Adrenal Glands pp 115-126 | Cite as

Overview of Mineralocorticoid Excess Syndromes

  • Richard D. Gordon
  • Michael Stowasser


Congenital Adrenal Hyperplasia Mineralocorticoid Receptor Primary Aldosteronism Laparoscopic Adrenalectomy Adrenal Vein 
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  1. 1.
    Biglieri EG, Herron MA, Brust N (1966) 17-Hydroxylation deficiency in man. J Clin Invest 45:1946–1954PubMedGoogle Scholar
  2. 2.
    Edwards CRW, Walker BR, Benediktsson R, Seckl JR (1993) Congenital and acquired syndromes of apparent mineralocorticoid excess. J Steroid Biochem Mol Biol 45:1–5CrossRefGoogle Scholar
  3. 3.
    Espiner EA, Tucci JR, Jagger MD, et al (1967) Effect of saline infusions on aldosterone secretion and electrolyte excretion in normal subjects and patients with primary aldosteronism. N Engl J Med 277:1–7PubMedGoogle Scholar
  4. 4.
    Gordon RD (2001) Diagnostic investigations in primary aldosteronism. In: Zanchetti A (ed) Clinical medicine series on hypertension. McGraw-Hill International, London, pp 101–114Google Scholar
  5. 5.
    Gordon RD (2001) Mineralocorticoid excess syndromes. In: Margioris AS, Chrousos GP (eds) Contemporary endocrinology: adrenal disorders. Humana Press, Totowa NJ, pp 355–377Google Scholar
  6. 6.
    Gordon RD, Stowasser M (1998) Familial forms broaden horizons in primary aldosteronism. Trends Endocrinol Metab 9:220–227CrossRefGoogle Scholar
  7. 7.
    Gordon RD, Hawkins PG, Hamlet SM, Tunny TJ, Klemm SA, Bachmann AW, Finn WL (1989) Reduced adrenal secretory mass after unilateral adrenalectomy for aldosterone-producing adenoma may explain unexpected incidence of hypotension. J Hypertens 7(Suppl 6):S210–S211Google Scholar
  8. 8.
    Gordon RD, Klemm SA, Tunny TJ, Stowasser M (1992) Primary aldosteronism: hypertension with a genetic basis. Lancet 340:159–161CrossRefPubMedGoogle Scholar
  9. 9.
    Gordon RD, Klemm SA, Stowasser M, Tunny TJ, Storie WJ, Rutherford JC (1993) How common is primary aldo-steronism? Is it the most frequent cause of curable hypertension? J Hypertens 11(Suppl 5):S2–S3Google Scholar
  10. 10.
    Gordon RD, Ziesak MD, Tunny TJ, Stowasser M, Klemm SA (1993) Evidence that primary aldosteronism may not be uncommon — twelve percent incidence among antihypertensive drug trial volunteers. Clin Exp Pharmacol Physiol 20:296–298PubMedGoogle Scholar
  11. 11.
    Gordon RD, Stowasser M, Klemm SA, Tunny TJ (1994) Primary aldosteronism and other forms of mineralo-corticoid hypertension. In: Swales JD (ed) Textbook of hypertension. Blackwell Scientific, London, pp 865–892Google Scholar
  12. 12.
    Gordon RD, Stowasser M, Tunny TJ, Klemm SA, Rutherford JC (1994) High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin Exp Pharmacol Physiol 21:315–318PubMedGoogle Scholar
  13. 13.
    Hamlet SM, Tunny TJ, Woodland E, Gordon RD (1985) Is aldosterone/renin ratio useful to screen a hypertensive population for primary aldosteronism? Clin Exp Pharmacol Physiol 12:249–252PubMedGoogle Scholar
  14. 14.
    Hiramatsu K, Yamada T, Yukimura Y, Komiya I, Ichikawa K, Ishihara M, et al (1981) A screening test to identify aldosterone-producing adenoma by measuring plasma renin activity. Arch Intern Med 141:1589–1593CrossRefPubMedGoogle Scholar
  15. 15.
    Holland OB, Brown H, Kuhnert LV, Fairchild C, Risk M, Gomez-Sanchez CE (1984) Further evaluation of saline infusion for the diagnosis of primary aldosteronism. Hypertension 6:717–723PubMedGoogle Scholar
  16. 16.
    Jonsson JR, Klemm SA, Tunny TJ, Stowasser M, Gordon RD (1995) A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension. Biochem Biophys Res Comm 207:565–571CrossRefPubMedGoogle Scholar
  17. 17.
    Kondo K, Saruta T, Saito I, et al (1976) Benign desoxycor-ticosterone-producing adrenal tumor. JAMA 236:1042–1044CrossRefPubMedGoogle Scholar
  18. 18.
    Lafferty AR, Torpy D, Stowasser M, Taymans SE, Lin JP, Huggard P, Gordon RD, Stratakis CA (2000) A novel genetic locus for low-renin hypertension: familial hyper-aldosteronism type-II maps to chromosome 7 (7p22). J Med Genet 37:831–835CrossRefPubMedGoogle Scholar
  19. 19.
    Lifton RP, Dluhy RG, Powers M, et al (1992) A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355:262–265CrossRefPubMedGoogle Scholar
  20. 20.
    Litchfield WR, Dluhy RG (1995) Primary aldosteronism. Endocrinol Metab Clin North Am 24:593–612PubMedGoogle Scholar
  21. 21.
    Loh K-C, Koay ES, Khaw M-C, et al (2000) Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore. J Clin Endocrinol Metab 85:2854–2859CrossRefPubMedGoogle Scholar
  22. 22.
    Pascoe L, Jeunemaitre X, Lebrethon MC, et al (1995) Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. J Clin Invest 96:2236–2246PubMedGoogle Scholar
  23. 23.
    Rutherford JC, Gordon RD, Stowasser M, Tunny TJ, Klemm SA (1995) Laparoscopic adrenalectomy for adrenal tumours causing hypertension and for “incidentalomas” of the adrenal on CT scanning. Clin Exp Pharmacol Physiol 22:490–492PubMedGoogle Scholar
  24. 24.
    Rutherford JC, Stowasser M, Tunny TJ, Klemm SA, Gordon RD (1996) Laparoscopic adrenalectomy. World J Surg 20:758–760CrossRefPubMedGoogle Scholar
  25. 25.
    Rutherford JC, Taylor WL, Stowasser M, Gordon R (1998) Success of surgery in primary aldosteronism judged by residual autonomous aldosterone production. World J Surg 22:1243–1245CrossRefPubMedGoogle Scholar
  26. 26.
    Stowasser M, Bachmann AW, Huggard PJ, Rossetti TR, Gordon RD (2000) Treatment of familial hyperaldosteronism type I: only partial suppression of hybrid gene required to correct hypertension. J Clin Endocrinol Metab 85:3313–3318CrossRefPubMedGoogle Scholar
  27. 27.
    Stowasser M, Gordon RD (2000) Primary aldosteronism: learning from the study of familial varieties. J Hypertens 18:1165–76CrossRefPubMedGoogle Scholar
  28. 28.
    Stowasser M, Gordon RD (2003) Primary aldosteronism. Best Prac Res Clin Endocrinol Metab 14:310–317Google Scholar
  29. 29.
    Stowasser M, Gordon RD (in press) Primary aldosteronism: from genesis to genetics. Trends Endocrinol MetabGoogle Scholar
  30. 30.
    Sutherland DJA, Ruse JL, Laidlaw JC (1966) Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J 95:1109–1119PubMedGoogle Scholar
  31. 31.
    Warnock DG (1998) Liddle syndrome: an autosomal dominant form of human hypertension. Kidney Int 53: 18–24CrossRefPubMedGoogle Scholar
  32. 32.
    Young WF Jr (1997) Primary aldosteronism: update on diagnosis and treatment. Endocrinologist 7:213–221Google Scholar
  33. 33.
    Zachmann M, Tassinari D, Prade RA (1983) Clinical and biochemical variability of congenital adrenal hyperplasia due to 11ß-hydroxylase deficiency. A study of 25 patients. J Clin Endocrinol Metab 56:222–229PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Richard D. Gordon
  • Michael Stowasser

There are no affiliations available

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