Skip to main content
Book cover

Advances in Radiation Oncology in Lung Cancer pp 3–11Cite as

Molecular Biology and Genetics of Lung Cancer

  • Chapter

  • 912 Accesses

Part of the Medical Radiology Radiation Oncology book series (Med Radiol Radiat Oncol)

Keywords

  • Lung Cancer
  • Clin Oncol
  • Small Cell Lung Cancer
  • Radiation Resistance
  • Small Cell Lung Carcinoma

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/3-540-26632-1_1
  • Chapter length: 9 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   259.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-26632-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adjei AA, Mauer A, Bruzek L et al (2003) Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J Clin Oncol 21:1760–1766

    CrossRef  PubMed  Google Scholar 

  • Beier R, Burgin A, Kiermaier A et al (2000) Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events. EMBO J 19:5813–5823

    CrossRef  PubMed  Google Scholar 

  • Bergqvist M, Brattstrom D, Gullbo J et al (2003) p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer. Anticancer Res 23:1207–1212

    PubMed  Google Scholar 

  • Brunner TB, Hahn SM, Gupta AK et al (2003) Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res 63:5656–5668

    PubMed  Google Scholar 

  • Cohen-Jonathan E, Muschel RJ, McKenna WG et al (2000) Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS. Radiat Res 154:125–132

    PubMed  Google Scholar 

  • Crick FH (1958) On protein synthesis. Symp Soc Exp Biol 12:138–163

    PubMed  Google Scholar 

  • Gao N, Hu YD, Cao XY et al (2001) The exogenous wild-type p14ARF gene induces growth arrest and promotes radio-sensitivity in human lung cancer cell lines. J Cancer Res Clin Oncol 127:359–367

    CrossRef  PubMed  Google Scholar 

  • Gazzeri S, Brambilla E, Caron de Fromentel C et al (1994) p53 genetic abnormalities and myc activation in human lung carcinoma. Int J Cancer 58:24–32

    PubMed  Google Scholar 

  • Gorski DH, Beckett MA, Jaskowiak NT et al (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59:3374–3378

    PubMed  Google Scholar 

  • Graziano SL, Gamble GP, Newman NB et al (1999) Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer. J Clin Oncol 17:668–675

    PubMed  Google Scholar 

  • Gupta AK, McKenna WG, Weber CN et al (2002) Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin Cancer Res 8:885–892

    PubMed  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    CrossRef  PubMed  Google Scholar 

  • Heasley LE (2001) Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene 20:1563–1569

    PubMed  Google Scholar 

  • Henriksson M, Luscher B (1996) Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 68:109–182

    PubMed  Google Scholar 

  • Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042–2054

    PubMed  Google Scholar 

  • Hiyama K, Hiyama E, Ishioka S et al (1995) Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 87:895–902

    PubMed  Google Scholar 

  • Huncharek M, Muscat J, Geschwind JF (1999) K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases. Carcinogenesis 20:1507–1510

    CrossRef  PubMed  Google Scholar 

  • Johnson BE, Fischer T, Fischer B et al (2003) Phase II study of imatinib in patients with small cell lung cancer. Clin Cancer Res 9:5880–5887

    PubMed  Google Scholar 

  • Johnson DH, DeVore R, Kabbinavar F et al (2001) Carboplatin (C) + Paclitaxel (T) + RhuMab-VEGF (AVF) may prolong survival in advanced non-squamous lung cancer. Proc Am Soc Clin Oncol 20:1256a

    Google Scholar 

  • Kaye FJ (2002) RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer. Oncogene 21:6908–6914

    CrossRef  PubMed  Google Scholar 

  • Knudson AG Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820–823

    PubMed  Google Scholar 

  • Kraus AC, Ferber I, Bachmann SO et al (2002) In vitro chemo-and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 21:8683–8695

    CrossRef  PubMed  Google Scholar 

  • Kris MG, Natale RB, Herbst RS et al (2002) A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum-and docetaxel-based regimens (IDEAL 2). Proc Am Soc Clin Oncol 21:2929a

    Google Scholar 

  • Kroemer G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614–620

    CrossRef  PubMed  Google Scholar 

  • Krystal G, Birrer M, Way J et al (1988) Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer. Mol Cell Biol 8:3373–3381

    PubMed  Google Scholar 

  • Lander ES, Linton LM, Birren B et al (2001) Initial sequencing and analysis of the human genome. Nature 409:860–921

    CrossRef  PubMed  Google Scholar 

  • Lantuejoul S, Moro D, Michalides RJ et al (1998) Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors. Am J Surg Pathol 22:1267–1276

    CrossRef  PubMed  Google Scholar 

  • Laskey RA, Earnshaw WC (1980) Nucleosome assembly. Nature 286:763–767

    CrossRef  PubMed  Google Scholar 

  • Lebowitz PF, Prendergast GC (1998) Non-Ras targets of farne-syltransferase inhibitors: focus on Rho. Oncogene 17:1439–1445

    CrossRef  PubMed  Google Scholar 

  • Lucchi M, Mussi A, Fontanini G et al (2002) Small cell lung carcinoma (SCLC): the angiogenic phenomenon. Eur J Cardiothorac Surg 21:1105–1110

    CrossRef  PubMed  Google Scholar 

  • Macaulay VM, Salisbury AJ, Bohula EA et al (2001) Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radio-sensitivity and impaired activation of Atm kinase. Oncogene 20:4029–4040

    CrossRef  PubMed  Google Scholar 

  • Martin B, Paesmans M, Berghmans T et al (2003) Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 89:55–64

    CrossRef  PubMed  Google Scholar 

  • McKenna WG, Weiss MC, Endlich B et al (1990) Synergistic effect of the v-myc oncogene with H-ras on radioresistance. Cancer Res 50:97–102

    PubMed  Google Scholar 

  • Meert AP, Martin B, Delmotte P et al (2002) The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis. Eur Respir J 20:975–981

    CrossRef  PubMed  Google Scholar 

  • Meert AP, Martin B, Paesmans M et al (2003) The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature. Br J Cancer 89:959–965

    CrossRef  PubMed  Google Scholar 

  • Misawa M, Tauchi T, Sashida G et al (2002) Inhibition of human telomerase enhances the effect of chemotherapeutic agents in lung cancer cells. Int J Oncol 21:1087–1092

    PubMed  Google Scholar 

  • Mitsudomi T, Hamajima N, Ogawa M et al (2000) Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis. Clin Cancer Res 6:4055–4063

    PubMed  Google Scholar 

  • Moriya Y, Niki T, Yamada T et al (2001) Increased expression of laminin-5 and its prognostic significance in lung adenocarcinomas of small size. An immunohistochemical analysis of 102 cases. Cancer 91:1129–1141

    CrossRef  PubMed  Google Scholar 

  • Olivier M, Eeles R, Hollstein M et al (2002) The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19:607–614

    CrossRef  PubMed  Google Scholar 

  • Osada H, Takahashi T (2002) Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene 21:7421–7434

    CrossRef  PubMed  Google Scholar 

  • Pietras RJ, Poen JC, Gallardo D et al (1999) Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 59:1347–1355

    PubMed  Google Scholar 

  • Potti A, Willardson J, Forseen C et al (2002) Predictive role of HER-2/neu overexpression and clinical features at initial presentation in patients with extensive stage small cell lung carcinoma. Lung Cancer 36:257–261

    CrossRef  PubMed  Google Scholar 

  • Protopopov AI, Li J, Winberg G et al (2002) Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21. J Gene Med 4:397–406

    CrossRef  PubMed  Google Scholar 

  • Robles AI, Linke SP, Harris CC (2002) The p53 network in lung carcinogenesis. Oncogene 21:6898–6907

    CrossRef  PubMed  Google Scholar 

  • Rodenhuis S, Slebos RJ (1992) Clinical significance of ras oncogene activation in human lung cancer. Cancer Res 52:2665s–2669s

    PubMed  Google Scholar 

  • Ronen A, Glickman BW (2001) Human DNA repair genes. Environ Mol Mutagen 37:241–283

    CrossRef  PubMed  Google Scholar 

  • Santoni-Rugiu E, Falck J, Mailand N et al (2000) Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway. Mol Cell Biol 20:3497–3509

    CrossRef  PubMed  Google Scholar 

  • Sathyanarayana UG, Toyooka S, Padar A et al (2003) Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Clin Cancer Res 9:2665–2672

    PubMed  Google Scholar 

  • Shapiro GI, Supko JG, Patterson A et al (2001) A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer. Clin Cancer Res 7:1590–1599

    PubMed  Google Scholar 

  • Shields JM, Pruitt K, McFall A et al (2000) Understanding Ras: ‘it ain't over ‘til it's over'. Trends Cell Biol 10:147–154

    CrossRef  PubMed  Google Scholar 

  • Shimizu E, Coxon A, Otterson GA et al (1994) RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9:2441–2448

    PubMed  Google Scholar 

  • Sklar MD (1988) The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 239:645–647

    PubMed  Google Scholar 

  • Slebos RJ, Kibbelaar RE, Dalesio O et al (1990) K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 323:561–565

    PubMed  Google Scholar 

  • Soria JC, Lee HY, Lee JI et al (2002) Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 8:1178–1184

    PubMed  Google Scholar 

  • Sozzi G, Veronese ML, Negrini M et al (1996) The FHIT gene 3p14.2 is abnormal in lung cancer. Cell 85:17–26

    PubMed  Google Scholar 

  • Sridhar SS, Seymour L, Shepherd FA (2003) Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol 4:397–406

    CrossRef  PubMed  Google Scholar 

  • Volm M, Drings P, Wodrich W et al (1993) Expression of oncoproteins in primary human non-small cell lung cancer and incidence of metastases. Clin Exp Metastasis 11:325–329

    CrossRef  PubMed  Google Scholar 

  • Watson JD, Crick FH (1953) Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 171:737–738

    PubMed  Google Scholar 

  • Westra WH, Baas IO, Hruban RH et al (1996) K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res 56:2224–2228

    PubMed  Google Scholar 

  • Wistuba II, Behrens C, Virmani AK et al (2000) High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res 60:1949–1960

    PubMed  Google Scholar 

  • Wistuba II, Gazdar AF, Minna JD (2001) Molecular genetics of small cell lung carcinoma. Semin Oncol 28:3–13

    CrossRef  Google Scholar 

  • Wolff H, Saukkonen K, Anttila S et al (1998) Expression of cyclooxygenase-2 in human lung carcinoma. Cancer Res 58:4997–5001

    PubMed  Google Scholar 

  • Wong JM, Collins K (2003) Telomere maintenance and disease. Lancet 362:983–988

    CrossRef  PubMed  Google Scholar 

  • Yashima K, Litzky LA, Kaiser L et al (1997) Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res 57:2373–2377

    PubMed  Google Scholar 

  • Yu H, Spitz MR, Mistry J et al (1999) Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst 91:151–156

    CrossRef  PubMed  Google Scholar 

  • Zabarovsky ER, Lerman MI, Minna JD (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21:6915–6935

    CrossRef  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Associate Professor, Chairman and Professor, Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3400 Spruce Street, 2 Donner, Philadelphia, PA, 19104, USA

    Neil E. Martin MD, Stephen M. Hahn MD & W. Gillies McKenna MD, PhD

Authors
  1. Neil E. Martin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen M. Hahn MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Gillies McKenna MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 226, 81657, München, Germany

    Branislav Jeremić MD, PhD

Rights and permissions

Reprints and Permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Martin, N.E., Hahn, S.M., McKenna, W.G. (2005). Molecular Biology and Genetics of Lung Cancer. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology Radiation Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26632-1_1

Download citation

  • DOI: https://doi.org/10.1007/3-540-26632-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00522-3

  • Online ISBN: 978-3-540-26632-7

  • eBook Packages: MedicineMedicine (R0)