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Atomic Force Microscopy in Nanomedicine

  • Dessy Nikova
  • Tobias Lange
  • Hans Oberleithner
  • Hermann Schillers
  • Andreas Ebner
  • Peter Hinterdorfer
Part of the NanoScience and Technology book series (NANO)

12.6 Summary

The combination of AFM with conventional techniques, as well as AFM itself, allows answering biomedical questions of high interest. We could show this clearly for CFTR with single molecule imaging and observation of structural dynamics in native cell membranes. AFM also allows identification and determination of CFTR at single molecule level. The observation that the lack of CFTR influences the mechanical and, therefore, rheological properties of RBC could lead to a novel therapeutic approach for CF treatment. Regarding the fact that the defect of a single protein causes lethal diseases, research at the single molecule level would become vital in the future.

Keywords

Atomic Force Micro Mica Surface Membrane Patch Single Molecule Level Membrane Isolation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Dessy Nikova
    • 1
  • Tobias Lange
    • 1
  • Hans Oberleithner
    • 1
  • Hermann Schillers
    • 1
  • Andreas Ebner
    • 2
  • Peter Hinterdorfer
    • 2
  1. 1.Institute of Physiology IIMuensterGermany
  2. 2.Institute for BiophysicsJ. Kepler UniversityLinzAustria

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