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Imaging Protein-Protein Interactions in Whole Cells and Living Animals

  • D. Piwnica-Worms
  • K. E. Luker
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 49)

2.4 Conclusions

These studies demonstrate that noninvasive molecular imaging of protein-protein interactions may enable investigators to determine how intrinsic binding specificities of proteins are regulated in a wide variety of normal and pathophysiologic conditions. These tools provide a platform for detection of regulated and small molecule-induced protein-protein interactions in intact cells and living animals and should enable a wide range of novel applications in biomedi-cine, drug discovery, chemical genetics, and proteomics research.

Keywords

Living Animal Hybrid Protein Fragment Complementation Sharma Versus Tron Emission Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • D. Piwnica-Worms
    • 1
  • K. E. Luker
    • 2
  1. 1.Washington University School of Medicine Molecular Imaging CenterSt. LouisUSA
  2. 2.Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and PharmacologyWashington University Medical SchoolSt. LouisUSA

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