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Peptide Vaccination of Myeloid Leukemia

  • D. Kurbegov
  • J. J. Molldrem
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 11)

9.4 Conclusion

In summary, we are beginning to learn more about the nature of the antigens targeted by T cells that mediate autologous antileukemia immunity and those that are the targets of the GVL effect. Some self-antigens might also be the targets of alloreactive CTL, as we have shown for PR1. If more antigens were identified, logical immunotherapy strategies such as vaccines or adoptive cellular therapies could be tested in patients. Obstacles to this approach remain, however. We must identify which of the hematopoietic tissue-restricted peptides are recognized by T cells and we must improve our understanding of the nature of peripheral T cell tolerance so that we might break immune tolerance to certain peptide determinants without causing potentially destructive autoimmunity. In the future, allogeneic stem cell transplantation is likely to evolve as a platform for delivering antigen-specific adoptive cellular therapies and for post-transplant vaccination strategies where donor CTL are elicited in the recipient. Both autologous and allogeneic transplant may reset T cell homeostasis and allow a more complete T cell repertoire to emerge postgrafting that could be further expanded selectively against tumor antigens by vaccination posttransplant, as in a vaccination by proxy therapy in the case of allogeneic transplantation.

Keywords

Peptide Vaccination Acute Myelogenous Leukemia Patient Minor Histocompatibility Antigen Adoptive Cellular Therapy Donor Lymphocyte Transfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • D. Kurbegov
    • 1
  • J. J. Molldrem
    • 1
  1. 1.MD Anderson Cancer CenterHoustonUSA

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