Immunogenetics of Ocular Inflammatory Disease

  • Ralph D. Levinson
Part of the Essentials in Ophthalmology book series (ESSENTIALS)


Giant Cell Arteritis Acute Anterior Uveitis Sympathetic Ophthalmia Ocular Inflammatory Disease TINU Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Agardh D, Gaur LK, Agardh E, et al. (1996) HLA-DQB1⋆ 0201/0302 is associated with severe retinopathy in patients with IDDM. Diabetologia 39:1313–1317CrossRefPubMedGoogle Scholar
  2. 2.
    Ahmad T, Wallace GR, James T, et al. (2003) Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms? Arthritis Rheum 48:807–813CrossRefPubMedGoogle Scholar
  3. 3.
    Aksentijevich I, Nowak M, Mallah M, et al. (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum 46:3340–3348CrossRefPubMedGoogle Scholar
  4. 4.
    Alaez C, del Pilar MM, Arellanes L, et al. (1999) Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease. Hum Immunol 60:875–882PubMedGoogle Scholar
  5. 5.
    Ambati J, Anand A, Fernandez S, et al. (2003) An animal model of age-related macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice. Nat Med 9:1390–1397PubMedGoogle Scholar
  6. 6.
    Amoli MM, Shelley E, Mattey DL, et al. (2001) Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis. J Rheumatol 28:1600–1604PubMedGoogle Scholar
  7. 7.
    Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134:411–431CrossRefPubMedGoogle Scholar
  8. 8.
    Arellanes-Garcia L, Bautista N, Mora P, et al. (1998) HLA-DR is strongly associated with Vogt-Koyanagi-Harada disease in Mexican Mestizo patients. Ocul Immunol Inflamm 6:93–100CrossRefPubMedGoogle Scholar
  9. 9.
    Batioglu F, Atmaca LS, Karabulut HG, Beyza SD (2003) Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease. Acta Ophthalmol Scand 81:283–285PubMedGoogle Scholar
  10. 10.
    Bloch-Michel E, Frau E (1991) Birdshot retino-choroidopathy and HLA-A29+ and HLA-A29-idiopathic retinal vasculitis: comparative study of 56 cases. Can J Ophthalmol 26:361–366PubMedGoogle Scholar
  11. 11.
    Borruat FX, Herbort CP, Spertini F, Desarnaulds AB (1998) HLA typing in patients with multiple evanescent white dot syndrome (MEWDS). Ocul Immunol Inflamm 6:39–41CrossRefPubMedGoogle Scholar
  12. 12.
    Buckner JH, Nepom GT (2002) Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association? Curr Opin Rheumatol 14:254–259PubMedGoogle Scholar
  13. 13.
    Capeans C, De Rojas MV, Lojo S, Salorio MS (1998) C-C chemokines in the vitreous of patients with proliferative vitreoretinopathy and proliferative diabetic retinopathy. Retina 18:546–550PubMedGoogle Scholar
  14. 14.
    Chen QY, Huang W, She JX, et al. (1999) HLA-DRB1⋆ 08, DRB1⋆03/DRB3⋆0101, and DRB3⋆0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1⋆07 is protective. J Clin Endocrinol Metab 84:3182–3186CrossRefPubMedGoogle Scholar
  15. 15.
    Chen Y, Vaughan RW, Kondeatis E, et al. (2004) Chemokine gene polymorphisms associate with gender in patients with uveitis. Tissue Antigens 63:41–45CrossRefPubMedGoogle Scholar
  16. 16.
    Davey MP, Rosenbaum JT (2000) The human leukocyte antigen complex and chronic ocular inflammatory disorders. Am J Ophthalmol 129:235–243CrossRefPubMedGoogle Scholar
  17. 17.
    Donn RP, Farhan AJ, Barrett JH, et al. (1999) Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. Rheumatology (Oxford) 38:171–175PubMedGoogle Scholar
  18. 18.
    du Bois RM (2002) The genetic predisposition to interstitial lung disease: functional relevance. Chest 121:14S–20SCrossRefGoogle Scholar
  19. 19.
    Elner SG, Elner VM, Jaffe GJ, et al. (1995) Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Curr Eye Res 14:1045–1053PubMedGoogle Scholar
  20. 20.
    Elner SG, Strieter R, Bian ZM, et al. (1998) Interferon-induced protein 10 and interleukin 8. C-XC chemokines present in proliferative diabetic retinopathy. Arch Ophthalmol 116:1597–1601PubMedGoogle Scholar
  21. 21.
    Feron EJ, Klaren VN, Wierenga EA, et al. (2001) Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with ocular toxoplasmosis. Invest Ophthalmol Vis Sci 42:3228–3232PubMedGoogle Scholar
  22. 22.
    Flynn JC, Rao PV, Gora M, et al. (2004) Graves' hyperthyroidism and thyroiditis in HLADRB1⋆ 0301 (DR3) transgenic mice after immunization with thyrotropin receptor DNA. Clin Exp Immunol 135:35–40CrossRefPubMedGoogle Scholar
  23. 23.
    Foley PJ, McGrath DS, Puscinska E, et al. (2001) Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis. Am J Respir Cell Mol Biol 25:272–277PubMedGoogle Scholar
  24. 24.
    Gardner TW, Antonetti DA, Barber AJ, et al. (2002) Diabetic retinopathy:more than meets the eye. Surv Ophthalmol 47Suppl 2:S253–S262CrossRefPubMedGoogle Scholar
  25. 25.
    Gaudio PA, Kaye DB, Crawford JB (2002) Histopathology of birdshot retinochoroidopathy. Br J Ophthalmol 86:1439–1441CrossRefPubMedGoogle Scholar
  26. 26.
    Geggel HS, Nettles JW, Nepom BS (1992) HLA-DR alleles and sterile ulcerative keratitis. Cornea 11:505–509PubMedGoogle Scholar
  27. 27.
    Giannini EH, Malagon CN, Van Kerckhove C, et al. (1991) Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis. J Rheumatol 18:1394–1397PubMedGoogle Scholar
  28. 28.
    Gil-Carrasco F, Vargas-Alarcon G, Zuniga J, et al. (1999) HLA-DRB and HLA-DQB loci in the genetic susceptibility to develop glaucoma in Mexicans. Am J Ophthalmol 128:297–300PubMedGoogle Scholar
  29. 29.
    Gonzalez-Gay MA, Amoli MM, Garcia-Porrua C, Ollier WE (2003) Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. Semin Arthritis Rheum 33:38–48PubMedGoogle Scholar
  30. 30.
    Gonzalez-Gay MA, Hajeer AH, Dababneh A, et al. (2002) IL-6 promoter polymorphism at position-174 modulates the phenotypic expression of polymyalgia rheumatica in biopsy-proven giant cell arteritis. Clin Exp Rheumatol 20:179–184PubMedGoogle Scholar
  31. 31.
    Goto K, Ota M, Ando H, et al. (1998) MICA gene polymorphisms and HLA-B⋆27 subtypes in Japanese patients with HLA-B⋆27-associated acute anterior uveitis. Invest Ophthalmol Vis Sci 39:634–637PubMedGoogle Scholar
  32. 32.
    Goto K, Ota M, Maksymowych WP, et al. (1998) Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B⋆27. Am J Ophthalmol 126:436–441CrossRefPubMedGoogle Scholar
  33. 33.
    Greiner KH, Wilson DW, Thomson J, et al. (2003) Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. Eur J Ophthalmol 13:433–438PubMedGoogle Scholar
  34. 34.
    Grunewald J, Eklund A, Olerup O (2004) Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients. Am J Respir Crit Care Med 169:696–702CrossRefPubMedGoogle Scholar
  35. 35.
    Haas JP, Truckenbrodt H, Paul C, et al. (1994) Subtypes of HLA-DRB1⋆03, ⋆08, ⋆11, ⋆12, ⋆13 and ⋆14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. Clin Exp Rheumatol 12Suppl 10:S7–14PubMedGoogle Scholar
  36. 36.
    Hall FC, Rabinowitz JD, Busch R, et al. (2002) Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur J Immunol 32:662–670CrossRefPubMedGoogle Scholar
  37. 37.
    Hohler T, Schaper T, Schneider PM, et al. (1997) No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies. Ann Rheum Dis 56:741–743PubMedGoogle Scholar
  38. 38.
    Holland GN, Cornell PJ, Park MS, et al. (1989) An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62, DR4. Am J Ophthalmol 108:370–374PubMedGoogle Scholar
  39. 39.
    Huang SM, Wu TJ, Lee TD, et al. (2003) The association of HLA-A,-B, and-DRB1 genotypes with Graves' disease in Taiwanese people. Tissue Antigens 61:154–158PubMedGoogle Scholar
  40. 40.
    Hugot JP, Chamaillard M, Zouali H, et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599–603CrossRefPubMedGoogle Scholar
  41. 41.
    Islam SM, Numaga J, Matsuki K, et al. (1994) Influence of HLA-DRB1 gene variation on the clinical course of Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci 35:752–756PubMedGoogle Scholar
  42. 42.
    Jacobsen S, Baslund B, Madsen HO, et al. (2002) Mannose-binding lectin variant alleles and HLADR4 alleles are associated with giant cell arteritis. J Rheumatol 29:2148–2153PubMedGoogle Scholar
  43. 43.
    Joko S, Numaga J, Maeda H (1999) Immunogenetics of uveitis in leprosy. Jpn J Ophthalmol 43:97–102CrossRefPubMedGoogle Scholar
  44. 44.
    Kang HI, Fei HM, Saito I, et al. (1993) Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome. J Immunol 150:3615–3623PubMedGoogle Scholar
  45. 45.
    Karasneh J, Hajeer AH, Barrett J, et al. (2003) Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behçet's disease. Rheumatology (Oxford) 42:860–864CrossRefPubMedGoogle Scholar
  46. 46.
    Kilmartin DJ, Wilson D, Liversidge J, et al. (2001) Immunogenetics and clinical phenotype of sympathetic ophthalmia in British and Irish patients. Br J Ophthalmol 85:281–286CrossRefPubMedGoogle Scholar
  47. 47.
    Kim MH, Seong MC, Kwak NH, et al. (2000) Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans. Am J Ophthalmol 129:173–177PubMedGoogle Scholar
  48. 48.
    Kojima S, Yamada T, Tamai M (2001) Quantitative analysis of interleukin-6 in vitreous from patients with proliferative vitreoretinal diseases. Jpn J Ophthalmol 45:40–45CrossRefPubMedGoogle Scholar
  49. 49.
    Konno Y, Numaga J, Mochizuki M, et al. (1998) TAP polymorphism is not associated with ankylosing spondylitis and complications with acute anterior uveitis in HLA-B⋆27-positive Japanese. Tissue Antigens 52:478–483PubMedGoogle Scholar
  50. 50.
    Konno Y, Numaga J, Tsuchiya N, et al. (1999) HLAB⋆ 27 subtypes and HLA class II alleles in Japanese patients with anterior uveitis. Invest Ophthalmol Vis Sci 40:1838–1844PubMedGoogle Scholar
  51. 51.
    Kurhan-Yavuz S, Direskeneli H, Bozkurt N, et al. (2000) Anti-MHC autoimmunity in Behçet's disease: T cell responses to an HLA-B-derived peptide cross-reactive with retinal-S antigen in patients with uveitis. Clin Exp Immunol 120:162–166CrossRefPubMedGoogle Scholar
  52. 52.
    Laatikainen L, Erkkila H (1981) A follow-up study on serpiginous choroiditis. Acta Ophthalmol (Copenh) 59:707–718Google Scholar
  53. 53.
    Lee EB, Kim JY, Lee YJ, et al. (2003) TNF and TNF receptor polymorphisms in Korean Behçet's disease patients. Hum Immunol 64:614–620PubMedGoogle Scholar
  54. 54.
    Levinson RD, Gonzales CR (2002) Birdshot retinochoroidopathy: immunopathogenesis, evaluation, and treatment. Ophthalmol Clin North Am 15:343–350CrossRefPubMedGoogle Scholar
  55. 55.
    Levinson RD, Greenhill LH (2002) The monthly variation in acute anterior uveitis in a community-based ophthalmology practice. Ocul Immunol Inflamm 10:133–139CrossRefPubMedGoogle Scholar
  56. 56.
    Levinson RD, Park MS, Rikkers SM, et al. (2003) Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Invest Ophthalmol Vis Sci 44:653–657CrossRefPubMedGoogle Scholar
  57. 57.
    Lin HJ, Tsai FJ, Chen WC, et al. (2003) Association of tumour necrosis factor alpha-308 gene polymorphism with primary open-angle glaucoma in Chinese. Eye 17:31–34CrossRefPubMedGoogle Scholar
  58. 58.
    Liu NH, LaBree LD, Feldon SE, Rao NA (2001) The epidemiology of giant cell arteritis: a 12-year retrospective study. Ophthalmology 108:1145–1149CrossRefPubMedGoogle Scholar
  59. 59.
    Mack DG, Johnson JJ, Roberts F, et al. (1999) HLAclass II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol 29:1351–1358CrossRefPubMedGoogle Scholar
  60. 60.
    Maksymowych WP, Jhangri GS, Gorodezky C, et al. (1997) The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B⋆27 positive juvenile and adult Mexican subjects with ankylosing spondylitis. Ann Rheum Dis 56:488–492PubMedGoogle Scholar
  61. 61.
    Maksymowych WP, Tao S, Vaile J, et al. (2000) LMP2 polymorphism is associated with extraspinal disease in HLA-B⋆27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis. J Rheumatol 27:183–189PubMedGoogle Scholar
  62. 62.
    Malinowski SM, Pulido JS, Goeken NE, et al. (1993) The association of HLA-B⋆8, B51, DR2, and multiple sclerosis in pars planitis. Ophthalmology 100:1199–1205PubMedGoogle Scholar
  63. 63.
    Martin TM, Doyle TM, Smith JR, et al. (2003) Uveitis in patients with sarcoidosis is not associated with mutations in NOD2 (CARD15). Am J Ophthalmol 136:933–935CrossRefPubMedGoogle Scholar
  64. 64.
    Matsuo T, Matsuo N (1991) HLA-DR9 associated with the severity of acute retinal necrosis syndrome. Ophthalmologica 203:133–137PubMedGoogle Scholar
  65. 65.
    Mattey DL, Hajeer AH, Dababneh A, et al. (2000) Association of giant cell arteritis and polymyalgia rheumatica with different tumor necrosis factor microsatellite polymorphisms. Arthritis Rheum 43:1749–1755CrossRefPubMedGoogle Scholar
  66. 66.
    McCannel CA, Holland GN, Helm CJ, et al. (1996) Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol 121:35–46PubMedGoogle Scholar
  67. 67.
    McDowell TL, Symons JA, Ploski R, et al. (1995) A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism. Arthritis Rheum 38:221–228PubMedGoogle Scholar
  68. 68.
    Meenken C, Rothova A, de Waal LP, et al. (1995) HLA typing in congenital toxoplasmosis. Br J Ophthalmol 79:494–497PubMedGoogle Scholar
  69. 69.
    Meredith TA, Smith RE, Duquesnoy RJ (1980) Association of HLA-DRw2 antigen with presumed ocular histoplasmosis. Am J Ophthalmol 89:70–76PubMedGoogle Scholar
  70. 70.
    Miceli-Richard C, Lesage S, Rybojad M, et al. (2001) CARD15 mutations in Blau syndrome. Nat Genet 29:19–20CrossRefPubMedGoogle Scholar
  71. 71.
    Mimura T, Funatsu H, Uchigata Y, et al. (2003) Relationship between human leukocyte antigen status and proliferative diabetic retinopathy in patients with younger-onset type 1 diabetes mellitus. Am J Ophthalmol 135:844–848CrossRefPubMedGoogle Scholar
  72. 72.
    Mizuki N, Ota M, Katsuyama Y, et al. (2001) HLAB⋆ 51 allele analysis by the PCR-SBT method and a strong association of HLA-B⋆5101 with Japanese patients with Behçet's disease. Tissue Antigens 58:181–184CrossRefPubMedGoogle Scholar
  73. 73.
    Mizuki N, Ota M, Katsuyama Y, et al. (2002) Sequencing-based typing of HLA-B⋆51 alleles and the significant association of HLA-B⋆5101 and-B⋆5108 with Behçet's disease in Greek patients. Tissue Antigens 59:118–121CrossRefPubMedGoogle Scholar
  74. 74.
    Mizuki N, Ota M, Katsuyama Y, et al. (2001) HLA class I genotyping including HLA-B⋆51 allele typing in the Iranian patients with Behçet's disease. Tissue Antigens 57:457–462CrossRefPubMedGoogle Scholar
  75. 75.
    Mizuki N, Ota M, Yabuki K, et al. (2000) Localization of the pathogenic gene of Behçet's disease by microsatellite analysis of three different populations. Invest Ophthalmol Vis Sci 41:3702–3708PubMedGoogle Scholar
  76. 76.
    Mizuki N, Yabuki K, Ota M, et al. (2002) Analysis of microsatellite polymorphism around the HLAB locus in Iranian patients with Behçet's disease. Tissue Antigens 60:396–399CrossRefPubMedGoogle Scholar
  77. 77.
    Mondino BJ, Brown SI, Biglan AW (1982) HLA antigens in Stevens-Johnson syndrome with ocular involvement. Arch Ophthalmol 100:1453–1454PubMedGoogle Scholar
  78. 78.
    Mondino BJ, Brown SI, Rabin BS (1979) HLA antigens in ocular cicatricial pemphigoid. Arch Ophthalmol 97:479PubMedGoogle Scholar
  79. 79.
    Newman B, Rubin LA, Siminovitch KA (2003) NOD2/CARD15 gene mutation is not associated with susceptibility to Wegener's granulomatosis. J Rheumatol 30:305–307PubMedGoogle Scholar
  80. 80.
    Nolle B, Faul S, Jenisch S, Westphal E (1998) Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients. Graefes Arch Clin Exp Ophthalmol 236:451–460CrossRefPubMedGoogle Scholar
  81. 81.
    Nussenblatt RB, Mittal KK (1981) Iridocyclitis in black Americans: association with HLA B8 suggests an autoimmune aetiology. Br J Ophthalmol 65:329–332PubMedGoogle Scholar
  82. 82.
    Nussenblatt RB, Mittal KK, Fuhrman S, et al. (1989) Lymphocyte proliferative responses of patients with ocular toxoplasmosis to parasite and retinal antigens. Am J Ophthalmol 107:632–641PubMedGoogle Scholar
  83. 83.
    Nussenblatt RB, Mittal KK, Ryan S, et al. (1982) Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol 94:147–158PubMedGoogle Scholar
  84. 84.
    Ogura Y, Bonen DK, Inohara N, et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603–606CrossRefPubMedGoogle Scholar
  85. 85.
    Ohno S, O'Connor GR, Kimura SJ (1977) HLA antigens and toxoplasmic retinochoroiditis. Tohoku J Exp Med 123:91–94PubMedGoogle Scholar
  86. 86.
    Oruc S, Duffy BF, Mohanakumar T, Kaplan HJ (2001) The association of HLA class II with pars planitis. Am J Ophthalmol 131:657–659CrossRefPubMedGoogle Scholar
  87. 87.
    Paroli MP, Speranza S, Marino M, et al. (2003) Prognosis of juvenile rheumatoid arthritis-associated uveitis. Eur J Ophthalmol 13:616–621PubMedGoogle Scholar
  88. 88.
    Paul M, Klein T, Krause I, et al. (2001) Allelic distribution of HLA-B⋆5 in HLA-B⋆5-positive Israeli patients with Behçet's disease. Tissue Antigens 58:185–186CrossRefPubMedGoogle Scholar
  89. 89.
    Penfold PL, Madigan MC, Gillies MC, Provis JM (2001) Immunological and aetiological aspects of macular degeneration. Prog Retin Eye Res 20:385–414CrossRefPubMedGoogle Scholar
  90. 90.
    Pratsidou-Gertsi P, Kanakoudi-Tsakalidou F, Spyropoulou M, et al. (1999) Nationwide collaborative study of HLA class II associations with distinct types of juvenile chronic arthritis (JCA) in Greece. Eur J Immunogenet 26:299–310CrossRefPubMedGoogle Scholar
  91. 91.
    Radosevich M, Ono SJ (2003) Novel mechanisms of class II major histocompatibility complex gene regulation. Immunol Res 27:85–106CrossRefPubMedGoogle Scholar
  92. 92.
    Raja SC, Jabs DA, Dunn JP, et al. (1999) Pars planitis: clinical features and class II HLA associations. Ophthalmology 106:594–599CrossRefPubMedGoogle Scholar
  93. 93.
    Rosenbaum JT, Planck SR, Davey MP, et al. (2003) With a mere nod, uveitis enters a new era. Am J Ophthalmol 136:729–732CrossRefPubMedGoogle Scholar
  94. 94.
    Salvarani C, Boiardi L, Mantovani V, et al. (1999) HLA-DRB1, DQA1, and DQB1 alleles associated with giant cell arteritis in northern Italy. J Rheumatol 26:2395–2399PubMedGoogle Scholar
  95. 95.
    Seddon JM, Gensler G, Milton RC, et al. (2004) Association between C-reactive protein and age-related macular degeneration. JAMA 291:704–710CrossRefPubMedGoogle Scholar
  96. 96.
    Seki N, Yamaguchi K, Yamada A, et al. (1999) Polymorphism of the 5'-flanking region of the tumor necrosis factor (TNF)-alpha gene and susceptibility to human T-cell lymphotropic virus type I (HTLV-I) uveitis. J Infect Dis 180:880–883CrossRefPubMedGoogle Scholar
  97. 97.
    Shindo Y, Inoko H, Yamamoto T, Ohno S (1994) HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RFLP and the strong association with DRB1⋆0405 and DRB1⋆0410. Br J Ophthalmol 78:223–226PubMedGoogle Scholar
  98. 98.
    Shindo Y, Ohno S, Usui M, et al. (1997) Immunogenetic study of sympathetic ophthalmia. Tissue Antigens 49:111–115PubMedGoogle Scholar
  99. 99.
    Shindo Y, Ohno S, Yamamoto T, et al. (1994) Complete association of the HLA-DRB1⋆04 and-DQB1⋆04 alleles with Vogt-Koyanagi-Harada's disease. Hum Immunol 39:169–176CrossRefPubMedGoogle Scholar
  100. 100.
    Smith JR (2002) HLA-B⋆27-associated uveitis. Ophthalmol Clin North Am 15:297–307CrossRefPubMedGoogle Scholar
  101. 101.
    Snijders A, Elferink DG, Geluk A, et al. (2001) An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs. J Immunol 166:4987–4993PubMedGoogle Scholar
  102. 102.
    Spaide RF, Skerry JE, Yannuzzi LA, DeRosa JT (1990) Lack of the HLA-DR2 specificity in multifocal choroiditis and panuveitis. Br J Ophthalmol 74:536–537PubMedGoogle Scholar
  103. 103.
    Suzuki Y (2002) Host resistance in the brain against Toxoplasma gondii. J Infect Dis 185Suppl 1:S58–S65CrossRefPubMedGoogle Scholar
  104. 104.
    Suzuki Y, Wong SY, Grumet FC, et al. (1996) Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients. J Infect Dis 173:265–268PubMedGoogle Scholar
  105. 105.
    Szpak Y, Vieville JC, Tabary T, et al. (2001) Spontaneous retinopathy in HLA-A29 transgenic mice. Proc Natl Acad Sci U S A 98:2572–2576CrossRefPubMedGoogle Scholar
  106. 106.
    Tang S, Le Ruppert KC (1995) Activated T lymphocytes in epiretinal membranes from eyes of patients with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 233:21–25CrossRefPubMedGoogle Scholar
  107. 107.
    Tang WM, Pulido JS, Eckels DD, et al. (1997) The association of HLA-DR15 and intermediate uveitis. Am J Ophthalmol 123:70–75PubMedGoogle Scholar
  108. 108.
    Taylor CJ, Smith SI, Morgan CH, et al. (2000) HLA and Mooren's ulceration. Br J Ophthalmol 84:72–75CrossRefPubMedGoogle Scholar
  109. 109.
    Thurau SR, Diedrichs-Mohring M, Fricke H, et al. (1999) Oral tolerance with an HLA-peptide mimicking retinal autoantigen as a treatment of autoimmune uveitis. Immunol Lett 68:205–212CrossRefPubMedGoogle Scholar
  110. 110.
    Tomer Y (2002) Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. Autoimmun Rev 1:198–204CrossRefPubMedGoogle Scholar
  111. 111.
    Verity DH, Wallace GR, Vaughan RW, et al. (1999) HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behçet's disease. Tissue Antigens 54:264–272CrossRefPubMedGoogle Scholar
  112. 112.
    Wang X, Kuivaniemi H, Bonavita G, et al. (2002) CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with largevessel arteritis and cranial neuropathy. Arthritis Rheum 46:3041–3045CrossRefPubMedGoogle Scholar
  113. 113.
    Wax MB, Tezel G (2002) Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection. Mol Neurobiol 26:45–55CrossRefPubMedGoogle Scholar
  114. 114.
    Weinshenker BG, Santrach P, Bissonet AS, et al. (1998) Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study. Neurology 51:742–747PubMedGoogle Scholar
  115. 115.
    Weisz JM, Holland GN, Roer LN, et al. (1995) Association between Vogt-Koyanagi-Harada syndrome and HLA-DR1 and-DR4 in Hispanic patients living in southern California. Ophthalmology 102:1012–1015PubMedGoogle Scholar
  116. 116.
    Wolf MD, Folk JC, Panknen CA, Goeken NE (1990) HLA-B⋆7 and HLA-DR2 antigens and acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol 108:698–700PubMedGoogle Scholar
  117. 117.
    Wong TY, Cruickshank KJ, Klein R, et al. (2002) HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy. Ophthalmology 109:275–281CrossRefPubMedGoogle Scholar
  118. 118.
    Yamaki K, Gocho K, Hayakawa K, et al. (2000) Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol 165:7323–7329PubMedGoogle Scholar
  119. 119.
    Yang J, Patil RV, Yu H, et al. (2001) T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma. Am J Ophthalmol 131:421–426CrossRefPubMedGoogle Scholar
  120. 120.
    Yuuki T, Kanda T, Kimura Y, et al. (2001) Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy. J Diabetes Complications 15:257–259CrossRefPubMedGoogle Scholar
  121. 121.
    Zamani M, Spaepen M, Bex M, et al. (2000) Primary role of the HLA class II DRB1⋆0301 allele in Graves disease. Am J Med Genet 95:432–437CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Ralph D. Levinson

There are no affiliations available

Personalised recommendations