Bone Marrow Cell Therapy for Genetic Disorders of Bone
Bone marrow cell therapy for nonhematopoietic disorders is extraordinary promising, but such therapy is still in early development. We believe that our work, begun in 1996, has established the proof of principle: bone marrow cell therapy can be applied to nonhematopoietic disorders and especially to disorders of bone. In fact, a recent paper reported that another genetic disorder of bone, hypophosphatasia, had been successfully treated with BMT and a subsequent marrow stem cell infusion (Whyte et al. 2003). Still required, however, are methods that will promote long-term, tissue-specific proliferation and differentiation, thus ensuring maximum clinical benefits from this cell-based treatment strategy.
KeywordsMesenchymal Stem Cell Bone Marrow Transplantation Mesenchymal Cell Osteogenesis Imperfecta Graft Versus Host Disease
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