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Apoptosis in Lupus Erythematosus

  • Felipe Andrade
  • Antony Rosen
  • Livia Casciola-Rosen

Keywords

Systemic Lupus Erythematosus Cutaneous Lupus Erythematosus Congenital Heart Block Systemic Lupus Erythe Neonatal Lupus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L (1998) Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis. Immunity 8:451–460CrossRefPubMedGoogle Scholar
  2. Andrade F, Casciola-Rosen L, Rosen A (2001) Novel covalent U1RNA-protein complexes are generated in cells by ultraviolet B (UVB) irradiation: implications for autoimmunity. Arthritis Rheum 44:S304Google Scholar
  3. Bach JF, Koutouzov S (1997) Immunology. New clues to systemic lupus. Lancet 350(Suppl 3):11CrossRefGoogle Scholar
  4. Berthou C, Michel L, Soulié A, Jean-Louis F, Flageul B, Dubertret L, Sigaux F, Zhang Y, Sasportes M (1997) Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense. J Immunol 159:5293–5300PubMedGoogle Scholar
  5. Botto M, Del l’Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, Walport MJ (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19:56–59PubMedGoogle Scholar
  6. Buyon JP (1996) Neonatal lupus: bedside to bench and back. Scand J Rheumatol 25:271–276PubMedGoogle Scholar
  7. Carroll MC (1998) The lupus paradox. Nat Genet 19:3–4PubMedGoogle Scholar
  8. Casciola-Rosen LA, Rosen A (1997) Ultraviolet light-induced keratinocyte apoptosis: apotential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 6:175–180PubMedGoogle Scholar
  9. Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317–1330CrossRefPubMedGoogle Scholar
  10. Casciola-Rosen LA, Anhalt GJ, Rosen A (1995) DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 182:1625–1634CrossRefPubMedGoogle Scholar
  11. Casciola-Rosen LA, Rosen A, Petri M, Schlissel M (1996) Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci USA 93:1624–1629CrossRefPubMedGoogle Scholar
  12. Casciola-Rosen LA, Andrade F, Ulanet D, Wong WB, Rosen A (1999) Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med 190:815–825CrossRefPubMedGoogle Scholar
  13. Chung JH, Kwon OS, Eun HC, Youn JI, Song YW, Kim JG, Cho KH (1998) Apoptosis in the pathogenesis of cutaneous lupus erythematosus. Am J Dermatopathol 20:233–241CrossRefPubMedGoogle Scholar
  14. Cocca BA, Seal SN, D’Agnillo P, Mueller YM, Katsikis PD, Rauch J, Weigert M, Radic MZ (2001) Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci U S A 98:13826–13831CrossRefPubMedGoogle Scholar
  15. Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD (1992) The role of somatic mutation in the pathogenic anti-DNA response. Ann Rev Immunol 10:731–757CrossRefGoogle Scholar
  16. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148:2207–2216PubMedGoogle Scholar
  17. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J Clin Invest 101:890–898PubMedGoogle Scholar
  18. Fadok VA, Bratton DL, Henson PM (2001) Phagocyte receptors for apoptotic cells: recognition, uptake,and consequences. J Clin Invest 108:957–962CrossRefPubMedGoogle Scholar
  19. Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA (1990) Binding of antibodies to the extractable nuclear antigens of SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 94:77–85CrossRefPubMedGoogle Scholar
  20. Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5:1249–1255CrossRefPubMedGoogle Scholar
  21. Gershov D, Kim S, Brot N, Elkon KB (2000) C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med 192:1353–1364CrossRefPubMedGoogle Scholar
  22. Golan TD, Elkon KB, Gharavi AE, Krueger JG (1992) Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation. J Clin Invest 90:1067–1076Google Scholar
  23. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776PubMedGoogle Scholar
  24. Henson PM, Bratton DL, Fadok VA (2001) Apoptotic cell removal. Curr Biol 11:R795–805CrossRefPubMedGoogle Scholar
  25. Hoffmann PR, deCathelineau AM, Ogden CA, Leverrier Y, Bratton DL, Daleke DL, Ridley AJ, Fadok VA, Henson PM (2001) Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 155:649–659CrossRefPubMedGoogle Scholar
  26. Huynh ML, Fadok VA, Henson PM (2002) Phosphatidylserine-dependent ingest ion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41–50CrossRefPubMedGoogle Scholar
  27. Lee LA, Frank MB, McCubbin VR, Reichlin M (1994a) Autoantibodies of neonatal lupus erythematosus. J Invest Dermatol 102:963–966CrossRefPubMedGoogle Scholar
  28. Lee LA, Roberts CM, Frank MB, McCubbin VR, Reichlin M (1994b) The autoantibody response to Ro/SSA in cutaneous lupus erythematosus. Arch Dermatol 130:1262–1268CrossRefPubMedGoogle Scholar
  29. LeFeber WP, Norris DA, Ryan SR, Huff JC, Lee LA, Kubo M, Boyce ST, Kotzin BL, Weston WL (1984) Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 74:1545–1551PubMedGoogle Scholar
  30. Lu Q, Lemke G (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293:306–311CrossRefPubMedGoogle Scholar
  31. Manfredi AA, Rovere P, Galati G, Heltai S, Bozzolo E, Soldini L, Davoust J, Balestrieri G, Tincani A, Sabbadini MG (1998) Apoptotic cell clearance in systemic lupus erythematosus. 1. Opsonization by antiphospholipid antibodies. Arthritis Rheum 41:205–214CrossRefPubMedGoogle Scholar
  32. Miranda ME, Tseng CE, Rashbaum W, Ochs RL, Casiano CA, Di Donato F, Chan EK, Buyon JP (1998) Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes. J Immunol 161:5061–5069PubMedGoogle Scholar
  33. Miranda-Carus ME, Askanase AD, Clancy RM, DiDonato F, Chou TM, Libera MR, Chan EK, Buyon JP (2000) Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. J Immunol 165: 5345–5351PubMedGoogle Scholar
  34. Natali PG, Tan EM (1973) Experimental skin lesions in mice resembling systemic lupus erythematosus. Arthritis Rheum 16:579–589PubMedGoogle Scholar
  35. Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A (2001) Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest 108:223–232CrossRefPubMedGoogle Scholar
  36. Orteu CH, Sontheimer RD, Dutz JP (2001) The pathophysiology of photosensitivity in lupus erythematosus. Photodermatol Photoimmunol Photomed 17:95–113CrossRefPubMedGoogle Scholar
  37. Pablos JL, Santiago B, Galindo M, Carreira PE, Ballestin C, Gomez-Reino JJ (1999) Keratinocyte apoptosis and p53 expression in cutaneous lupus and dermatomyositis. J Pathol 188:63–68CrossRefPubMedGoogle Scholar
  38. Price BE, Rauch J, Shia MA, Walsh MT, Lieberthal W, Gilligan HM, O’Laughlin T, Koh JS, Levine JS (1996) Anti-phospholipid autoantibodies bind to apoptotic, but not viable, thymocytes in a β2-glycoprotein I-dependent manner. J Immunol 157:2201–2208PubMedGoogle Scholar
  39. Provost TT, Reichlin M(1988) Immunopathologic studies of cutaneous lupus erythematosus. J Clin Invest 8:223–232Google Scholar
  40. Radic MZ, Weigert M (1994) Genetic and structural evidence for antigen selection of anti-DNA antibodies. Ann Rev Immunol 12:487–520CrossRefGoogle Scholar
  41. Rosen A, Casciola-Rosen L (1999) Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 6:6–12CrossRefPubMedGoogle Scholar
  42. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423–434CrossRefPubMedGoogle Scholar
  43. Savill J, Fadok V(2000) Corpse clearance defines the meaning of cell death. Nature 407:784–788CrossRefPubMedGoogle Scholar
  44. Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK (2001) Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411:207–211CrossRefPubMedGoogle Scholar
  45. Seery JP, Carroll JM, Cattell V, Watt FM (1997) Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. J Exp Med 186:1451–1459CrossRefPubMedGoogle Scholar
  46. Simmons-O’Brien E, Chen S, Watson R, Antoni C, Petri M, Hochberg M, Stevens MB, Provost TT (1995) One hundred anti-Ro (SS-A) antibody positive patients: a 10-year follow-up. Medicine (Baltimore) 74:109–130CrossRefPubMedGoogle Scholar
  47. Somersan S, Bhardwaj N (2001) Tethering and tickling: anew role for the phosphatidylserine receptor. J Cell Biol 155:501–504CrossRefPubMedGoogle Scholar
  48. Sontheimer RD (1989) Subacute cutaneous lupus erythematosus: a decade’s perspective. Med Clin North Am 73:1073–1090PubMedGoogle Scholar
  49. Taylor PR, Carugati A, Fadok VA, Cook HT, Andrews M, Carroll MC, Savill JS, Henson PM, Botto M, Walport MJ (2000) A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 192:359–366CrossRefPubMedGoogle Scholar
  50. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312–1316PubMedGoogle Scholar
  51. Tran HB, Ohlsson M, Beroukas D, Hiscock J, Bradley J, Buyon JP, Gordon TP (2002) Subcellular redistribution of la/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: a clue to the pathogenesis of congenital heart block. Arthritis Rheum 46:202–208CrossRefPubMedGoogle Scholar
  52. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I (1997) Immunosuppressive effects of apoptotic cells. Nature 390:350–351CrossRefPubMedGoogle Scholar
  53. Young AR (1987) The sunburn cell. Photoderm 4:127–134Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 2005

Authors and Affiliations

  • Felipe Andrade
  • Antony Rosen
  • Livia Casciola-Rosen

There are no affiliations available

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