6.4 Conclusion
Allogeneic MSC have a fully therapeutic potential in HSCT and possibly in bone marrow failure. However, there are still some questions.
The therapeutic dose of MSC needed in clinics is still unknown. Repetitive infusion of MSC might be necessary to maintain the therapeutic effect and to get a sufficient level of chimerism. MSC are immunosuppressive, can induce tolerance, and decrease GVHD; actually these immunological effects might be deleterious on the graft versus tumor effect. The place of allogeneic MSC from unique donors needs to be evaluated. The place of genetically modified MSC in HSCT also needs to be evaluated.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Almeida-Porada G, Porada CD, Tran N, Zanjani ED (2000) Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 95:3620–3627
Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, Mclntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R (2002) Mesenchymal stem cells suppress lymphocyte proliferation and prolong skin graft survival in vivo. Exp Hematol 30:42–48
Benshidoum M et al. Transplantation of human bone marrow stromal cells (MSC) into immunodeficient mice. The improvement of human hematopoiesis maintenance and the extent of tissue engraftment depend on the studied MSC subsets. Submitted
Deans RJ, Moseley AB (2000) Mesenchymal stem cells and potential clinical uses. Exp Hematol 28:875–884
Devine SM, Bartholomew AM, Mahmud N, Nelson M, Patil S, Hardy W, Sturgeon C, Hewett T, Chung T, Stock W, Sher D, Weissman S, Ferrer K, Mosca J, Deans R, Moseley A, Hoffman R (2001) Mesenchymal stem cells are capable of homing to the bone marrow of nonhuman primates following systemic infusion. Exp Hematol 29:244–255
Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T lymphocyte proliferation induced by cellular or non specific mitogen stimuli. Blood 99:3838–3843
Fouillard L, Benshidoum M, Bories D, Bonte H, Lopez M, Moseley AM, Smith A, Lesage S, Beaujean F, Thierry D, Gourmelon P, Najman A, Gorin NC (2003) Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe aplastic anemia improves stroma. Leukemia 17:474–476
Gurevitch O, Prigozhina TB, Pugatsch T, Slavin S (1999) Transplantation of allogeneic or xenogenic bone marrow within the donor stromal microenvironment. Transplantation 68:1362–1368
Holmberg LA, Seidel K, Leisenring W, Storb BT (1994) Aplastic anemia: analysis of stromal cell function in long-term marrow cultures. Blood 84:3685–3690
Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WK, Gordon PL, Neel M, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK (1999) Transplantation and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309–313
Ishida T, Inaba M, Hisha H, Sugiura K, Adachi Y, Nagata N, Ogawa R, Good RA, Ikehara S (1994) Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune disease in MRL/ MP-Ipr/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor. J Immunol 152:3119
Jo DY, Rafii S, Hamada T, Moore MA (2000) Chemotaxis of primitive hematopoetic cells in response to stromal cell-derived factor 1. J Clin Invest 105:101–111
Koç ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM (2000) Rapid hematopoietic recovery after coinfusion of autologous blood stem cells and culture expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high dose chemotherapy. J Clin Oncol 18:307–316
Koç ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W (2002) Allogeneic mesenchymal stem cell infusion for the treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 30:215–222
Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI (1995) Ex vivo expansion and subsequent infusion of bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implication for therapeutic use. Bone Marrow Transplant 16:557–564
Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW (2000) Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 6:1282–1286
Noort WA, Kruisselbrink AB, in’t Anker PS, Kruger M, van Bezooijen RL, de Paus RA, Heemskerk MH, Lowik CW, Falkenburg JH, Willemze R, Fibbe WE (2002) Mesenchymal stem cells promote engraftment of human umbilical cord blood derived CD34+ cells in NOD-SCID mice. Exp Hematol 30:870–878
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147
Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–73
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fouillard, L. (2005). Mesenchymal Stem Cells for the Treatment of Hematological Malignancies. In: Keating, A., Dicke, K., Gorin, N., Weber, R., Graf, H. (eds) Regenerative and Cell Therapy. Ernst Schering Research Foundation Workshop, vol 11. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-26843-X_6
Download citation
DOI: https://doi.org/10.1007/3-540-26843-X_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22093-0
Online ISBN: 978-3-540-26843-7
eBook Packages: MedicineMedicine (R0)