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Targets in Ocular Allergy

  • Alessandra Micera
  • Sergio Bonini
  • Alessandro Lambiase
  • Roberto Sgrulletta
  • Stefano Bonini
Part of the Essentials in Ophthalmology book series (ESSENTIALS)

Keywords

Nerve Growth Factor Allergy Clin Immunol Ocular Surface Allergic Conjunctivitis Ocular Allergy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Holgate ST, Church MK, Lichtenstein LM (2001) Allergy, 2nd edn. Mosby International, LondonGoogle Scholar
  2. 2.
    Metz DP, Hingorani M, Calder VL, et al. (1997) T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 100:817–824PubMedGoogle Scholar
  3. 3.
    Abelson MB, Chambers WA, Smith LM (1990) Conjunctival allergen challenge. A clinical approach to studying allergic conjunctivitis. Arch Ophthalmol 108:84–88PubMedGoogle Scholar
  4. 4.
    Bonini S, Bonini S, Vecchione A, et al. (1988) Inflammatory changes in conjunctival scrapings after allergen provocation in humans. J Allergy Clin Immunol 82:462–469CrossRefPubMedGoogle Scholar
  5. 5.
    Bonini S, Lambiase A, Sgrulletta R, Bonini S (2003) Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. Curr Opin Allergy Clin Immunol 3:381–387CrossRefPubMedGoogle Scholar
  6. 6.
    Bonini S, Lambiase A, Sacchetti M, Bonini S (2003) Cytokines in ocular allergy. Int Ophthalmol Clin 2003 43:27–32Google Scholar
  7. 7.
    Trocme SD, Sra KK (2002) Spectrum of ocular allergy. Curr Opin Allergy Clin Immunol 2:423–427CrossRefPubMedGoogle Scholar
  8. 8.
    Leonardi A (2002) Vernal keratoconjunctivitis: pathogenesis and treatment. Progr Retin Eye Res 21:319–339Google Scholar
  9. 9.
    Leonardi A, DeFranchis G, Zancanaro F, et al. (1999) Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. Invest Ophthalmol Vis Sci 40:3036–3040PubMedGoogle Scholar
  10. 10.
    Uchio E, Ono SY, Ikezawa Z, Ohno S (2000) Tear levels of interferon-g, interleukin (IL)-2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. Clin Exp Allergy 30:103–109PubMedGoogle Scholar
  11. 11.
    Galli SJ, Williams CMM (2000) The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 105:847–859CrossRefPubMedGoogle Scholar
  12. 12.
    Smith S, Levi-Schaffer F (2000) Cross-talk between eosinophils, mast cells and fibroblasts. Chem Immunol 78:81–92PubMedGoogle Scholar
  13. 13.
    Trocme SD, Aldave AJ (1994) The eye and the eosinophil. Surv Ophthalmol 39:241–52.CrossRefPubMedGoogle Scholar
  14. 14.
    Simon HU, Weber M, Becker E, Zilberman Y, Blaser K, Levi-Schaffer F (2000) Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J Immunol 165:4069–4075PubMedGoogle Scholar
  15. 15.
    Abu El-Asra AM, Geboes K, Al-Kharashi S, Tabbara KF, Missotten L, Desmet V (1997) Adhesion molecules in vernal keratoconjunctivitis. Br J Ophthalmol 81:1099–1106PubMedGoogle Scholar
  16. 16.
    Abu El-Asrar AM, Struyf S, Al-Kharashi SA, et al. (2000) Chemokines in the limbal form of vernal keratoconjunctivitis. Br J Ophthalmol 84:1360–1366CrossRefPubMedGoogle Scholar
  17. 17.
    Forssman U, Uguccioni M, Loetscher P, et al. (1997) Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 185:2171–2176CrossRefPubMedGoogle Scholar
  18. 18.
    Solomon A, Puxeddu I, Levi-Schaffer F (2003) Fibrosis in ocular allergic inflammation: recent concepts in the pathogenesis of ocular allergy. Curr Opin Allergic Clin Immunol 3:389–393CrossRefGoogle Scholar
  19. 19.
    Leonardi A, Jose PJ, Zhan H, Calder VL (2003) Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis. Ophthalmology 110:487–492PubMedGoogle Scholar
  20. 20.
    Lambiase A, Bonini S, Micera A, Tirassa P, Magrini L, Bonini S, Aloe A (1997) Increased plasma levels of substance P in vernal keratoconjunctivitis. Invest Ophthalmol Vis Sci 38:2161–2164PubMedGoogle Scholar
  21. 21.
    Micera A, Puxeddu I, Aloe L, Levi-Schaffer F (2003) New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis. Cytokine Growth Factor Rev 14:369–374CrossRefPubMedGoogle Scholar
  22. 22.
    Lambiase A, Bonini St, Bonini Se, Micera A, Magrini L, Bracci-Laudiero L, Aloe L (1995) Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. Invest Ophthalmol Vis Sci 36:2127–2132PubMedGoogle Scholar
  23. 23.
    Bonini S, Lambiase A, Bonini S, Angelucci F, Magrini L, Manni L, Aloe L (1996) Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Natl Acad Sci USA 93:10955–10960PubMedGoogle Scholar
  24. 24.
    Bonini S, Aloe L, Bonini S, Rama P, Lamagna A, Lambiase A (2002) Nerve growth factor (NGF): an important molecule for trophism and healing of the ocular surface. Adv Exp Med Biol 506:531–537PubMedGoogle Scholar
  25. 25.
    Levi-Schaffer F, Micera A, Zamir E, Mechoulam H, Puxeddu I, Piliponsky AM, Aloe L, Pe'er J (2002) Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus: a link with allergy. Invest Ophthalmol Vis Sci 43:1850–1856PubMedGoogle Scholar
  26. 26.
    Hingorani M, Calder V, Jolly G, Buckley RJ, Lightman SL (1998) Eosinophil surface antigen expression and cytokine production vary in different ocular allergic diseases. J Allergy Clin Immunol 102:821–830PubMedGoogle Scholar
  27. 27.
    Leonardi A, Borghesan F, DePaoli M, Plebani M, Secchi AG (1998) Procollagens and inflammatory cytokine concentrations in tarsal and limbal vernal keratoconjunctivitis. Exp Eye Res 67:105–112CrossRefPubMedGoogle Scholar
  28. 28.
    Leonardi A, Brun P, Abatangelo G, Plebani M, Secchi AG (2003) Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis. Invest Ophthalmol Vis Sci 44:3052–3058CrossRefPubMedGoogle Scholar
  29. 29.
    Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L (1999) Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med 338:1174–1180Google Scholar
  30. 30.
    Bawazeer AM, Hodge WG, Lorimer B (2000) Atopy and keratoconus: a multivariate analysis. Br J Ophthalmol 84:834–836PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Alessandra Micera
  • Sergio Bonini
  • Alessandro Lambiase
  • Roberto Sgrulletta
  • Stefano Bonini

There are no affiliations available

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