Cellular Heterogeneity

  • Robert A. Ross
Part of the Pediatric Oncology book series (PEDIATRICO)


Schwann Cell Neural Crest Human Neuroblastoma Cell Cellular Heterogeneity MYCN Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ambros IM, Ambros PF (1995) Schwann cells in neuroblastoma. Eur J Cancer 31A:429–434CrossRefPubMedGoogle Scholar
  2. Biedler JL, Spengler BA, Chang T-D, Ross RA (1988) Transdifferentiation of human neuroblastoma cells results in coordinate loss of neuronal and malignant properties. In: Evans AE, D'Angio GJ, Knudson AG, Seeger RC (eds) Advances in neuroblastoma research, vol 2. Liss, New York, pp 265–276Google Scholar
  3. Biedler JL, Spengler BA, Ross RA (1997) Human neuroblastoma cell differentiation. In: Raghavan D, Scher HI, Leibel SA, Lange PH (eds) Principles and practice of genitourinary oncology. Lippincott-Raven, Philadelphia, pp 1053–1061Google Scholar
  4. Brodeur GM (2003) Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3:203–216CrossRefPubMedGoogle Scholar
  5. Cohen N, Betts DR, Rechavi G, Amariglio N, Trakhtenbrot L (2003) Clonal expansion and not cell interconversion is the basis for the neuroblast and nonneuronal types of the SK-N-SH neuroblastoma cell line. Cancer Genet Cytogenet 143:80–84CrossRefPubMedGoogle Scholar
  6. Hemmati HD, Nakano I, Lazareff JA, Masteman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI (2003) Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100:15178–15183CrossRefPubMedGoogle Scholar
  7. Huang D, Rutkowski JL, Brodeur GM, Chou PM, Kwiatkowski JL, Babbo A, Cohn SL (2000) Schwann cell-conditioned medium inhibits angiogenesis. Cancer Res 60:5966–5971PubMedGoogle Scholar
  8. Jessen KR, Mirsky R (1999) Schwann cells and their precursors emerge as major regulators of nerve development. Trends Neurosci 22:402–410PubMedGoogle Scholar
  9. Jögi A, Øra I, Nilsson H, Lindeheim Å, Makino Y, Poellinger L, Axelson H, Påhlman S (2002) Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci USA 99:7021–7026PubMedGoogle Scholar
  10. Kwiatkowski JL, Rutkowski JL, Yamashiro DJ, Tennekoon GI, Brodeur GM (1998) Schwann cell-conditioned medium promotes neuroblastoma survival and differentiation. Cancer Res 58:4602–4606PubMedGoogle Scholar
  11. Le Douarin NM, Ziller C (1993) Plasticity in neural crest differentiation. Curr Opin Cell Biol 5:1036–1043CrossRefPubMedGoogle Scholar
  12. Liu Y, Rao MS (2003) Transdifferentiation: fact or artifact. J Cell Biochem 88:29–40PubMedGoogle Scholar
  13. Lo L, Dormand E, Greenwood A, Anderson DJ (2002) Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaetescute and atonal homologs in cultured neural progenitor cells. Development 129:1553–1567PubMedGoogle Scholar
  14. Luo R, Gao J, Wehrle-Haller B, Henion PD (2003) Molecular identification of distinct neurogenic and melanogenic neural crest sublineages. Development 130:321–330PubMedGoogle Scholar
  15. Mascorro JA, Yates RD (1989) Mitotic cell division in the extraadrenal chromaffin system of various species. J Electron Microsc Tech 12:323–330CrossRefPubMedGoogle Scholar
  16. Mora J, Cheung N-K, Juan G, Illei P, Cheung I, Akram M, Ladanyi M, Cordon-Cardo C, Gerald WL (2001) Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell. Cancer Res 61:6892–6898PubMedGoogle Scholar
  17. Rettig WJ, Spengler BA, Garin Chesa PG, Old LJ, Biedler JL (1987) Coordinate changes in neuronal phenotype and surface antigen expression in human neuroblastoma cell variants. Cancer Res 47:1383–1389PubMedGoogle Scholar
  18. Ross RA, Biedler JL (1985) Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro. Cancer Res 45:1628–1638PubMedGoogle Scholar
  19. Ross RA, Spengler BA, Domènech C, Porubcin M, Rettig WJ, Biedler JL (1995) Human neuroblastoma I-type cells are malignant neural crest stem cells. Cell Growth Differ 6:449–456PubMedGoogle Scholar
  20. Ross RA, Hein AM, Braca III, JA, Spengler BA, Biedler JL, Scammell JG (2002) Glucocorticoids induce neuroendocrine cell differentiation and increase expression of N-MYC in N-type human neuroblastoma cells. Oncol Res 13:87–94PubMedGoogle Scholar
  21. Ross RA, Biedler JL, Spengler BA (2003) The role of distinct cell types in regulation of malignancy in human neuroblastoma cell lines and tumors. Cancer Lett 197:35–39CrossRefPubMedGoogle Scholar
  22. Shimada H, Ambros IM, Dehner LP, Hata J-i, Joshi VV, Roald B (1999) Terminology and morphologic criteria of neuroblastoma tumors. Cancer 86:349–363CrossRefPubMedGoogle Scholar
  23. Spengler BA, Ross RA, Biedler JL (1986) Differential drug sensitivity of human neuroblastoma cells. Cancer Treat Rep 70:959–965PubMedGoogle Scholar
  24. Spengler BA, Lazarova DL, Ross RA, Biedler JL (1997) Cell lineage and differentiation state are primary determinants of MYCN gene expression and malignant potential in human neuroblastoma cells. Oncol Res 9:467–476PubMedGoogle Scholar
  25. Sugimoto T, Mine H, Horii Y, Takahashi K, Nagai R, Morishita R, Komada M, Asada Y, Sawada T (2000) Neuroblastoma cell lines showing smooth muscle cell phenotypes. Diagn Mol Pathol 9:221–228CrossRefPubMedGoogle Scholar
  26. Thomas SK (2003) Nestin is a potential mediator of malignancy in human neuroblastoma cells. PhD dissertation, Fordham University, New YorkGoogle Scholar
  27. Tsokos M, Scarpa S, Ross RA, Triche TJ (1987) Differentiation of human neuroblastoma recapitulates neural crest development. Am J Pathol 3:484–496Google Scholar
  28. Valent A, Bénard J, Venuat, A-M, da Silva J, Duverger A, Duarte N, Hartmann O, Spengler BA, Bernheim A (1999) Phenotypic and genotypic diversity of human neuroblastoma studies in three IGR cell line models derived from bone marrow metastases. Cancer Genet Cytogenet 112:124–129CrossRefPubMedGoogle Scholar
  29. Walton JD, Kattan DR, Thomas SK, Spengler BA, Guo H-F, Biedler JL, Cheung N-KV, Ross RA (2004) Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 6: in pressGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Robert A. Ross

There are no affiliations available

Personalised recommendations