57. Holz FG, Bellman C, Staudt S, Schutt F, Volcker H (2001) Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 1051–1056PubMedGoogle Scholar
  58. Hood DC, Hock PA (1973) Recovery of cone receptor activity in the frog’s isolated retina. Vis Res 13: 1943–1951PubMedGoogle Scholar
  59. Huang S, Wu D, Jiang F, Ma J, Wu L, Liang J, Luo G (2000) The multifocal electroretinogram in age-related maculopathies. Doc Ophthalmol 101: 115–124CrossRefPubMedGoogle Scholar
  60. Hussain AA, Rowe L, Marshall J (2002) Age-related alterations in the diffusional transport of amino acids across the human Bruchs-choroid complex. J Opt Soc Am A 19: 166–172Google Scholar
  61. Hyman L, Schachat AP, He Q, Leske MC (2000) Hypertension, cardiovascular disease, and age-related macular degeneration. Arch Opthalmol 117: 351–358Google Scholar
  62. Jackson GR, Owsley C (2000) Scotopic sensitivity during adulthood. Vis Res 40: 2467–2473PubMedGoogle Scholar
  63. Jackson GR, Owsley C, Cordle EP, Finley CD (1998) Aging and scotopic sensitivity. Vis Res 38: 3655–3662PubMedGoogle Scholar
  64. Jackson GR, Edwards DJ, McGwin G, Owsley C (1999a) Changes in dark adaptation in early AMD. Invest Ophthalmol Vis Sci (Suppl) 40: 739Google Scholar
  65. Jackson GR, Owsley C, McGwin G (1999b) Aging and dark adaptation. Vis Res 39: 3975–3982PubMedGoogle Scholar
  66. Jacobson SG, Voigt WJ, Parel J-M, Apathy PP, Nghiem-Phu L, Myers SW, Patella VM (1986) Automated light-and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology 93: 1604–1611PubMedGoogle Scholar
  67. Jacobson SG, Cideciyan AV, Regunath G, Rodriguez FJ, Vandenburgh K, Sheffield VC, Stone EM (1995) Night blindness in Sorsby’s fundus dystrophy reversed by vitamin A. Nat Genet 11: 27–32CrossRefPubMedGoogle Scholar
  68. Johnson PT, Lewis GP, Talaga KC, Brown MN, Kappel PJ, Fisher SK, Anderson DH, Johnson LV (2003) Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci 44: 4481–4488CrossRefPubMedGoogle Scholar
  69. Jones GJ, Crouch RK, Wiggert B, Cornwall MC, Chader GJ (1989) Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors. Proc Natl Acad Sci USA 86: 9606–9610PubMedGoogle Scholar
  70. Jurklies B, Weismann M, Husing J, Sutter EE, Bornfeld N (2002) Monitoring retinal function in neovascular maculopathy using multifocal electroretinography — early and long-term correlation with clinical findings. Graefes Arch Clin Exp Ophthalmol 240: 244–264PubMedGoogle Scholar
  71. Karwatowski W, Jeffried T, Duance V, Albon J, Bailey A, Easty D (1995) Preparation of Bruch’s membrane and analysis of the age-related changes in the structural collagens. Br J Ophthalmol 79: 944–952PubMedGoogle Scholar
  72. Katz M, Kutryb M, Norberg M, Gao C, White R, Stark W (1991) Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats. Invest Ophthalmol Vis Sci 32: 1968–1980PubMedGoogle Scholar
  73. Katz M, Gao C, Stientjes H (1993) Regulation of the interphotoreceptor retinoid-binding protein content of the retina by vitamin A. Exp Eye Res 57: 393–401CrossRefPubMedGoogle Scholar
  74. Kayden HJ, Traber MG (1993) Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res 34: 343–358PubMedGoogle Scholar
  75. Kemp C, Jacobson S, Faulkner D, Walt R (1988) Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res 46: 185–197PubMedGoogle Scholar
  76. Kemp C, Jacobson S, Borruat F, Chaitin M (1989) Rhodopsin levels and retinal function in cats during recovery from vitamin A deficiency. Exp Eye Res 49: 49–65PubMedGoogle Scholar
  77. Kim RY, Faktorovich EG, Kuo CY, Olson JL (1997) Retinal function abnormalities in membranoproliferative glomerulonephritis type II. Am J Ophthalmol 123: 619–628PubMedGoogle Scholar
  78. Klein BE, Klein R, Lee KE, Jensen SC (2001) Measures of obesity and age-related eye diseases. Ophthalmic Epidemiol 8: 251–262CrossRefPubMedGoogle Scholar
  79. Klein R, Davis MD, Magli YL, Segal P, Klein BEK, Hubbard L (1991) The Wisconsin Age-Related Maculopathy Grading System. Ophthalmology 98: 1128–1134PubMedGoogle Scholar
  80. Klein R, Wang Q, Klein BEK, Moss SE, Meuer SM (1995) The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 36: 182–191PubMedGoogle Scholar
  81. Klein R, Klein BEK, Jensen SC, Meuer SM (1997) The five-year incidence and progression of age-related maculopathy. Ophthalmology 104: 7–21PubMedGoogle Scholar
  82. Klein R, Klein BE, Tomany SC, Meuer SM, Huang GH (2002) Ten-year incidence and progression of age-related maculopathy: the Beaver Dam eye study. Ophthalmology 109: 1767–1779PubMedGoogle Scholar
  83. Kosnik W, Winslow L, Kline D, Rasinski K, Sekuler R (1988) Visual changes in daily life throughout adulthood. J Gerontol 43: P63–70PubMedGoogle Scholar
  84. Lamb TD, Cideciyan AV, Jacobson SG, Pugh EN (1998) Towards a molecular description of human dark adaptation. J Physiol (Lond) 506: 88Google Scholar
  85. Lambooij AC, Kliffen M, Kuijpers RWAM, Houtsmuller AB, Broese JJ, Mooy CM (2000) Apoptosis is present in the primate macula at all ages. Graefes Arch Clin Exp Ophthalmol 238: 508–514PubMedGoogle Scholar
  86. Landrum JT, Bone RA, Joa H, Kilburn MD, Moore LL, Sprague KE (1997) A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Exp Eye Res 65: 57–62CrossRefPubMedGoogle Scholar
  87. LaVail MM (1981) Analysis of neurological mutants with inherited retinal degeneration. Invest Ophthalmol Vis Sci 21: 638–657PubMedGoogle Scholar
  88. Leibrock CS, Reuter T, Lamb TD (1998) Molecular basis of dark adaptation in rod photoreceptors. Eye 12: 511–520PubMedGoogle Scholar
  89. Li T, Sandberg MA, Pawlyk BS, Rosner B, Hayes KC, Dryja TP, Berson EL (1998) Effect of vitamin A supplementation on rhodopsin mutants threonine-17 →methionine and proline-347_serine in transgenic mice and in cell cultures. Proc Natl Acad Sci USA 95: 11933–11938PubMedGoogle Scholar
  90. Linsenmeier RA, Padnick-Silver L (2000) Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci 41: 3117–3123PubMedGoogle Scholar
  91. Macular Photocoagulation Study Group (1997) Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol 115: 741–747Google Scholar
  92. Malek G, Li C-M, Guidry C, Medeiros NE, Curcio CA (2003) Apolipoprotein B in cholesterol-containing drusen and basal deposits in eyes with age-related maculopathy. Am J Pathol 162: 413–425PubMedGoogle Scholar
  93. Mangelsdorf DJ (1994) The retinoid receptors. In: Goodman D (ed) The retinoids: biology, chemistry, and medicine, 2nd edn. Raven Press, New York, pp 319–350Google Scholar
  94. Marshall J, Hussain AA, Starita C, Moore DJ, Patmore AL (1998) Aging and Bruch’s membrane. In: Wolfensberger TJ (ed) The retinal pigment epithelium: function and disease. Oxford University Press, New York, pp 669–692Google Scholar
  95. Mata N, Tzekov R, Liu X, Weng J, Birch D, Travis G (2001) Delayed dark-adaptation and lipofuscin accumulation in abcr+/− mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 1685–1690PubMedGoogle Scholar
  96. Mata N, Radu R, Clemmons R, Travis G (2002) Isomerization and oxidation of vitamin a in cone-dominant retinas. A novel pathway for visual-pigment regeneration in daylight. Neuron 36: 69CrossRefPubMedGoogle Scholar
  97. Mayer MJ, Ward B, Klein R, Talcott JB, Dougherty RF, Glucs A (1994) Flicker sensitivity and fundus appearance in pre-exudative age-related maculopathy. Invest Ophthalmol Vis Sci 35: 1138–1149PubMedGoogle Scholar
  98. McBee JK, Palczewski K, Baehr W, Pepperberg DR (2001) Confronting complexity: the interlink of photo-transduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res 20: 469–529CrossRefPubMedGoogle Scholar
  99. McGwin GJ, Owsley C, Curcio CA, Crain RJ (2003) The association between statin use ang age related maculopathy. Br J Ophthalmol 87: 1–5CrossRefGoogle Scholar
  100. Medeiros NE, Curcio CA (2001) Preservation of ganglion cell layer neurons in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 795–803PubMedGoogle Scholar
  101. Midena E, Degli Angeli C, Blarzino MC, Valenti M, Segato T (1997) Macular function impairment in eyes with early age-related macular degeneration. Invest Ophthalmol Vis Sci 38: 469–477PubMedGoogle Scholar
  102. Mohand-Said S, Deudon-Combe A, Hicks D, Simonutti M, Forster V, Fintz AC, Leveillard T, Dreyfus H, Sahel JA (1998) Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci USA 95: 8357–8362CrossRefPubMedGoogle Scholar
  103. Moore DJ, Clover GM (2001) The effect of age on the macromolecular permeability of human Bruch’s membrane. Invest Ophthalmol Vis Sci 42: 2970–2975PubMedGoogle Scholar
  104. Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch’s membrane. Invest Ophthalmol Vis Sci 36: 1290–1297PubMedGoogle Scholar
  105. Organisciak DT, Berman ER, Wang HM, Feeney-Burns L (1987) Vitamin E in human neural retina and retinal pigment epithelium: effect of age. Curr Eye Res 6: 1051–1055PubMedGoogle Scholar
  106. Østerberg GA (1935) Topography of the layer of rods and cones in the human retina. Acta Ophthalmol 13(Suppl 6): 1–103Google Scholar
  107. Owsley C, Jackson GR, Cideciyan AV, Huang Y, Fine SL, Ho AC, Maguire MG, Lolley V, Jacobson SG (2000) Psychophysical evidence for rod vulnerability in age-related macular degeneration. Invest Ophthalmol Vis Sci 41: 267–273PubMedGoogle Scholar
  108. Owsley C, Jackson GR, White M, Feist R, Edwards DJ (2001) Delays in rod-mediated dark adaptation in early age-related maculopathy. Ophthalmology 108: 1196–1202CrossRefPubMedGoogle Scholar
  109. Panda-Jonas S, Jonas JB, Jokobczyk-Zmija (1995) Retinal photoreceptor density decreases with age. Ophthalmology 102: 1853–1859PubMedGoogle Scholar
  110. Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J (1998) Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 95: 14609–14613CrossRefPubMedGoogle Scholar
  111. Pauleikhoff D, Harper CA, Marshall J, Bird AC (1990) Aging changes in Bruch’s membrane: a histochemical and morphological study. Ophthalmology 97: 171–178PubMedGoogle Scholar
  112. Phipps JA, Guymer RH, Vingrys AJ (2003) Loss of cone function in age-related maculopathy. Invest Ophthalmol Vis Sci 44: 2277–2283CrossRefPubMedGoogle Scholar
  113. Polyak SL (1941) The retina. University of Chicago, ChicagoGoogle Scholar
  114. Rakoczy PE, Zhang D, Robertson T, Barnett NL, Papadimitriou J, Constable IJ, Lai CM (2002) Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am J Pathol 161: 1515–1524PubMedGoogle Scholar
  115. Ramrattan RS, Schaft TL van der, Mooy CM, Bruijn WC de, Mulder PGH, Jong PTVM de (1994) Morphometric analysis of Bruch’s membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol Vis Sci 35: 2857–2864PubMedGoogle Scholar
  116. Remé CE, Grimm C, Hafezi F, Iseli HP, Wenzel A (2003) Why study rod cell death in retinal degenerations and how? Doc Ophthalmol 106: 25–29PubMedGoogle Scholar
  117. Remky A, Lichtenberg K, Elsner AE, Arend O (2001) Short wavelength automated perimetry in age related maculopathy. Br J Ophthalmol 85: 1432–1436CrossRefPubMedGoogle Scholar
  118. Ridge KD, Abdulaev NG, Sousa M, Palczewski K (2003) Phototransduction: crystal clear. Trends Biochem Sci 28: 479–487PubMedGoogle Scholar
  119. Robison WG Jr, Kuwabara T, Bieri JG (1980) Deficiencies of vitamins E and A in the rat. Retinal damage and lipofuscin accumulation. Invest Ophthalmol Vis Sci 19: 1030–1037PubMedGoogle Scholar
  120. Ruberti JW, Curcio CA, Millican CL, Menco BPM, Huang J-D, Johnson M (2003) Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch’s membrane. Invest Ophthalmol Vis Sci 44: 1753–1759CrossRefPubMedGoogle Scholar
  121. Rückmann A von, Fitzke FW, Bird AC (1997) Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38: 478–486Google Scholar
  122. Saari J (1994) Retinoids in photosensitive systems. In: Goodman D (ed) The retinoids: biology, chemistry, and medicine, 2nd edn. Raven Press, New York, pp 351–385Google Scholar
  123. Samuel W, Kutty RK, Nagineni S, Gordon JS, Prouty SM, Chandraratna RAS, Wiggert B (2001) Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid. J Biol Chem 276: 28744–28750PubMedGoogle Scholar
  124. Sarks SH (1976) Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol 60: 324–341PubMedGoogle Scholar
  125. Schutt F, Davies S, Kopitz J, Holz F, Boulton M (2000) Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 41: 2303–2308PubMedGoogle Scholar
  126. Scilley K, Jackson GR, Cideciyan AV, Maguire MG, Jacobson SG, Owsley C (2002) Early age-related maculopathy and self-reported visual difficulty in daily life. Ophthalmology 109(7): 1235–1242CrossRefPubMedGoogle Scholar
  127. Seddon JM, Cote J, Davis N, Rosner B (2003) Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Opthalmol 121: 785–792Google Scholar
  128. Smith W, Assink J, Klein R, Mitchell P, Klaver CCW, Klein BEK, Hofman A, Jensen S, Wang JJ, Jong PTVM de (2001) Risk factors for age-related macular degeneration. Pooled findings from three continents. Ophthalmology 108: 697–704CrossRefPubMedGoogle Scholar
  129. Snodderly DM (1995) Evidence for protection against age-related macular degeneration (AMD) by carotenoids and antioxidant vitamins. Am J Clin Nutr 62(Suppl): 1448S–1461SPubMedGoogle Scholar
  130. Spraul CW, Grossniklaus HE (1997) Characteristics of drusen and Bruch’s membrane in postmortem eyes with age-related macular degeneration. Arch Opthalmol 115: 267–273Google Scholar
  131. Spraul CW, Lang GE, Grossniklaus HE (1996) Morphometric analysis of the choroid, Bruch’s membrane, and retinal pigment epithelium in eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci 37: 2724–2735PubMedGoogle Scholar
  132. Stone E, Sheffield V, Hageman G (2001) Molecular genetics of age-related macular degeneration. Hum Mol Genet 10: 2285–2292CrossRefPubMedGoogle Scholar
  133. Streeten BW (1969) Development of the human retinal pigment epithelium and the posterior segment. Arch Opthalmol 81: 383–394Google Scholar
  134. Sunness J, Massof R, Johnson M, Rubin G, Fine SL (1989)Google Scholar
  135. Dimished foveal sensitivity may predict the development of advanced age-related macular degeneration. Ophthalmology 96: 375–381Google Scholar
  136. Suter M, Reme C, Grimm C, Wenzel A, Jaattela M, Esser P, Kociok N, Leist M, Richter C (2000) Age-related macular degeneration. The lipofusion component Nretinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem 275: 39625–39630PubMedGoogle Scholar
  137. Thompson DA, Gal A (2003) Vitamin A metabolism in the retinal pigment epithelium: genes, mutations, and diseases. Prog Retin Eye Res 22: 683–703CrossRefPubMedGoogle Scholar
  138. Tolentino MJ, Miller S, Gaudio AR, Sandberg MA (1994) Visual field deficits in early age-related macular degeneration. Vis Res 34: 409–413PubMedGoogle Scholar
  139. Tso MOM, Friedman E (1968) The retinal pigment epithelium. III. Growth and development. Arch Opthalmol 80: 214–216Google Scholar
  140. Van Hooser JP, Aleman TS, He Y-G, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K (2000) Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA 97: 8623–8628PubMedGoogle Scholar
  141. Vogel S, Piantedosi R, O’Byrne SM, Kako Y, Quadro L, Gottesman ME, Goldberg IJ, Blaner WS (2002) Retinol-binding protein-deficient mice: biochemical basis for impaired vision. Biochemistry 41: 15360–15368PubMedGoogle Scholar
  142. Wald G (1935) Carotenoids and the visual cycle. J Gen Physiol 19: 351CrossRefGoogle Scholar
  143. Wang Q, Chappell RJ, Klein R, Eisner A, Klein BEK, Jensen SC, Moss SE (1996) Pattern of age-related maculopathy in the macular area. The Beaver Dam eye study. Invest Ophthalmol Vis Sci 37: 2234–2242PubMedGoogle Scholar
  144. Watzke RC, Soldevilla JD, Trune DR (1993) Morphometric analysis of human retinal pigment epithelium: correlation with age and location. Curr Eye Res 12: 133–142PubMedGoogle Scholar
  145. Weber BH, Lin B, White K, Kohler K, Soboleva G, Herterich S, Seeliger MW, Jaissle GB, Grimm C, Reme C, Wenzel A, Asan E, Schrewe H (2002) A mouse model for Sorsby fundus dystrophy. Invest Ophthalmol Vis Sci 43: 2732–2740PubMedGoogle Scholar
  146. Werner JS, Donnelly SK, Kliegl R (1987) Aging and human macular pigment density. Vis Res 27: 257–268PubMedGoogle Scholar
  147. Xu GZ, Li WW, Tso MO (1996) Apoptosis in human retinal degenerations. Trans Am Ophthalmol Soc 94: 411–430; 430–431PubMedGoogle Scholar
  148. Yamada E (1969) Some structural features of the fovea centralis of the human retina. Arch Opthalmol 82: 151–159Google Scholar
  149. Yokota T, Shiojiri T, Gotoda T, Arita M, Arai H, Ohga T, Kanda T, Suzuki J, Imai T, Matsumoto H, Harino S, Kiyosawa M, Mizusawa H, Inoue K (1997) Friedreich-like ataxia with retinitis pigmentosa caused by the His101Gln mutation of the alpha-tocopherol transfer protein gene. Ann Neurol 41: 826–832CrossRefPubMedGoogle Scholar
  150. Yokota T, Igarashi K, Uchihara T, Jishage K-i, Tomita H, Inaba A, Li Y, Arita M, Suzuki H, Mizusawa H, Arai H (2001) Delayed-onset ataxia in mice lacking alpha-tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci USA 98: 15185–15190CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Gregory R. Jackson
  • Christine A. Curcio
  • Kenneth R. Sloan
  • Cynthia Owsley

There are no affiliations available

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