• Dan V. Nicolau
  • Linnette Demers
  • David S. Ginger
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


Atomic Force Microscope Molecular Motor Linear Motor Motility Assay Rotary Motor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dammel, R. Diazonaphthoquinone-based Resists; SPIE Tutorial Texts; SPIE: Bellingham, WA, 1993; Vol. 11, Chapter 1Google Scholar
  2. 2.
    Pirrung, M. C. Angew. Chem. Int. Ed. 2002, 41, 1276–1289CrossRefGoogle Scholar
  3. 3.
    Lander, E. S. Nature Genet. 1999, 21, 3–4PubMedCrossRefGoogle Scholar
  4. 4.
    Xia, Y.; Rogers, J. A.; Paul, K. E.; Whitesides, G. M. Chem. Rev. 1999, 99, 1823–1848PubMedCrossRefGoogle Scholar
  5. 5.
    Geppert, L. IEEE Spectrum 1996, 33–38Google Scholar
  6. 6.
    Ivanova, E., Wright, J.P., Pham, D.K., Filipponi, L., Viezolli, A., Nicolau, D.V. Langmuir, 18, 9539–9546, 2002CrossRefGoogle Scholar
  7. 7.
    Liu, G.-Y.; Xu, S.; Qian, Y. Acc. Chem. Res. 2000, 33, 457–466PubMedCrossRefGoogle Scholar
  8. 8.
    Xu, S.; Liu, G. Langmuir 1997, 13, 127–129CrossRefGoogle Scholar
  9. 9.
    Shoer, J. K.; Crooks, R. M. Langmuir 1997, 13Google Scholar
  10. 10.
    Bruckbauer, A.; Ying, L.; Rothery, A. M.; Zhou, D.; Shevchuk, A. I.; Abell, C.; Korchev, Y. E.; Klenerman, D. J. Am. Chem. Soc. 2002, 124, 8810–8811CrossRefGoogle Scholar
  11. 11.
    Piner, R. D.; Zhu, J.; Xu, F.; Hong, S.; Mirkin, C. A. Science 1999, 283, 661–663PubMedCrossRefGoogle Scholar
  12. 12.
    Hong, S. H.; Mirkin, C. A. Science 2000, 288, 1808–1811PubMedCrossRefGoogle Scholar
  13. 13.
    Hong, S. H.; Zhu, J.; Mirkin, C. A. Langmuir 1999, 15, 7897–7900CrossRefGoogle Scholar
  14. 14.
    Hong, S. H.; Zhu, J.; Mirkin, C. A. Science 1999, 286, 523–525PubMedCrossRefGoogle Scholar
  15. 15.
    Piner, R. P.; Hong, S.; Mirkin, C. A. Langmuir 1999, 15, 5457–5460CrossRefGoogle Scholar
  16. 16.
    Ivanisevic, A.; Mirkin, C. A. J. Am. Chem. Soc. 2001, 123, 7887–7889PubMedCrossRefGoogle Scholar
  17. 17.
    Wilson, D. L.; Martin, R.; Hong, S.; Cronin-Golomb, M.; Mirkin, C. A.; Kaplan, D. L. Proc. Natl. Acad. Sci. USA 2002, 98, 13660–13664CrossRefGoogle Scholar
  18. 18.
    Demers, L. M.; Ginger, D. S.; Park, S.-J.; Li, Z.; Chung, S.-W.; Mirkin, C. A. Science 2002, 298, 1836–1838CrossRefGoogle Scholar
  19. 19.
    Su, M.; Liu, X.; Li, S.-Y.; Dravid, V. P.; Mirkin, C. A. J. Am. Chem. Soc. 2002, 124, 1560–1561PubMedCrossRefGoogle Scholar
  20. 20.
    Troughton, E. B.; Bain, C. D.; Whitesides, G. M.; Nuzzo, R. G.; Allara, D. L.; Porter, M. D. Langmuir 1988, 4, 365–385CrossRefGoogle Scholar
  21. 21.
    Bain, C. D.; Whitesides, G. M. J. Am. Chem. Soc. 1989, 111, 7164–7175CrossRefGoogle Scholar
  22. 22.
    Pique, A.; Chrisey, D. B., Eds. Direct-write technologies for rapid prototyping applications: sensors, electronics, and integrated power sources; Academic Press: San Diego, CA, 2002Google Scholar
  23. 23.
    Noy, A.; Miller, A. E.; Klare, J. E.; Weeks, B. L.; Woods, B. W.; DeYoreo, J. J. Nano Letters 2002, 2, 109–112CrossRefGoogle Scholar
  24. 24.
    Lim, J. H.; Ginger, D. S.; Lee, K. B.; Heo, J.; Nam, J. M.; Mirkin, C. A. Angew. Chem. Int. Ed. Engl. 2003, 42, 2309–2312PubMedCrossRefGoogle Scholar
  25. 25.
    Lee, K. B.; Lim, J. H.; Mirkin, C. A. J. Am. Chem. Soc. 2003, 125, 5588–5589PubMedCrossRefGoogle Scholar
  26. 26.
    Lee, K.-B.; Park, S. J.; Mirkin, C. A. Science 2002, 295, 1702–1705PubMedCrossRefGoogle Scholar
  27. 27.
    Vettiger, P.; Cross, G.; Despont, M.; Drechsler, U.; Durig, U.; Gotsmann, B.; Haberle, W.; Lantz, M. A.; Rothuizen, H. E.; Stutz, R.; Binnig, G. K. IEEE Transactions on Nanotechnology 2002, 1, 39–55CrossRefGoogle Scholar
  28. 28.
    Chow, E. M.; Yaralioglu, G. G.; Quate, C. F.; Kenny, T. W. Appl. Phys. Lett. 2002, 80, 664–666CrossRefGoogle Scholar
  29. 29.
    Sulchek, T.; Grow, R. J.; Yaralioglu, G. G.; Minne, S. C.; Quate, C. F.; Manalis, S. R.; Kiraz, A.; Aydine, A.; Atalar, A. Appl. Phys. Lett. 2001, 78, 1787–1789CrossRefGoogle Scholar
  30. 30.
    Degertekin, F. L.; Hadimioglu, B.; Sulchek, T.; Quate, C. F. Appl. Phys. Lett. 2001, 78, 1628–1630CrossRefGoogle Scholar
  31. 31.
    Zhang, M.; Bullen, D.; Chung, S.-W.; Hong, S.; Ryu, K. S.; Fan, Z.; Mirkin, C. A.; Liu, C. Nanotechnology 2002, 13, 212–217CrossRefGoogle Scholar
  32. 32.
    Thorsen, T.; Maerkl, S. J.; Quake, S. R. Science 2002, 298, 580–584PubMedCrossRefGoogle Scholar
  33. 33.
    Storhoff, J. J.; Mucic, R. C.; Mirkin, C. A. J. Cluster Sci. 1997, 8, 179–216CrossRefGoogle Scholar
  34. 34.
    Storhoff, J. J.; Elghanian, R.; Mucic, R. C.; Mirkin, C. A.; Letsinger, R. L. J. Am. Chem. Soc. 1998, 120, 1959–1964CrossRefGoogle Scholar
  35. 35.
    Niemeyer, C. M.; Burger, W.; Peplies, J. Angew. Chem. Int. Ed. 1998, 37, 2265–2268CrossRefGoogle Scholar
  36. 36.
    Niemeyer, C. M. Angew. Chem. Int. Ed. Engl. 2001, 40, 4128–4158CrossRefGoogle Scholar
  37. 37.
    Park, S. J.; Taton, T. A.; Mirkin, C. A. Science 2002, 295, 1503–1506PubMedCrossRefGoogle Scholar
  38. 38.
    Haes, A. J.; Van Duyne, R. P. J. Am. Chem. Soc. 2002, 124, 10596–10604PubMedCrossRefGoogle Scholar
  39. 39.
    Taton, T. A.; Lu, G.; Mirkin, C. A. J. Am. Chem. Soc. 2001, 123, 5164–5165PubMedCrossRefGoogle Scholar
  40. 40.
    Taton, T. A.; Mirkin, C. A.; Letsinger, R. L. Science 2000, 289, 1757PubMedCrossRefGoogle Scholar
  41. 41.
    Parak, W. J.; Boudreau, R.; Le Gros, M.; Gerion, D.; Zanchet, D.; Micheel, C. M.; Williams, S. C.; Alivisatos, A. P.; Larabell, C. Adv. Mater. 2002, 14, 882–885CrossRefGoogle Scholar
  42. 42.
    Demers, L. M.; Park, S. J.; Taton, T. A.; Li, Z.; Mirkin, C. A. Angew. Chem. Int. Ed. Engl. 2001, 40, 3071–3073PubMedCrossRefGoogle Scholar
  43. 43.
    Adleman, L. M. Molecular computation of solutions to combinatorial problems. Science 1994, 266, 11 NovemberGoogle Scholar
  44. 44.
    Lipton, R. J. DNA solution of hard computational problem. 1995, Science 268, 28 AprilGoogle Scholar
  45. 45.
    Ouyang, Q.; Kaplan, P. D.; Liu, S.; Libchaber, A. DNA solution of the maximal clique problem. Science 1997, 278, 17 OctoberGoogle Scholar
  46. 46.
    Liu, Y., Xu, J. Pan, L., Wang, S. DNA Solution of a graph coloring problem. J. Chem. Inf. Comput. Sci. 2002, 42, 524–528PubMedCrossRefGoogle Scholar
  47. 47.
    Smith L. M, Corn R. M, Condon A. E, Lagally M. G, Frutos A. G, Liu Q, Thiel A. J. A surface-based approach to DNA computation. J Comput Biol. 1998 Summer, 5(2):255–67PubMedCrossRefGoogle Scholar
  48. 48.
    Frutos, A. G., Smith, L. M., and Corn, R. M. (1998) Enzymatic ligation reactions of DNA “words” on surfaces for DNA computing. J. Am. Chem. Soc. 120, 10277–10282. York, Vol. 1CrossRefGoogle Scholar
  49. 49.
    Liu, Q, Wang, L., Frutos, A. G., Condon, A.E. Corn, R. M. Smith, L. M. DNA computing on surfaces. Nature, Vol. 403, 13 Jan 2000 175–178PubMedCrossRefGoogle Scholar
  50. 50.
    Schöning, U. in Proc. 40th Ann. IEEE Conf. Found. Comp. Sci. (FOCS) 410–414 (IEEE Comp. Sci., Los Alamitos, California, 1999)Google Scholar
  51. 51.
    Ogihara M. Ray, A. DNA computing on a chip. Nature Vol 403, 143–144, 2000PubMedCrossRefGoogle Scholar
  52. 52.
    Kinosita Jr, K., Yashida, R., Noji, H., Ishiwata, S., Yoshida, M. Cell 93, 21 (1998)PubMedCrossRefGoogle Scholar
  53. 53.
    Noji, H., Yasuda, R., Yoshida, M., Kinosita Jr, K., Direct observation of the rotation of F1ATPase. Nature, 386, 299–302, 1997PubMedCrossRefGoogle Scholar
  54. 54.
    Bachand, G.D. Montemagno, C. D. Constructing Organic/Inorganic NEMS Devices Powered by Biomolecular Motors. Biomedical Microdevices 2:3, 179–184, 2000CrossRefGoogle Scholar
  55. 55.
    Yoshida M, Muneyuki E, Hisabori T. ATP synthase-a marvelous rotary engine of the cell. Nat Rev Mol Cell Biol. 2001 Sep;2(9):669–77PubMedCrossRefGoogle Scholar
  56. 56.
    Noji H, Yasuda R, Yoshida M, Kinosita K Jr. Direct observation of the rotation of F1-ATPase. Nature, 1997, 386:299–302.PubMedCrossRefGoogle Scholar
  57. 57.
    Soong, R.K., Bachand, G.D., Neves, H.P., Olkhovets, A.G., Craighead, H.G., Montemagno, C.D. Powering a nanodevice with a biomolecular motor. Science, 290, 1555–, 2000PubMedCrossRefGoogle Scholar
  58. 58.
    Bachand, G.D. Montemagno, C. D. Constructing Organic/Inorganic NEMS Devices Powered by Biomolecular Motors. Biomedical Microdevices 2:3, 179–184, 2000CrossRefGoogle Scholar
  59. 59.
    Soong, R.K., Neves, H.P., Schmidt, J.J., Bachand, G.D., Montemagno, C.D. Engineering Issues in the fabrication of a hybrid nano-propeller system powered by F1-ATPase, Biomedical Microdevices, 3:1, 71–73, 2001CrossRefGoogle Scholar
  60. 60.
    Hess H, Vogel V. Molecular shuttles based on motor proteins: active transport in synthetic environments. J Biotechnol. 2001 Nov; 82(1):67–85PubMedGoogle Scholar
  61. 61.
    Yanagida, T., Nakase, M., Nishiyama, K. & Oosawa, F. (1984). Direct observation of motion of single F-actin filaments in the presence of myosin. Nature 307, 58–60PubMedCrossRefGoogle Scholar
  62. 62.
    Spudich, J. A., Kron, S. J. & Sheetz, M. P. (1985) Nature, 315, 584–586PubMedCrossRefGoogle Scholar
  63. 63.
    Suzuki, H., Oiwa, K., Yamada, A., Sakakibara, H., H. Nakayama and Mashiko S. 1995. Linear arrangement of motor protein on a mechanically deposited fluoropolymer thin film. Jpn. J. Appl. Phys. 34:3937–3941CrossRefGoogle Scholar
  64. 64.
    Suzuki, H., Yamada, A., Oiwa K., H. Nakayama and S. Mashiko. 1997. Control of actin moving trajectory by patterned poly(methylmethacrylate) tracks. Biophys. J. 72:1997–2001PubMedGoogle Scholar
  65. 65.
    Nicolau, D.V., Suzuki, H., Mashiko, S., Taguchi, T., Yoshikawa, S. Movement of actin filaments on microlithographically-functionalized myosin tracks. Biophysical Journal, 77(2), 99044–99065, 1999Google Scholar
  66. 66.
    Dennis, J. R., Howard, J. & Vogel, V. (1999). Molecular shuttles: directing the motion of microtubules on nanoscale kinesin tracks. Nanotechnology 10, 232–236CrossRefGoogle Scholar
  67. 67.
    Mahanivong, C., Wright, J. P., Kekic, M., Pham, D. K., dos Remedios, C., Nicolau, D.V. Manipulation of the Motility of Protein Molecular Motors on Microfabricated Substrates. Biomedical Microdevices 4(2): 111–116; 2002CrossRefGoogle Scholar
  68. 68.
    Clemmens, J.; Hess, H.; Howard, J.; Vogel, V. Analysis of Microtubule Guidance in Open Microfabricated Channels Coated with the Motor Protein Kinesin. Langmuir; 2003; 19(5); 1738–1744CrossRefGoogle Scholar
  69. 69.
    Bunk, R., Klinth, J., Rosengren, J., Nicholls, I., Tagerud, S., Omling, P., Mansson, A., Montelius, L. Towards a ‘nano-traffic’ system powered by molecular motors. Microelectronic Engineering 67–68 (2003) 899–904CrossRefGoogle Scholar
  70. 70.
    Turner, D. C., Chang, C., Fang K., S. L. Brandow and D. B. Murphy. 1995. Selective adhesion of functional microtubules to patterned silane surfaces. Biophys. J. 69:2782–2789PubMedCrossRefGoogle Scholar
  71. 71.
    Riveline, D., Ott, A., Julicher, F., Winkelmann, D. A., Cardoso, O., Lacapere, J. J., Magnusdottir, S., Viovy, J. L., Gorre-Talini, L. & Prost, J. (1998). Acting on actin: the electric motility assay. Eur Biophys J 27, 403–8PubMedCrossRefGoogle Scholar
  72. 72.
    Hiratsuka, Y., Tada, T., Oiwa, K., Kanayama, T., Uyeda, T.Q. P. Controlling the Direction of Kinesin-Driven Microtubule Movements along Microlithographic Tracks. Biophysical Journal, 81 2001 1555–1561PubMedGoogle Scholar
  73. 73.
    Fulga, F., Myhra, S., Nicolau, Jr. D. V., D.V. Nicolau, Interrogation of the dynamics of magnetic microbeads on the meso-scale via electromagnetic detection. Smart Materials & Structures, 11(5) 722–727, 2002CrossRefGoogle Scholar
  74. 74.
    Hess, H., Clemmens, J., Qin, D., Howard, J. & Vogel, V. (2001). Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces. Nano Letters 1, 235–239CrossRefGoogle Scholar
  75. 75.
    Hess, H.; Howard, J.; Vogel, V. A Piconewton Forcemeter Assembled from Microtubules and Kinesins. Nano Lett. 2002; 2(10); 1113–1115CrossRefGoogle Scholar
  76. 76.
    Hess, H.; Clemmens, J.; Howard, J.; Vogel, V. Surface Imaging by Self-Propelled Nanoscale Probes. Nano Lett. 2002; 2(2); 113–116CrossRefGoogle Scholar
  77. 77.
    Nicolau, D. V., Jr.; Nicolau, D. V. Computing with the Actin-Myosin molecular motor system. In Biomedical Applications of Micro-and Nanoengineering. Nicolau, Dan V. (Ed.) SPIE Proc. 4937, 219–225, 2002Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Dan V. Nicolau
  • Linnette Demers
  • David S. Ginger

There are no affiliations available

Personalised recommendations