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Epicardial Mapping in Isolated Hearts — Use in Safety Pharmacology, Analysis of Torsade de Pointes Arrhythmia and Ischemia-Reperfusion-Related Arrhythmia

  • Stefan Dhein

Keywords

Isolate Rabbit Heart Epicardial Mapping Total Activation Time Occlude Zone Activation Recovery Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allessie MA, Bonke FIM, Schopman FJG (1977) Circus movement in rabbit atrial muscle as a mechanism of tachycardia III. The leading circle concept. Circ Res 41: 9–18PubMedGoogle Scholar
  2. Arisi G, Macchi E, Baruffi S, Spaggiari S, Taccardi B (1983) Potential field on the ventricular surface of the exposed dog heart during normal excitation. Circ Res 52: 706–715PubMedGoogle Scholar
  3. Brugada P, Wellens HJJ (1988) Arrhythmogenesis of antiarrhythmic drugs. Am J Cardiol 61: 1108–1111CrossRefPubMedGoogle Scholar
  4. Buchanan JW, Saito T, Gettes LS (1985) The effects of antiarrhythmic drugs, stimulation frequency and potassium induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium. Circ Res 56: 696–703PubMedGoogle Scholar
  5. Burgess MJ, Steinhaus BM, Spiker KW, Ershler PR (1988) Nonuniform epicardial activation and repolarization properties of in vivo canine pulmonary conus. Circ Res 62: 233–246PubMedGoogle Scholar
  6. Carlsson L, Almgren O, Duker G (1990) QTU-prolongation and torsade de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. J Cardiovasc Pharmacol 16: 276–285PubMedGoogle Scholar
  7. Coronel R, Fiolet JWT, Wilms-Schopman FJG, Schaapherder AFM, Johnson TA, Gettes LS, Janse MJ (1988) Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart. Circulation 77: 1125–1138PubMedGoogle Scholar
  8. Dekker LRC, Fiolet JWT, Van Bavel E, Coronel R, Opthof T, Spaan JAE, Janse MJ (1996) Intracellular Ca++, intercellular electrical coupling, and mechanical activity in ischemic rabbit papillary muscle. Effects of preconditioning and metabolic blockade. Circ Res 79: 237–246PubMedGoogle Scholar
  9. Delmar M, Michaels DC, Johnson T, Jalife J (1987) Effects of increasing intercellular resistance on transverse and longitudinal propagation in sheep epicardial muscle. Circ Res 60: 780–785PubMedGoogle Scholar
  10. Dhein S, Rutten P, Klaus W (1988) A new method for analysing the geometry and timecourse of epicardial potential spreading. Int J Biomed Computing 23: 201–207Google Scholar
  11. Dhein S, Krüsemann K, Schaefer T (1999) Effects of the gap junction uncoupler palmitoleic acid on activation and repolarization pattern in isolated rabbit hearts. A mapping study. Br J Pharmacol 128: 1375–1384CrossRefPubMedGoogle Scholar
  12. Dhein S, Müller A, Gerwin R, Klaus W (1993) Comparative study on the proarrhythmic effects of some antiarrhythmic agents. Circulation 87: 617–630PubMedGoogle Scholar
  13. Dhein S, Krüsemann K, Engelmann F, Gottwald M (1998) Effects of type 1 Na+/H+-exchange inhibitor cariporide (HOE 642) on cardiac tissue. Naunyn Schmiedeberg’s Arch Pharmacol 357: 662–670Google Scholar
  14. Dhein S, Pejman P, Krüsemann K (2000) Effects of the IK.ATP-blockers glibenclamide and HMR 1883 on cardiac electrophysiology during regional ischemia and reperfusion. Eur J Pharmacol 398: 273–284CrossRefPubMedGoogle Scholar
  15. Dhein S, Perlitz F (2002) Haloperidol induces Torsade de Pointes Arrhythmia in an isolated rabbit heart model. A mapping study. Naunyn Schmiedeberg’s Arch Pharmacol 365[Suppl]: R98Google Scholar
  16. Durrer D, Van der Tweel LH (1954) Spread of activation in the left ventricular wall of the dog. Activation conditions at the epicardial surface. Am Heart J 47: 192–203CrossRefPubMedGoogle Scholar
  17. Gottwald E Gottwald M Dhein S (1998) Enhanced dispersion of epicardial activation-recovery intervals at sites of histological inhomogeneity during regional ischaemia and reperfusion. Heart 79: 474–480PubMedGoogle Scholar
  18. Hindricks G, Kottkamp H, Vogt B, Haverkamp W, Shenasa M, Borggrefe M, Breithardt G (1993) Mapping of anisotropic conduction in myocardial infarction. In: Shenasa M, Borggrefe M, Breithardt G (eds) Cardiac mapping. Futura Publishing Company Inc, Mount Kisco, NY, pp 225–235Google Scholar
  19. Janse MJ (1993) Mapping in acutely ischemic myocardium. In: Shenasa M, Borggrefe M, Breithardt G (eds) Cardiac mapping. Futura Publishing Company Inc, Mount Kisco, NY, pp 115–123Google Scholar
  20. Janse MJ, van Capelle FJL, Morsink H, Kleber AG, Wilms-Schopman F, Cardinal R, Naumann dálnoncourt C, Durrer D (1980) Flow of “injury cirrent” and patterns of excitation during early ventricular arrhythmias in acute myocardial ischemia in isolated porcine and canine hearts. Circ Res 47: 151–165PubMedGoogle Scholar
  21. Kléber AG, Janse MJ, van Capelle FJL, Durrer D (1978) Mechanism and time course of ST and TQ segment changes during acute regional myocardial ischemia in the pig heart determined by extracellular and intracellular recordings. Circ Res 42: 603–613PubMedGoogle Scholar
  22. Kléber AG, Janse MJ, Wilms-Schopman FJG et al. (1986) Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. Circulation 73: 189–198PubMedGoogle Scholar
  23. Kuo CS, Munakata K, Reddy CP, Surawicz B (1983) Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations. Circulation 67: 1356–1367PubMedGoogle Scholar
  24. Lesh MD, Pring M, Spear JF (1989) Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. Circ Res 65: 1426–1440PubMedGoogle Scholar
  25. Millar CK, Kralios FA, Lux RL (1985). Correlation between refractory periods and activation recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation 72: 1372–1379PubMedGoogle Scholar
  26. Müller A, Klaus W, Dhein S (1991) Heterogeneously distributed sensitivities to potassium as a cause of hypocalemic arrhythmias in isolated rabbit hearts. J Cardiovasc Electrophysiol 2: 145–155Google Scholar
  27. Spach MS, Dolber PC, Heidlage JF, Kootsey JM, Johnson EA (1987) Propagating depolarization in anisotropic human and canine cardiac muscle: apparent directional differences in membrane capacitance. Circ Res 60: 206–219PubMedGoogle Scholar
  28. Spach MS, Dolber PC (1986) Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Circ Res 58: 356–371PubMedGoogle Scholar
  29. Spach MS, Dolber PC (1985) The relation between discontinuous propagation in anisotropic cardiac muscle and the “vulnerable period of reentry”. In: Zipes DP, Jalife J (eds) Cardiac Electrophysiology and Arrhythmias. Grune and Statton, New York, NY, pp 241–252Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Stefan Dhein
    • 1
  1. 1.Herzzentrum, Klinik für HerzchirurgieUniversität LeipzigLeipzigGermany

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