Neuroblastoma pp 213-222 | Cite as

Management of Neurologic Complications

  • Kim Kramer
  • Michael R. Pranzatelli
Part of the Pediatric Oncology book series (PEDIATRICO)


Brain Metastasis Spinal Cord Compression Central Nervous System Metastasis Central Nervous System Relapse Pediatric Oncology Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Antunes NL (2000) Acute neurologic complications in children with systemic cancer. J Child Neurol 15:705–716PubMedGoogle Scholar
  2. Antunes NL, Khakoo Y, Matthay KK et al. (2000) Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus. J Pediatr Hematol Oncol 22:315–320CrossRefPubMedGoogle Scholar
  3. Banerjee S, Marwaha RK, Bajwa RPS (1995) Primary pelvic neuroblastoma with central nervous system metastases. Pediatr Hematol Oncol 12:309–312PubMedGoogle Scholar
  4. Bataller L, Rosenfeld MR, Graus F et al. (2003) Autoantigen diversity in the opsoclonus-myoclonus syndrome. Ann Neurol 53:347–353CrossRefPubMedGoogle Scholar
  5. Bergman I, Barmada MA, Heller G, Griffin JA, Cheung NKV (1999) Treatment of neoplastic meningeal xenografts by intraventricular administration of an anti-ganglioside monoclonal antibody 3F8. Int J Cancer 82:538–548CrossRefPubMedGoogle Scholar
  6. Bigner DD, Brown MT, Friedman AH (1998) Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas:phase I trial results. J Clin Oncol 16:2202–2212PubMedGoogle Scholar
  7. Blaes F (2002) Immunotherapeutic approaches to paraneoplastic neurological disorders. Exp Opin Biol Ther 2:419–430CrossRefGoogle Scholar
  8. Blatt J, Fitz C, Mirro J (1997) Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma. Pediatr Hematol Oncol 14:233–241PubMedGoogle Scholar
  9. Cheung IY, Cheung NKV (2001) Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR. Clin Can Res 7:1698–1705Google Scholar
  10. Cheung NK, Kushner BH, Kramer K (2001) Monoclonal antibody-based therapy of neuroblastoma. Hematol Oncol Clin North Am 15:853–866CrossRefPubMedGoogle Scholar
  11. Clerico A, Tenore A, Bartolozzi S et al. (1993) Adrenocorticotropic hormone-secreting ganglioneuroblastoma associated with opsomyoclonic encephalopathy: a case report with immunohistochemical study. Med Pediatr Oncol 21:690–694PubMedGoogle Scholar
  12. Connolly AM, Pestronk A, Shobhna M et al. (1997) Serum autoantibodies in childhood opsoclonus-myoclonus syndrome: an analysis of antigenic targets in neural tissues. J Pediatr 130:878–884PubMedGoogle Scholar
  13. Conrad E, Olsewski AD, Berger M et al. (1992) Pediatric spine tumors with spinal cord compression. J Pediatr Orthop 12:454–460PubMedGoogle Scholar
  14. Cooper R, Khakoo Y, Matthay KK et al. (2001) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features — a report from the children's cancer group. Med Pediatr Oncol 36:623–629CrossRefPubMedGoogle Scholar
  15. De Bernardi B, Pianca C, Pistamiglio P et al. (2001) Neuroblastoma with symptomatic spinal cord compression at diagnosis: treatment and results with 76 cases. J Clin Oncol 19:183–190PubMedGoogle Scholar
  16. DuBois SG, Kalika Y, Lukens JN et al. (1999) Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol Oncol 21:181–189Google Scholar
  17. Everson TC, Cole WH (1956) Spontaneous regression of neuroblastoma. In: Everson TC, Cole WH (eds) Spontaneous regression of cancer. Saunders, PhiladephiaGoogle Scholar
  18. Fisher PG, Wechsler DS, Singer HS (1994) Anti-Hu antibody in a neuroblastoma-associated paraneoplastic syndrome. Pediatr Neurol 10:309–312CrossRefPubMedGoogle Scholar
  19. Flickinger JC (2001) Radiotherapy and radiosurgical management of brain metastases. Curr Oncol Rep 3:484–489PubMedGoogle Scholar
  20. Fuchs AF, Kaneko CRS, Seudder CA (1985) Brainstem control of saccadic eye movements. Annu Rev Neurosci 8:307–337PubMedGoogle Scholar
  21. Gambini C, Conte M, Bernini G et al. (2003) Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases. Virchows Arch 442:555–562PubMedGoogle Scholar
  22. Gutierrez FA, Oi S, McLone DG (1983) Intraspinal tumors in children: clinical review, surgical results and follow-up in 51 cases. Concepts Pediatr Neurosurg 4:291–405Google Scholar
  23. Hayes FA, Green AA, O'Connor DM (1989) Chemotherapeutic management of epidural neuroblastoma. Med Pediatr Oncol 17:6–8PubMedGoogle Scholar
  24. Hayward K, Jeremy RJ, Jenkins S et al. (2001) Long-term neurobehavioral outcomes in children with neuroblastoma and opsoclonus-myoclonus-ataxia syndrome: relationship to MRI findings and anti-neuronal antibodies. J Pediatr 139:552–559CrossRefPubMedGoogle Scholar
  25. Hoover M, Bowman LC, Crawford SE et al. (1999) Long-term outcome of patients with intraspinal neuroblastoma. Med Pediatr Oncol 32:353–359CrossRefPubMedGoogle Scholar
  26. Yu AL, Uttenreuther-Fischer M, Huang C-S et al. (1998) Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch 14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol 16:2169–2180PubMedGoogle Scholar
  27. Katzenstein HM, Kent PM, London WB, Cohn SL (2001) Treatment and outcome of 83 children with intraspinal neuroblastoma: the Pediatric Oncology Group experience. J Clin Oncol 19:1047–1055PubMedGoogle Scholar
  28. Kellie JJ, Hayes A, Bowman L et al. (1991) Primary extracranial neuroblastoma with central nervous system metastases: characterization by clinicopathologic findings and neuroimaging. Cancer 68:1999–2006PubMedGoogle Scholar
  29. Koh PS, Raffensperger JG, Berry S et al. (1994) Long-term outcome in children with opsoclonus-myoclonus and ataxia and coincident neuroblastoma. J Pediatr 125:712–716PubMedGoogle Scholar
  30. Kramer K, Cheung NKV, Humm JL et al. (2000) Targeted radioimmunotherapy for leptomeningeal cancer using 131-I-3F8: patient imaging and dosimetry. Med Ped Oncol 35:716–718CrossRefGoogle Scholar
  31. Kramer K, Kushner BH, Cheung NKV (2001) Neuroblastoma metastatic to the central nervous system: the Memorial Sloan-Kettering Cancer Center experience and a literature review. Cancer 91:1510–1519CrossRefPubMedGoogle Scholar
  32. Lassman AB, DeAngelis LM (2003) Brain metastases. Neurol Clin 21:1–15CrossRefPubMedGoogle Scholar
  33. Lieberman P (2002) On the nature and evolution of the neural bases of human language. Am J Phys Anthropol 35(Suppl):36–62CrossRefPubMedGoogle Scholar
  34. LoPiccolo MS, Cheung NK, Cheung IY (2001) GD2 synthase: a new molecular marker for detecting neuroblastoma. Cancer 92:924–931CrossRefPubMedGoogle Scholar
  35. Martin EF, Beckwith JB (1968) Lymphoid infiltrates in neuroblastoma: their occurrence and prognostic significance. J Pediatr Surg 3:161–164CrossRefPubMedGoogle Scholar
  36. Massad M, Haddad F, Slim M et al. (1985) Spinal cord compression in neuroblastoma. Surg Neurol 23:567–572CrossRefPubMedGoogle Scholar
  37. Matthay KK, Brisse H, Couanet D et al. (2003) Central nervous system metastases in neuroblastoma: radiologic, clinical, and biologic features in 23 patients. Cancer 98:155–165CrossRefPubMedGoogle Scholar
  38. Mitchell WG, Davalos-Gonzalez Y, Brumm VL et al. (2002) Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics 109:86–98CrossRefPubMedGoogle Scholar
  39. Papero PH, Pranzatelli MR, Margolis CJ et al. (1995) Neurobehavioral and psychosocial functioning of children with opsoclonus-myoclonus syndrome. Dev Med Child Neurol 37:915–932PubMedGoogle Scholar
  40. Plantaz D, Hartmann O, Kalifa C, Sainte-Rose C, Lemoine G, Lemerle J (1993) Localized dumbbell neuroblastoma: a study of 25 cases treated between 1982 and 1987 using the same protocol. Med Pediatr Oncol 21:249–253PubMedGoogle Scholar
  41. Plantaz D, Rubie H, Michon J et al. (1996) The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease. Cancer 78:311–319CrossRefPubMedGoogle Scholar
  42. Posner JB (1995) Neurologic complications of cancer. Davis, PhiladelphiaGoogle Scholar
  43. Pranzatelli MR (1992) The neurobiology of opsoclonus-myoclonus. Clin Neuropharmacol 15:186–228PubMedGoogle Scholar
  44. Pranzatelli MR (1994) On the molecular mechanism of adrenocorticotrophic hormone: neurotransmitters and receptors. Exp Neurol 125:142–161CrossRefPubMedGoogle Scholar
  45. Pranzatelli MR (1996) The immunopharmacology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 19:1–47PubMedGoogle Scholar
  46. Pranzatelli MR (2000) Friendly fire. Discover April:35–36Google Scholar
  47. Pranzatelli MR, Huang Y, Tate E et al. (1998a) Effect of high dose corticotropin on cerebrospinal fluid monoaminergic neurotransmitters or metabolites in corticotropin-responsive pediatric opsoclonus-myoclonus. Mov Disord 13:522–528CrossRefPubMedGoogle Scholar
  48. Pranzatelli MR, Hanin I, Tate E et al. (1998b) Cerebrospinal fluid free choline in movement disorders of pediatric onset. Eur J Pediatr Neurol 1:33–39CrossRefGoogle Scholar
  49. Pranzatelli MR, Tate ED, Kinsbourne M et al. (2002a) Forty-one year follow-up of childhood-onset opsoclonus-myoclonus: cerebellar atrophy, multiphasic relapses, response to IVIG. Mov Disord 17:1387–1390PubMedGoogle Scholar
  50. Pranzatelli MR, Tate ED, Wheeler A et al. (2002b) Screening for autoantibodies in children with opsoclonus-myoclonus-ataxia. Pediatr Neurol 27:384–387CrossRefPubMedGoogle Scholar
  51. Punt J, Pritchard J, Pincott JR et al. (1980) Neuroblastoma: a review of 21 cases presenting with intra-spinal extension. Cancer 45:3095–3101PubMedGoogle Scholar
  52. Reddy AT, Witek K (2003) Neurologic complications of chemotherapy for children with cancer. Curr Neurol Neurosci Rep 3:137–142PubMedGoogle Scholar
  53. Rohrlich P, Hartmann O, Couanet D et al. (1989) Localisations neuro-meninges metastaques secondaires dans les neuroblastomes de l'enfant. Arch Fr Pediatric 46:5–10Google Scholar
  54. Rudnick E, Khakoo Y, Antunes N, Seeger RC, Brodeur GM, Shimada H, Gerbing RB, Stram DO, Matthay KK (2001a) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and anti-neuronal antibodies: a Children's Cancer Group study. Med Pediatr Oncol 36:612–622CrossRefPubMedGoogle Scholar
  55. Rudnick E, Khakoo Y, Antunes NL et al. (2001b) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies — a report from the Children's Cancer Group Study. Med Pediatr Oncol 36:612–622CrossRefPubMedGoogle Scholar
  56. Russo C, Cohn SL, Petruzzi MJ, de Alarcon PA (1997) Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: a report from the Pediatric Oncology Group. Med Pediatr Oncol 28:284–288CrossRefPubMedGoogle Scholar
  57. Sandberg DI, Bilsky M, Kushner BH et al. (2003) Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg 39:291–298CrossRefPubMedGoogle Scholar
  58. Shaw PJ (1992) Neuroblastoma with intracranial involvement: an ENSG Study. Med Pediatr Oncol 20:149–155PubMedGoogle Scholar
  59. Stubbs EB Jr, Lawlor MW, Richards MP et al. (2003) Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. Acta Neuropathol (Berl) 105:109–116PubMedGoogle Scholar
  60. Tasdemiroglu E, Patchell RA (1997) Neurologic examinations of the primary pediatric extracranial neuroblastomas. Neurol Res 19:45–50PubMedGoogle Scholar
  61. Tasdemiroglu E, Ayan I, Kebudi R (1998) Extracranial neuroblastomas and neurologic complications. Child Nerv Syst 14:713–718CrossRefGoogle Scholar
  62. Tate ED, Pranzatelli MR, Huang Y et al. (1994) An innovative approach to the problem of sedating children with opsoclonus-myoclonus syndrome: effects of myoclonus and CSF monoamine metabolites. Ann Neurol 36:543–544Google Scholar
  63. Vines EF, Le Pechoux C, Arriagada R (2003) Prophylactic cranial irradiation in small cell lung cancer. Semin Oncol 30:38–46CrossRefGoogle Scholar
  64. Weinberg JS, Lang FF, Sawaya R (2001) Surgical management of brain metastases. Curr Oncol Rep 3:476–483PubMedGoogle Scholar
  65. Wilberg JE, Muceniece R, Mandrika I et al. (2000) New aspects on the melanocortins and their receptors. Pharmacol Res 42:393–420CrossRefPubMedGoogle Scholar
  66. Yu AL, Uttenreuther-Fischer M, Huang C-S et al. (1998) Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch 14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol 16:2169–2180PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Kim Kramer
  • Michael R. Pranzatelli

There are no affiliations available

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