Skip to main content
SpringerLink
Log in
Book cover

Therapie gastroenterologischer Krankheiten pp 111–122Cite as

Medikamentös induzierte Gastroenteropathien

  • Chapter

  • 1228 Accesses

Zusammenfassung

Im Hinblick auf gastrointestinale Nebenwirkungen kommt im Vergleich zu anderen Medikamenten nichtsteroidalen Antirheumatika (NSAR) bzgl. Häufigkeit und Schwere eine überragende Rolle zu. NSAR zählen zu den weltweit am häufigsten verordneten Medikamenten. In den Jahren 1970–1985 kam es zu einer dramatischen Zunahme der ärztlichen Verordnungen. NSAR werden in analgetischer, antiinflammatorischer und antipyretischer Absicht bei einer Vielzahl von Krankheiten eingesetzt. Da die Häufigkeit mehrerer Indikationen mit dem Alter ansteigt, kommt es bei zunehmender überalterung zwangsläufig zur stetigen Zunahme des NSAR-Konsums [Wallace 1997].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aalykke C, Lauritsen JM, Hallas J et al. (1999) Helicobacter pylori and risk of ulcer bleeding among users of nonsteroidal anti-inflammatory drugs: a case-control study. Gastroenterology 116: 1305–1309

    PubMed  Google Scholar 

  • Bjarnason I, Fehilly B, Smethurst P, Menzies IS, Levi AJ (1992). Importance of local versus systemic effects of nonsteroidal anti-inflammatory drugs in increasing small intestinal permeability in man. Gut 32: 275–277

    Google Scholar 

  • Bjarnason IJ, Hayllar J, MacPherson AJ, Russell AS (1993). Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104: 1832–1847

    PubMed  Google Scholar 

  • Bjarnason IJ, Hayllar J, Smethurst P, Price A, Gumpel MJ (1992). Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy. Gut 33: 1204–1208

    PubMed  Google Scholar 

  • Bocanegra TS, Weaver AL, Tindall EA et al. (1998) Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group. J Rheumatol 25: 1602–1611

    PubMed  Google Scholar 

  • Bombardier C, Laine L, Reicin A et al. (2000) Comparison of upper gastrointestinal toxicity of Rofecoxib and Naproxen in patients with rheumatoid arthritis. Engl J Med 343: 1520–1528

    Article  Google Scholar 

  • Chan FKL, Chung SCS, Suen BY et al. (2001) Preventing recurrent upper gastrointestinalbleeding in patients with helicobacter pylori infection who are taking low-dose Aspirin or Naproxen. N Engl J Med 344: 967–973

    PubMed  Google Scholar 

  • Chan FKL, Sung JJY, Chung SCS et al. (1997) Randomised trial of eradication of helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet 350: 975–979

    Article  PubMed  Google Scholar 

  • Chan FKL (2002) Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage. Eur J Gastroenterol Hepatol 4: 1–3

    Article  Google Scholar 

  • Chan FKL, Hung LCT, Suen BY et al. (2002) Celecoxib vs Diclofenac and Omeprazole in reducing the risk of recurrent rlcer bleeding in patients with arthritis. N Engl J Med 347: 2104–2110

    PubMed  Google Scholar 

  • Cryer B (2002) Non-steroidal anti-inflammatory drugs and gastrointestinal disease. In: Feldman M, Friedmann, Sleisenger MH (eds). Sleisenger & Fordtran's gastrointestinal and liver disease, 7 nd ed. WB Saunders, Philadelphia, p 408–430

    Google Scholar 

  • Davies NM, Saleh JY, Skjodt NM (2000) Detection and prevention of NSAID-induced enteropathy. J Pharm Pharmaceut Sci 3: 137–155

    Google Scholar 

  • Deeks JJ, Smith LA, Bradley MD (2002) Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomized controlled trials. BMJ 325: 1–8

    Article  PubMed  Google Scholar 

  • Dignass AU (2001) Mechanisms and modulation of intestinal epithelial repair. Inflamm Bowel Dis 7: 68–77

    PubMed  Google Scholar 

  • Evans JM, McMahon AD, Murray FE et al. (1997) Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease. Gut 40: 619–622

    PubMed  Google Scholar 

  • Etienney I, Beaugerie L, Viboud C, Flahault A (2003) Nonsteroidal-anti-inflammatory drugs as a risk factor for acute diarrhoea: a case cross over study. Gut 52: 260–263

    Article  PubMed  Google Scholar 

  • Felder JB, Korelitz BI, Rajapakse R et al. (2000) Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study. Amm J Gastroenterol 95: 1949–1954

    Article  Google Scholar 

  • Fiorucci S, Santucci L, Gresele P et al. (2003) Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. Gastroenterology 124: 600–607

    Article  PubMed  Google Scholar 

  • Guslandi M (1997) Gastric toxicity of antiplatelet therapy with low-dose aspirin. Drugs 53: 1–5

    Google Scholar 

  • Huang JQ, Sridar S, Hunt RH (2002) Role of helicobacter pylory infection and non-steroidal anti-inflammatory drugs in peptic ulcerb disease. A meta-analysis. Lancet 359: 14–22

    Article  PubMed  Google Scholar 

  • Hawkey CJ, Karrasch JA, Szczepañski L et al. (1998) Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Engl J Med 338: 727–734

    Article  Google Scholar 

  • Hawkey CJ, Tulassay Z, Szczepanski L et al. (1998) Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP-NSAID-study. Helicobacter Eradication for Lesion Prevention. Lancet 352: 1016–1021

    Article  PubMed  Google Scholar 

  • Hawkey CJ, Langman MJ (2003) Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors. Gut 52: 600–608

    Article  PubMed  Google Scholar 

  • Hawkey CJ, Laine L, Simon T et al. (2003) Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study. Gut 52: 820–826

    Article  PubMed  Google Scholar 

  • Hunt RH, Bazzoli F (2004) Should NSAID/low-dose aspirin takers be tested routinely for H.pylori infection and treated if positive? Implications for prmary risk of ulcr and ulcer relapse after initial healing. Aliment Pharmacol Ther 19: 9–16

    Article  PubMed  Google Scholar 

  • Jackson LM, Hawkey CJ (2000) COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages? Drugs 59: 1207–1216

    PubMed  Google Scholar 

  • Jaspersen D (2000) Drug-induced oesophageal disorders: pathogenesis, incidence, prevention and management. Drug Saf 22: 237–249

    PubMed  Google Scholar 

  • Konstam MA, Weir MR, Reich A et al. (2001) Cardiovascular trombotic events in controlled, clinical trials of rofecoxib. Circulation 104: R15–R23

    Google Scholar 

  • Konturek SJ, Bielanski, Plonka M, et al. (2003) Helicobacter pylori, non-steroidal anti-inflammatory drugs and smoking in risk pattern of gastroduodenal ulcers. Scand J Gastroenterol 28: 923–930

    Google Scholar 

  • Labens J, Blum AL, Bolten WW et al. (2002) Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in helicobacter positive patients: a randomised, double blind, placebo controlled, clinical trial. Gut 51: 329–335

    Article  PubMed  Google Scholar 

  • Lai KC, Lam SK, Chu KM et al. (2002) Lansoprazole for the prevention of recurrence of ulcer complications from long-term low-dose aspirin use. N Engl J Med 346: 2033–2038

    Article  PubMed  Google Scholar 

  • Lai KC, Lau CS, Ip WY et al. (2003) Effect of treatment of helicobacter pylori o the prevention of gastroduodenal ulcers in patients receiving long-term NSAIDs: a double-blind, placebo-controlled trial. Aliment Pharmacol Ther 17: 799–805

    Article  PubMed  Google Scholar 

  • Laine L, Bombardier C, Hawkey CJ et al. (2002) Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology 123: 1006–1012

    Article  PubMed  Google Scholar 

  • Laine L, Conners LG, Reicin A et al. (2003) Serious lower gastrointestinal clinical events with nonselective NSAIDs of of Coxib use. Gastroenterology 124: 288–292

    Article  PubMed  Google Scholar 

  • Lang J, Price AB, Levi AJ et al. (1988) Diaphragm disease: pathology of disease of small intestine induced by non steroidal anti-inflammatory drugs. J Clin Pathol 41: 516–526

    PubMed  Google Scholar 

  • Lanas A, Bajador E, Serrano P et al. (2000) Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 343: 834–839

    Article  PubMed  Google Scholar 

  • Lanas A, Rpdrigo I, Marquez JL et al. (2003) Low frequency of upper gastrointestinal complications in acohort of high-risk patients taking low dose aspirin or NSAIDs and omeprazole. Scand J Gastroenterol 38: 693–700

    Article  PubMed  Google Scholar 

  • Layton D, Hughes K, Harris S et al. (2003) Comparison of the incidence rates of thromboembolic events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring (PME) data. Rheumatology (Oxford) 42: 1342–1353

    Article  PubMed  Google Scholar 

  • Layton D, Hughes K, Harris S et al. (2003) Comparison of the incidence rates of thromboembolic events reported for patients prescribed celecoxib and meloxicam in general practice in England using prescription-event monitoring (PME) data. Rheumatology (Oxford) 42: 1354–1364

    Article  PubMed  Google Scholar 

  • Lisse JR, Perlmann L, Johansson G et al. (2003) Gastrointestinal tolerability and effectivness of rofecoxib versus naproxen in the treatment of osteoarthritis. Ann Intern Med 139: 539–546

    PubMed  Google Scholar 

  • Mamdani M, Rochon PA, Juurlink DN et al. (2002) Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitor or conventional non-steroidal anti-inflammatory drugs. BMJ 325: 624–627

    Article  PubMed  Google Scholar 

  • MacDonald TM, Morant SV, Goldstein JL et al. (2003) Channelling bias and the incidence of gastrointestinal haemorrhage in users of meloxicam, coxibs, and older, nonspecific non-steroidal anti-inflammatory drugs. Gut 52: 1265–1270

    Article  PubMed  Google Scholar 

  • Mutschler E, Geisslinger G, Kroemer HK, Schäfer-Kortwig M (2001) Mutschler Arzneimittelwirkungen. Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 229

    Google Scholar 

  • Piper JM, Ray WA, Daugherty JR, Griffin MR (1991) Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 114: 735–740

    PubMed  Google Scholar 

  • Pohle T, Brzozowski T, Becker JC et al. (2001) Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastropotectin by vitamin C. Aliment Pharmacol Ther 15: 677–687

    Article  PubMed  Google Scholar 

  • Raskin JB, White RH, Jaszewski R (1996) Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: A prospective, double blind, multicenter study. Am J Gastroenterol 91: 223–227

    PubMed  Google Scholar 

  • Reinisch W, Miehsler W, Dejaco C et al. (2003) An open-label trial of the selective cyclo-oxygenase-2 inhibitor, rofecoxib, in inflammatory bowel disease-associated peripheral arthritis and arthralgia. Aliment Pharmacol Ther 17: 1371–1380

    Article  PubMed  Google Scholar 

  • Renfrey S, Downton C, Featherstone J (2003) The painful reality. Nature Rev Drug Discovery 2: 175–176

    Article  Google Scholar 

  • Silverstein FE, Graham DY, Senior JR et al. (1995) Misoprostol reduces serious gastrointestinal complications in patients in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: a randomized, double, placebo controlled trial. Ann Intern Med 123: 241–249

    PubMed  Google Scholar 

  • Silverstein FE, Faich G, Goldstein JL et al. (2000) Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. JAMA 284: 1247–1255

    Article  PubMed  Google Scholar 

  • Somasundaram S, Hayllar J, Macpherson AJ, Bjarnason IJ (1992) Enterocyte mitochondrial damage due to NSAIDs in the rat. Gut 33: 1992

    Google Scholar 

  • Stein J (1999) NSAR-Enteropathie. In: Caspary WF, Stein J (Hrsg) Darmkrankheiten. Springer, Berlin Heidelberg New York, S. 501–506

    Google Scholar 

  • Taha AS, Hundal O, Hawkey CJ et al. (1996) Famotidine for the prevention of gastric and duodenal ulcer caused by nonsteroidal antiinflammatory drugs. New Engl J Med 334: 1435–1439

    Article  PubMed  Google Scholar 

  • Tanner AR, Raghunath AS (1988) Colonic inflammation and nonsteroidal anti-inflammatory drug administration. An assessment of the frequency of the problem. Digestion 41: 116–120

    PubMed  Google Scholar 

  • Wallace JL (1997) Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 112: 1000–1016

    Article  PubMed  Google Scholar 

  • Wolfe MM, Lichtenstein D, Sing G (1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340: 1888–1899

    Article  PubMed  Google Scholar 

  • Yeomans ND, Tulassay Z, Juhász L et al. (1998) A comparison of Omeprazole with Ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 338: 719–726

    Article  PubMed  Google Scholar 

Download references

Authors
  1. J. Stein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Schwerpunkte Gastroenterologie/Hepatologie/Pneumologie/Allergologie, Universitätsklinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main

    Wolfgang F. Caspary

  2. Medizinische Klinik und Poliklinik II, Universitätsklinikum Leipzig, Philipp-Rosenthal-Str. 27, 04103, Leipzig

    Joachim Mössner

  3. Zentrum Innere Medizin, Medizinische Klinik II, Gastroenterologie/Hepatologie/Pneumologie/Allergologie/Klinische Ernährung, Theodor-Stern-Kai 7, 60590, Frankfurt am Main

    Jürgen Stein

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Stein, J. (2005). Medikamentös induzierte Gastroenteropathien. In: Caspary, W.F., Mössner, J., Stein, J. (eds) Therapie gastroenterologischer Krankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26660-7_13

Download citation

  • DOI: https://doi.org/10.1007/3-540-26660-7_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-44174-8

  • Online ISBN: 978-3-540-26660-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation