Immune-Based Cell Therapy for Acute and Chronic Neurodegeneratlve Disorders
5.7 Concluding Remarks
Our findings show that CNS homeostasis is controlled not only locally, but also systemically by the adaptive arm of the immune response directed against antigens residing at the site of glutamate stress. They also provide the first direct evidence that stress-induced immune responses mediate an ongoing dialog between T cells and CNS tissue. As glutamate is a key player in brain activity, and lack of its proper regulation a key factor in cognitive, neural, psychogenic, and neurodegenerative disorders, the novel concept of immune system participation in glutamate regulation might represent a landmark in our understanding of how the body controls the brain and the development of therapies, not only for an excess but also for a deficiency of glutamate.
KeywordsSpinal Cord Injury Amyotrophic Lateral Sclerosis Traumatic Spinal Cord Injury Glutamate Toxicity Interphotoreceptor Retinoid Binding Protein
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