From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice
Psoriasis is one of the most prevalent T cell-mediated chronic inflammatory diseases. However, there is still a poor understanding of this disease’s pathogenesis, as well as an array of therapeutic agents with ill-defined mechanisms of action. Newer xenotransplantation mouse models such as the AGR129 mouse model hopefully will provide the necessary scientific insights to connect new therapeutic measures such as biological agents with disease pathogenesis in this enigmatic disease.
KeywordsSCID Mouse Knockout Mouse Model Inflammatory Skin Disease Transform Growth Factor Alpha Epidermal Hyperplasia
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