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Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer

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Part of the Medical Radiology Radiation Oncology book series (Med Radiol Radiat Oncol)

Keywords

  • Clin Oncol
  • Small Cell Lung Cancer
  • Radiat Oncol Biol Phys
  • Radiation Therapy Oncology Group
  • Concurrent Radiochemotherapy

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Albain KS, Crowley JJ, Turrisi AT III, Gandara DR, Farrar WB, Clark JI, Beasley KR, Livingston RB (2002) Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB non-small-cell lung cancer: a Southwest Oncology Group Phase II study, SWOG 9019. J Clin Oncol 20:3454–3460

    CrossRef  PubMed  Google Scholar 

  • Albain KS, Scott CB, Rusch VR, Turrisi AT, Shepherd FA, Smith C, Gandara DR, Johnson DH, Green MR, Miller RC (2003) Phase III comparison of concurrent chemotherapy plus radiotherapy (CT/RT) and CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): initial results from intergroup trial 0139 (RTOG 93-09). Proc Am Soc Clin Oncol 21:621 (abstract 2497)

    Google Scholar 

  • Antonodou D, Coliarakis N, Synodinou M, Athanassiou H, Kouveli A, Verigos C, Georgakopolous G, Panousaaki K, Karageorgis P, Throuvalas N, Clinical Radiation Oncology Hellenic Group (2001) Randomized phase III trial of radiation treatment +/− amifostine in patients with advanced-stage lung cancer. Int J Radiat Oncol Biol Phys 51:915–922

    CrossRef  PubMed  Google Scholar 

  • Armstrong JG, Burman C, Leibel SA, Fontenla D, Kutcher G, Zelefsky M, Fuks Z (1993) Three-dimensional conformal radiation therapy may improve the therapeutic ratio of high dose radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 26:685–689

    PubMed  Google Scholar 

  • Armstrong JG, Raben A, Zelefsky M, Burt M, Leibel SA, Burman C, Kutcher G, Harrison LB, Hahn C, Ginsberg R, Rusch V, Kris M, Fuks Z (1997) Promising survival with three-dimensional conformal radiation therapy for non-small cell lung cancer. Radiother Oncol 44:17–22

    CrossRef  PubMed  Google Scholar 

  • Arriagada R, Le Chevalier T, Rekacewicz C, Quoix E, de Cremoux H, Douillard JY, Tarayre M (1997) Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC): late analysis of a French randomized trial. Proc Am Soc Clin Oncol 16:16 (abstract)

    Google Scholar 

  • Ball D, Bishop J, Smith J, O'Brien P, Davis S, Ryan G, Olver I, Toner G, Walker Q, Joseph D (1999) A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: final report of a multi-centre trial. Radiother Oncol 52:129–136

    Google Scholar 

  • Belani CP, Wang W, Johnson DH, Wagner H, Schiller J, Veeder M, Mehta M. (2003) Induction chemotherapy followed by standard thoracic radiotherapy (Std.TRT) vs. hyperfractionated accelerated radiotherapy (HART) for patients with unresectable stage III A & B non-small cell lung cancer (NSCLC): phase III study of the Eastern Cooperative Oncology Group (ECOG 2597). Proc Am Soc Clin Oncol 21:622 (abstract 2500)

    Google Scholar 

  • Blanke C, Ansari R, Mantravadi R, Gonin R, Tokars R, Fisher W, Pennington K, O'Connor T, Rynard S, Miller M (1995) Phase III trial of thoracic irradiation with or without cisplatin for locally advanced unresectable non-small cell lung cancer: a Hoosier Oncology Group Protocol. J Clin Oncol 13:1425–1429

    PubMed  Google Scholar 

  • Bonner JA, McGinnis WL, Stella PJ, Marschke RF Jr, Sloan JA, Shaw EG, Mailliard JA, Creagan ET, Ahuja RK, Johnson PA (1998) The possible advantage of hyperfractionated thoracic radiotherapy in the treatment of locally advanced non small cell lung cancer. Results of a North Central Cancer Treatment Group phase III study. Cancer 82:1037–1048

    CrossRef  PubMed  Google Scholar 

  • Byhardt RW (1999) Toxicities in RTOG combined-modality trials for inoperable non-small-cell lung cancer. Oncology (Huntingt) 13[Suppl 5]:116–120

    Google Scholar 

  • Byhardt RW, Pajak TF, Emami B, Herskovic A, Doggett RS, Olsen LA (1993) A phase I/II study to evaluate accelerated fractionation via concomitant boost for squamous, adeno, and large cell carcinoma of the lung: report of Radiation Therapy Oncology Group 84-07. Int J Radiat Oncol Biol Phys 26:459–468

    PubMed  Google Scholar 

  • Byhardt RW, Scott CB, Ettinger DS, Curran WJ, Doggett RL, Coughlin C, Scarantino C, Rotman M, Emami B (1995) Concurrent hyperfractionated irradiation and chemotherapy for unresectable nonsmall cell lung cancer. Results of Radiation Therapy Oncology Group 90-15. Cancer 75:2337–2344

    PubMed  Google Scholar 

  • Byhardt RW, Scott C, Sause WT, Emami B, Komaki R, Fisher B, Lee JS, Lawton C (1998) Response, toxicity, failure patterns, and survival in five Radiation Therapy Oncology Group (RTOG) trials of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 42:469–478

    CrossRef  PubMed  Google Scholar 

  • Cakir S, Egehan I (2004) A randomized clinical trial of radiotherapy plus cisplatin versus radiotherapy alone in stage III non-small cell lung cancer. Lung Cancer 43:309–316

    CrossRef  PubMed  Google Scholar 

  • Choy H, Akerley W, Safran, Graziano S, Chung C, Williams T, Cole B, Kennedy T (1998) Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer. J Clin Oncol 16:3316–3322

    PubMed  Google Scholar 

  • Choy H, DeVore RF, Hande KR, Porter LL, Rosenblatt P, Yunus F, Schlabach L, Smith C, Shyr Y, Johnson DH (2000) A Phase II study of paclitaxel, carboplatin, and hyperfractionated radiation therapy for locally advanced inopearble non-small cell lung cancer (a Vanderbilt cancer center affiliate network study). Int J Radiat Oncol Biol Phys 47:931–937

    CrossRef  PubMed  Google Scholar 

  • Choy H, Curran WJ, Scott CB (2002) Preliminary report of locally advanced multimodality protocol (LAMP): ACR 427: a randomized phase II study of three chemo-radiation regimens with paclitaxel, carboplatin, and thoracic radiation (TRT) for patients with locally advanced non small cell lung cancer (LA-NSCLC). Proc Am Soc Clin Oncol, 291a pp (abstract no 1160)

    Google Scholar 

  • Clamon G, Herndon J, Cooper R, Chang AY, Rosenman J, Green MR (1999) Radiosensitization with carboplatin for patients with unresectable stage III non-small-cell lung cancer: a phase III trial of the cancer and Leukemia group B and the Eastern Cooperative Oncology Group. J Clin Oncol 17:4–11

    PubMed  Google Scholar 

  • Cox JD, Yesner R, Mietlowski W, Petrovich Z (1979) Influence of cell type on failure pattern after irradiation for locally advanced carcinoma of the lung. Cancer 44:94–98

    PubMed  Google Scholar 

  • Cox JD, Azarnia N, Byhardt RW, Shin KH, Emami B, Pajak TF (1990) A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: Possible survival benefit with > 69.6 Gy in favorable patients with Radiation Therapy Oncology Group Stage III non-small cell lung carcinoma: Report of Radiation Therapy Oncology Group 83-11. J Clin Oncol 8:1543–1555

    PubMed  Google Scholar 

  • Cox JD, Pajak TF, Asbell S, Russell AH, Pederson J, Byhardt RW, Emami B, Roach M 3rd (1993) Interruptions of high-dose radiation therapy decrease long-term survival of favorable patients with unresectable non-small cell carcinoma of the lung: analysis of 1244 cases from 3 Radiation Therapy Oncology Group (RTOG) trials. Int J Radiat Oncol Biol Phys 27:493–498

    PubMed  Google Scholar 

  • Crino L, Latini P, Meacci M, Corgna E, Maranzano E, Darwish S, Minotti V, Santucci A, Tonato M (1993) Induction chemotherapy plus high-dose radiotherapy versus radiotherapy alone in locally advanced unresectable non-small-cell lung cancer. Ann Oncol 4:847–851

    PubMed  Google Scholar 

  • Cullen MH, Billingham LJ, Woodroffe CM, Gower N, Souhami RL, Chetiyawaedana AD, Joshi R, Rudd R, Trask C, Spiro S (1997) Mitomycin, ifosfamide and cisplatin (MIC) in non-small cell lung cancer (NSCLC) 1. Results of a randomised trial in patients with localised, inoperable disease. Lung Cancer 18[Suppl 1]:5 (abstract 10)

    Google Scholar 

  • Curran WJ Jr, Scott C, Langer C (2000) Phase III comparison of sequential Vs concurrent chemoradiation for pts with unresected stage III non-small cell lung cancer (NSCLC): initial report of Radiation Therapy Oncology Group (RTOG) 9410. Proc Am Soc Clin Oncol 19:484a (abstract 1891)

    Google Scholar 

  • Dillman RO, Seagren SL, Propert KJ, Guerra J, Eaton WL, Perry MC, Carey RW, Frei EF 3rd, Green MR (1990) A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl I Med 323:940–945

    Google Scholar 

  • Dillman RO, Herndon J, Seagren SL, Eaton WL Jr, Green MR (1996) Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 8433 trial. J Natl Cancer Inst 88:1210–1215

    PubMed  Google Scholar 

  • El Sharouni SY, Kal HB, Battermann JJ (2003) Accelerated regrowth of non-small-cell lung tumors after induction chemotherapy. Br J Cancer 89:2184–2189

    PubMed  Google Scholar 

  • Fukumoto S, Shirato H, Shimizu S, Ogura S, Onimaru R, Kitamura K, Yamazaki K, Miyasaka K, Nishimura M, Dosaka-Akita H (2002) Small-volume image-guided radiotherapy using hypofractionated coplanar and noncoplanar multiple fields with inoperable stage I nonsmall cell lung carcinomas. Cancer 95:1546–1553

    PubMed  Google Scholar 

  • Fukuoka M, Niitani H, Suzuki A, Motomiya M, Hasegawa K, Nishiwaki Y, Kuriyama T, Ariyoshi Y, Negoro S, Masuda N (1992) Phase II study of CPT-11, a new derivative of camptothecin for previously untreated non-small cell lung cancer. J Clin Oncol 10:16–20

    PubMed  Google Scholar 

  • Furuse K, Nishikawa H, Takada Y, Nishikawa H, Takada Y, Kudoh S, Katagami N, Ariyoshi Y (1999) Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol 17:2692–2699

    PubMed  Google Scholar 

  • Furuse K, Hosoe S, Masuda N (2000) Impact of tumor control on survival in unresectable stage III non-small cell lung cancer (NSCLC) treated with concurrent thoracic radio-therapy (TRT) and chemotherapy (CT). Proc Am Soc Clin Oncol 19 (abstract 1893)

    Google Scholar 

  • Gandara DR, Chansky K, Albain KS, Leigh BR, Gaspar LE, Lara PN Jr, Burris H, Gumerlock P, Kuebler JP, Bearden JD 3rd, Crowley J, Livingston R (2003) Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J Clin Oncol 21:2004–2010

    CrossRef  PubMed  Google Scholar 

  • Giraud P, Rosenzweig KE, Yorke E (2001) Radiotherapy for lung cancer: can IMRT decrease the risk of esophagitis? Proc Am Soc Ther Radiol Oncol (ASTRO), San Francisco, Int J Radiat Oncol Biol Phys, pp 355–356 (abstract 2250)

    Google Scholar 

  • Graham MV (1997) Prediciting radiation response. Int J Radiat Oncol Biol Phys 39:561–562

    PubMed  Google Scholar 

  • Groen HJG, van de Leest AHW, Fokkema E, Timmer PR, Nossent GD, Smit WJ, Nabers J, Oosterhuis B, Hoekstra HJ, Hermans J, Otter R, van Putten JWG, De Vries EG, Mulder NH (2004) Phase III study of continuous carboplatin over 6 weeks with radiation versus radiation alone in stage III non small cell lung cancer. Ann Oncol 15: 427–432

    CrossRef  PubMed  Google Scholar 

  • Hara R, Itami J, Kondo T, Aruga T, Abe Y, Ito M, Fuse M, Shinohara D, Nagaoka T, Kobiki T (2002) Stereotactic single high dose irradiation of lung tumors under respiratory gating. Radiother Oncol 63:159–163

    CrossRef  PubMed  Google Scholar 

  • Herscher LL, Hahn SM, Kroog G, Pass H, Temeck B, Goldspiel B, Cook J, Mitchell JB, Liebmann J (1998) Phase I study of paclitaxel as a radiation sensitizer in the treatment of mesothelioma and non-small-cell lung cancer. J Clin Oncol 16:635–641

    PubMed  Google Scholar 

  • Hof H, Herfarth K, Munter M, Hoess A, Motsch J, Wannenmacher M, Debus J (2003) Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 56:3345–341

    CrossRef  Google Scholar 

  • Holsti LR, Matson K (1980) A randomized study of split-course radiotherapy of lung cancer: long term results. Int J Radiat Oncol Biol Phys 6:977–981

    PubMed  Google Scholar 

  • Jeremic B, Shibamoto Y, Acimovic L, Djuric L (1995) Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer. J Clin Oncol 13:452–458

    PubMed  Google Scholar 

  • Jeremic B, Shibamoto Y, Acimovic LJ, Milisavljevic S (1996) Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study. J Clin Oncol 14:1065–1070

    PubMed  Google Scholar 

  • Jeremic B, Shibamoto Y, Milicic B, Nikolic N, Dagovic A, Milisavljevic S (1998) Concurrent radiochemotherapy for patients with stage III non-small cell lung cancer (NSCLC). Long-term results of a phase II study. Int J Radiat Oncol Biol Phys 42:1091–1096

    CrossRef  PubMed  Google Scholar 

  • Jeremic B, Shibamoto Y, Acimovic LJ et al (2001) Hyperfractionated radiation therapy and concurrent low-dose, daily carboplatin/etoposide with or without week-end carboplatin/etoposide chemotherapy in stage III non-small-cell lung cancer: a randomized trial. Int J Radiat Oncol Biol Phys 50:19–25

    CrossRef  PubMed  Google Scholar 

  • Johnson DH, Einhorn LH, Bartolucci A, Birch R, Omura G, Perez CA, Greco FA (1990) Thoracic radiotherapy does not prolong survival in patients with locally advanced unresectable non-small cell lung cancer. Ann Intern Med 113:33–38

    PubMed  Google Scholar 

  • Johnson DH, Paul DM, Hande KR, Shyr Y, Blanke C, Murphy B, Lewis M, De Vore RF 3rd (1996) Paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a phase II trial. J Clin Oncol 14:2054–2060

    PubMed  Google Scholar 

  • Kelly K, Crowley J, Bunn PA Jr, Presant CA, Grevstad PK, Moinpour CM, Ramsey SD, Wozniak AJ, Weiss GR, Moore DF, Israel VK, Livingston RB, Gandara DR (2001) Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced NSCLC: a SWOG trial. J Clin Oncol 19:3210–3218

    PubMed  Google Scholar 

  • Komaki R, Scott C, Ettinger D, Lee JS, Fossella FV, Curran W, Evans RF, Rubin P, Byhardt RW (1997) Randomized study of chemotherapy / radiation therapy combinations for favorable patients with locally advanced inoperable nonsmall cell lung cancer: Radiation Therapy Oncology Group (RTOG) 92-04. Int J Radiat Oncol Biol Phys 38:149–155

    CrossRef  PubMed  Google Scholar 

  • Komaki R, Seiferheld W, Curran W (2000) Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Proc Am Soc Ther Radiol Oncol 42:113 (abstract 5)

    Google Scholar 

  • Komaki R, Lee JS, Kaplan B, Allen P, Kelly JF, Liao Z, Stevens CW, Fossella FV, Zinner R, Papadimitrakopolou V, Khuri F, Glisson B, Pisters K, Kurie J, Herbst R, Milas L, Ro J, Thames HD, Hong WK, Cox JD (2002) Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II–III non-small cell lung cancer: preliminary results. Semin Radiat Oncol 12[Suppl 1]:46–49

    CrossRef  PubMed  Google Scholar 

  • Kwa Sl, Lebesque JV, Theuws JC, Marks LB, Munley MT, Bentel G, Oetzel D, Spahn U, Graham MV, Drzymala RE, Purdy JA, Lichter AS, Martel MK, Ten Haken RK (1998) Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys 42:1–9

    CrossRef  PubMed  Google Scholar 

  • Lau D, Leigh B, Gandara D, Edelman M, Morgan R, Israel V, Lara P, Wilder R, Ruy J, Doroshow J (2001) Twice-weekly paclitaxel and weekly carboplatin with concurrent thoracic radaition followed by carboplatin/paclitaxel consolidation for stage III non-small-cell lung cancer: a California Cancer Consortium phase II study. J Clin Oncol 19:442–447

    PubMed  Google Scholar 

  • LeChevalier T, Arriagada R, Quoix E, Ruffie P, Martin M, Tarayre M, Lacombe-Terrier MJ, Douillard JY, Laplanche A (1991) Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: first analysis of a randomized trial in 353 patients. J Natl Cancer Inst 83:417–423

    PubMed  Google Scholar 

  • LeChevalier T, Arriagada R, Tarayre M, Lacombe-Terrier MJ, Laplanche A, Quoix E, Ruffie P, Martin M, Douillard JY (1992) Significant effect of adjuvant chemotherapy on survival in locally advanced non-small cell lung carcinoma. J Natl Cancer Inst 84:58 (letter)

    PubMed  Google Scholar 

  • LeChevalier T, Brisgand D, Douillard J-Y, Pujol JL, Alberola V, Monnier A, Riviere A, Lianes P, Chomy P, Cigolari S (1994) Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 12:360–367

    PubMed  Google Scholar 

  • Lee JS, Scott C, Komaki R, Fossella FV, Dundas GS, McDonald S, Byhardt RW, Curran WJ Jr (1996) Concurrent chemoradiation therapy with oral etoposide and cisplatin for locally advanced inoperable non-small-cell lung cancer: Radiation Therapy Oncology Group protocol 91-06. J Clin Oncol 14:1055–1064

    PubMed  Google Scholar 

  • Leong SS, Tan EH, Fong KW, Wilder-Smith E, Ong YK, Tai BC, Chew L, Liem SH, Wee J, Foo KM, Ang P, Ang PT (2003) Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer. J Clin Oncol 21:1767–1774

    CrossRef  PubMed  Google Scholar 

  • Lynch TJ Jr, Kalish L, Strauss G, Elias A, Skarin A, Shulman LN, Posner M, Frei E 3rd (1994) Phase II study of topotecan in metastatic non-small-cell lung cancer. J Clin Oncol 12:347–352

    PubMed  Google Scholar 

  • Manegold C, Bergman B, Chemaissani A, Dornoff W, Drings P, Kellokumpu-Lehtinen P, Liippo K, Mattson K, van Pawel J, Ricci S, Sederholm C, Stahel RA, Wagenius G, van Walree N, ten Bokkel-Huinink W (1997) Single-agent gemcitabine versus cisplatin-etoposide: early results of a randomized phase II study in locally-advanced or metastatic non-small cell lung cancer. Ann Oncol 8:525–529

    CrossRef  PubMed  Google Scholar 

  • Marino P, Preatoni A, Cantoni A (1995) Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages IIIa and IIIb nonsmall cell lung cancer. A meta-analysis. Cancer 76:593–601

    PubMed  Google Scholar 

  • Martel MK, Sahijdak WM, Hayman JA (1999) Incidental dose to clinically negative nodes from conformal treatment fields for nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys 45:244 (abstract)

    CrossRef  Google Scholar 

  • Masters GA, Haraf DJ, Hoffman PC, Drinkard LC, Krauss SA, Ferguson MK, Olak J, Samuels BL, Golomb HM, Vokes EE (1998) Phase I study of vinorelbine, cisplatin and concomitant thoracic radiation in the treatment of advanced chest malignancies. J Clin Oncol 16:2157–2163

    PubMed  Google Scholar 

  • Mattson K, Holsti LR, Holsti P, Jakobsson M, Kajanti M, Liippo K, Mantyla M, Niitamo-Korhonen S, Nikkanen V, Nordman E, Platin L-H, Pyrhonen S, Romppanen M-L, Salmi R, Tammilehto L, Taskinen PJ (1988) Inoperable non-small cell lung cancer: Radiation with or without chemotherapy. Eur J Cancer Clin Oncol 24:477–482

    CrossRef  PubMed  Google Scholar 

  • Mauer AM, Masters GA, Haraf DJ, Hoffman PC, Watson SM, Golomb HM, Vokes EE (1998) Phase I study of docetaxel with concomitant thoracic radiation therapy. J Clin Oncol 16:159–164

    PubMed  Google Scholar 

  • Millward MJ, Zalcberg J, Bishop JF, Webster LK, Zimet A, Rischin D, Toner GC, Laird J, Cosolo W, Urch M, Bruno R, Loret C, James R, Blanc C (1996) Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small cell lung cancer. J Clin Oncol 14: 750–758

    Google Scholar 

  • Morton RF, Jett JR, McGinnis WL, Earle JD, Therneau TM, Krook JE, Elliott TE, Mailliard JA, Nelimark RA, Maksymiuk AW, Drummond RG, Laurie JA, Kugler JW, Anderson RT (1991) Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non-small cell lung cancer. A randomized, phase III trial. Ann Intern Med 115:681–686

    PubMed  Google Scholar 

  • Mountain CF (1986) A new international staging system for lung cancer. Chest 89:225S–233S

    PubMed  Google Scholar 

  • Mountain CF (1997) Revisions in the international system for staging lung cancer. Chest 111:1710–1717

    PubMed  Google Scholar 

  • Movsas B, Scott C, Langer (2003) Phase III study of amifostine in patients with locally advanced non-small cell lung cancer (NSCLC) receiving chemotherapy and hyperfractionated radiation (chemo/HFxRT): Radiation Therapy Oncology Group (RTOG) 98-01. Proc Am Soc Clin Oncol 21:636 (abstract 2559)

    Google Scholar 

  • Nagata Y, Negoro Y, Aoki T, Mizowaki T, Takayama K, Kokubo M, Araki N, Mitsumori M, Sasai K, Shibamoto Y, Koga S, Yano S, Hiraoka M (2002) Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame. Int J Radiat Oncol Biol Phys 52:1041–1046

    CrossRef  PubMed  Google Scholar 

  • Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Br Med J 311:899–909

    Google Scholar 

  • Onimaru R, Shirato H, Shimizu S, Kitamura K, Xu B, Fukumoto S, Chang T-C, Fujita K, Oita M, Miyasaka K, Nishimura M, Dosaka-Akita H (2003) Tolerance of organs at riskin small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys 56:126–135

    CrossRef  PubMed  Google Scholar 

  • Oshita F, Noda K, Nishiwaki Y, Fujita A, Kurita Y, Nakabayashi T, Tobise K, Abe S, Suzuki S, Hayashi I, Kawakami Y, Matsuda T, Tsuchiya S, Takahashi S, Tamura T, Saijo N (1997) Phase II study of irinotecan and etoposide in patients with metastatic non-small-cell lung cancer. J Clin Oncol 15:304–309

    PubMed  Google Scholar 

  • Perez CA, Bauer M, Edelstein S, Gillespie BW, Birch R (1986) Impact of tumor control on survival in carcinoma of the lung treated with irradiation. Int J Radiat Oncol Biol Phys 12:539–547

    PubMed  Google Scholar 

  • Perez CA, Pajak TF, Rubin P, Simpson JR, Mohiuddin M, Brady LW, Perez-Tamayo R, Rotman M (1987) Long term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy. Report by the Radiation Therapy Oncology Group. Cancer 59:1874–1881

    PubMed  Google Scholar 

  • Perez-Soler R, Fossella FV, Glisson BS, Lee JS, Murphy WK, Shin DM, Kemp BL, Lee JJ, Kane J, Robinson RA, Lippman SM, Kurie JM, Huber MH, Raber MN, Hong WK (1996) Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy. J Clin Oncol 14:503–513

    PubMed  Google Scholar 

  • Petrovich Z, Mietlowski W, Ohanian M, Cox J (1977) Clinical report on the treatment of locally advanced lung cancer. Cancer 40:72–77

    PubMed  Google Scholar 

  • Petrovich Z, Stanley K, Cox JD, Paig C (1981) Radiotherapy in the management of locally advanced lung cancer of all cell types: final report of randomized trial. Cancer 48:1335–1340

    PubMed  Google Scholar 

  • Planting A, Helle P, Drings P, Dalesio O, Kirkpatrick A, McVie G, Giaccone G (1996) A randomized study of high-dose split course radiotherapy preceded by high-dose chemotherapy versus high-dose radiotherapy only in locally advanced non-small-cell lung cancer. An EORTC Lung Cancer Cooperative Group trial. Ann Oncol 7:139–144

    PubMed  Google Scholar 

  • Pritchard RS, Anthony SP (1996) Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced, unresectable, non-small-cell lung cancer: A meta-analysis. Ann Intern Med 125:723–729

    PubMed  Google Scholar 

  • Rakowitch E, Tsao M, Ung Y, Pignol J-P, Cheung P, Chow E (2004) Comparison of the efficacy and acute toxicity of weekly versus daily chemoradiotherapy for non-small-cell lung cancer: a meta-analysis. Int J Radiat Oncol Biol 58:196–203

    CrossRef  Google Scholar 

  • Reinfuss M, Glinski B, Kowalska T, Kulpa J, Zawila K, Reinfuss K, Dymek P, Herman K, Skolyszewski J (1999) Radiotherapy for stage III, inoperable, asymptomatic non-small cell lung cancer. Final results of a prospective randomized study (240 patients). Cancer Radiother 3:475–479

    PubMed  Google Scholar 

  • Reynolds RD, O'Dell S (1978) Combination modality therapy in lung cancer: a survival study showing beneficial results of AMCOF (Adriamycin, Metotrexate, Cyclophosphamide, Oncobin and 5-Fluorouracil). Cancer 30:315–324

    Google Scholar 

  • Robertson JM, Ten Haken RK, Hazuka MB (1997) Dose escalation for non small cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys 37:1079–1085

    CrossRef  PubMed  Google Scholar 

  • Rosenzweig KE, Sim SE, Mychalczak B, Braban LE, Schindelheim R, Leibel SA (2001) Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 50:681–685

    CrossRef  PubMed  Google Scholar 

  • Roswit B, Patno ME, Rapp R, Veinbergs A, Feder B, Stuhlbarg J, Reid CB (1968) The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo. Radiology 90:688–697

    PubMed  Google Scholar 

  • Sakai H, Yoneda S, Kobayashi K, Komagata H, Kosaihira S, Kazumoto T, Saito Y (2004) Phase II study of bi-weekly docetaxel and carboplatin with concurrent thoracic radiation therapy followed by consolidation chemotherapy with docetaxel plus carboplatin for stage III unresectable non-small cell lung cancer. Lung Cancer 43:195–201

    CrossRef  PubMed  Google Scholar 

  • Saunders MI, Dische S (1990) Continuous, hyperfractionated, accelerated radiotherapy (CHART) in non-small cell carcinoma of the bronchus. Int J Radiat Oncol Biol Phys 19:1211–1215

    PubMed  Google Scholar 

  • Saunders M, Dische S, Barrett A, Harvey A, Griffiths G, Palmar M (1999) Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. Radiother Oncol 52:137–148

    CrossRef  PubMed  Google Scholar 

  • Sause WT, Scott C, Taylor S, Johnson D, Livingston R, Komaki R, Emami B, Curran WJ, Byhardt RW, Turrisi AT, Dar AR, Cox JD (1995) Radiation Therapy Oncology Group 88-08 and Eastern Cooperative Oncology Group 4588: preliminary results of a phase III trial in regionally advanced, unresectable nonsmall cell lung cancer. J Natl Cancer Inst 87:198–205

    PubMed  Google Scholar 

  • Sause W, Kolesar P, Taylor S IV, Johnson D, Livingston R, Komaki R, Emami B, Curran W Jr, Byhardt R, Dar AR, Turrisi A 3rd (2000) Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group. Chest 117:358–364

    CrossRef  PubMed  Google Scholar 

  • Schaake-Koning C, van den Bogaert W, Dalesio O, Festen J, Hoogenhout J, van Houtte P, Kirkpatrick A, Koolen M, Maat B, Nijs A (1992) Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N Engl J Med 326:524–530

    PubMed  Google Scholar 

  • Schild SE, Stella PJ, Geyer SM, Bonner JA, Marks RS, McGinnis WL, Goetz SP, Kuross SA, Mailliard JA, Kugler MD, Schaeffer PL, Jett JR (2002) Phase III trial comparing chemotherapy plus once-daily or twice-daily radiotherapy in stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 54:370–378

    CrossRef  PubMed  Google Scholar 

  • Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH (2002) Comparison of four chemotherapy regimens for advanced NSCLC. N Engl J Med 346:92–98

    CrossRef  PubMed  Google Scholar 

  • Soresi E, Borghini U, Zucali R, Leoni M, Botturi M, Vergari C, Luporini G, Scoccia S (1988) A randomized clinical trial comparing radiation therapy versus radiation therapy plus cis-Dichlorodiamine Pltinum (II) in the treatment of locally advanced non small cell lung cancer. Semin Oncol 15[Suppl 7]:20–25

    Google Scholar 

  • Steel GG, Peckham MJ (1979) Exploitable mechanisms in combined radiotherapy-chemotherapy. Int J Radiat Oncol Biol Phys 5:85–91

    Google Scholar 

  • Taylor NA, Liao ZX, Cox JD, Stevens C, Roth J, Walsh G, Chang JY, Guerrero T, Jeter M, Putnam J, Jr., Fossella FV, Allen P, Komaki R (2004) Equivalent outcome of patients with clinical stage IIIA non-small-cell lung cancer treated with concurrent chemoradiation compared with induction chemotherapy followed by surgical resection. Int J Radiat Oncol Biol Phys 58:204–212

    CrossRef  PubMed  Google Scholar 

  • Trovo MG, Minatel E, Franchin G, Boccieri MG, Nascimben O, Bolzicco G, Pizzi G, Torretta A, Veronesi A, Gobitti C (1992) Radiotherapy versus radiotherapy emhanced by cisplatin in stage III non small cell lung cancer. Int J Radiat Oncol Biol Phys 24:11–15

    PubMed  Google Scholar 

  • Timmerman R, Papiez L, McGarry R, Likes L, DesRosiers C, Frost S, Williams M (2003) Extracranial stereotactic radioablation. Results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124:1946–1955

    CrossRef  PubMed  Google Scholar 

  • Uematsu M, Shioda A, Tahara K, Fukui T, Yamamoto F, Tsumatori G, Ozeki Y, Aoki T, Watanabe M, Kusano S (1998) Focal, high-dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients. A preliminary experience. Cancer 82:1062–1070

    CrossRef  PubMed  Google Scholar 

  • Ulutin HC, Pak Y (2003) Preliminary results of radiotherapy with or without weekly paclitaxel in locally advanced non-small cell lung cancer. J Cancer Res Clin Oncol 129:52–56

    PubMed  Google Scholar 

  • Vokes EE, Gregor A, Turrisi AT (1998) Gemcitabine and radiation therapy for non-small cell lung cancer. Semin Oncol 25[Suppl 4]:66–69

    Google Scholar 

  • Vokes EE, Herndon JE II, Crawford J, Leopold KA, Perry MC, Miller AA, Green MR (2002) Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small-cell lung cancer: Cancer and Leukemia Group B Study 9431. J Clin Oncol 20:4191–4198

    CrossRef  PubMed  Google Scholar 

  • White JE, Chen T, Reed R, Mira J, Stuckey WJ, Weatherall T, O'Bryan R, Samson MK, Seydel HG (1982) Limited squamous cell carcinoma of the lung: a Southwest Oncology Group randomised study of radiation with or without doxorubicin chemotherapy and with or without levamisole immunotherapy. Cancer Treat Rep 66:1113–1120

    PubMed  Google Scholar 

  • Whyte RI, Crownover R, Murphy MJ, Martin DP, Rice TW, DeCamp MM Jr, Rodebaugh R, Weinhous MS, Le QT (2003) Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. Ann Thorac Surg 75:1097–1101

    CrossRef  PubMed  Google Scholar 

  • Yorke E (2001) Advantages of IMRT for dose escalation in radiation therapy for lung cancer. Med Phys 28:1291–1294

    Google Scholar 

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Jeremić, B., Dagović, A. (2005). Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology Radiation Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26632-1_16

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