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Clinical Aspects of MALT

  • Erich Knop
  • Nadja Knop
  • Uwe Pleyer
Part of the Essentials in Ophthalmology book series (ESSENTIALS)

Keywords

Ocular Surface Lacrimal Gland Mucosal Immune System Ocular Allergy Conjunctival Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Abu El-Asrar AM, Geboes K, al-Kharashi S, Tabbara KF, Missotten L, Desmet V (1997) Adhesion molecules in vernal keratoconjunctivitis. Br J Ophthalmol 81:1099–1106PubMedGoogle Scholar
  2. 2.
    Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252CrossRefPubMedGoogle Scholar
  3. 3.
    Bielory L, Mongia A (2002) Current opinion of immunotherapy for ocular allergy. Curr Opin Allergy Clin Immunol 2:447–452CrossRefPubMedGoogle Scholar
  4. 4.
    Brandtzaeg P, Baekkevold ES, Morton HC (2001) From B to A the mucosal way. Nat Immunol 2:1093–1094PubMedGoogle Scholar
  5. 5.
    Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272:60–66PubMedGoogle Scholar
  6. 6.
    Dua HS, Gomes JA, Jindal VK, Appa SN, Schwarting R, Eagle RC Jr, Donoso LA, Laibson PR (1994) Mucosa specific lymphocytes in the human conjunctiva, corneoscleral limbus and lacrimal gland. Curr Eye Res 13:87–93PubMedGoogle Scholar
  7. 7.
    Fox RI (1998) Sjogren's syndrome. Pathogenesis and new approaches to therapy. Adv Exp Med Biol 438:891–902PubMedGoogle Scholar
  8. 8.
    Fox RI, Stern M (2002) Sjogren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand J Rheumatol Suppl 2002:3–13CrossRefGoogle Scholar
  9. 9.
    Fukagawa K, Tsubota K, Simmura S, Saito H, Tachimoto H, Akasawa A, Oguchi Y (1998) Chemokine production in conjunctival epithelial cells. Adv Exp Med Biol 438:471–478PubMedGoogle Scholar
  10. 10.
    Galli SJ, Gordon JR, Wershil BK (1993) Mast cell cytokines in allergy and inflammation. Agents Actions Suppl 43:209–220PubMedGoogle Scholar
  11. 11.
    Gallucci S, Matzinger P (2001) Danger signals: SOS to the immune system. Curr Opin Immunol 13:114–119PubMedGoogle Scholar
  12. 12.
    Gamache DA, Dimitrijevich SD, Weimer LK, Lang LS, Spellman JM, Graff G, Yanni JM (1997) Secretion of proinflammatory cytokines by human conjunctival epithelial cells. Ocul Immunol Inflamm 5:117–128PubMedGoogle Scholar
  13. 13.
    Garrana RM, Zieske JD, Assouline M, Gipson IK (1999) Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci 40:1266–1270PubMedGoogle Scholar
  14. 14.
    Gilbard J (1985) Tear film osmolarity and keratoconjunctivitis sicca. In: Holly FJ (ed) Proc 1 Int Tear Film Symposium, Lubbock, Texas, pp 127–139Google Scholar
  15. 15.
    Hamrah P, Zhang Q, Liu Y, Dana MR (2002) Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci 43:639–646Google Scholar
  16. 16.
    Hingorani M, Calder VL, Buckley RJ, Lightman S (1999) The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. Invest Ophthalmol Vis Sci 40:392–399PubMedGoogle Scholar
  17. 17.
    Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res 67:491–500CrossRefPubMedGoogle Scholar
  18. 18.
    Hingorani M, Metz D, Lightman SL (1997) Characterisation of the normal conjunctival leukocyte population. Exp Eye Res 64:905–912CrossRefPubMedGoogle Scholar
  19. 19.
    Iwasaki A, Kelsall BL (1999) Mucosal immunity and inflammation. I. Mucosal dendritic cells: their specialized role in initiating T cell responses. Am J Physiol 276:G1074–G1078PubMedGoogle Scholar
  20. 20.
    Katelaris CH (2003) Ocular allergy: implications for the clinical immunologist. Ann Allergy Asthma Immunol 90:23–27Google Scholar
  21. 21.
    Knop E, Claus P, Knop N (2003) Eye-associated lymphoid tissue (EALT): RT-PCR verifies the presence of mRNA for IgA and its transporter (secretory component) in the normal human conjunctiva. Invest Ophthalmol Vis Sci 44:S3801Google Scholar
  22. 22.
    Knop E, Knop N (2001) Lacrimal drainage associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol Vis Sci 2001:566–574Google Scholar
  23. 23.
    Knop E, Knop N (2002) A functional unit for ocular surface immune defense formed by the lacrimal gland, conjunctiva and lacrimal drainage system. Adv Exp Med Biol 506:835–844PubMedGoogle Scholar
  24. 24.
    Knop E, Knop N (2002) Human lacrimal drainage-associated lymphoid tissue (LDALT) belongs to the common mucosal immune system. Adv Exp Med Biol 506:861–866PubMedGoogle Scholar
  25. 25.
    Knop E, Knop N (2003) [Eye-associated lymphoid tissue (EALT) is continuously spread throughout the ocular surface from the lacrimal gland to the lacrimal drainage system]. Ophthalmologe 100:929–942PubMedGoogle Scholar
  26. 26.
    Knop E, Knop N (2004) Lymphocyte homing in the mucosal immune system to the eye-associated lymphoid tissue (EALT). In: Zierhut M, Sullivan DA, Stern ME (eds) Immunology of the ocular surface and tearfilm. Swets & Zeitlinger, AmsterdamGoogle Scholar
  27. 27.
    Knop E, Knop N, Brewitt H (2003) [Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New impulses to understanding dry eye disease]. Ophthalmologe 100:917–928CrossRefPubMedGoogle Scholar
  28. 28.
    Knop N, Knop E (2000) Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 41:1270–1279PubMedGoogle Scholar
  29. 29.
    Kraehenbuhl JP, Neutra MR (1992) Molecular and cellular basis of immune protection of mucosal surfaces. Physiol Rev 72:853–879PubMedGoogle Scholar
  30. 30.
    Lemp MA (1995) Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes. CLAO J 21:221–232PubMedGoogle Scholar
  31. 31.
    Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC (2001) Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res 73:449–459CrossRefPubMedGoogle Scholar
  32. 32.
    Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR (2002) Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med 195:259–268PubMedGoogle Scholar
  33. 33.
    Liu Z, Sun YK, Xi YP, Maffei A, Reed E, Harris P, Suciu-Foca N (1993) Contribution of direct and indirect recognition pathways to T cell alloreactivity. J Exp Med 177:1643–1650CrossRefPubMedGoogle Scholar
  34. 34.
    MacDonald TT, Bajaj-Elliott M, Pender SL (1999) T cells orchestrate intestinal mucosal shape and integrity. Immunol Today 20:505–510CrossRefPubMedGoogle Scholar
  35. 35.
    McMenamin PG, Crewe J, Morrison S, Holt PG (1994) Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci 35:3234–3250PubMedGoogle Scholar
  36. 36.
    Meller D, Li DQ, Tseng SC (2000) Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1 beta and tumor necrosis factor-alpha. Invest Ophthalmol Vis Sci 41:2922–2929PubMedGoogle Scholar
  37. 37.
    Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255–258CrossRefPubMedGoogle Scholar
  38. 38.
    Metz DP, Hingorani M, Calder VL, Buckley RJ, Lightman SL (1997) T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 100:817–824PubMedGoogle Scholar
  39. 39.
    Morgan SJ, Williams JH, Walls AF, Church MK, Holgate ST, McGill JI (1991) Mast cell numbers and staining characteristics in the normal and allergic human conjunctiva. J Allergy Clin Immunol 87:111–116CrossRefPubMedGoogle Scholar
  40. 40.
    Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348–2357PubMedGoogle Scholar
  41. 41.
    Nelson JD, Helms H, Fiscella R, Southwell Y, Hirsch JD (2000) A new look at dry eye disease and its treatment. Adv Ther 17:84–93PubMedGoogle Scholar
  42. 42.
    Novak N, Siepmann K, Zierhut M, Bieber T (2003) The good, the bad and the ugly — APCs of the eye. Trends Immunol 24:570–574CrossRefPubMedGoogle Scholar
  43. 43.
    Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, Yamada A, Itoh K, Nomoto K (1996) Cytokine messenger RNA expression in the labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 39:1376–1384PubMedGoogle Scholar
  44. 44.
    Osterlind G (1944) An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biological and clinical importance. Acta Ophthalmol Copenh Suppl 23:1–79Google Scholar
  45. 45.
    Paulsen FP, Paulsen JI, Thale AB, Schaudig U, Tillmann BN (2002) Organized mucosa-associated lymphoid tissue in human naso-lacrimal ducts. Adv Exp Med Biol 506:873–876PubMedGoogle Scholar
  46. 46.
    Pepose JS, Akata RF, Pflugfelder SC, Voigt W (1990) Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjogren's syndrome. Ophthalmology 97:1599–1605PubMedGoogle Scholar
  47. 47.
    Pflugfelder SC (2004) Antiinflammatory therapy for dry eye. Am J Ophthalmol 137:337–342CrossRefPubMedGoogle Scholar
  48. 48.
    Pflugfelder SC, Solomon A, Stern ME (2000) The diagnosis and management of dry eye: a twenty-five-year review. Cornea 19:644–649CrossRefPubMedGoogle Scholar
  49. 49.
    Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, Reis BL (1997) Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology 104:223–235PubMedGoogle Scholar
  50. 50.
    Pleyer U, Dannowski H, Volk HD, Ritter T (2001) Corneal allograft rejection: current understanding. 2. Immunobiology and basic mechanisms. Ophthalmologica 215:254–262CrossRefPubMedGoogle Scholar
  51. 51.
    Pleyer U, Ritter T (2003) Gene therapy in immune-mediated diseases of the eye. Prog Retin Eye Res 22:277–293CrossRefPubMedGoogle Scholar
  52. 52.
    Rhodus NL (1999) Sjogren's syndrome. Quintessence Int 30:689–699PubMedGoogle Scholar
  53. 53.
    Sacks EH, Wieczorek R, Jakobiec FA, Knowles DM (1986) Lymphocytic subpopulations in the normal human conjunctiva. A monoclonal antibody study. Ophthalmology 93:1276–1283PubMedGoogle Scholar
  54. 54.
    Sall K, Stevenson OD, Mundorf TK, Reis BL (2000) Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 107:631–639CrossRefPubMedGoogle Scholar
  55. 55.
    Sayegh MH, Turka LA (1998) The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 338:1813–1821CrossRefPubMedGoogle Scholar
  56. 56.
    Schaumberg DA, Sullivan DA, Dana MR (2002) Epidemiology of dry eye syndrome. Adv Exp Med Biol 506:989–998PubMedGoogle Scholar
  57. 57.
    Stahl JL, Cook EB, Barney NP, Graziano FM (2002) Pathophysiology of ocular allergy: the roles of conjunctival mast cells and epithelial cells. Curr Allergy Asthma Rep 2:332–339PubMedGoogle Scholar
  58. 58.
    Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–589CrossRefPubMedGoogle Scholar
  59. 59.
    Stern ME, Gao J, Schwalb TA, et al. (2002) Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci 43:2609–2614PubMedGoogle Scholar
  60. 60.
    Sullivan DA, Edwards JA (1997) Androgen stimulation of lacrimal gland function in mouse models of Sjogren's syndrome. J Steroid Biochem Mol Biol 60:237–245CrossRefPubMedGoogle Scholar
  61. 61.
    von Andrian UH, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343:1020–1034CrossRefPubMedGoogle Scholar
  62. 62.
    Wedemeyer J, Tsai M, Galli SJ (2000) Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 12:624–631CrossRefPubMedGoogle Scholar
  63. 63.
    Westermann J, Engelhardt B, Hoffmann JC (2001) Migration of T cells in vivo: molecular mechanisms and clinical implications. Ann Intern Med 135:279–295PubMedGoogle Scholar
  64. 64.
    Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM (1988) The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology 95:100–109PubMedGoogle Scholar
  65. 65.
    Worda C, Nepp J, Huber JC, Sator MO (2001) Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 37:209–212CrossRefPubMedGoogle Scholar
  66. 66.
    Yokoi K, Yokoi N, Kinoshita S (1998) Impairment of ocular surface epithelium barrier function in patients with atopic dermatitis. Br J Ophthalmol 82:797–800PubMedGoogle Scholar
  67. 67.
    Zelenika D, Adams E, Humm S, Lin CY, Waldmann H, Cobbold SP (2001) The role of CD4+ T-cell subsets in determining transplantation, rejection or tolerance. Immunol Rev 182:164–179CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Erich Knop
  • Nadja Knop
  • Uwe Pleyer

There are no affiliations available

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