Hypothalamic-Pituitary-Adrenal Axis

  • Ioannis Kyrou
  • Constantine Tsigos


Anorexia Nervosa Chronic Fatigue Syndrome Hypothalamic Pituitary Adrenal Axis Corticotrophin Release Hormone ACTH Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Aghajanian GK, Van der Maelen CP (1982) α2-Adrenoreceptor-mediated hyperpolarization of locus ceruleus neurons: Intracellular studies in vivo. Science 215:1394–1396PubMedGoogle Scholar
  2. 2.
    Aguilera G, Flores M, Carvallo P, et al (1990) Receptors for corticotropin-releasing factor. In: DeSouza EB, Nemeroff CB (eds) Corticotropin-releasing factor: Basic and clinical studies of a neuropeptide. CRC Press, Boca Raton, FL, pp 154–159Google Scholar
  3. 3.
    Aguilera G, Millan MA, Hauger RL, et al (1987) Corticotropin-releasing factor receptors: Distribution and regulation in brain, pituitary, and peripheral tissues. Ann NY Acad Sci 512:48–66PubMedGoogle Scholar
  4. 4.
    Aguilera G (1993) Factors controlling steroid biosynthesis in the zona glomerulosa of the adrenal. J Steroid Biochem Mol Biol 45:147–151CrossRefPubMedGoogle Scholar
  5. 5.
    Akira S, Hirano T, Taga T, et al (1990) Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 4:2860–2867PubMedGoogle Scholar
  6. 6.
    Al-Damluji S, Cunnah D, Grossman A, et al (1987) Effect of adrenaline on basal and ovine corticotropin-releasing factor-stimulated ACTH secretion in man. J Endocrinol 112:145–150PubMedGoogle Scholar
  7. 7.
    Alzein J, Jeandel L, Lutz-Bucher B, et al (1984) Evidence that CRF stimulates vasopressin secretion from isolated neurointermediate pituitary [letter]. Neuroendocrinology 6:151Google Scholar
  8. 8.
    Antoni FA (1987) Receptors mediating the CRH effects of vasopressin and oxytocin. Ann NY Acad Sci 512: 195–204PubMedGoogle Scholar
  9. 9.
    Antoni FA (1993) Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front Neuroendocrinol 14:76–122CrossRefPubMedGoogle Scholar
  10. 10.
    Bardeleben U, Heuser I, Holsboer F (1989) Human CRH stimulation response during acute withdrawal and after medium-term abstention from alcohol abuse. Psychoneuroendocrinology 14:441–449CrossRefPubMedGoogle Scholar
  11. 11.
    Benker G, Raida M, Olbricht T, et al (1990) TSH secretion in Cushing’s syndrome: Relation to glucocorticoid excess, diabetes, goiter, and the “the sick euthyroid syndrome.” Clin Endocrinol 133:779–786Google Scholar
  12. 12.
    Bernardini R, Chiarenza A, Calogero AE, et al (1989) Arachidonic acid metabolites modulate rat hypothalamic corticotropin releasing hormone in vitro. Neuroendocrinology 50:708–715PubMedGoogle Scholar
  13. 13.
    Bernardini R, Kamilaris TC, Calogero AE, et al (1990) Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology 126:2876–2881PubMedGoogle Scholar
  14. 14.
    Besedovsky HO, del Rey A (1992) Immune-neuroendocrine circuits: Integrative role of cytokines. Frontiers Neuroendocrinol 13:61–94Google Scholar
  15. 15.
    Burguera B, Muruais C, Penalva A, et al (1990) Dual and selective actions of glucocorticoids upon basal and stimulated growth hormone release in man. Neuroendocrinology 51:51–58PubMedGoogle Scholar
  16. 16.
    Calogero AE, Gallucci WT, Chrousos GP, et al (1988) Effect of the catecholamines upon rat hypothalamic corticotropin releasing hormone secretion in vitro. J Clin Invest 82:839–846PubMedGoogle Scholar
  17. 17.
    Calogero AE, Gallucci WT, Chrousos GP, et al (1988) Interaction between GABAergic neurotransmission and rat hypothalamic CRH in vitro. Brain Res 463:28–36CrossRefPubMedGoogle Scholar
  18. 18.
    Calogero AE, Gallucci WT, Gold PW, et al (1988) Multiple regulatory feedback loops on hypothalamic CRH secretion. Potential clinical implications. J Clin Invest 82:767–774PubMedGoogle Scholar
  19. 19.
    Casanueva FF, Burguera B, Muruais C, et al (1990) Acute administration of corticosteroids: A new and peculiar stimulus of growth hormone secretion in man. J Clin Endocrinol Metab 70:234–237PubMedGoogle Scholar
  20. 20.
    Cavagnini F, Croci M, Putignano P, Petroni ML, Invitti C (2000) Glucocorticoids and neuroendocrine function. Int J Obesity 24Suppl 2:S77–S79CrossRefGoogle Scholar
  21. 21.
    Chen R, Lewis KA, Perrin MH, et al (1993) Expression cloning of a human corticotropin releasing factor receptor. Proc Natl Acad Sci USA 90:8967–8971PubMedGoogle Scholar
  22. 22.
    Chikanza IC, Petrou Ñ, Chrousos GP, Kingsley Ï, Panayi G (1992) Defective hypothalamic response to immune/inflammatory stimuli in patients with rheumatoid arthritis. Arthr Rheumatol 35:1281–1288Google Scholar
  23. 23.
    Chrousos GP, Detera-Wadleigh S, Karl M (1993) NIH Conference. Syndromes of glucocorticoid resistance. Ann Intern Med 119:1113–1124PubMedGoogle Scholar
  24. 24.
    Chrousos GP, Gold PW (1992) The concepts of stress system disorders: Overview of behavioral and physical homeostasis. JAMA 267:1244–1252CrossRefPubMedGoogle Scholar
  25. 25.
    Chrousos GP, Torpy DJ, Gold PW (1998) Interactions between the hypothalamic pituitary adrenal axis and the female reproductive system: Clinical implications. Ann Intern Med. 129:229–240PubMedGoogle Scholar
  26. 26.
    Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med. 332:1351–1362CrossRefPubMedGoogle Scholar
  27. 27.
    Chrousos GP (2000) The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord 24Suppl 2:S50–55CrossRefPubMedGoogle Scholar
  28. 28.
    Chrousos GP (1992) Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis: The corticotropin-releasing hormone perspective. Endocrinol Metab Clin N Am 21:833–858Google Scholar
  29. 29.
    Crofford LJ, Sano H, Karalis K, et al (1993) Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. J Immunol 151:1587–1596PubMedGoogle Scholar
  30. 30.
    Cunningham ET Jr, Bohn MC, Sawchenko PE (1990) The organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 292:651–667CrossRefPubMedGoogle Scholar
  31. 31.
    de Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269–301CrossRefPubMedGoogle Scholar
  32. 32.
    Demitrack M, Dale J, Straus S, et al (1991) Evidence of impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 73:1224–1234PubMedGoogle Scholar
  33. 33.
    DeSouza EB, Insel TR, Perrin MH, et al (1985) Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system. J Neurosci 5:3189–3203PubMedGoogle Scholar
  34. 34.
    Dieguez C, Page MD, Scanlon MF (1988) Growth hormone neuroregulation and its alterations in disease states. Clin Endocrinol (Oxf) 28:109–143Google Scholar
  35. 35.
    Doherty GM, Nieman LK, Cutler GB Jr, et al (1990) Time to recovery of the hypothalamic pituitary adrenal axis following curative resection of adrenal tumors in patients with Cushing’s syndrome. Surgery 108:1085–1090PubMedGoogle Scholar
  36. 36.
    Duick DS, Wahner HW (1979) Thyroid axis in patients with Cushing’s syndrome. Arch Intern Med 139:767–772CrossRefPubMedGoogle Scholar
  37. 37.
    Dunlap JC (1999) Molecular bases for circadian clocks. Cell 96:271–290CrossRefPubMedGoogle Scholar
  38. 38.
    Eipper BA, Mains RE (1980) Structure and biosynthesis of proadrenocorticotropin/endorphin and related peptides. Endocr Rev 1:1–27PubMedGoogle Scholar
  39. 39.
    Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP (1999) Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: Acute and chronic effects. Ann N Y Acad Sci 876:1–11; discussion 11–13PubMedGoogle Scholar
  40. 40.
    Engler D, Pham T, Fullerton MJ, et al (1989) Studies on the secretion of corticotropin releasing factor and arginine vasopressin into hypophyseal portal circulation of the conscious sheep. Neuroendocrinology 49: 367–381PubMedGoogle Scholar
  41. 41.
    Foote SL, Bloom FE, Aston-Jones G (1983) Nucleus locus ceruleus: New evidence for anatomical and physiological specificity. Physiol Rev 63:844–914PubMedGoogle Scholar
  42. 42.
    Frim DM, Robinson BG, Pasieka KB, et al (1990) Differential regulation of corticotropin releasing hormone mRNA in rat brain. Am J Physiol 258:E686–692PubMedGoogle Scholar
  43. 43.
    Fukata J, Usui T, Naitoh Y, et al (1988) Effects of recombinant human interleukin-1α, IL-1β, IL-2 and IL-6 on ACTH synthesis and release in the mouse pituitary tumor cell line AtT-20. J Endocrinol 122:33–39Google Scholar
  44. 44.
    Fuller RW (1992) The involvement of serotonin in regulation of pituitary-adrenocortical function. Front Neuroendocrinol 13:250–270PubMedGoogle Scholar
  45. 45.
    Gillies GE, Linton EA, Lowry PJ (1982) Corticotropin-releasing activity of the new CRF is potentiated several times by vasopressin. Nature 299:355–357CrossRefPubMedGoogle Scholar
  46. 46.
    Gold PW, Chrousos GP (1999) The endocrinology of melancholic and atypical depression: Relation to neurocircuitry and somatic consequences. Proc Assoc Am Physicians 111:22–34CrossRefGoogle Scholar
  47. 47.
    Gold PW, Gwirtsman H, Avgerinos P, et al (1986) Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa: Pathophysiologic mechanisms in underweight and weight-corrected patients. N Engl J Med 314:1335–1342PubMedGoogle Scholar
  48. 48.
    Gold PW, Loriaux DL, Roy A, et al (1986) Responses to the corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease: Pathophysiologic and diagnostic implications. N Engl J Med 314:1329–1335PubMedGoogle Scholar
  49. 49.
    Gomez MT, Magiakou MA, Mastorakos G, Chrousos GP (1993) The pituitary corticotroph is not the rate-limiting step in the postoperative recovery of the hypothalamic pituitary adrenal axis in patients with Cushing’s syndrome. J Clin Endocrinol Metab 77:173–177CrossRefPubMedGoogle Scholar
  50. 50.
    Griep EN, Boersma JW, de Kloet ER (1993) Altered reactivity of the hypothalamic pituitary adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 20:469–474PubMedGoogle Scholar
  51. 51.
    Gwynne JT, Strauss JF 3rd (1982) The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr Rev 3:299–329PubMedGoogle Scholar
  52. 52.
    Hackney AC (2001) Endurance exercise training and reproductive endocrine dysfunction in men: Alterations in the hypothalamic-pituitary-testicular axis. Curr Pharm Des 7:261–273CrossRefPubMedGoogle Scholar
  53. 53.
    Harris (1948) Neural control of the pituitary gland. Physiol Rev 28:139Google Scholar
  54. 54.
    Horrocks PM, Jones AF, Ratcliffe WA, et al (1990) Patterns of ACTH and cortisol pulsatility over 24 hours in normal males and females. Clin Endocrinol (Oxf) 32:127–134Google Scholar
  55. 55.
    Hurley DM, Accili D, Stratakis C, et al (1991) Mutation of the glucocorticoid receptor gene in familial glucocorticoid resistance. J Clin Invest 87:680–686PubMedGoogle Scholar
  56. 56.
    Insel TR, Kalin NH, Guttmacher LB, et al (1982) The dexamethasone suppression test in obsessive-compulsive disorder. Psychiatry Res 6:153–160CrossRefPubMedGoogle Scholar
  57. 57.
    Jonat C, Rahmsdorf HJ, Park KK, et al (1990) Antitumor promotion and anti-inflammation: Down modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62:1189–1204CrossRefPubMedGoogle Scholar
  58. 58.
    Kahri AI, Huhtaniemi I, Salmenpera M (1976) Steroid formation and differentiation of cortical cells in tissue culture of human fetal adrenals in the presence and absence of ACTH. Endocrinology 98:33–41PubMedGoogle Scholar
  59. 59.
    Kamilaris TC, Calogero AE, Johnson EO, et al (1989) Effects of hypothyroidism and hyperthyroidism on the basal activity of the hypothalamic-pituitary-adrenal axis (abstract). Clin Res 37:360AGoogle Scholar
  60. 60.
    Kamilaris TC, DeBold CR, Pavlou SN, et al (1987) Effect of altered thyroid hormone levels on hypothalamic-pituitary-adrenal function. J Clin Endocrinol Metab 65:994–999PubMedGoogle Scholar
  61. 61.
    Karalis K, Sano H, Redwine J, et al (1991) Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science 254:421–423PubMedGoogle Scholar
  62. 62.
    Kazis K, Iglesias E (2003) The female athlete triad. Adolesc Med 14:87–95PubMedGoogle Scholar
  63. 63.
    Keller-Wood ME, Dallman MF (1984) Corticosteroid inhibition of ACTH secretion. Endocr Rev 5:1–24PubMedGoogle Scholar
  64. 64.
    Korbonits M, Kaltsas G, Perry LA, et al (1999) The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. J Clin Endocrinol Metab 84:2489–2495CrossRefPubMedGoogle Scholar
  65. 65.
    Krieger DT, Liotta AS, Brownstein MS, et al (1980) ACTH, β-lipotropin, and related peptides in brain, pituitary and blood. Recent Prog Horm Res 36:277–344PubMedGoogle Scholar
  66. 66.
    Krieger DT (1975) Rhythms of ACTH and corticosteroid secretion in health and disease and their experimental modification. J Steroid Biochem 6:785–791CrossRefPubMedGoogle Scholar
  67. 67.
    Lamberts SW, Verleun T, Oosterom R, et al (1984) Corticotropin-releasing factor and vasopressin exert a synergistic effect on adrenocorticotropin release in man. J Clin Endocrinol Metab 58:298–303PubMedGoogle Scholar
  68. 68.
    Laue L, Gold PW, Richmond A, Chrousos GP (1991) The hypothalamic-pituitary-adrenal axis in anorexia nervosa and bulimia nervosa: Pathophysiologic implications. Adv Pediatr 38:287–316PubMedGoogle Scholar
  69. 69.
    Linton EA, Wolfe CD, Behan DP, et al (1988) A specific carrier substance for human corticotropin releasing factor in late gestational maternal plasma which could mask the ACTH releasing activity. Clin Endocrinol (Oxf) 28:315–324Google Scholar
  70. 70.
    Luger A, Deuster P, Kyle SB, et al (1987) Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise: Physiologic adaptations to physical training. N Engl J Med 316:1309–1315PubMedGoogle Scholar
  71. 71.
    Lundblad JR, Roberts JL (1988) Regulation of proopiomelanocortin gene expression in pituitary. Endocr Rev 9:135–158PubMedGoogle Scholar
  72. 72.
    MacAdams MR, White RH, Chipps BE (1986) Reduction in serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 140:648–651Google Scholar
  73. 73.
    Malozowski S, Muzzo S, Burrows R, et al (1990) The hypothalamic-pituitary-adrenal axis in infantile malnutrition. Clin Endocrinol (Oxf) 32:461–465Google Scholar
  74. 74.
    Masi AT, Chatterton RT, Aldag JC, Malamet RL (2002) Perspectives on the relationship of adrenal steroids to rheumatoid arthritis. Ann N Y Acad Sci 966:1–12PubMedGoogle Scholar
  75. 75.
    Mastorakos G, Chrousos GP, Weber J (1993) Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 77: 1690–1694CrossRefPubMedGoogle Scholar
  76. 76.
    Mountjoy KG, Robbins LS, Mortrud MT, et al (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248–1251PubMedGoogle Scholar
  77. 77.
    Munck A, Guyre PM, Holbrook NJ (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5:25–44PubMedGoogle Scholar
  78. 78.
    Naitoh Y, Fukata J, Tominaga T, et al (1988) Interleukin-6 stimulates the secretion of adrenocorticotropin hormone in conscious freely moving rats. Biochem Biophys Res Commun 155:1459–1463CrossRefPubMedGoogle Scholar
  79. 79.
    Oki S, Nakao K, Tanaka I, et al (1981) Concomitant secretion of adrenocorticotropin, β-endorphin and γ-melanotropin from perfused pituitary tumor cells of Cushing’s disease. J Clin Endocrinol Metab 52:42–49PubMedGoogle Scholar
  80. 80.
    Orth DN (1992) Corticotropin-releasing hormone in humans. Endocr Rev 13:164–191CrossRefPubMedGoogle Scholar
  81. 81.
    Pasquali R, Cantobelli S, Casimirri F, et al (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341–346CrossRefPubMedGoogle Scholar
  82. 82.
    Plotsky PM (1986) Opioid inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation of rats. Regul Pept 30:235–242CrossRefGoogle Scholar
  83. 83.
    Potter E, Behan DP, Fischer WH, et al (1991) Cloning and characterization of the cDNAs for human and rat corticotropin-releasing factor-binding proteins. Nature 349:423–426CrossRefPubMedGoogle Scholar
  84. 84.
    Potter E, Behan DP, Linton EA, et al (1992) The central distribution of a corticotrophin releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF. Proc Natl Acad Sci USA 89:4192–4196PubMedGoogle Scholar
  85. 85.
    Pratt WB (1990) Glucocorticoid receptor structure and the initial events in signal transduction. Prog Clin Biol Res 322:119–320PubMedGoogle Scholar
  86. 86.
    Rabin D, Gold PW, Margioris A, et al (1988) Stress and reproduction: Interactions between the stress and reproductive axis. In: Chrousos GP, Loriaux DL, Gold PW (eds) Mechanisms of physical and emotional stress. Plenum Press, New York, pp 377–390Google Scholar
  87. 87.
    Rabin D, Schmidt P, Gold PW, et al (1990) Hypothalamic-pituitary-adrenal function in patients with the premenstrual syndrome. J Clin Endocrinol Metab 71:1158–1162PubMedGoogle Scholar
  88. 88.
    Reichlin S (1993) Neuroendocrine-immune interactions. N Engl J Med 329:1246–1253CrossRefPubMedGoogle Scholar
  89. 89.
    Richard D, Lin Q, Timofeeva E (2002) The corticotropin-releasing factor family of peptides and CRF receptors: Their roles in the regulation of energy balance. Eur J Pharmacol 12:189–197CrossRefGoogle Scholar
  90. 90.
    Risher-Flowers D, Adinoff B, Ravitz B, et al (1988) Circadian rhythms of cortisol during alcohol withdrawal. Adv Alcohol Subst Abuse 7:37–41PubMedGoogle Scholar
  91. 91.
    Rittmaster RS, Cutler GB Jr, Brandon D, et al (1987) The relationship of saline-induced changes in vasopressin secretion to basal and corticotropin-releasing hormone-stimulated adrenocorticotropin and cortisol secretion in man. J Clin Endocrinol Metab 64:371–376PubMedGoogle Scholar
  92. 92.
    Rivier C, Plotsky PM (1986) Mediation by corticotropin-releasing factor (CRF) of adenohypophysial hormone secretion. Ann Rev Physiol 48:475–494CrossRefGoogle Scholar
  93. 93.
    Rivier C, Rivest S (1991) Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: Peripheral and central mechanisms. Biol Reprod 45:523–532PubMedGoogle Scholar
  94. 94.
    Rivier C, Rivier J, Mormede P, et al (1984) Studies on the nature of the interaction between vasopressin and corticotropin-releasing factor on adrenocorticotropin release in the rat. Endocrinology 115:882–886PubMedGoogle Scholar
  95. 95.
    Rivier C, Rivier J, Vale W (1986) Stress-induced inhibition of reproductive function: Role of endogenous corticotropin releasing factor. Science 231:607–609PubMedGoogle Scholar
  96. 96.
    Rivier C, Vale W (1985) Involvement of corticotropin-releasing factor and somatostatin in stress induced inhibition of growth hormone secretion in the rat. Endocrinology 117:2478–2482PubMedGoogle Scholar
  97. 97.
    Roth KA, Weber E, Barchas JD, et al (1983) Immunoreactive dynorphin-(1–8) and CRH in subpopulation of hypothalamic neurons. Science 219:189–191PubMedGoogle Scholar
  98. 98.
    Saffran M, Schally AV (1955) The release of corticotropin by anterior pituitary tissue in vitro. Can J Biochem Physiol 33:408–415PubMedGoogle Scholar
  99. 99.
    Salas MA, Evans SW, Levell MJ, et al (1990) Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin Exp Immunol 79:470–473PubMedGoogle Scholar
  100. 100.
    Sanchez ER, Faber LE, Henzel WJ, et al (1990) The 56–59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70 and 90 kilodalton heat shock proteins. Biochemistry 29:5145–5152CrossRefPubMedGoogle Scholar
  101. 101.
    Saper CB, Loewy AD, Swanson LW, et al (1979) Direct hypothalamoautonomic connections. Brain Res 117:305–312CrossRefGoogle Scholar
  102. 102.
    Sapolsky R, Rivier C, Yamamoto G, et al (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin releasing factor. Science 238:522–524PubMedGoogle Scholar
  103. 103.
    Sasaki A, Shinkawa O, Margioris AN, et al (1987) Immunoreactive corticotropin releasing hormone in human plasma during pregnancy, labor and delivery. J Clin Endocrinol Metab 64:224–229PubMedGoogle Scholar
  104. 104.
    Selye H (1950) Stress. Acta Medical, Montreal, QuebecGoogle Scholar
  105. 105.
    Sirinathsinghji DJ, Rees LH, Rivier J, et al (1983) Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature 305:232–235CrossRefPubMedGoogle Scholar
  106. 106.
    Smith AI, Funder JW (1988) Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 9:159–179PubMedGoogle Scholar
  107. 107.
    Smith DF, Toft DO (1993) Steroid receptors and their associated proteins. Mol Endocrinol 7:4–11CrossRefPubMedGoogle Scholar
  108. 108.
    Smith GW, Aubry JM, Dellu F, et al (1998) Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20:1093–1102CrossRefPubMedGoogle Scholar
  109. 109.
    Sternberg EM, Chrousos GP, Wilder RL, et al (1992) The stress response and the regulation of inflammatory disease. Ann Intern Med 117:854–866PubMedGoogle Scholar
  110. 110.
    Sutton RE, Koob GF, Le Moal M, et al (1982) Corticotropin-releasing factor produces behavioral activation in the rat. Nature 297:331–333CrossRefPubMedGoogle Scholar
  111. 111.
    Tait SAS, Schulster D, Okamoto M, et al (1970) Production of steroids by in vitro superfusion of endocrine tissue: II. Steroid output from whole, capsular and decapsulated adrenals of normal intact, hypophysec-tomized and hypophysectomized-nephrectomized rats as a function of time of perfusion. Endocrinology 86:360–382PubMedGoogle Scholar
  112. 112.
    Torpy DJ, Tsigos C, Lotsikas AJ, Defensor R, Chrousos GP, Papanicolaou DA (1998) Acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans. Metabolism 47:1289–1293CrossRefPubMedGoogle Scholar
  113. 113.
    Tsigos C, Arai K, Hung W, et al (1993) Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. J Clin Invest 92:2485–2561Google Scholar
  114. 114.
    Tsigos C, Chrousos GP (1994) Physiology of the hypothalamic-pituitary-adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinol Metab Clin North Am 23:451–466PubMedGoogle Scholar
  115. 115.
    Tsigos C, Crosby SR, Gibson S, et al (1993) Proopiomelanocortin is the predominant ACTH related peptide in human cerebrospinal fluid. J Clin Endocrinol Metab 76:620–624CrossRefPubMedGoogle Scholar
  116. 116.
    Tsigos C, Kyrou I, Chala E, Tsapogas P, Stavridis JC, Raptis SA, Katsilambros N (1999) Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. Metabolism 48: 1332–1335CrossRefPubMedGoogle Scholar
  117. 117.
    Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Kyrou I, Chrousos GP (1997) Dose-dependent effects of recombinant human interleukin-6 on anterior pituitary hormone secretion and thermogenesis. Neuroendocrinology 66:54–62PubMedGoogle Scholar
  118. 118.
    Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis CS, Chrousos GP (1997) Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. J Clin Endocrinol Metab 82:4167–4170CrossRefPubMedGoogle Scholar
  119. 119.
    Tsigos C, Papanicolaou DA, Kyrou I, Raptis SA, Chrousos GP (1999) Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J Interferon Cytokine Res 19:1271–1276CrossRefPubMedGoogle Scholar
  120. 120.
    Tsigos C, Young RJ, White A (1993) Diabetic neuropathy is associated with increased activity of the hypothalamic-pituitary-adrenal axis. J Clin Endocr Metab 76:554–558CrossRefPubMedGoogle Scholar
  121. 121.
    Turnbull AV, Rivier C (1997) Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides. Proc Soc Exp Biol Med 215:1–10PubMedGoogle Scholar
  122. 122.
    Unterman TG, Phillips LS (1985) Glucocorticoid effects on somatomedins and somatomedin inhibitors. J Clin Endocrinol Metab 61:618–626PubMedGoogle Scholar
  123. 123.
    Vale W, Spiess J, Rivier C, et al (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394–1397PubMedGoogle Scholar
  124. 124.
    Vale W, Vaughan J, Smith M, et al (1983) Effects of synthetic ovine corticotropin-releasing factor, glucocorticoid, catecholamines, neuro-hypophyseal peptides, and other substances on cultured corticotropic cells. Endocrinology 113:1121–1131PubMedGoogle Scholar
  125. 125.
    Valentino RJ, Foote SL, Aston-Jones G (1983) Corticotropin-releasing hormone activates noradrenergic neurons of the locus ceruleus. Brain Res 270:363–367CrossRefPubMedGoogle Scholar
  126. 126.
    Vamvakopoulos NC, Chrousos GP (1993) Evidence of direct estrogen regulation of human corticotropin releasing hormone gene expression: Potential implications for the sexual dimorphism of the stress response and immune/inflammatory reaction. J Clin Invest 92: 1896–1902PubMedGoogle Scholar
  127. 127.
    Vanderpool J, Rosenthal N, Chrousos GP, et al (1991) Abnormal pituitary-adrenal responses to corticotropin-releasing hormone in patients with seasonal affective disorder: Clinical and pathophysiological implications. J Clin Endocrinol Metab 72:1382–1387PubMedGoogle Scholar
  128. 128.
    Veldhuis JD, Iranmanesh A, Johnson ML, et al (1990) Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of corticotropic axis in man. J Clin Endocrinol Metab 71:452–463PubMedGoogle Scholar
  129. 129.
    Wand GS, Dobs AS (1991) Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. J Clin Endocrinol Metab 72:1290–1295PubMedGoogle Scholar
  130. 130.
    Weitzman ED, Fukushima D, Nogeire C, et al (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 33:14–22PubMedGoogle Scholar
  131. 131.
    Winter JS, Cow KW, Perry YS, et al (1990) A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. Endocrinology 127: 1904–1909PubMedGoogle Scholar
  132. 132.
    Wong ML, Licinio J, Pasternak KI, Gold PW (1994) Localization of corticotrophin releasing hormone (CRH) receptor mRNA in adult rat brain by in situ hybridization histochemistry. Endocrinology 135:2275–2278CrossRefPubMedGoogle Scholar
  133. 133.
    Yang-Yen HF, Chambard JC, Sun YL, et al (1990) Transcriptional interference between c-jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205–1215CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Ioannis Kyrou
  • Constantine Tsigos

There are no affiliations available

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