Target Volumes in Small Cell Lung Cancer

  • Yolanda I. Garces
  • James A. Bonner
Part of the Medical Radiology Radiation Oncology book series (MEDRAD)


Small Cell Lung Cancer Gross Tumor Volume Prophylactic Cranial Irradiation Therapy Volume Supraclavicular Fossa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arriagada R, Pellae-Cosset B, de Guevara JCL et al (1991) Alternating radiotherapy and chemotherapy schedules in limited small cell lung cancer: analysis of local chest recurrences. Radiother Oncol 20:91–98CrossRefPubMedGoogle Scholar
  2. Aupérin A, Arriagada R, Pignon J-P et al for the Prophylactic Cranial Irradiation Overview Collaborative Group (1999) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. N Engl J Med 341:476–484CrossRefPubMedGoogle Scholar
  3. Bonner JA, Sloan JA, Shanahan TG et al (1999) Phase III comparison of twice-daily split-course irradiation versus once-daily irradiation for patients with limited stage small-cell lung carcinoma. J Clin Oncol 17:2681–2691PubMedGoogle Scholar
  4. Bonner JA, Hillman S, Vigliotti APG et al (2003) High dose, twice-daily thoracic radiotherapy (TRT) with daily chemotherapy in limited stage small cell lung cancer (abstract). Lung Cancer 41[Suppl 2]:S24CrossRefGoogle Scholar
  5. Brodin O, Rikner G, Steinholtz L, et al (1990) Local failure in patients treated with radiotherapy and multidrug chemotherapy for small cell lung cancer. Acta Oncol 29:739–746PubMedGoogle Scholar
  6. Fried DB, Morris DE, Hensing TA et al (2003) Timing of thoracic radiation therapy in combined modality therapy for limited-stage small cell lung cancer: a meta-analysis (abstract). Lung Cancer 41[Suppl 2]:S23CrossRefGoogle Scholar
  7. Greene FL, Page DL, Fleming ID et al (eds) (2002) AJCC cancer staging manual, 6th edn. Springer, Berlin Heidelberg New YorkGoogle Scholar
  8. International Commission on Radiation Units and Measurements (1999) Prescribing, recording, and reporting photon beam therapy, ICRU report 62 (Suppl to ICRU report 50). International Commission on Radiation Units and Measurements, Bethesda, MD, pp 1–47Google Scholar
  9. James LE, Spiro S, O'Donnell KM et al (2003) A randomised study of timing of thoracic irradiation in small cell lung cancer (SCLC)-study 8 (abstract). Lung Cancer 41Suppl 2:S23CrossRefGoogle Scholar
  10. Kies MS, Mira JG, Crowley JJ et al (1987) Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group study. J Clin Oncol 5:592–600PubMedGoogle Scholar
  11. Komaki R, Glisson B, Allen P et al (2003) Hyperfractionated and accelerated thoracic radiation therapy (HFXA/TRT) increased survival compared to daily TRT for limited small cell lung cancer (LSCLC) patients treated with concurrent chemotherapy (abstract). Lung Cancer 41[Suppl 2]:S24CrossRefGoogle Scholar
  12. Kubota K, Nishiwaki Y, Sugiura T et al (2003) A pilot study of cisplatin and etoposide plus concurrent accelerated hyper-fractionated thoracic radiotherapy (TRT) followed by three cycles of irinotecan and cisplatin for the treatment of limited-stage small-cell lung cancer (SCLC): JCOG 9903-DI (abstract). Lung Cancer 41[Suppl 2]:S24CrossRefGoogle Scholar
  13. Lagerwaard FJ, van de Vaart PJ, Voet PW et al (2002) Can errors in reconstructing pre-chemotherapy target volumes contribute to the inferiority of sequential chemoradiation in stage III non-small cell lung cancer (NSCLC)? Lung Cancer 38:297–301CrossRefPubMedGoogle Scholar
  14. Liengswangwong V, Bonner JA, Shaw EG et al (1994) Limited-stage small-cell lung cancer: patterns of intrathoracic recurrence and the implications for thoracic radiotherapy. J Clin Oncol 12:496–502PubMedGoogle Scholar
  15. Mira JG, Livingston RB (1980) Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with radiotherapy-chemotherapy: study of 34 cases and review of the literature. Cancer 46:2557–2565PubMedGoogle Scholar
  16. Murray N (1998) Timing of thoracic irradiation for limited small-cell lung cancer. J Clin Oncol 16:1633–1635PubMedGoogle Scholar
  17. Perez CA, Krauss S, Bartolucci AA et al (1981) Thoracic and elective brain irradiation with concomitant or delayed multiagent chemotherapy in the treatment of localized small cell carcinoma of the lung: a randomized prospective study by the Southeastern Cancer Study Group. Cancer 47:2407–2413PubMedGoogle Scholar
  18. Pignon J-P, Arriagada R, Ihde DC et al (1992) A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 327:1618–1624PubMedGoogle Scholar
  19. Schild SE, Brindle JS, Geyer SM et al (2003) Long term results of a phase III trial comparing once a day radiotherapy (qd RT) or twice a day radiotherapy (bid RT) in limited stage small cell lung cancer (LSCLC) (abstract). Lung Cancer 41[Suppl 2]:S23CrossRefGoogle Scholar
  20. Turrisi AT III, Kim K, Blum R et al (1999) Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 340:265–271CrossRefPubMedGoogle Scholar
  21. Wagner H Jr (1997) Thoracic irradiation of limited small cell lung cancer: have we defined optimal dose, time, and fractionation? Lung Cancer 17[Suppl 1]:S137–S148CrossRefPubMedGoogle Scholar
  22. Warde P, Payne D (1992) Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis. J Clin Oncol 10:890–895PubMedGoogle Scholar
  23. Williams TE, Turrisi AT III (1997) Role of radiotherapy in the treatment of small cell lung carcinoma. Chest Surg Clin North Am 7:135–149Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Yolanda I. Garces
    • 1
  • James A. Bonner
    • 2
    • 3
  1. 1.Division of Radiation OncologyMayo Clinic College of MedicineRochesterUSA
  2. 2.Department of Radiation OncologyUniveristy of AlabamaBirmingham
  3. 3.Wallace Tumor InstituteBirminghamUSA

Personalised recommendations