Acute and Chronic Models of Allergic Contact Dermatitis: Advantages and Limitations
Basic immunological research has not only provided a deeper insight into the pathophysiology of ACD but has also generated a plethora of appealing animal models for both acute and chronic ACD. Some of the more established models are already extensively characterized and have proven to be T cell-dependent with an involvement of Th1 and Tc1 cells. They display at least some of the classical histological hallmarks of human ACD, and responses to experimental therapies in rodents do to a large extent reflect the human situation. However, the established models are mostly acute, self-limited inflammation models. More recent developments such as mice overexpressing costimulatory or angiogenic molecules need further characterization. Gene and protein expression profiling would allow comparisons of expression profiles in human disease with those obtained from different animal models. More systematic investigations regarding the effects of well established effective therapeutic approaches in humans and in model situations compared to drugs effective only in contact dermatitis models, not in humans would be desirable. In the future, this may help to select relevant models for specific needs such as functional target validation and compound characterization and may finally provide the desired, more predictive in vivo models.
KeywordsContact Dermatitis Allergic Contact Dermatitis Allergen Challenge Mometasone Furoate Contact Hypersensitivity
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