Palliative External Beam Thoracic Radiotherapy

  • Jason Lester
  • Fergus Macbeth
Part of the Medical Radiology Radiation Oncology book series (MEDRAD)


Radiat Oncol Biol Phys Thoracic Radiotherapy High Dose Regimen Radiation Myelopathy Lung Cancer Symptom Scale 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abratt RP, Shepherd LJ, Salton DG (1995) Palliative radiation for stage 3 non-small cell lung cancer-a prospective study of two moderately high dose regimens. Lung Cancer 13:137–143CrossRefPubMedGoogle Scholar
  2. Bezjak A, Dixon P, Brundage M et al (2002) Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (NCIC CTG SC.15). Int J Radiat Oncol Biol Phys 54:719–728CrossRefPubMedGoogle Scholar
  3. Carroll M, Morgan SA, Yarnold JR et al (1986) Prospective evaluation of a watch policy in patients with inoperable non-small cell lung cancer. Eur J Cancer Clin Oncol 22:1353–1356CrossRefPubMedGoogle Scholar
  4. Collins TM, Ash DU, Close HJ et al (1988) An evaluation of the palliative role of radiotherapy in inoperable carcinoma of the bronchus. Clin Radiol 39:284–286PubMedGoogle Scholar
  5. Devereux S, Hatton MQ, Macbeth FR (1997) Immediate side effects of large fraction radiotherapy. Clin Oncol 9:96–99CrossRefGoogle Scholar
  6. Erridge SC, Murray N (2003) Thoracic radiotherapy for limited-stage small cell lung cancer: issues of timing, volumes, dose, and fractionation. Semin Oncol 30:26–37CrossRefGoogle Scholar
  7. Gaze MN, Kerr GR, MacDougall RH et al (2001) Improved symptom relief with fractionated palliative radiotherapy in patients with lung cancer. Br J Cancer 85[Suppl 1]:18Google Scholar
  8. Hatton MQ, Nixon DL, Macbeth FR et al (1997) Acute changes in peak expiratory flow rate following palliative radiotherapy for bronchial carcinoma. Radiother Oncol 44: 31–34CrossRefPubMedGoogle Scholar
  9. Kramer GWPM, Wanders SL, Noordijk EM et al (2003) Randomized Dutch National Study of the effect of irradiation with different treatment schemes in the palliation of Non-Small Cell Lung Cancer (NSCLC) Proc World Conference on Lung Cancer S38, abstract 121Google Scholar
  10. Lupattelli M, Maranzano E, Bellavita R et al (2000) Short course palliative radiotherapy in non-small cell lung cancer: results of a prospective study. Am J Clin Oncol 23:89–93CrossRefPubMedGoogle Scholar
  11. Lutz ST, Huang DT, Ferguson CL et al (1997) A retrospective quality of life analysis using the Lung Cancer Symptom Scale in patients treated with palliative radiotherapy for advanced non-small cell lung cancer. Int J Radiat Oncol Biol Phys 37:117–122PubMedGoogle Scholar
  12. Macbeth FR, Wheldon TE, Girling DJ et al (1996) Radiation myelopathy: estimates of risk 1048 patients in three randomised trials of palliative radiotherapy for non-small cell lung cancer. The Medical research Council Lung Cancer Working Party. Clin Oncol 8:176–181CrossRefGoogle Scholar
  13. Maher EJ, Coia L, Duncan G et al (1992) Treatment strategies in advanced and metastatic lung cancer: differences in attitude between the USA, Canada and Europe. Int J Radiat Oncol Biol Phys 23:239–244PubMedGoogle Scholar
  14. Medical Research Council Lung Cancer Working Party (1991) Inoperable non-small cell lung cancer (NSCLC): a Medical Research Council trial of palliative radiotherapy with two fractions or ten fractions. Report to the Medical Research Council by its Lung Cancer Working Party. Br J Cancer 63:265–270Google Scholar
  15. Medical Research Council Lung Cancer Working Party (1992) A Medical Research Council (MRC) randomised trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small cell lung cancer (NSCLC) and poor performance status. Br J Cancer 65:931–941Google Scholar
  16. Medical Research Council Lung Cancer Working Party (1996) Randomised trial of palliative 2-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status. Clin Oncol 8:167–175Google Scholar
  17. Medical Research Council Lung Cancer Working Party (2002) Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomized controlled trial. BMJ 325:465–472Google Scholar
  18. Muers MF, Round CE (1993) Palliation of symptoms in non-small cell lung cancer; a study by the Yorkshire Regional Cancer Organization Thoracic Group. Thorax 48:339–343PubMedGoogle Scholar
  19. Nestle U, Nieder C, Walter K et al (2000) A palliative accelerated radiotherapy regimen for advanced non-small cell lung cancer vs conventionally fractionated 60Gy: results of a randomized equivalence study. Int J Radiat Oncol Biol Phys 48:95–103CrossRefPubMedGoogle Scholar
  20. Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised trials. BMJ 311:899–909Google Scholar
  21. Priestman TJ, Bullimore JA, Godden TP et al (1989) The Royal College of Radiologists’ Fractionation survey. Clin Oncol 1:39–46CrossRefGoogle Scholar
  22. Rees GJ, Deverell CE, Barley CL et al (1997) Palliative radiotherapy for lung cancer: two versus five fractions. Clin Oncol 9:90–95Google Scholar
  23. Reinfuss M, Skolyszewski J, Kowalska T et al (1993) Palliative radiotherapy in asymptomatic patients with locally advanced, unresectable, non-small cell lung cancer. Strahlenther Onkol 169:709–715PubMedGoogle Scholar
  24. Reinfuss M, Glinski B, Kowalska T, Kulpa J, Zawila K, Reinfuss K, Dymek P, Herman K, Skolyszewski J (1999) Radiotherapy for stage III, inoperable, asymptomatic small cell lung cancer. Final results of a prospective randomized study (240 patients). Cancer Radiother 3:475–479PubMedGoogle Scholar
  25. Senkus-Konefka E, Jassem J, Bednaruk-Mlynski E et al (2001) A prospective randomized study to compare the value of two fractionation schedules of palliative radiotherapy (RT) for inoperable non-small cell lung cancer (NSCLC). Eur J Cancer 37[Suppl 6]:S52, abstract 180CrossRefGoogle Scholar
  26. Simpson JR, Francis ME, Perez-Tamayo R et al (1985) Palliative radiotherapy for inoperable carcinoma of the lung: final report of an RTOG multi-institutional trial. Int J Radiat Oncol Biol Phys 11:751–758PubMedGoogle Scholar
  27. Stephens RJ, Hopwood P, Girling DJ (1997) Randomised trials with quality of life endpoints: are doctors’ ratings of patients’ physical symptoms interchangeable with patients’ self-ratings? Qual Life Res 6:225–236CrossRefPubMedGoogle Scholar
  28. Stevens MJ, Begbie SD (1995) Hypofractionated irradiation for inoperable non-small cell lung cancer. Austr Radiol 39:265–270Google Scholar
  29. Sundstrom S, Bremnes RM, Aasebo U et al (2002) Effect of hypofractionated palliative radiotherapy (17Gy/2 fractions) is comparable with standard fractionation in non-small cell lung cancer. Proc Am Soc Clin Oncol 21:300aGoogle Scholar
  30. Teo P, Tai TH, Choy D et al (1988) A randomized study on palliative radiation therapy fro inoperable non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 14:867–871PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Jason Lester
    • 1
  • Fergus Macbeth
    • 1
  1. 1.Velindre HospitalWhitchurch, CardiffUK

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