Skip to main content

Morbidität und Mortalität in der Neugeborenen- und Säuglingsperiode — Grundlagen für die molekulare Epidemiologie in der Neonatologie

  • Chapter
Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

  • 1125 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

1.2.7 Literatur

  • Annual NICU Quality Management Reports. Vermont Oxford Network. Burlington, Vermont

    Google Scholar 

  • Baird PA, Anderson TW, Newcombe HB, Lowry RB (1988) Genetic disorders in children and young adults: a population study. Am J Hum Genet 42:677–693

    PubMed  CAS  Google Scholar 

  • Barker DJP (1995) Fetal origins of coronary heart disease. Br Med J 311:171–174

    CAS  Google Scholar 

  • Beers MF et al (2000) Pulmonary surfactant metabolism in infants lacking surfactant protein B. Am J Respir Cell Mol Biol:380–391

    Google Scholar 

  • Bellee H, Goertchen R, Tiller R, Muller K, Grunow N (2000) Autopsy in peri-and neonatology — an essential Step in quality control. Data on autopsy frequency in Saxony. Z Arztl Fortbild Qualitätssich 94:155–160

    PubMed  CAS  Google Scholar 

  • Bergh T, Ericson A, Hillensjö T et al (1999) Deliveries and children born after in-vitro fertilization in Sweden 1982–95: a retrospective cohort study. Lancet 354:1579–1585

    Article  PubMed  CAS  Google Scholar 

  • Bergmann RL, Richter R, Dudenhausen JW (2001) Warum nimmt die Prävalenz von niedrigem Geburtsgewicht in Berlin zu? Geburtsh Frauenheilk 61:686–691

    Article  Google Scholar 

  • Berner R (2002) Group B streptococci in pregnancy and infancy. Curr Opin Infect Dis 15:307–313

    PubMed  Google Scholar 

  • Berry RJ, Buehler JW, Strauss LT et al (1987) Birth weight-specific infant mortality due to congenital abnormalities, 1960 and 1980. Public Health Rep 102:171–181

    PubMed  CAS  Google Scholar 

  • Beyer C (1999) Estrogen and the developing mammalian brain. Anat Embryol 199:379–390

    Article  PubMed  CAS  Google Scholar 

  • Bhaumik U, Aitken I, Kawachi I, Ringer S, Orav J, Lieberman E (2004) Narrowing of sex differences in infant mortality in Massachusetts. J Perinatol 24:94–99

    Article  PubMed  Google Scholar 

  • Bijlsma F (1998) Mortality by congenital anomalies, 1979–1995. Mndber Gezondheid 6:15–20

    Google Scholar 

  • Blickstein I, Goldman RD, Mazkereth R (2000) Risk for one or two very low birth weight twins: a population study. Obstet Gynecol 96:400–402

    Article  PubMed  CAS  Google Scholar 

  • Blickstein I, Keith LG (2001) Iatrogenic multiple pregnancy: clinical implications. Parthenon, New York

    Google Scholar 

  • Blickstein I, Keith LG (2001) The epidemic of multiple pregnancies. Postgrad Obstet Gynecol 21:1–7

    Google Scholar 

  • Blickstein I, Weissman A (1999) Estimating the risk of cerebral palsy following assisted conceptions. N Engl J Med 341:1313–1314

    Article  PubMed  CAS  Google Scholar 

  • Botto LD, Khoury MJ, Mulinare J (1996) Periconceptional use of vitamins and the prevention of conotruncal heart defects: evidence from a population-based case-control study. Pediatrics 98:911–917

    PubMed  CAS  Google Scholar 

  • Brinkmann BA, Du Chesne B, Vennemann M (2002) Aktuelle Daten zur Obduktionsfrequenz in Deutschland. Dtsch Med Wochenschr:791–795

    Google Scholar 

  • Bouchon A, Facchetti F, Weigand MA, Colonna M (2001) TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410:1103–1107

    Article  PubMed  CAS  Google Scholar 

  • Bundesärztekammer, wissenschaftlicher Beirat (1998) Erklärung zum Schwangerschaftsabbruch nach Pränataldiag-nostik. Stand: 20.11.1998. http://www.aerztetag.de/30/Richtlinien/Empfidx/Schwanger.html

    Google Scholar 

  • Bundesministerium für Familie, Senioren, Frauen und Jugend (2001) Bericht zur gesundheitlichen Situation von Frauen in Deutschland. Eine Bestandsaufnahme unter Berücksichtigung der unterschiedlichen Entwicklung in West-und Ostdeutschland, 1. Aufl. Kohlhammer, Berlin

    Google Scholar 

  • Bundesärztekammer (1998) Richtlinien zur pränatalen Diagnostik von Krankheiten und Krankheitsdispositionen, überarbeitet 2002. Bekanntgaben der Herausgeber. Dt. Ärztebl 95:A3236–3242 (http://www.aerztetag.de/30/Richt-Iinien/Richtidx/Praediag.html)

    Google Scholar 

  • Campbell DM, MacGillivray I, Carr-Hill R, Samphier M (1983) Fetal sex and pre-eclampsia in primigravidae. Br J Obstet Gynaecol 90:26–27

    PubMed  CAS  Google Scholar 

  • Carrer HF, Cambiasso MJ (2002) Sexual differentiation of the brain: genes, estrogen, and neurotrophic factors cellular and molecular neurobiology22:479–500

    CAS  Google Scholar 

  • CDC (1989) Contribution of birth defects to infant mortality — United States 1986. MMWR 38:633–635

    Google Scholar 

  • Carr BR (1995) The maternal-fetal-placental unit. In: Becker KL (ed) Principles and practice of endocrinology and metabolism, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  • Centers for Disease Control and Prevention (2000) Health, United States, 2000. DHHS Publication No 00-1232

    Google Scholar 

  • Coggon D, Rose G, Barker DJ (1997) Epidemiology for the Uninitiated, 4th edn. BMJ, London

    Google Scholar 

  • Collins FS, Green ED, Guttmacher AE, Guyer MS (2003) A vision for the future of genomic research. Nature 422:835–847

    Article  PubMed  CAS  Google Scholar 

  • Conrad K, Fritzler M, Meurer M, Sack U, Shoenfeld Y (2002) From proteomics to molecular epidemiology — relevance of autoantibodies. 6th Dresden Symposium on Autoantibodies, September 4–7, 2002

    Google Scholar 

  • Cooperstock M, Campbell J (1996) Excess males in preterm birth: interactions with gestational age, race, and multiple birth. Obstet Gynecol 88:189–193

    Article  PubMed  CAS  Google Scholar 

  • Cornel MC, Breed AS, Beekhuis JR et al (1993) Down syndrome: effects of demographic factors and prenatal diagnosis on the future lifebirth prevalence. Hum Genet 92:163–168

    Article  PubMed  CAS  Google Scholar 

  • Crowley P (2000) Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev 2000:2

    Google Scholar 

  • Czeizel AE, Dudas I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832–1835

    Article  PubMed  CAS  Google Scholar 

  • Czeizel AE (1995) Folie acid in the prevention of neural tube defects. J Pediatr Gastroenterol Nutr 20:4–16

    Article  PubMed  CAS  Google Scholar 

  • deMello DE, Lin Z (2001) Pulmonary alveolar proteinosis: a review. Pediatr Pathol Mol Med 20:413–432

    Article  PubMed  CAS  Google Scholar 

  • De-Zheger F, Francois I, Boehmer AL et al (1998) Androgens and fetal growth. Horm Res 50:243–244

    Article  Google Scholar 

  • Dhont M, De Sutter P, Ruyssinck G et al (1999) Perinatal outcome of pregnancies after assisted reproduction: a case control study. Am J Obstet Gynecol 181:688–695

    Article  PubMed  CAS  Google Scholar 

  • Dirksen U et al (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common chain expression. J Clin Invest 100:2211–2217

    Article  PubMed  CAS  Google Scholar 

  • Dorman JS (2004) http://www.pitt.edu/~kkr/molepi.html

    Google Scholar 

  • Dorman, JS on behalf of the International Molecular Epidemiology Task Force (1994) Molecular epidemiology and DNA technology transfer: a program for developing countries standardization of epidemiologic studies of host suseeptibility. Plenum, New York

    Google Scholar 

  • Dressel MK (2001) Über die Bedeutung der Plazenta im Androgenstoffwechsel der Perinatalperiode unter Berücksichtigung des fetalen Geschlechts und möglicher Zusammenhänge zwischen fetalen Reifungsprozessen und maternalen sowie fetalen Androgenserumkonzentrationen. Inaugural-Dissertation, Justus-Liebig-Universität Gießen

    Google Scholar 

  • Drosten C, Günther S, Preiser W (2003) Identification of a novel coronarvirus in patients with SARS. N Engl J Med 348:1967–1976

    Article  PubMed  CAS  Google Scholar 

  • EMNID (2000) Image von Menschen mit Down-Syndrom. Nationaler Ethikrat 2003, S 72 ff

    Google Scholar 

  • Encarta Enzyklopädie 2004(c), Microsoft Corporation

    Google Scholar 

  • ESHRE Recommendations (2001) Prevention of twin pregnancies after IVF/ICSI by Single embryo transfer. ESHRE Campus Course Report Human Reproduction 16:790–800 http://humrep.oupjournals.Org/cgi/content/full/16/4/790

    Google Scholar 

  • EUROCAT Working Group (1997) EUROCAT report 7. 15 years of surveillance of congenital anomalies in Europe 1980–1994. Scientific Institute of Public Health, Brüssels

    Google Scholar 

  • EUROCAT Working Group (1997) EUROCAT report 7 update.17 years of surveillance of congenital anomalies in Europe 1980–1996. Scientific Institute of Public Health, Brüssels

    Google Scholar 

  • FIDD (2004) http://archive.uwcm.ac.uk/uwcm/mg/fidd/introduction.html, http://www.hon.ch/HONcode/German/index.html

    Google Scholar 

  • Fitch RH, Denenberg VH (1998) A role for ovarian hormones in sexual differentiation of the brain. Behav Brain Sci 21:311–352

    PubMed  CAS  Google Scholar 

  • Floros J et al (2000) Surfactant protein genetic markers alleles identify a subgroup of tuberculosis in a Mexican population. J Infect Dis 182:1473–1478

    Article  PubMed  CAS  Google Scholar 

  • Fritsche U, Wolk E (1990) Schwangerschaftshäufigkeit und Geburtenrate bei adoleszenten und jungen Frauen in der früheren DDR. Z Arztl Fortbild (Jena) 84:1227–1233

    CAS  Google Scholar 

  • FitzPatrick DR, Skeoch CH, Tolmie JL (1991) Genetic aspects of admission to a paediatric intensive care unit. Arch Dis Chüd 66:639–641

    CAS  Google Scholar 

  • Furness M, Pollock K (2001) Industry and the human ge-nom. In: Mattei J-F (ed) The human genome. Council of Europe Publishing, pp 85–107

    Google Scholar 

  • GBE: Glossar für die Gesundheitsberichterstattung des Bundes, www.rki.de/GBE/GLOSSAR/GLOSSAR.HTM

    Google Scholar 

  • Gelehrter TD, Collins FS, Ginsburg D (1998) Principles of medical genetics, 2nd ed. Williams & Willems, Baltimore

    Google Scholar 

  • Gerris J, De Neubourg D, Mangelschots K, Royen van E, Meerssche Van de M, Valkenburg M (1999) Prevention of twin pregnancy after in-vitro fertilization or intracyto-plasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial. Hum Reprod 14:2581–2587

    Article  PubMed  CAS  Google Scholar 

  • Gill JW, Hosking BJ (1995) Acute prenatal androgen treatment increases birth weights and growth rates in lambs. J Anim Sci 73:2600–2608

    PubMed  CAS  Google Scholar 

  • Gissler M, Ollola E, Teperi J, Hemminki E (1994) Impact of induced abortions and statistical definitions on perinatal mortality figures. Paediatr Perinatal Epidemiol 8:391–400

    Article  CAS  Google Scholar 

  • Glasser SW et al (2003) Pneumonitis and emphysema in SPC gene targeted mice. J Biol Chem 278:14291–14298

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg RL, Humphrey JL, Haie CB, Wayne JB (1983) Lethal congenital anomalies as a cause of birth-weight-specific neonatal mortality. JAMA 250:513–515

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg RL, Hauth JC, Andrews WW (2000) Intrauterine infection and preterm delivery. N Engl J Med 342:1500–1507

    Article  PubMed  CAS  Google Scholar 

  • Gross I, Wilson CM, Ingleson LD, Brehier A, Rooney SA (1979) The influence of hormones on the biochemical development of fetal rat lung in organ eulture. Biochim Biophys Acta 575:375–383

    PubMed  CAS  Google Scholar 

  • Guggenmos J, Matz S (2002) Kurzstudie zu einer Todesfallstatistik über Kinder und Jugendliche in Münster/Westf. Eine empirische Erhebung zu Todesfällen für den Zeitraum 1991–1998. In: „Duisburger Beiträge zur soziologischen Forschung“, Institut für Soziologie, Gerhard-Mercator-Universität Duisburg (Duisburger Beiträge zur soziologischen Forschung) No 2/2002

    Google Scholar 

  • Guillem P, Fabre B, Cans C, Robert-Gnansia E, Jouk PS (2003) Trends in elective terminations of pregnancy between 1989 and 2000 in a French county (the Isere). Prenat Diagn 23: 877–883

    Article  PubMed  CAS  Google Scholar 

  • Guttmacher AE (2003) Welcome to the genomic era. N Engl J Med 349:10–12

    Article  Google Scholar 

  • Guttmacher AE, Collins FS (2002) Genomic medicine-a primer. N Engl J Med 347:1512–1520

    Article  PubMed  CAS  Google Scholar 

  • Haataja R, Marttila R, Uimari P, Lofgren J, Ramet M, Hallman M (2001) Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test. Hum Genet 109:351–355

    Article  PubMed  CAS  Google Scholar 

  • Hall JG (1997) The impact of birth defects and genetic diseases. Arch Pediatr Adolesc Med 151:1082–1083

    PubMed  CAS  Google Scholar 

  • Hall MH, Carr-Hill R (1982) Impact of sex ratio on onset and management of labour. Br Med J (Clin Res) 285:401–403

    CAS  Google Scholar 

  • Hart CD, Flozak AS, Simmons RA (1998) Modulation of glucose transport in fetal rat lung: a sexual dimorphism. Am J Respir Cell Mol Biol 19:63–70

    PubMed  CAS  Google Scholar 

  • Höhn C (1998) Demographische Trends, Bevölkerungswissenschaft und Politikberatung. Aus der Arbeit des Bundesinstituts für Bevölkerungsforschung (BiB), 1973–1998. Schriftenreihe des Bundesinstituts für Bevölkerungsforschung, Band 28. Leske & Budrich, Opladen

    Google Scholar 

  • Hoekelman RA, Pless IB (1988) Decline in mortality among young American during the 20th Century: prospects for reaching national mortality reduction goals for 1990. Pediatrics 82:582–595

    PubMed  CAS  Google Scholar 

  • Hook EB (1994) Down’s syndrome epidemiology and biochemical screening. In: Grudzinskas JG, Chard T, Chapman M et al (eds) Screening for Down’s syndrome. Cambridge University Press, Cambridge

    Google Scholar 

  • Horbar JD, Wright EC, Onstad L (1993) Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. Pediatrics 92:191–196

    PubMed  CAS  Google Scholar 

  • Horbar J, Badger D, Carpenter GJ, et al (2002) Trends in mortality and morbidity for very low birth weight infants 1991–1999. Pediatrics 110:143–151

    Article  PubMed  Google Scholar 

  • Human gene database (2004) http://www.jbirc.aist.go.jp/hinv/index.jsp

    Google Scholar 

  • James WH (1996) Evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels at the time of conception. J Theor Biol 180:271–286

    Article  PubMed  CAS  Google Scholar 

  • Hutchison JB, Wozniak A, Beyer C, Karolczak M, Hutchison RE (1999) Steroid metabolising enzymes in the determination of brain gender. J Steroid Biochem Mol Biol 69:85–96

    Article  PubMed  CAS  Google Scholar 

  • James WH (1997) A potential mechanism for sex ratio Variation in mammals. J Theor Biol 189:253–255

    Article  PubMed  CAS  Google Scholar 

  • James WH (2004) Further evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels around the time of conception. Hum Reprod 19:1250–1256

    Article  PubMed  CAS  Google Scholar 

  • Jaster HJ (1997) Qualitätssicherung im Gesundheitswesen. Thieme, Stuttgart

    Google Scholar 

  • Jobe AH (2002) Indications for and questions about antenatal steroids. Adv Pediatr 49:227–243

    PubMed  Google Scholar 

  • Jobe AH, Mitchell BR, Gunkel JH (1993) Beneficial effects of the combined use of prenatal corticosteroids and postnatal surfactant on preterm infants. Am J Obstet Gynecol 168:508–513

    PubMed  CAS  Google Scholar 

  • Jost A, Vigier B, Prepin J, Perchellet JP (1973) Studies on sex differentiation in mammals. Recent Prog Horm Res 29:1–35

    PubMed  CAS  Google Scholar 

  • Kala P et al (1998) Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B. Pediatr Res 43:169–177

    Article  PubMed  CAS  Google Scholar 

  • Kalter H, Warkany J (1983) Medical progress. Congenital malformations: etiologic factors and their role in prevention. N Engl J Med 308:424–431 (Ist part), 308:491–497 (2nd part)

    PubMed  CAS  Google Scholar 

  • Kari MA, Hallman M, Eronen M et al (1994) Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo-controlled multicenter study. Pediatrics 93:730–736

    PubMed  CAS  Google Scholar 

  • Kitamura T et al (1999) Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 190:875–880

    Article  PubMed  CAS  Google Scholar 

  • Klein JM et al (1998) Transient surfactant protein B deficiency in a term infant with severe respiratory failure. J Pediatr 132:244–248

    Article  PubMed  CAS  Google Scholar 

  • Klemperer D (2004) Medizinische und sozialmedizinische Grundlagen: Epidemiologie, Kurs 2003–2004. http://www.klemperer11.de.ms/

    Google Scholar 

  • Körblein A, Küchenhoff H (1997) Perinatal mortality in Germany following the Chernobyl accident. Radiat Environ Biophys 36:3–7

    Article  PubMed  Google Scholar 

  • Khoury MJ, Marks JS, McCarthy BJ, Zaro SM (1985) Factors affecting the sex differential in neonatal mortality: the role of respiratory distress syndrome. Am J Obstet Gynecol 151:777–782

    PubMed  CAS  Google Scholar 

  • Koletzko B, Pietrzik K (2004) Gesundheitliche Bedeutung der Folsäurezufuhr. Dt Ärztebl 101:A1670–A1681

    Google Scholar 

  • Kumar P, Radhakrishnan J, Chowdhary M, Giampietro PF (2001) Prevalence and patterns of presentation of genetic disorders in a pediatric emergency department. Mayo Clin Proc 76:777–783

    Article  PubMed  CAS  Google Scholar 

  • Lary JM, Paulozzi LJ (2001) Sex differences in the prevalence of human birth defects: a population-based study. Teratology 64:237–251

    Article  PubMed  CAS  Google Scholar 

  • Lephart ED, Lund TD, Horvath TL (2001) Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Res Rev 37:25–37

    Article  PubMed  CAS  Google Scholar 

  • Liu S, Joseph KS, Wen SW (2002) Trends in fetal and infant deaths caused by congenital anomalies. Semin Perinatol 26:268–276

    Article  PubMed  Google Scholar 

  • Liu S, Joseph KS, Kramer MS, Allen AC, Sauve R, Rusen ID, Wen SW for the fetal and infant health study group of the Canadian Perinatal Surveillance System (2002) Relationship of prenatal diagnosis and pregnancy termination to Overall infant mortality in Canada. JAMA 27:1561–1567

    Article  Google Scholar 

  • Loriaux DL, Ruder HJ, Knab DR, Lipsett MB (1972) Estrone sulfate, estrone, estradiol and estriol plasma levels in human pregnancy. J Clin Endocrinol Metab 35:887–891

    PubMed  CAS  Google Scholar 

  • Lubinsky MS (1997) Classifying sex-biased congenital anomalies. Am J Med Genet 69:225–228

    Article  PubMed  CAS  Google Scholar 

  • Makri V, Hospes B, Stoll-Becker S, Borkhardt A, Gortner L (2002) Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome. Eur J Pediatr 161:604–608

    Article  PubMed  CAS  Google Scholar 

  • Manaranche R (2001) Gene therapy. In: Mattei J-F (ed) The human genome. Council of Europe Publishing, pp 69–83

    Google Scholar 

  • Mattei J-F (2001) The human genome. Council of Europe Publishing. http://book.coe.int

    Google Scholar 

  • McGregor JA, Leff M, Orleans M, Baron A (1992) Fetal gender differences in preterm birth: findings in a North American cohort. Am J Perinatol 9:43–48

    PubMed  CAS  Google Scholar 

  • Medgenetik (2004) Vorwort Themenschwerpunkt genetische Epidemiologie/medizinische Genetik 4-2000. http://www.medgenetik.de/medgenetik/suche/themenhefte/2000_4_22.html

    Google Scholar 

  • Moyers S, Bailey LB (2001) Fetal malformations and folate metabolism: review of recent evidence. Nutr Rev 59:215–235

    Article  PubMed  CAS  Google Scholar 

  • Muskala B, Wauer RR (2002) Die Validität der Neonatalerhebungen für respiratorische Morbidität und Mortalität in Deutschland 1997–99, Kinderarztl Praxis 73(Suppl 21)

    Google Scholar 

  • National Center for Health Statistics (2000) Health, United States. With Adolescent Health Chartbook. Hyattsville, Maryland

    Google Scholar 

  • Nationaler Ethikrat (2003) Stellungnahme „Genetische Diagnostik vor und während der Schwangerschaft“. www.ethikrat.org

    Google Scholar 

  • Nationaler Ethikrat (2004) Stellungnahme „Polkörperdiagnostik“. www.ethikrat.org

    Google Scholar 

  • OMIM (2004) Online Mendelian Inheritance in Man (OMIN(tm)). McKusick-Nathans Institute for Genetic Medicine, John Hopkins University, Baltimore. www.ncbi.nlm.nih.gov/Omim

    Google Scholar 

  • Pal-van-der-Bruin KM de, Graafmans W, Biermans CMJ et al (2002) The influence of prenatal screening and termina-tion of pregnancy on perinatal mortality rates. Prenat Diagn 22:966–972

    Article  Google Scholar 

  • Pepe GJ, Ballard PL, Albrecht ED (2003) Fetal lung maturation in estrogen-deprived baboons. J Clin Endocrinol Metab 88:471–477

    Article  PubMed  CAS  Google Scholar 

  • Plagemann A, Heidrich, Götz F, Rohde W, Dörner G (1992) Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding. Exp Clin Endocrinol 99:154–158

    PubMed  CAS  Google Scholar 

  • Pritchard DJ, Korf BR (2003) Medical genetics at a glance. Blackwell Science, Oxford

    Google Scholar 

  • Rabinovichi J, Jaffe RB (1990) Development and regulation of growth and differentiated function in human and sub-human primate fetal gonads. Endocr Rev 11:532–556

    Google Scholar 

  • Renlund M (2001) Hospital for Children and Adolescents, Helsinki University Central Hospital Hot Topics 2001. Prevention of multiple births by elective Single embryo transfer in IVF/ICSI: less twins but acceptable pregnancy rate

    Google Scholar 

  • Rettwitz-Volk W (2003) Mortalität und Morbidität von Frühgeborenen — eine Zusammenfassung der deutschen Neonatalerhebungen 2001. Z Geburtsh Neonatol 207:143–147

    Article  CAS  Google Scholar 

  • Richardus JH, Graafmans WC, Pal van der-Bruin de KM, Amelink-Verburg MP, Verloove-Vanhorick SP, Mackenbach JP (1997) An European concerted action investigating the validity of perinatal mortality as an outcome indicator for the quality of antenatal and perinatal care. J Perinat Med 25:313–324

    Article  PubMed  CAS  Google Scholar 

  • Rich-Edwards JW, Stampfer MJ, Manson JE et al (1997) Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. Br Med J 315:396–400

    CAS  Google Scholar 

  • Rieder MJ (1994) Prevention of neural tube defects with periconceptional folic acid. Clin Perinatol 21:483–503

    PubMed  CAS  Google Scholar 

  • Robertson PA, Sniderman SH, Laros RK Jr et al (1992) Neonatal morbidity according to gestational age and birth weight from five tertiary care centers in the United States, 1983 through 1986. Am J Obstet Gynecol 166:1629–1641

    PubMed  CAS  Google Scholar 

  • Robinson A, Linden MG (1993) Clinical genetic handbook., Blackwell, Boston

    Google Scholar 

  • Rösch Ch, Steinbicker V (1999) Senkung der fehlbildungsbedingten Frühsterblichkeit — eine Möglichkeit zur Beeinflussung der perinatalen Mortalität. Gesundheitswesen 61:469–472

    PubMed  Google Scholar 

  • Rösch C, Götz D, Kawa S et al (2002) Jahresbericht des Bundeslandes Sachsen-Anhalt zur Häufigkeit von congenitalen Fehlbildungen und Anomalien sowie genetisch bedingten Erkrankungen 2001. Fehlbildungsmonitoring Sachsen-Anhalt an der Medizinischen Fakultät der Otto-von-Guericke-Universität, Magdeburg, http://www.med. uni-magdeburg.de/fme/zkh/mz/jahresbericht2001/bericht2001.pdf

    Google Scholar 

  • Roy EJ, Mackay R (1962) The concentration of estrogens in blood during pregnancy. J Obstet Gynecol 69:13–17

    CAS  Google Scholar 

  • Saunders DM, Lancaster P (1989) The wider perinatal significance of the Australian in vitro fertilization data collection program. Am J Perinatol 6:252–257

    Article  PubMed  CAS  Google Scholar 

  • Scherb H, Weigelt E (2004) Zunahme der Perinatalsterblichkeit, Totgeburten und Fehlbildungen in Deutschland, Europa und in hochbelasteten Regionen nach 1986. Schriftliche Fassung: Daten, Methoden, Ergebnisse, Interpretation, Begriffe. GSF-Forschungszentrum für Umwelt und Gesundheit. Reihe Loccum-Vorträge, Neuherberg

    Google Scholar 

  • Scherb H, Weigelt E, Brüske-Hohlfeld I (1999) European stillbirth proportions before and after the Chernobyl accident. Int J Epidemiol 28:932–940

    Article  PubMed  CAS  Google Scholar 

  • Schmid RD (2002) Taschenatlas der Biotechnologie und Gentechnik. Wyley-VCH, Weinheim

    Google Scholar 

  • Schubert I, Horch K (2004) Gesundheit von Kindern und Jugendlichen. In: Horch K, Tiese Th (Hrsg) Schwerpunktbericht der Gesundheitsberichterstattung des Bundes, Robert-Koch-Institut, Berlin

    Google Scholar 

  • Schuchat A (2001) Group B streptococcal disease: from trials and tribulations to triumph and trepidation. Clin Infect Dis 33:751–756

    Article  PubMed  CAS  Google Scholar 

  • Schull WJ, Neel JV (1958) Radiation and the sex ratio in man. Science 128:343–348

    Article  PubMed  CAS  Google Scholar 

  • Schwartz RM, Luby AM, Scanion JW, Kellog RJ (1994) Effect of surfactant on morbidity, mortality and resource use in newborn infants weighing 500–1500 g. N Engl J Med 330:1476–1480

    Article  PubMed  CAS  Google Scholar 

  • Scriver CR, Neal JL, Saginur R, Clow A (1973) The frequency of genetic disease and congenital malformation among patients in a pediatric hospital. Can Med Ass J 108:1111–1115

    PubMed  CAS  Google Scholar 

  • Shankaran S et al (2002) Whole-body hypothermia for neo-natal encephalopathy: animal observations as a basis for randomized, controlled pilot study in term infants. Pediatrics 110:377–385

    Article  PubMed  Google Scholar 

  • Siiteri PK, Wilson JD (1974) Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metabol 38:113–125

    CAS  Google Scholar 

  • Sinhal A, Cole TJ, Lucas A (2001) Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 357:413–419

    Article  Google Scholar 

  • Sinhal A, Fewtrell M, Cole TJ, Lucas A (2003) Low nutricient intake and early growth for later insulin resistance in adolescents born preterm. Lancet 361:1089–1097

    Article  CAS  Google Scholar 

  • Smith GC (2000) Sex, birth weight, and the risk of stillbirth in Scotland, 1980–1996. Am J Epidemiol 151:614–619

    PubMed  CAS  Google Scholar 

  • Sommer B (1998) Sterblichkeit in Deutschland verglichen zu regionalen und europäischen Trends. Wirtsch Stat 12:960–970

    PubMed  Google Scholar 

  • Stevenson DK, Verter J, Fanaroff AA et al (2000) Sex differences in outcomes of very low birth weight infants: the newborn male disadvantage. Arch Dis Child 83:F182–185

    CAS  Google Scholar 

  • Statistisches Bundesamt (2001) Fachserie 12, Reihe 4, Tab. 2.6, und Daten zu Entbindungen, Lebendgeborene und Schwangerschaften in Deutschland, Mainz 2001. http://www.destatis.de/themen/d/thm_gesundheit.htm

    Google Scholar 

  • Stevens PA (2004) Das Surfactantsystem. In: Wauer RR (Hrsg) Surfactanttherapie, 3. Aufl. Thieme, Stuttgart

    Google Scholar 

  • Stevens PA et al (2004a) Interstitial pneumonitis and pulmonary lipoproteinosis in a patient with a novel mutation in the surfactant protein C gene. Unique intracellular trafficking of expressed mutant isoforms (in press)

    Google Scholar 

  • Stoll C, Tenconi R, Clementi M (2001) Detection of congenital anomalies by fetal ultrasonographic examination across Europe. Community Genet 4:225–232

    Article  PubMed  Google Scholar 

  • Swart E (2002) Nutzungsmöglichkeiten der amtlichen Statistik für die Versorgungsforschung. Gesundheitswesen 64:253–258

    Article  PubMed  CAS  Google Scholar 

  • Takeyama J, Suzuki T, Inoue S, Kaneko C, Nagura H, Harada N, Sasano H (2001) Expression and cellular localization of estrogen receptors alpha and beta in the human fetus. J Clin Endocrinol Metab 86:2258–2262

    Article  PubMed  CAS  Google Scholar 

  • Tanaka N et al (1999) Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor. FEBS Letters 44:246–250

    Article  Google Scholar 

  • Tasker RC (1999) Pharmacological advance in the treatment of acute brain injury. Arch Dis Child 81:90–95

    Article  PubMed  CAS  Google Scholar 

  • Tauji M, Saul JP, du Plesala A, Eichenwald E, Volpe J (2000) Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 195:188–192

    Google Scholar 

  • Tönz O (1999) Folsäureprophylaxe — nicht nur zur Verhütung von Neuralrohrdefekten. Gynäkologe 4:272–280

    Google Scholar 

  • Tönz O, Lüthy J, Raunhardt O (1996) Folsäure zur Verhütung von Neuralrohrdefekten. Schweiz Med Wochenschr 126:177–187

    PubMed  Google Scholar 

  • Tulchinsky D (1973) Placental secretion of unconjugated estrone, estradiol and estriol into the maternal and the fetal circulation. J Clin Endocrinol Metab 26:1079–1087

    Google Scholar 

  • Ulizzi L, Zonta LA (1994) Sex ratio and selection by early mortality in humans: fifty-year analysis in different ethnic groups. Hum Biol 66:1037–1048

    PubMed  CAS  Google Scholar 

  • Vartiainen et al (1999) Environmental chemicals and changes in sex ratio: analysis over 250 years in Finland. Environ Health Perspect 107:813–815

    Article  PubMed  CAS  Google Scholar 

  • Väyrynen O, Glumoff V, Hallman M (2002) Regulation of surfactant proteins by LPS and proinflammatory cytokines in fetal and newborn lung. Am J Physiol Lung Cell and Mol Physiol 282:L803–810

    Google Scholar 

  • Ventura SJ, Martin JA, Curtin SC, Menacker F, Hamilton BE (2001) Births: final data for 1999. National vital statistics reports, Vol 49 No 1. National Center for Health Statistics, Hyattsville, Maryland

    Google Scholar 

  • Volpe JJ (2003) Cerebral white matter injury of the premature infant — more common than you think. Pediatrics 112:176–179

    Article  PubMed  Google Scholar 

  • Volpe JJ (2003a) Prevention of brain injury in premature infants. Hot topics in neonatology 2003, Ross Products Dev, Abbot Laboratories, Syllabus, Abstract S 20/21

    Google Scholar 

  • Verloove-Vanhorick SP, Veen S, Ens-Dokkum MH, Schreuder AM, Brand R, Ruys JH (1994) Sex difference in disability and handicap at five years of age in children born at very Short gestation. Pediatrics 93:576–579

    PubMed  CAS  Google Scholar 

  • Warne GL, Reyes FI, Faiman C, Winter JS (1978) Studies on human sexual development. VI. Concentrations of unconjugated dehydroepiandrosterone, estradiol, and estriol in amniotic fluid throughout gestation. J Clin Endocrinol Metab 47:1363–1367

    Article  PubMed  CAS  Google Scholar 

  • Washington State Vital Statistics 2000 (2002) Center for Health Statistics, Olympia, Washington

    Google Scholar 

  • Wauer RR (2004) Surfactanttherapie, 3. Aufl. Thieme, Stuttgart

    Google Scholar 

  • Wegner RD, Becker R (1997) Prenatal diagnosis in Germany. Eur J Hum Genet 5(Suppl l):32–38

    PubMed  Google Scholar 

  • Wen SW, Liu S, Joseph KS, Trouton K, Allen A (1999) Regional patterns of infant mortality caused by lethal congenital anomalies. Can J Public Health 90:316–319

    PubMed  CAS  Google Scholar 

  • Wen SW, Liu S, Joseph KS, Trouton K, Allen A (2000). Patterns of infant mortality caused by lethal congenital anomalies. Teratology 61:342–346

    Article  PubMed  CAS  Google Scholar 

  • Wheeler AP, Bernard GR (1999) Treating patients with severe sepsis. N Engl J Med 3:207–214

    Article  Google Scholar 

  • Witkowski R, Prokop O, Ullrich E (1999) Lexikon der Syn-drome und Fehlbildungen. Ursache, Genetik und Risiken. Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  • Yoon PW, Olney RS, Khoury MJ et al (1997) Contribution of birth defects and genetic diseases to pediatric hospitalisations: a population based study. Arch Pediatr Adolesc Med 151:1096–1103

    PubMed  CAS  Google Scholar 

  • Xu B, Rantakallio P, Jarvelin MR, Fang XL (1997) Sex differentials in perinatal mortality in China and Finland. Soc Biol 44:170–178

    PubMed  CAS  Google Scholar 

  • Zeitlin J, Saurel-Cubizolles M-J, de Mouzon J, Rivera L, Ancel P-Y, Blondel B, Kaminski M (2002) Fetal sex and preterm birth: are males at greater risk? Hum Reprod 17:2762–2768

    Article  PubMed  Google Scholar 

  • Ziegler A (2002) Genetische Epidemiologie — Gegenwart und Zukunft. Dt Ärztebl 99:B1996–B2000

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wauer, R.R. (2005). Morbidität und Mortalität in der Neugeborenen- und Säuglingsperiode — Grundlagen für die molekulare Epidemiologie in der Neonatologie. In: Ganten, D., Ruckpaul, K. (eds) Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26524-4_2

Download citation

Publish with us

Policies and ethics