Additional Topical Preparations


Retinoic Acid Hyaluronic Acid Zinc Oxide Topical Preparation Cutaneous Ulcer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Prutkin L: Wound healing and vitamin A acid. Acta Derm Venereal 1972; 52:489–492Google Scholar
  2. 2.
    Tumberello J: Using vitamin A + D Ointment for wounds. Oncol Nurs Forum 1995; 22:989Google Scholar
  3. 3.
    Brandaleone H: The effect of the direct application of cod liver upon the healing of ulcers of the feet in patients with diabetes mellitus. Ann Surg 1938; 108:141–152Google Scholar
  4. 4.
    Steel JP: The cod-liver oil treatment of wounds. Lan-cet 1935; 2:290–292Google Scholar
  5. 5.
    Anstead GM: Steroids, retinoids, and wound healing. Adv Wound Care 1998; 11:277–285PubMedGoogle Scholar
  6. 6.
    Hunt TK, Ehrlich HP, Garcia JA, et al: Effects of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man. Ann Surg 1969; 170:633–641PubMedGoogle Scholar
  7. 7.
    Terkelsen LH, Eskild-Jensen A, Kjeldsen H, et al: Topical application of cod liver oil ointment accelerates wound healing: an experimental study in wounds in the ears of hairless mice. Scand J Plast Reconstr Hand Surg 2000; 34:15–20Google Scholar
  8. 8.
    Watcher MA, Wheeland RG: The role of topical agents in the healing of full-thickness wounds. J Dermatol Surg Oncol 1989; 15:1188–1195PubMedGoogle Scholar
  9. 9.
    Lee KH, Tong TG: Mechanism of action of retinyl compounds on wound healing. 2. Effect of active retinyl derivatives on granuloma formation. J Pharm Sci 1970; 59:1195–1197PubMedGoogle Scholar
  10. 10.
    Hung VC, Lee JY, Zitelli JA, et al: Topical tretinoin and epithelial wound healing. Arch Dermatol 1989; 125:65–69CrossRefPubMedGoogle Scholar
  11. 11.
    Popp C, Kligman AM, Stoudemayer TJ: Pretreatment of photoaged forearm skin with topical tretinoin accelerates healing of full-thickness wounds. Br J Dermatol 1995; 132:46–53PubMedGoogle Scholar
  12. 12.
    Paquette D, Badiavas E, Falanga V: Short-contact topical tretinoin therapy to stimulate granulation tissue in chronic wounds. J Am Acad Dermatol 2001; 45:382–386CrossRefPubMedGoogle Scholar
  13. 13.
    Hevia O, Nemeth AJ, Taylor JR: Tretinoin accelerates healing after trichloroacetic acid chemical peel. Arch Dermatol 1991; 127:678–682CrossRefPubMedGoogle Scholar
  14. 14.
    Mandy SH: Tretinoin in the preoperative and post-operative management of dermabrasion. J Am Acad Dermatol 1986; 15[Suppl]:878–879, 888–889PubMedGoogle Scholar
  15. 15.
    Griffiths CE, Kang S, Ellis CN, et al: Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.0025% tretinoin creams. Arch Dermatol 1995; 131:1037–1044PubMedGoogle Scholar
  16. 16.
    Griffiths CE, Voorhees JJ: Topical retinoic acid for photoaging: clinical response and underlying mechanisms. Skin Pharmacol 1993; 6[Suppl 1]:70–77PubMedGoogle Scholar
  17. 17.
    Driessen C, Hirv K, Kirchner H, et al: Zinc regulates cytokine induction by superantigens and lipopoly-saccharide. Immunology 1995; 84:272–277PubMedGoogle Scholar
  18. 18.
    Driessen C, Hirv K, Rink L, et al: Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes. Lymphokine Cytokine Res 1994; 13:15–20PubMedGoogle Scholar
  19. 19.
    Tarnow P, Agren M, Steenfos H, et al: Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor 1 in granulation from porcine wounds. Scand J Plast Reconstr Surg Hand Surg 1994; 28:255–259PubMedGoogle Scholar
  20. 20.
    Watanabe S, Wang XE, Hirose M, et al: Insulin-like growth factor 1 plays a role in gastric wound healing: evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair model. Aliment Pharmacol Ther 1998; 12:1131–1138CrossRefPubMedGoogle Scholar
  21. 21.
    Kohn S, Kohn D, Schiller D: Effect of zinc supple mentation on epidermal Langerhans' cells of elderly patients with decubital ulcers. J Dermatol 2000; 27: 258–263PubMedGoogle Scholar
  22. 22.
    Jin L, Murakami TH, Janjua NA, et al: The effects of zinc oxide diethyldithiocarbamate on the mitotic index of epidermal basal cells of mouse skin. Acta Med Okayama 1994; 48:231–236PubMedGoogle Scholar
  23. 23.
    Solomon LM: Eczema. In: Moschella SL, Hurley HJ (eds) Dermatology, 2nd edn. Philadelphia: WB Saunders. 1985; pp 354–388Google Scholar
  24. 24.
    Sulzberger MB, Wolf J: Eczematous Dermatoses. In: Sulzberger MB, Wolf J: Dermatologic Therapy in General Practice, 2nd edn. Illinois: Year Book Publishers. 1942; pp 88–124Google Scholar
  25. 25.
    Ryan TJ: Wound healing and current dermatologic dressings. Clin Dermato 1990; 8:21–29CrossRefGoogle Scholar
  26. 26.
    Keefer KA, Iocono JA, Ehrlich HP: Zinc-containing wound dressings encourage autolytic debridement of dermal burns. Wounds 1998; 10:54–58Google Scholar
  27. 27.
    Agren MS, Stromberg HE: Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg 1985; 19:97–100PubMedGoogle Scholar
  28. 28.
    Stromberg HE, Agren MS: Topical zinc oxide treatment improves arterial and venous leg ulcers. Br J Dermatol 1984; 111:461–468PubMedGoogle Scholar
  29. 29.
    Agren MS: Zinc in wound repair. Arch Dermatol 1999; 135:1273–1274CrossRefGoogle Scholar
  30. 30.
    Williams KJ, Meltzer R, Brown RA, et al: The effect of topically applied zinc on the healing of open wounds. J Surg Res 1979; 27:62–67CrossRefPubMedGoogle Scholar
  31. 31.
    Brandrup F, Menne T, Agren MS, et al: A randomized trial of two occlusive dressings in the treatment of leg ulcers. Acta Derm Venereol (Stockh) 1990; 70:231–235Google Scholar
  32. 32.
    Davis SC, Mertz PM, Bilevich ED, et al: Early debridement of second-degree burn wounds enhances the rate of epithelization — an animal model to evaluate burn wound therapies. J Burn Care Rehabil 1996;17:558–561PubMedGoogle Scholar
  33. 33.
    Fodor PB: Scarlet red. Ann Plast Surg 1980; 4:45–47PubMedGoogle Scholar
  34. 34.
    Parfitt K (ed) Disinfectants and preservatives. In: Martindale — The complete drug reference, 32nd edn. London: Pharmaceutical Press. 1999; pp 1097–1127Google Scholar
  35. 35.
    Fischer B: Die experimentelle Erzeugung atypischer Epithelwucherungen und die Entstehung bösartiger Geschwülste. Minch Med Wochenschr 1906; 42:2041–2047Google Scholar
  36. 36.
    Davis JS: The effect of scarlet red in various combinations upon the epithelization of granulating surfaces. Ann Surg 1910; 51:40–51Google Scholar
  37. 37.
    Davis JS: A further note on the clinical use of scarlet red and its component amido-azotolud in stimulating the epitheliation of granulated surfaces. Ann Surg 1911; 53:702–719Google Scholar
  38. 38.
    Bettman AG: A simpler technic for promoting epithelialization and protecting skin grafts. JAMA 1931; 97:1879–1881Google Scholar
  39. 39.
    Fisher LB, Maibach HI: The effect of occlusive and semipermeable dressings on the mitotic activity of normal and wounded human epidermis. Br J Dermatol 1972; 86:593–600PubMedGoogle Scholar
  40. 40.
    Prasad JK, Feller I, Thomson PD: A prospective controlled trial of Biobrane versus scarlet red on skin graft donor areas. J Burn Care Rehabil 1987; 8:384–386PubMedGoogle Scholar
  41. 41.
    Zapata-Sirvent R, Hansbrough JF, Carroll W, et al: Comparison of Biobrane and scarlet red dressings for treatment of donor site wounds. Arch Surg 1985; 120:743–745PubMedGoogle Scholar
  42. 42.
    Cannon B: Scarlet red. Plast Reconstr Surg 1983; 72:116PubMedGoogle Scholar
  43. 43.
    West DC, Hampson IN, Arnold F, et al: Angiogenesis induced by degradation products of hyaluronic acid. Science 1985; 228:1324–1326PubMedGoogle Scholar
  44. 44.
    Deed R, Rooney P, Kumar P, et al: Early response gene signalling is induced by angiogenic oligosaccharides of hyaluronan in endothelial cells. Inhibition by non-angiogenic, high-molecular-weight hyaluronan. Int J Cancer 1997; 10::251–256CrossRefGoogle Scholar
  45. 45.
    Doillon CJ, Silver FH: Collagen based wound dressing: effects of hyaluronic acid and fibronectin on wound healing. Biomaterials 1986; 7:3–8CrossRefPubMedGoogle Scholar
  46. 46.
    Iocono JA, Ehrlich HP, Keefer KA, et al: Hyaluronan induces scarless repair in mouse limb organ culture. J Pediatr Surg 1998; 33:564–567CrossRefPubMedGoogle Scholar
  47. 47.
    Ellis IR, Schor SL: Differential effects of TGF-beta 1 on hyaluronan synthesis by fetal and adult skin fibroblasts: Implications for cell migration and wound healing. Exp Cell Res 1996; 228:326–333CrossRefPubMedGoogle Scholar
  48. 48.
    Hollander DA, Schmandra T, Windolf J: A new approach to the treatment of recalcitrant wounds: A case report demonstrating the use of a hyaluronan esters fleece. Wounds 2000; 12:111–117Google Scholar
  49. 49.
    Wollina U, Karamfilov T: Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix. J Eur Acad Dermatol Venereol 2000; 14:187–190CrossRefPubMedGoogle Scholar
  50. 50.
    Ortonne JP: Comparative study of the activity of hyaluronic acid and dextranomer in the treatment of leg ulcers of venous origin. Ann Dermatol Venereol 2001; [Suppl]:13–16Google Scholar
  51. 51.
    Mekkes JR, Nahuys M: Induction of granulation tissue formation in chronic wounds by hyaluronic acid. Wounds 2001; 13:159–164Google Scholar
  52. 52.
    Koev D, Tankova T, Dakovska G: Hyaluricht in the treatment of diabetic foot ulcers. Diabetic Foot Study Group of the EASD. Balatonfured, Hungary. September, 2002Google Scholar
  53. 53.
    Szumacher E, Wighton A, Franssen E, et al: Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. Int J Radiat Oncol Biol Phys 2001; 51:81–86CrossRefPubMedGoogle Scholar
  54. 54.
    Coulomb B, Friteau L, Dubertret L: Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/ IL-6 ratio. Skin Pharmacol 1997; 100:281–287Google Scholar
  55. 55.
    Fisher J, Scott C, Stevens R, et al: Randomized phase-III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97–13. Int J Radiat Oncol Biol Phys 2000; 48:1307–1310CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Personalised recommendations