Skip to main content
SpringerLink
Log in

Molecular Cytogenetics

  • Chapter
Neuroblastoma

Part of the book series: Pediatric Oncology ((PEDIATRICO))

  • 1349 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 159.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abel F, Ejeskar K, Kogner P et al. (1999) Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24. Br J Cancer 81:1402–1409

    Google Scholar 

  • Alaminos M, Mora J, Cheung NK et al. (2003) Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma. Cancer Res 63:4538–4546

    PubMed  Google Scholar 

  • Alt FW, Kellems RE, Bertino JR et al. (1978) Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 253:1357–1370

    PubMed  Google Scholar 

  • Amler LC, Corvi R, Praml C et al. (1995) A reciprocal translocation (1;15) (36.2;q24) in a neuroblastoma cell line is accompanied by DNA duplication and may signal the site of a putative tumor suppressor-gene. Oncogene 10:1095–1101

    PubMed  Google Scholar 

  • Amler LC, Bauer A, Corvi R et al. (2000) Identification and characterization of novel genes located at the t(1;15) (p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. Genomics 64:195–202

    Article  PubMed  Google Scholar 

  • Balaban-Malenbaum G, Gilbert F (1977) Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line. Science 198:739–741

    PubMed  Google Scholar 

  • Barton K, Nucifora G (2000) AML1 haploinsufficiency, gene dosage, and the predisposition to acute leukemia. Bioessays 22:214–218

    Article  PubMed  Google Scholar 

  • Bauer A, Savelyeva L, Claas A et al (2001) Smallest region of overlapping deletion in 1p36 in human neuroblastoma: a 1 Mbp cosmid and PAC contig. Genes Chromosomes Cancer 31:228–239

    Article  PubMed  Google Scholar 

  • Beheshti B, Braude I, Marrano P et al. (2003) Chromosomal localization of DNA amplifications in neuroblastoma tumors using cDNA microarray comparative genomic hybridization. Neoplasia 5:53–62

    PubMed  Google Scholar 

  • Berwanger B, Hartmann O, Bergmann E et al. (2002) Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Cancer Cell 2:377–386

    Article  PubMed  Google Scholar 

  • Biedler JL, Spengler BA (1976) A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture. J Natl Cancer Inst 57:683–695

    PubMed  Google Scholar 

  • Biegel JA, White PS, Marshall HN et al. (1993) Constitutional 1p36 deletion in a child with neuroblastoma. Am J Hum Genet 52:176–182

    PubMed  Google Scholar 

  • Bishop JM (1981) Enemies within: the genesis of retrovirus oncogenes. Cell 23:5–6

    Article  PubMed  Google Scholar 

  • Bishop JM (1982) Retroviruses and cancer genes. Adv Cancer Res 37:1–32

    PubMed  Google Scholar 

  • Bishop JM (1987) The molecular genetics of cancer. Science 235:305–311

    PubMed  Google Scholar 

  • Bown N, Pearson AD, Reid MM (1993) High incidence of constitutional balanced translocations in neuroblastoma. Cancer Genet Cytogenet 69:166–167

    Article  PubMed  Google Scholar 

  • Bown N, Cotterill S, Lastowska M et al. (1999) Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma. N Engl J Med 340:1954–1961

    PubMed  Google Scholar 

  • Bown N, Lastowska M, Cotterill S et al. (2001) 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group. Med Pediatr Oncol 36:14–19

    Article  PubMed  Google Scholar 

  • Brinkley BR (2001) Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 11:18–21

    Article  PubMed  Google Scholar 

  • Brinkschmidt C, Christiansen H, Terpe HJ et al. (1997) Comparative genomic hybridization (CGH) analysis of neuroblastomas: an important methodological approach in paediatric tumour pathology. J Pathol 181:394–400

    Article  PubMed  Google Scholar 

  • Brodeur GM, Sekhon G, Goldstein MN (1977) Chromosomal aberrations in human neuroblastomas. Cancer 40:2256–2263

    PubMed  Google Scholar 

  • Brodeur GM, Green AA, Hayes FA et al. (1981) Cytogenetic features of human neuroblastomas and cell lines. Cancer Res 41:4678–4686

    PubMed  Google Scholar 

  • Caron H (1995) Allelic loss of chromosome 1 and additional chromosome 17 material are both unfavourable prognostic markers in neuroblastoma. Med Pediatr Oncol 24:215–221

    PubMed  Google Scholar 

  • Caron H, van Sluis P, van Hoeve M et al. (1993) Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification. Nat Genet 4:187–190

    Article  PubMed  Google Scholar 

  • Caron H, van Sluis P, van Roy N et al. (1994) Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity. Am J Hum Genet 55:341–347

    PubMed  Google Scholar 

  • Caron H, Peter M, van Sluis P et al (1995) Evidence for two tumour suppressor loci on chromosomal bands 1p35–36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. Hum Mol Genet 4:535–539

    PubMed  Google Scholar 

  • Caron H, van Sluis P, de Kraker J et al. (1996) Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. N Engl J Med 334:225–230

    Article  PubMed  Google Scholar 

  • Caron H, Spieker N, Godfried M et al. (2001) Chromosome bands 1p35–36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted. Genes Chromosomes Cancer 30:168–174

    Article  PubMed  Google Scholar 

  • Caspersson T, Farber S, Foley GE et al. (1968) Chemical differentiation along metaphase chromosomes. Exp Cell Res 49:219–222

    Article  PubMed  Google Scholar 

  • Cavenee WK, Dryja TP, Phillips RA et al. (1983) Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779–784

    Article  PubMed  Google Scholar 

  • Cavenee WK, Hansen MF, Nordenskjold M et al (1985) Genetic origin of mutations predisposing to retinoblastoma. Science 228:501–503

    PubMed  Google Scholar 

  • Celeste A, Difilippantonio S, Difilippantonio MJ et al. (2003) H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114:371–383

    Article  PubMed  Google Scholar 

  • Chatten J, Voorhess ML (1967) Familial neuroblastoma. Report of a kindred with multiple disorders, including neuroblastomas in four siblings. N Engl J Med 277:1230–1236

    PubMed  Google Scholar 

  • Cheng NC, van Roy N, Chan A, Beitsma M et al. (1995) Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35–36 region, only one of which is associated with N-myc amplification. Oncogene 10:291–297

    PubMed  Google Scholar 

  • Comings DE (1973) A general theory of carcinogenesis. Proc Natl Acad Sci USA 70:3324–3328

    PubMed  Google Scholar 

  • Corvi R, Savelyeva L, Schwab M (1995) Duplication of N-MYC at its resident site 2p24 may be a mechanism of activation alternative to amplification in human neuroblastoma cells. Cancer Res 55:3471–3474

    PubMed  Google Scholar 

  • Cowel JK, Nowak NJ (2003) High-resolution analysis of genetic events in cancer cells using bacterial artificial chromosome arrays and comparative genome hybridization. Adv Cancer Res 90:91–125

    PubMed  Google Scholar 

  • Cox D, Yuncken C, Spriggs AI (1965) Minute chromatin bodies in malignant tumours of childhood. Lancet 62:55–58

    Article  PubMed  Google Scholar 

  • Cunsolo CL, Bicocchi MP, Petti AR, Tonini GP (2000) Numerical and structural aberrations in advanced neuroblastoma tumours by CGH analysis; survival correlates with chromosome 17 status. Br J Cancer 83:1295–1300

    Article  PubMed  Google Scholar 

  • Dalla-Favera R, Bregni M, Erikson J et al. (1982) Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 79:7824–7827

    PubMed  Google Scholar 

  • Der CJ, Krontiris TG, Cooper GM (1982) Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci USA 79:3637–3640

    PubMed  Google Scholar 

  • Dryja TP, Cavenee W, White R et al (1984) Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med 310:550–553

    PubMed  Google Scholar 

  • Dumon-Jones V, Frappart PO, Tong WM et al. (2003) Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res 63:7263–7269

    PubMed  Google Scholar 

  • Ejeskar K, Sjoberg RM, Abel F et al. (2001) Fine mapping of a tumour suppressor candidate gene region in 1p36.2–3, commonly deleted in neuroblastomas and germ cell tumours. Med Pediatr Oncol 36:61–66

    Article  PubMed  Google Scholar 

  • Fan J, Tam P, Woude GV et al (2004) Normalization and analysis of cDNA microarrays using within-array replications applied to neuroblastoma cell response to a cytokine. Proc Natl Acad Sci USA 101:1135–1140

    Article  PubMed  Google Scholar 

  • Fero ML, Randel E, Gurley KE et al. (1998) The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396:177–180

    Article  PubMed  Google Scholar 

  • Fong CT, Dracopoli NC, White PS et al. (1989) Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci USA 86:3753–3757

    PubMed  Google Scholar 

  • Fong CT, White PS, Peterson K et al. (1992) Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res 52:1780–1785

    PubMed  Google Scholar 

  • Friend SH, Bernards R, Rogelj S et al. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643–646

    PubMed  Google Scholar 

  • Fung YK, Murphree AL, T'Ang A et al. (1987) Structural evidence for the authenticity of the human retinoblastoma gene. Science 236:1657–1661

    PubMed  Google Scholar 

  • Gehring M, Berthold F, Edler L et al. (1995) The 1p deletion is not a reliable marker for the prognosis of patients with neuroblastoma. Cancer Res 55:5366–5369

    PubMed  Google Scholar 

  • Gennett IN, Cavenee WK (1990) Molecular genetics in the pathology and diagnosis of retinoblastoma. Brain Pathol 1:25–32

    PubMed  Google Scholar 

  • Gilbert F, Balaban G, Moorhead P et al. (1982) Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines. Cancer Genet Cytogenet 7:33–42

    Article  PubMed  Google Scholar 

  • Goss KH, Risinger MA, Kordich JJ et al. (2002) Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297:2051–2053

    Article  PubMed  Google Scholar 

  • Gratacos M, Nadal M, Martin-Santos R et al. (2001) A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell 106:367–379

    Article  PubMed  Google Scholar 

  • Groffen J, Stephenson JR, Heisterkamp N et al. (1984) Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93–99

    Article  PubMed  Google Scholar 

  • Gruber SB, Ellis NA, Scott KK et al. (2002) BLM heterozygosity and the risk of colorectal cancer. Science 297:2013

    Article  PubMed  Google Scholar 

  • Guo C, White PS, Weiss MJ et al. (1999) Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas. Oncogene 18:4948–4957

    PubMed  Google Scholar 

  • Guo C, White PS, Hogarty MD et al. (2000) Deletion of 11q23 is a frequent event in the evolution of MYCN single-copy high-risk neuroblastomas. Med Pediatr Oncol 35:544–546

    Article  PubMed  Google Scholar 

  • Hecht F, Hecht BK, Northrup JC et al. (1982) Genetics of familial neuroblastoma: long-range studies. Cancer Genet Cytogenet 7:227–230

    Article  PubMed  Google Scholar 

  • Heisterkamp N, Stephenson JR, Groffen J et al. (1983) Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 306:239–242

    Article  PubMed  Google Scholar 

  • Hiyama E, Hiyama K, Ohtsu K et al. (2001) Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1. Med Pediatr Oncol 36:67–74

    Article  PubMed  Google Scholar 

  • Hogarty MD, Liu X, Guo C et al. (2000) Identificaiton of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas. Med Pediatr Oncol 35:512–515

    Article  PubMed  Google Scholar 

  • Hoshi M, Otagiri N, Shiwaku HO et al. (2000) Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. Br J Cancer 82:1801–1807

    Article  PubMed  Google Scholar 

  • Ide F, Kitada M, Sakashita H et al. (2003) p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene. Am J Pathol 163:1729–1733

    PubMed  Google Scholar 

  • Inoue K, Zindy F, Randle DH et al. (2001) Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev 15:2934–2939

    Article  PubMed  Google Scholar 

  • Kallioniemi A, Kallioniemi OP, Sudar D et al. (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818–821

    PubMed  Google Scholar 

  • Kaneko Y, Knudson AG (2000) Mechanism and relevance of ploidy in neuroblastoma. Genes Chromosomes Cancer 29:89–95

    Article  PubMed  Google Scholar 

  • Khan J, Wei JS, Ringner M et al. (2001) Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 7:673–679

    Article  PubMed  Google Scholar 

  • Knudson AG Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820–823

    PubMed  Google Scholar 

  • Knudson AG Jr, Strong LC (1972) Mutation and cancer: neuroblastoma and pheochromocytoma. Am J Hum Genet 24:514–532

    PubMed  Google Scholar 

  • Koiffmann CP, Gonzalez CH, Vianna-Morgante AM et al. (1995) Neuroblastoma in a boy with MCA/MR syndrome, deletion 11q, and duplication 12q. Am J Med Genet 58:46–49

    Article  PubMed  Google Scholar 

  • Kucherlapati M, Yang K, Kuraguchi M et al. (2002) Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci USA 99:9924–9929

    Article  PubMed  Google Scholar 

  • Kushner BH, Gilbert F, Helson L (1986) Familial neuroblastoma. Case reports, literature review, and etiologic considerations. Cancer 57:1887–1893

    PubMed  Google Scholar 

  • Kwabi-Addo B, Giri D, Schmidt K et al. (2001) Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci USA 98:11563–11568

    Article  PubMed  Google Scholar 

  • Lastowska M, Cotterill S, Pearson AD et al. (1997a) Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients.U.K.Children's Cancer Study Group and the U.K. Cancer Cytogenetics Group. Eur J Cancer 33:1627–1633

    Article  PubMed  Google Scholar 

  • Lastowska M, Nacheva E, McGuckin A et al. (1997b) Comparative genomic hybridization study of primary neuroblastoma tumors. United Kingdom Children's Cancer Study Group. Genes Chromosomes Cancer 18:162–169

    Article  PubMed  Google Scholar 

  • Lastowska M, Roberts P, Pearson AD et al. (1997c) Promiscuous translocations of chromosome arm 17q in human neuroblastomas. Genes Chromosomes Cancer 19:143–149

    Article  PubMed  Google Scholar 

  • Lastowska M, Cotterill S, Bown N et al. (2002) Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors. Genes Chromosomes Cancer 34:428–436

    Article  PubMed  Google Scholar 

  • Laureys G, Speleman F, Opdenakker G et al. (1990) Constitutional translocation t(1;17)(p36;q12–21) in a patient with neuroblastoma. Genes Chromosomes Cancer 2:252–254

    PubMed  Google Scholar 

  • Lee WH, Bookstein R, Hong F et al. (1987) Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235:1394–1399

    PubMed  Google Scholar 

  • Maris JM, Kyemba SM, Rebbeck TR et al. (1996) Familial predisposition to neuroblastoma does not map to chromosome band 1p36. Cancer Res 56:3421–3425

    PubMed  Google Scholar 

  • Maris JM, Weiss MJ, Guo C et al. (2000) Loss of heterozygosity at 1p36 independently predicts for disease progression but not decreased overall survival probability in neuroblastoma patients: a Children's Cancer Group study. J Clin Oncol 18:1888–1899

    PubMed  Google Scholar 

  • Maris JM, Guo C, White PS et al. (2001a) Allelic deletion at chromosome bands 11q14–23 is common in neuroblastoma. Med Pediatr Oncol 36:24–27

    Article  PubMed  Google Scholar 

  • Maris JM, Guo C, Blake D et al. (2001b) Comprehensive analysis of chromosome 1p deletions in neuroblastoma. Med Pediatr Oncol 36:32–36

    Article  PubMed  Google Scholar 

  • Marshall B, Isidro G, Martins AG et al. (1997) Loss of heterozygosity at chromosome 9p21 in primary neuroblastomas: evidence for two deleted regions. Cancer Genet Cytogenet 96:134–139

    Article  PubMed  Google Scholar 

  • Martinsson T, Sjoberg RM, Hedborg F et al. (1995) Deletion of chromosome 1p loci and microsatellite instability in neuroblastomas analyzed with short-tandem repeat polymorphisms. Cancer Res 55:5681–5686

    PubMed  Google Scholar 

  • Martinsson T, Sjoberg RM, Hallstensson K et al. (1997) Delimitation of a critical tumour suppressor region at distal 1p in neuroblasoma tumours. Eur J Cancer 33:1997–2001

    Article  PubMed  Google Scholar 

  • Meddeb M, Danglot G, Chudoba I et al. (1996) Additional copies of a 25 Mb chromosomal region originating from 17q23.1–17qter are present in 90% of high-grade neuroblastomas. Genes Chromosomes Cancer 17:156–165

    Article  PubMed  Google Scholar 

  • Mertens F, Johansson B, Hoglund M et al. (1997) Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 57:2765–2780

    PubMed  Google Scholar 

  • Miller RW, Fraumeni JF Jr, Hill JA (1968) Neuroblastoma: epidemiologic approach to its origin. Am J Dis Child 115: 253–261

    PubMed  Google Scholar 

  • Miyoshi H, Nakau M, Ishikawa TO et al. (2002) Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 62:2261–2266

    PubMed  Google Scholar 

  • Mora J, Cheung NK, Kushner BH et al. (2000) Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p. J Mol Diagn 2:37–46

    PubMed  Google Scholar 

  • Mora J, Gerald WL, Cheung NK (2003) Evolving significance of prognostic markers associated with new treatment strategies in neuroblastoma. Cancer Lett 197:119–124

    Article  PubMed  Google Scholar 

  • Mosse Y, Greshock J, King A et al. (2003) Identification and high-resolution mapping of a constitutional 11q deletion in an infant with multifocal neuroblastoma. Lancet Oncol 4:769–771

    Article  PubMed  Google Scholar 

  • Neel BG, Jhanwar SC, Chaganti RS et al. (1982) Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci USA 79:7842–7846

    PubMed  Google Scholar 

  • Nowell PC, Hungerford DA (1960a) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85–109

    PubMed  Google Scholar 

  • Nowell PC, Hungerford DA (1960b) A minute chromosome in human granulocytic leukemia. Science 132:1497–1499

    Google Scholar 

  • Ohira M, Kageyama H, Mihara M et al. (2000) Identification and characterization of a 500-kb homozygously deleted region at 1p36.2–p36.3 in a neuroblastoma cell line. Oncogene 19:4302–4307

    Article  PubMed  Google Scholar 

  • Parada LF, Tabin CJ, Shih C et al. (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297:474–478

    Article  PubMed  Google Scholar 

  • Perri P, Longo L, Cusano R et al. (2002) Weak linkage at 4p16 to predisposition for human neuroblastoma. Oncogene 21:8356–8360

    Article  PubMed  Google Scholar 

  • Plantaz D, Mohapatra G, Matthay KK et al. (1997) Gain of chromosome 17 is the most frequent abnormality detected in neuroblastoma by comparative genomic hybridization. Am J Pathol 150:81–89

    PubMed  Google Scholar 

  • Plantaz D, Vandesompele J, van Roy N et al. (2001) Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11q deletion in tumors lacking MYCN amplification. Int J Cancer 91:680–686

    Article  PubMed  Google Scholar 

  • Sandberg AA, Sakurai M, Holdsworth RN (1972) Chromosomes and causation of human cancer and leukemia. 8. DMS chromosomes in a neuroblastoma. Cancer 29:1671–1679

    PubMed  Google Scholar 

  • Santos E, Tronick SR, Aaronson SA et al. (1982) T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB-and Harvey-MSV transforming genes. Nature 298:343–347

    Article  PubMed  Google Scholar 

  • Satge D, Moore SW, Stiller CA et al. (2003) Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature. Cancer Genet Cytogenet 147:89–98

    Article  PubMed  Google Scholar 

  • Savelyeva L, Claas A, Matzner I et al. (2001) Constitutional genomic instability with inversions, duplications, and amplifications in 9p23–24 in BRCA2 mutation carriers. Cancer Res 61:5179–5185

    PubMed  Google Scholar 

  • Savelyeva L, Corvi R, Schwab M (1994) Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells. Am J Hum Genet 55:334–340

    PubMed  Google Scholar 

  • Schleiermacher G, Peter M, Michon J et al. (1994) Two distinct deleted regions on the short arm of chromosome 1 in neuroblastoma. Genes Chromosomes Cancer 10:275–281

    PubMed  Google Scholar 

  • Schleiermacher G, Delattre O, Peter M et al. (1996) Clinical relevance of loss heterozygosity of the short arm of chromosome 1 in neuroblastoma: a single-institution study. Int J Cancer 69:73–78

    Article  PubMed  Google Scholar 

  • Schleiermacher G, Janoueix-Lerosey I, Combaret V et al. (2003) Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma. Cancer Genet Cytogenet 141:32–42

    Article  PubMed  Google Scholar 

  • Schleiermacher G, Raynal V, Janoueix-Lerosey I et al. (2004) Variety and complexity of chromosome 17 translocations in neuroblastoma. Genes Chromosomes Cancer 39:143–150

    Article  PubMed  Google Scholar 

  • Schwab M (1998) Amplification of oncogenes in human cancer cells. Bioessays 20:473–479

    Article  PubMed  Google Scholar 

  • Schwab M, Alitalo K, Klempnauer KH et al. (1983a) Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 305:245–248

    Article  PubMed  Google Scholar 

  • Schwab M, Alitalo K, Varmus HE et al. (1983b) A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature 303:497–501

    Article  PubMed  Google Scholar 

  • Schwab M, Varmus HE, Bishop JM et al. (1984) Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature 308:288–291

    Article  PubMed  Google Scholar 

  • Schwab M, Varmus HE, Bishop JM (1985) Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature 316:160–162

    Article  PubMed  Google Scholar 

  • Schwab M, Praml C, Amler LC et al. (1996) Genomic instability in 1p and human malignancies. Genes Chromosomes Cancer 16:211–229

    Article  PubMed  Google Scholar 

  • Schwab M, Westermann F, Hero B et al. (2003) Neuroblastoma: biology and molecular and chromosomal pathology. Lancet Oncol 4:472–480

    Article  PubMed  Google Scholar 

  • Shaffer LG, Heilstedt HA (2001) Terminal deletion of 1p36. Lancet 358(Suppl):S9

    Article  PubMed  Google Scholar 

  • Shapira SK, McCaskill C, Northrup H et al. (1997) Chromosome 1p36 deletions: the clinical phenotype and molecular characterization of a common newly delineated syndrome. Am J Hum Genet 61:642–650

    PubMed  Google Scholar 

  • Smits R, Ruiz P, Diaz-Cano S et al. (2000) E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology 119: 1045–1053

    Article  PubMed  Google Scholar 

  • Song WJ, Sullivan MG, Legare RD et al. (1999) Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 23:166–175

    Article  PubMed  Google Scholar 

  • Sotiriou C, Khanna C, Jazaeri AA et al. (2002) Core biopsies can be used to distinguish differences in expression profiling by cDNA microarrays. J Mol Diagn 4:30–36

    PubMed  Google Scholar 

  • Sparkes RS, Sparkes MC, Wilson MG et al. (1980) Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14. Science 208:1042–1044

    PubMed  Google Scholar 

  • Sparkes RS, Murphree AL, Lingua RW et al. (1983) Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science 219:971–973

    PubMed  Google Scholar 

  • Spieker N, Beitsma M, van Sluis P et al. (2001) Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1. Genes Chromosomes Cancer 31:172–181

    Article  PubMed  Google Scholar 

  • Spitz R, Hero B, Westermann F et al. (2002) Fluorescence in situ hybridization analyses of chromosome band 1p36 in neuroblastoma detect two classes of alterations. Genes Chromosomes Cancer 34:299–305

    Article  PubMed  Google Scholar 

  • Spitz R, Hero B, Ernestus K et al. (2003) Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma. Clin Cancer Res 9:4835–4840

    PubMed  Google Scholar 

  • Spring K, Ahangari F, Scott SP et al. (2002) Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet 32:185–190

    Article  PubMed  Google Scholar 

  • Squire J, Gallie BL, Phillips RA (1985) A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma. Hum Genet 70:291–301

    Article  PubMed  Google Scholar 

  • Srivastava M, Montagna C, Leighton X et al. (2003) Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Proc Natl Acad Sci USA 100:14287–14292

    Article  PubMed  Google Scholar 

  • Stallings RL, Howard J, Dunlop A et al. (2003) Are gains of chromosomal regions 7q and 11p important abnormalities in neuroblastoma? Cancer Genet Cytogenet 140:133–137

    Article  PubMed  Google Scholar 

  • Swanstrom R, Parker RC, Varmus HE et al. (1983) Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proc Natl Acad Sci USA 80:2519–2523

    PubMed  Google Scholar 

  • Takayama H, Suzuki T, Mugishima et al. (1992) Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene 7:1185–1189

    PubMed  Google Scholar 

  • Takeda O, Homma C, Maseki N et al. (1994) There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma. Genes Chromosomes Cancer 10:30–39

    PubMed  Google Scholar 

  • Takeda O, Handa M, Uehara T et al. (1996) An increased NM23H1 copy number may be a poor prognostic factor independent of LOH on 1p in neuroblastomas. Br J Cancer 74:1620–1626

    PubMed  Google Scholar 

  • Takita J, Hayashi Y, Kohno T et al. (1995) Allelotype of neuroblastoma. Oncogene 11:1829–1834

    PubMed  Google Scholar 

  • Thompson PM, Seifried BA, Kyemba SK et al. (2001) Loss of heterozygosity for chromosome 14q in neuroblastoma. Med Pediatr Oncol 36:28–31

    Article  PubMed  Google Scholar 

  • Tonini GP, Longo L, Coco S et al. (2003) Familial neuroblastoma: a complex heritable disease. Cancer Lett 197:41–45

    Article  PubMed  Google Scholar 

  • Turleau C, de Grouchy J, Chavin-Colin F et al. (1985) Cytogenetic forms of retinoblastoma: their incidence in a survey of 66 patients. Cancer Genet Cytogenet 16:321–334

    Article  PubMed  Google Scholar 

  • Van Roy N, Laureys G, Cheng NC et al. (1994) 1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines. Genes Chromosomes Cancer 10:103–114

    PubMed  Google Scholar 

  • Van Roy N, Cheng NC, Laureys G et al. (1995) Molecular cytogenetic analysis of 1;17 translocations in neuroblastoma. Eur J Cancer 31A:530–535

    PubMed  Google Scholar 

  • Vandesompele J, van Roy N, van Gele M et al. (1998) Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization. Genes Chromosomes Cancer 23: 141–152

    Article  PubMed  Google Scholar 

  • Vandesompele J, Speleman F, van Roy N et al. (2001) Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: how many genetic subgroups are there? Med Pediatr Oncol 36:5–10

    Article  PubMed  Google Scholar 

  • Varmus HE (1982) Form and function of retroviral proviruses. Science 216:812–820

    PubMed  Google Scholar 

  • Venkatachalam S, Shi YP, Jones SN et al. (1998) Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J 17:4657–4667

    Article  PubMed  Google Scholar 

  • Vettenranta K, Aalto Y, Wikstrom S et al. (2001) Comparative genomic hybridization reveals changes in DNA-copy number in poor-risk neuroblastoma. Cancer Genet Cytogenet 125:125–130

    Article  PubMed  Google Scholar 

  • Weith A, Martinsson T, Cziepluch C et al. (1989) Neuroblastoma consensus deletion maps to 1p36.1–2. Genes Chromosomes Cancer 1:159–166

    PubMed  Google Scholar 

  • Westermann F, Schwab M (2002) Genetic parameters of neuroblastomas. Cancer Lett 184:127–147

    Article  PubMed  Google Scholar 

  • Wetmore C, Eberhart DE, Curran T (2000) The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res 60:2239–2246

    PubMed  Google Scholar 

  • White PS, Maris JM, Beltinger C et al. (1995) A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2–36.3. Proc Natl Acad Sci USA 92: 5520–5524

    PubMed  Google Scholar 

  • White PS, Thompson PM, Seifried BA et al. (2001) Detailed molecular analysis of 1p36 in neuroblastoma. Med Pediatr Oncol 36:37–41

    Article  PubMed  Google Scholar 

  • Wu YQ, Heilstedt HA, Bedell JA et al. (1999) Molecular refinement of the 1p36 deletion syndrome reveals size diversity and a preponderance of maternally derived deletions. Hum Mol Genet 8:313–321

    Article  PubMed  Google Scholar 

  • Yunis JJ (1983) The chromosomal basis of human neoplasia. Science 221:227–236

    PubMed  Google Scholar 

  • Zhu Y, Ghosh P, Charnay P et al. (2002) Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296:920–922

    Article  PubMed  Google Scholar 

Download references

Authors
  1. Manfred Schwab
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Nai-Kong V. Cheung MD, PhD

  2. Department of Pediatrics and the Comprehensive Robert H. Lurie Cancer Center, Northwestern University, 2300 Children's Plaza, Chicago, IL, 60614, USA

    Susan L. Cohn MD

  3. Feinberg School of Medicine, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL, 60614, USA

    Susan L. Cohn MD

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schwab, M. (2005). Molecular Cytogenetics. In: Cheung, NK.V., Cohn, S.L. (eds) Neuroblastoma. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26616-X_4

Download citation

  • DOI: https://doi.org/10.1007/3-540-26616-X_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40841-3

  • Online ISBN: 978-3-540-26616-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation