Ectopic Cushing’s Syndrome

  • D. Vassiliadi
  • S. Tsagarakis
  • N. Thalassinos


Bronchial Carcinoid POMC mRNA Thymic Carcinoid Ectopic ACTH Syndrome POMC Gene 
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  1. 1.
    Ajani JA, Legha SS, Karlin DA, Stratton Hill C (1983) Combination chemotherapy of metastatic carcinoid tumors with 5-FU, adriamycin, mitomycin and methyl-CCNU. Proc Am Assoc Clin Oncol 2:124 (Abstract C-486)Google Scholar
  2. 2.
    Amikura K, Alexander HR, Norton JA, Doppman JL, Jensen RT, Nieman L, Cutler G, Chrousos G, Fraker DL (1995) Role of surgery in management of adrenocorticotropic hormone-producing islet cell tumors of the pancreas. Surgery 118:1125–1130PubMedGoogle Scholar
  3. 3.
    Aniszewski JP, Young WF Jr, Thompson GB, Grant CS, van Heerden JA (2001) Cushing syndrome due to ectopic adrenocorticotropic hormone secretion. World J Surg 25:934–940CrossRefPubMedGoogle Scholar
  4. 4.
    Arioglu E, Doppman J, Gomes M, Kleiner D, Mauro D, Barlow C, Papanicolaou DA (1998) Cushing’s syndrome caused by corticotropin secretion by pulmonary tumor-lets. N Engl J Med 24;339:883–886CrossRefGoogle Scholar
  5. 5.
    Arnaldi G, de Keyzer Y, Gasc JM, Clauser E, Bertagna X (1998) Vasopressin receptors modulate the pharmacological phenotypes of Cushing’s syndrome. Endocr Res 24: 807–816PubMedGoogle Scholar
  6. 6.
    Aron DC, Raff H, Findling JW (1997) Effectiveness versus efficacy: the limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 82:1780–1785CrossRefPubMedGoogle Scholar
  7. 7.
    Bertagna X (1994) Proopiomelanocortin-derived peptides. Endocrinol Metab Clin North Am 23:467–485PubMedGoogle Scholar
  8. 8.
    Beuschlein F, Hammer GD (2002) Ectopic proopiomelanocortin syndrome. Endocrinol Metab Clin North Am 31:191–234CrossRefPubMedGoogle Scholar
  9. 9.
    Blumgart LH, Allison DJ (1982) Resection and embolization in the management of secondary hepatic tumors. World J Surg 6:32–45CrossRefPubMedGoogle Scholar
  10. 10.
    Bukowski RM, John KG, Peterson RF, Stephens RL, Rivkin SE, Neilan B, Costanzi JH (1987) A phase II trial of combination chemotherapy in patients with metastatic carcinoid tumors. A Southwest Oncology Group Study. Cancer 60:2891–2895PubMedGoogle Scholar
  11. 11.
    Christin-Maitre S, Chabbert-Buffet N, Mure A, Boukhris R, Bouchard P (1996) Use of somatostatin analog for localization and treatment of ACTH secreting bronchial carcinoid tumor. Chest 109:845–846PubMedGoogle Scholar
  12. 12.
    Clark ES, Carney JA (1984) Pancreatic islet cell tumor associated with Cushing’s syndrome. Am J Surg Pathol 8:917–924PubMedGoogle Scholar
  13. 13.
    Comi RJ, Gorden P (1998) Long-term medical treatment of ectopic ACTH syndrome. South Med J 91:1014–1018PubMedGoogle Scholar
  14. 14.
    De Keyzer Y, Bertagna X, Lenne F, Girard F, Luton JP, Kahn A (1985) Altered proopiomelanocortin gene expression in adrenocorticotropin-producing nonpituitary tumors. Comparative studies with corticotropic adenomas and normal pituitaries. J Clin Invest 76:1892–1898PubMedGoogle Scholar
  15. 15.
    De Keyzer Y, Bertagna X, Luton JP, Kahn A (1989) Variable modes of proopiomelanocortin gene transcription in human tumors. Mol Endocrinol 3:215–223PubMedGoogle Scholar
  16. 16.
    De Keyzer Y, Lenne F, Auzan C, Jegou S, Rene P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X (1996) The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J Clin Invest 97:1311–1318PubMedGoogle Scholar
  17. 17.
    De Keyzer Y, Raffin-Sanson ML, Picon A, Bertagna X (2001) Syndromes of ectopic ACTH secretion: recent pathophysiological aspects. In: Margioris AN, Chrousos GP (eds) Adrenal disorders. Humana Press, Totowa, NJ, pp 165–178Google Scholar
  18. 18.
    DeBold CR, Menefee JK, Nicholson WE, Orth DN (1988) Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Mol Endocrinol 2:862–870PubMedGoogle Scholar
  19. 19.
    Delisle L, Boyer MJ, Warr D, Killinger D, Payne D, Yeoh JL, Feld R (1993) Ectopic corticotropin syndrome and small-cell carcinoma of the lung. Clinical features, outcome, and complications. Ann Intern Med 153:746–752CrossRefGoogle Scholar
  20. 20.
    Dichek HL, Nieman LK, Oldfield EH, Pass HI, Malley JD, Cutler GB Jr (1994) A comparison of the standard high dose dexamethasone suppression test and the overnight 8-mg dexamethasone suppression test for the differential diagnosis of adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 78:418–422CrossRefPubMedGoogle Scholar
  21. 21.
    Doppman JL, Chang R, Oldfield EH, Chrousos G, Stratakis CA, Nieman LK (1999) The hypoplastic inferior petrosal sinus: a potential source of false-negative results in petrosal sampling for Cushing’s disease. J Clin Endocrinol Metab 84:533–540CrossRefPubMedGoogle Scholar
  22. 22.
    Doppman JL, Nieman LK, Cutler GB Jr, Chrousos GP, Fraker DL, Norton JA, Jensen RT (1994) Adrenocorticotropic hormone-secreting islet cell tumors: are they always malignant? Radiology 190:59–64PubMedGoogle Scholar
  23. 23.
    Doppman JL, Pass HI, Nieman LK, Findling JW, Dwyer AJ, Feuerstein IM, Ling A, Travis WD, Cutler GB Jr, Chrousos GP, Loriaux DL (1991) Detection of ACTH-producing bronchial carcinoid tumors: MR imaging vs CT. AJR 156:39–43PubMedGoogle Scholar
  24. 24.
    Doppman JL (1994) Somatostatin receptor scintigraphy and the ectopic ACTH syndrome. The solution or just another test? Am J Med 96:303–304CrossRefPubMedGoogle Scholar
  25. 25.
    Du Pont AG, Somers G, Van Steiterghem AC, Warson F, Vanhaelst L (1984) Ectopic adrenocorticotropin production: disappearance after removal of inflammatory tissue. J Clin Endocrinol Metab 58:654–658PubMedGoogle Scholar
  26. 26.
    Eriksson B, Oberg K, Alm G, Karlsson A, Lundqvist G, Andersson T, Wilander E, Wide L (1986) Treatment of malignant endocrine pancreatic tumors with human leucocyte interferon. Lancet 2:1307–1309CrossRefPubMedGoogle Scholar
  27. 27.
    Farwell AP, Devlin JT, Stewart JA (1988) Total suppression of cortisol excretion by ketoconazole in the therapy of the ectopic adrenocorticotropic hormone syndrome. Am J Med 84:1063–1066CrossRefPubMedGoogle Scholar
  28. 28.
    Findling JW, Kehoe ME, Shaker JL, Raff H (1991) Routine inferior petrosal sinus sampling in the differential diagnosis of adrenocortical (ACTH)-dependent Cushing’s syndrome: early recognition of the occult ectopic ACTH syndrome. J Clin Endocrinol Metab 73:408–413PubMedGoogle Scholar
  29. 29.
    Friedman TC, Loh YP, Birch NP (1994) In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3). Endocrinology 135:854–862CrossRefPubMedGoogle Scholar
  30. 30.
    Grossman AB, Howlett TA, Perry L, Coy DH, Savage MO, Lavender-P, Rees LH, Besser GM (1988) CRF in the differential diagnosis of Cushing’s syndrome: a comparison with the dexamethasone suppression test. Clin Endocrinol (Oxf) 29:167–178Google Scholar
  31. 31.
    Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353–357PubMedGoogle Scholar
  32. 32.
    Howlett TA, Drury PL, Perry L, Doniach I, Rees LH, Besser GM (1986) Diagnosis and management of ACTH-dependent Cushing’s syndrome: comparison of the features in ectopic and pituitary ACTH production. Clin Endocrinol (Oxf) 24:699–713Google Scholar
  33. 33.
    Invitti C, Giraldi FP, Cavagnini F (1999) Inferior petrosal sinus sampling in patients with Cushing’s syndrome and contradictory responses to dynamic testing. Clin Endocrinol (Oxf) 51:255–257CrossRefGoogle Scholar
  34. 34.
    Invitti C, Giraldi FP, de Martin M, Cavagnini F (1999) Diagnosis and management of Cushing’s syndrome: results of an Italian multicentre study. Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis. J Clin Endocrinol Metab 84:440–448CrossRefPubMedGoogle Scholar
  35. 35.
    Ishido H, Yamashita N, Kitaoka M, Tanaka Y, Ogata E (1994) A case of ectopic ACTH syndrome associated with Zollinger-Ellison syndrome: long-term survival with chemical adrenalectomy. Endocr J 41:171–176PubMedGoogle Scholar
  36. 36.
    Jeannotte L, Burbach JP, Drouin J (1987) Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues: intronless transcripts in testes and log poly(A) tails in hypothalamus. Mol Endocr 1:749–757Google Scholar
  37. 37.
    Kaltsas T, Krassas GE, Pontikides N, Tsotsia E, Tsagarakis S (2003) Cyclical Cushing syndrome caused by intermittent ectopic ACTH hormonogenesis responsive to somatostatin analogues. Endocrinologist 13:7–11Google Scholar
  38. 38.
    Kato Y, Ferguson TB, Bennett DE, Burford TH (1969) Oat cell carcinoma of the lung. A review of 138 cases. Cancer 23:517–524PubMedGoogle Scholar
  39. 39.
    Kaye TB, Crapo L (1990) The Cushing syndrome: An update on diagnostic tests. Ann Intern Med 112:434–444PubMedGoogle Scholar
  40. 40.
    Kuhn JM, Proeschel MF, Seurin DJ, Bertagna XY, Luton JP, Girard FL (1989) Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing’s syndrome: a study of 210 cases. Am J Med 86:678–684CrossRefPubMedGoogle Scholar
  41. 41.
    Kulke MH, Mayer RJ (1999) Carcinoid tumors. N Engl J Med 340:858–868CrossRefPubMedGoogle Scholar
  42. 42.
    Lam EW, La Thangue NB (1994) DP and E2F proteins: coordinating transcription with cell cycle progression. Curr Opin Cell Biol 6:859–866. ReviewCrossRefPubMedGoogle Scholar
  43. 43.
    Lamberts SWS, Krenning EP, Reubi JC (1991) The role of somatostatin and its analogue in the diagnosis and treatment of tumors. Endocr Rev 12:450–482PubMedGoogle Scholar
  44. 44.
    Liddle GW, Island DP, Meador CK (1962) Normal and abnormal regulation of corticotropin secretion in man. Recent Prog Horm Res 18:125–166Google Scholar
  45. 45.
    Lyons DF, Eisen BR, Clark MR, Pysher TJ, Welsh JD, Kem DC (1984) Concurrent Cushing’s and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. Am J Med 76: 729–733CrossRefPubMedGoogle Scholar
  46. 46.
    Makita M, Maeda Y, Hashimoto K, Nakase K, Takenaka K, Shinagawa K, Ishimaru F, Ikeda K, Niiya K, Ogura T, Harada M (2003) Acute lymphoblastic leukemia with large molecular ACTH production. Ann Hematol 82: 448–451CrossRefPubMedGoogle Scholar
  47. 47.
    Malerbi DA, Mendonca BB, Liberman B, Toledo SP, Corradini MC, Cunha-Neto MB, Fragoso MC, Wajchenberg BL (1993) The desmopressin stimulation test in the differential diagnosis of Cushing’s syndrome. Clin Endocrinol (Oxf) 38:463–472Google Scholar
  48. 48.
    Miller JW, Crapo L (1993) The medical treatment of Cushing’s syndrome. Endocr Rev 14:443–458Google Scholar
  49. 49.
    Moertel CG, Kvols LK, O’Connell MJ, Rubin J (1991) Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 68:227–232PubMedGoogle Scholar
  50. 50.
    Naidich DP (1990) CT/MR correlation in the evaluation of tracheobronchial neoplasia. Radiol Clin North Am 28: 555–571PubMedGoogle Scholar
  51. 51.
    Newell-Price J, Perry L, Medbak S, Monson J, Savage M, Besser M, Grossman A (1997) A combined test using desmopressin and corticotropin-releasing hormone in the differential diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 82:176–181CrossRefPubMedGoogle Scholar
  52. 52.
    Newell-Price J, Trainer P, Besser M, Grossman A (1998) The diagnosis and differential diagnosis of Cushing’s syndrome and pseudo-Cushing’s states. Endocr Rev 19: 647–672CrossRefPubMedGoogle Scholar
  53. 53.
    Nieman LK, Chrousos GP, Oldfield EH, Avgerinos PC, Cutler GB Jr, Loriaux DL (1986) The ovine corticotropin-releasing hormone stimulation test and the dexamethasone suppression test in the differential diagnosis of Cushing’s syndrome. Ann Intern Med 105:862–867PubMedGoogle Scholar
  54. 54.
    Oberg K, Norheim I, Alm G (1989) Treatment of malignant carcinoid tumors: a randomized controlled study of streptozotocin plus 5-FU and human leucocyte interferon. Eur J Cancer Clin Oncol 25:1475–1479CrossRefPubMedGoogle Scholar
  55. 55.
    Odell WD (1991) Ectopic ACTH secretion: a misnomer. Endocrinol Metab Clin North Am 20:371–379PubMedGoogle Scholar
  56. 56.
    Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Ktaz DA, Cutler GB Jr, Loriaux DL (1991) Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing’s syndrome. N Engl J Med 325:896–905Google Scholar
  57. 57.
    Orth DN (1995) Cushing’s syndrome. N Engl J Med 332:791–803CrossRefPubMedGoogle Scholar
  58. 58.
    Phlipponneau M, Nocaudie M, Epelbaum J, De Keyzer Y, Lalau JD, Marchandise X, Bertagna X (1994) Somatostatin analogs for the localization and preoperative treatment of an adrenocorticotropin-secreting bronchial carcinoid tumor. J Clin Endocrinol Metab 78:20–24CrossRefPubMedGoogle Scholar
  59. 59.
    Picon A, Bertagna X, de Keyzer Y (1999) Analysis of the human proopiomelanocortin gene promoter in a small cell lung carcinoma cell line reveals an unusual role for E2F transcription factors. Oncogene 18:2627–2633CrossRefPubMedGoogle Scholar
  60. 60.
    Raffin-Sanson ML, Massias JF, Dumont C, Raux-Demay MC, Proeschel MF, Luton JP, Bertagna X (1996) High plasma proopiomelanocortin in aggressive adrenocorticotropin-secreting tumors. J Clin Endocrinol Metab 81: 4272–4277CrossRefPubMedGoogle Scholar
  61. 61.
    Raffin-Sanson ML, de Keyzer Y, Bertagna X (2003) Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions. Eur J Endocrinol 149:79–90CrossRefPubMedGoogle Scholar
  62. 62.
    Rena O, Filosso PL, Maggi G, Casadio C (2003) Neuroendocrine tumors (carcinoid) of the thymic gland. Ann Thorac Surg 75:633CrossRefGoogle Scholar
  63. 63.
    Seidah NG, Marcinkiewicz M, Benjannet S, Gaspar L, Beaubien G, Mattei MG et al. (1991) Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol 5:111–122PubMedGoogle Scholar
  64. 64.
    Shepherd FA, Laskey J, Evans WK, et al. (1992) Cushing’s syndrome associated with ectopic corticotropin production and small-cell lung cancer. J Clin Oncol 10:21–27PubMedGoogle Scholar
  65. 65.
    Shrager JB, Wright CD, Wain JC, Torchiana DF, Grillo HC, Mathisen DJ (1997) Bronchopulmonary carcinoid tumors associated with Cushing’s syndrome: a more aggressive type of typical carcinoids. J Thorac Cardiovasc Surg 114:367–375PubMedGoogle Scholar
  66. 66.
    Smeekens SP, Steiner DF (1990) Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex 2. J Biol Chem 265:2997–3000PubMedGoogle Scholar
  67. 67.
    Tabarin A, Valli N, Chanson P, Bachelot Y, Rohmer V, Bex-Bachellerie B, Catargi B, Roger P, Laurent F (1999) Usefulness of somatostatin receptor scintigraphy in patients with occult ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 84:1193–1202CrossRefPubMedGoogle Scholar
  68. 68.
    Takahashi H, Hakamata Y, Watanabe Y, Kikuno R, Miyata T, Numa S (1983) Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene. Nucleic Acids Res 11:6847–6858PubMedGoogle Scholar
  69. 69.
    Terzolo M, Reimondo G, Ali A, Borretta G, Cesario F, Pia A, Paccotti P, Angeli A (2001) The limited value of the desmopressin test in the diagnostic approach to Cushing’s syndrome. Clin Endocrinol (Oxf) 54:609–616CrossRefGoogle Scholar
  70. 70.
    Terzolo M, Reimondo G, Ali A, Bovio S, Daffara F, Paccotti P, Angeli A (2001) Ectopic ACTH syndrome: molecular bases and clinical heterogeneity. Ann Oncol 12Suppl 2:S83–87CrossRefPubMedGoogle Scholar
  71. 71.
    Texier PL, De Keyzer Y, Lacave R, Vieau D, Lenne F, Rojas-Miranda A, Verley JM, Luton JP, Kahn A, Bertagna X (1991) Proopiomelanocortin gene expression in normal and tumoral human lung. J Clin Endocrinol Metab 73:414–420PubMedGoogle Scholar
  72. 72.
    Torpy DJ, Chen CC, Mullen N, Doppman JL, Carrasquillo JA, Chrousos GP, Nieman LK (1999) Lack of utility of 111In-Pentetreotide scintigraphy in localizing ectopic ACTH producing tumors: follow-up of 18 patients. J Clin Endocrinol Metab 84:1186–1192CrossRefPubMedGoogle Scholar
  73. 73.
    Trainer PJ, Grossman A (1991) The diagnosis and differential diagnosis of Cushing’s syndrome. Clin Endocrinol (Oxf) 34:317–330Google Scholar
  74. 74.
    Tsagarakis S, Christoforaki M, Giannopoulou H, Rondogianni F, Housianakou I, Malagari C, Rontogianni D, Bellenis I, Thalassinos N (2003) A reappraisal of the utility of somatostatin receptor scintigraphy in patients with ectopic adrenocorticotropin Cushing’s syndrome. J Clin Endocrinol Metab 88:4754–4758CrossRefPubMedGoogle Scholar
  75. 75.
    Tsagarakis S, Giannakenas C, Vassilakos PJ, Platis O, Belenis I, Kaskarelis J, Rontoyianni D, Thalassinos N (1995) Successful localization of an occult ACTH-secreting bronchial carcinoid tumour with 111 indium-DTPA labelled octreotide. Clin Endocrinol (Oxf). 43:763–767Google Scholar
  76. 76.
    Tsagarakis S, Kaskarelis IS, Kokkoris P, Malagari C, Thalassinos N (2000) The application of combined stimulation with CRH and desmopressin during bilateral petrosal sinus sampling in patients with Cushing’s syndrome. Clin Endocrinol (Oxf) 52:355–361CrossRefGoogle Scholar
  77. 77.
    Tsagarakis S, Thalassinos N (2001) The desmopressin test: a new tool in the functional evaluation of the pituitary-adrenal axis in patients with Cushing’s syndrome? In: Margioris AN, Chrousos GP (eds) Adrenal disorders. Humana Press, Totowa, NJ, pp 193–202Google Scholar
  78. 78.
    Tsagarakis S, Tsigos C, Vasiliou V, Tsiotra P, Kaskarelis J, Sotiropoulou C, Raptis SA, Thalassinos N (2002) The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing’s syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion. J Clin Endocrinol Metab 87:1646–1653CrossRefPubMedGoogle Scholar
  79. 79.
    Vaidya B, Richardson D, Hilton CJ, Kendall-Taylor P (1997) Adrenocorticotropin-secreting carcinoid tumour identified and treated 12 years after presentation with Cushing’s syndrome. Postgrad Med J 73:737–739PubMedGoogle Scholar
  80. 80.
    Van Coevorden A, Laurent E, Rickaert F, van Reeth O, Van Cauter E, Mockel J (1990) Cushing’s syndrome with intermittent ectopic ACTH production. J Endocrinol Invest 13:317–326PubMedGoogle Scholar
  81. 81.
    Van den Bruel A, Bex M, Van Dorpe J, Heyns W, Bouillon R (1998) Occult ectopic ACTH secretion due to recurrent lung carcinoid: long-term control of hypercortisolism by continuous subcutaneous infusion of octreotide. Clin Endocrinol (Oxf) 49:541–546CrossRefGoogle Scholar
  82. 82.
    Vella A, Thompson GB, Grant CS, van Heerden JA, Farley DR, Young WF Jr (2001) Laparoscopic adrenalectomy for adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 86:1596–1599CrossRefPubMedGoogle Scholar
  83. 83.
    Vieau D, Seidah NG, Mbikay M, Chretien M, Bertagna X (1994) Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors. J Clin Endocrinol Metab 79:1503–1506CrossRefPubMedGoogle Scholar
  84. 84.
    Vignati F, Loli P (1996) Additive effect of ketoconazole and octreotide in the treatment of severe adrenocorticotropin-dependent hypercortisolism. J Clin Endocrinol Metab 81:2885–2890CrossRefPubMedGoogle Scholar
  85. 85.
    Vincent JM, Trainer PJ, Reznek RH, Marcus AJ, Dacie JE, Armstrong P, Besser GM (1993) The radiological investigation of occult ectopic ACTH-dependent Cushing’s syndrome. Clin Radiol 48:11–17PubMedGoogle Scholar
  86. 86.
    Wajchenberg BL, Mendonca BB, Liberman B, Pereira MA, Carneiro PC, Wakamatsu A, Kirschner MA (1994) Ectopic adrenocorticotropic hormone syndrome. Endocr Rev 15:752–787Google Scholar
  87. 87.
    Weiss M, Yellin A, Husza’r M, Eisenstein Z, Bar-Ziv J, Krausz Y (1994) Localization of adrenocorticotropic hormone-secreting bronchial carcinoid tumor by somatostatin-receptor scintigraphy. Ann Intern Med 121: 198–199PubMedGoogle Scholar
  88. 88.
    White A, Clark AJL (1993) The cellular and molecular basis of the ectopic ACTH syndrome. Clin Endocrinol (Oxf) 39:131–141Google Scholar
  89. 89.
    White A, Gibson S (1998) ACTH precursors: biological significance and clinical relevance. Clin Endocrinol (Oxf) 48:251–255CrossRefGoogle Scholar
  90. 90.
    Winocour PH, Tong P, White J, Edwards A, White A, Gibson GJ, Clark F (1993) Unusual presentation and course of Cushing’s syndrome due to ectopic ACTH secretion by a bronchial carcinoma. Respir Med 87:149–151CrossRefPubMedGoogle Scholar
  91. 91.
    Zeiger MA, Pass HI, Doppman JD, Nieman LK, Chrousos GP, Cutler GB Jr, Jensen RT, Norton JA (1992) Surgical strategy in the management of non-small cell ectopic adrenocorticotropic hormone syndrome. Surgery 112: 994–1000PubMedGoogle Scholar
  92. 92.
    Zhou A, Bloomquist BT, Mains RE (1993) The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J Biol Chem 268:1763–1769PubMedGoogle Scholar
  93. 93.
    Zhu L, Domenico DR, Howard JM (1996) Metastatic pancreatic neuroendocrine carcinoma causing Cushing’s syndrome. ACTH secretion by metastases 3 years after resection of nonfunctioning primary cancer. Int J Pancreatol 19:205–208PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • D. Vassiliadi
  • S. Tsagarakis
  • N. Thalassinos

There are no affiliations available

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