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From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice

  • F. O. Nestle
  • B. J. Nickoloff
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 50)

11.6 Conclusions

Psoriasis is one of the most prevalent T cell-mediated chronic inflammatory diseases. However, there is still a poor understanding of this disease’s pathogenesis, as well as an array of therapeutic agents with ill-defined mechanisms of action. Newer xenotransplantation mouse models such as the AGR129 mouse model hopefully will provide the necessary scientific insights to connect new therapeutic measures such as biological agents with disease pathogenesis in this enigmatic disease.

Keywords

SCID Mouse Knockout Mouse Model Inflammatory Skin Disease Transform Growth Factor Alpha Epidermal Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • F. O. Nestle
    • 1
  • B. J. Nickoloff
    • 2
  1. 1.Department of Dermatology, Medical SchoolUniversity of ZurichZürichSwitzerland
  2. 2.Department of Pathology, Oncology InstituteLoyola University Medical CenterChicagoUSA

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