Skip to main content

Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fcε Receptor

  • Chapter
  • 487 Accesses

Part of the Springer Series in Biophysics book series (BIOPHYSICS,volume 8)

Keywords

  • Mast Cell
  • Tyrosine Phosphorylation
  • Mouse Mast Cell
  • Bone Marrow Mast Cell

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/3-540-26511-2_8
  • Chapter length: 53 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   219.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-26511-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   279.99
Price excludes VAT (USA)
Hardcover Book
USD   249.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abramson J, Pecht I (2002) Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62(Dok) and SHIP and affects RBL-2H3 cell cycle. Immunol Lett 82:23–28

    CrossRef  PubMed  Google Scholar 

  • Abramson J, Rozenblum G, Pecht I (2003) Dok protein family members are involved in signaling mediated by the type 1 Fc epsilon receptor. Eur J Immunol 33:85–91

    CrossRef  PubMed  Google Scholar 

  • Adachi M, Miyachi T, Sekiya M, Hinoda Y, Yachi A, Imai K (1994) Structure of the human Lc-Ptp (Heptp) gene — similarity in genomic organization within protein-tyrosine-phosphatase genes. Oncogene 9:3031–3035

    PubMed  Google Scholar 

  • Adamczewski M, Numerof RP, Koretzky GA, Kinet JP (1995) Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta-and gamma-chains. J Immunol 154:3047–3055

    PubMed  Google Scholar 

  • Adams S, van der Laan LJW, Vernon-Wilson E, de Lavalette CR, Dopp EA, Dijkstra CD, Simmons DL, van den Berg TK (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 161:1853–1859

    PubMed  Google Scholar 

  • Arm JP, Gurish MF, Reynolds DS, Scott HC, Gartner CS, Austen KF, Katz HR (1991) Molecular-cloning of Gp49, a cell-surface antigen that is preferentially expressed by mouse mast-cell progenitors and is a new member of the immunoglobulin superfamily. J Biol Chem 266:15966–15973

    PubMed  Google Scholar 

  • Arm JP, Nwankwo C, Austen KF (1997) Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. J Immunol 159:2342–2349

    PubMed  Google Scholar 

  • Arudchandran R, Brown MJ, Peirce MJ, Song JS, Zhang J, Siraganian RP, Blank U, Rivera J (2000) The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med 191:47–60

    CrossRef  PubMed  Google Scholar 

  • Asai K, Kitaura J, Kawakami Y, Yamagata N, Tsai M, Carbone DP, Liu FT, Galli SJ, Kawakami T (2001) Regulation of mast cell survival by IgE. Immunity 14:791–800

    CrossRef  PubMed  Google Scholar 

  • Baird B, Sheets ED, Holowka D (1999) How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E? Biophys Chem 82:109–119

    CrossRef  PubMed  Google Scholar 

  • Bankaitis VA, Malehorn DE, Emr SD, Greene R (1989) The Saccharomyces-cerevisiae Sec14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi-complex. J Cell Biol 108:1271–1281

    CrossRef  PubMed  Google Scholar 

  • Barker SA, Caldwell KK, Hall A, Martinez AM, Pfeiffer JR, Oliver JM, Wilson BS (1995) Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking. Mol Biol Cell 6:1145–1158

    PubMed  Google Scholar 

  • Barker SA, Caldwell KK, Pfeiffer JR, Wilson BS (1998) Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells. Mol Biol Cell 9:483–496

    PubMed  Google Scholar 

  • Barsumian EL, Isersky C, Petrino MG, Siraganian RP (1981) IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. Eur J Immunol 11:317–323

    PubMed  Google Scholar 

  • Beaven MA, Metzger H (1993) Signal-transduction by Fc-receptors — the Fc-epsilon-RI case. Immunol Today 14:222–226

    CrossRef  PubMed  Google Scholar 

  • Bellon T, Kitzig F, Sayos J, Lopez-Botet M (2002) Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol 168:3351–3359

    PubMed  Google Scholar 

  • Berger SA, Mak TW, Paige CJ (1994) Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells. J Exp Med 180:471–476

    CrossRef  PubMed  Google Scholar 

  • Bieber T, Delasalle H, Wollenberg A, Hakimi J, Chizzonite R, Ring J, Hanau D, Delasalle C (1992) Human epidermal Langerhans cells express the high-affinity receptor for immunoglobulin-e (Fc-epsilon-RI). J Exp Med 175:1285–1290

    CrossRef  PubMed  Google Scholar 

  • Binsack R, Pecht I (1997) The mast cell function-associated antigen exhibits saccharide binding capacity. Eur J Immunol 27:2557–2561

    PubMed  Google Scholar 

  • Blaser C, Kaufmann M, Pircher H (1998) Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin. J Immunol 161:6451–6454

    PubMed  Google Scholar 

  • Blery M, Kubagawa H, Chen CC, Vely F, Cooper MD, Vivier E (1998) The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc Natl Acad Sci USA 95:2446–2451

    CrossRef  PubMed  Google Scholar 

  • Bolland S, Ravetch JV (1999) Inhibitory pathways triggered by ITIM-containing receptors. Adv Immunol 72:149–177

    PubMed  Google Scholar 

  • Borkowski TA, Jouvin MH, Lin SY, Kinet JP (2001) Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI. J Immunol 167:1290–1296

    PubMed  Google Scholar 

  • Brdicka T, Pavilstova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (2000) Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation. J Exp Med 191: 1591–1604

    CrossRef  PubMed  Google Scholar 

  • Brdickova N, Brdicka T, Andera L, Spicka J, Angelisova P, Milgram SL, Horejsi V (2001) Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. FEBS Lett 507:133–136

    CrossRef  PubMed  Google Scholar 

  • Butcher S, Arney KL, Cook GP (1998) MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. Eur J Immunol 28:3755–3762

    CrossRef  PubMed  Google Scholar 

  • Cambier JC (1995) New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL). Immunol Today 16:110

    CrossRef  Google Scholar 

  • Castells MC, Wu XY, Arm JP, Austen KF, Katz HR (1994) Cloning of the Gp49B gene of the immunoglobulin superfamily and demonstration that one of its 2 products is an early-expressed mast-cell surface protein originally described as Gp49. J Biol Chem 269:8393–8401

    PubMed  Google Scholar 

  • Castells MC, Klickstein LB, Hassani K, Cumplido JA, Lacouture ME, Austen KF, Katz HR (2001) gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. Nat Immunol 2:436–442

    PubMed  Google Scholar 

  • Chang EY, Szallasi Z, Acs P, Raizada V, Wolfe PC, Fewtrell C, Blumberg PM, Rivera J (1997) Functional effects of overexpression of protein kinase C-alpha,-beta,-delta,-epsilon, and-eta in the mast cell line RBL-2H3. J Immunol 159:2624–2632

    PubMed  Google Scholar 

  • Chen CC, Gartland GL, Kubagawa H, Cooper MD (1998) Cellular distribution and function of paired immunoglobulin-like receptors, PIR-A and PIR-B. FASEB J 12:A917

    Google Scholar 

  • Chong H, Vikis HG, Guan KL (2003) Mechanisms of regulating the Raf kinase family. Cell Signal 15:463–469

    CrossRef  PubMed  Google Scholar 

  • Chow LML, Fournel M, Davidson D, Veillette A (1993) Negative regulation of T-cell receptor signaling by tyrosine protein-kinase p50(csk). Nature 365:156–160

    CrossRef  PubMed  Google Scholar 

  • Cloutier JF, Veillette A (1996) Association of inhibitory tyrosine protein kinase p50(csk) with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J 15:4909–4918

    PubMed  Google Scholar 

  • Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, LopezBotet M (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186:1809–1818

    CrossRef  PubMed  Google Scholar 

  • Cooper JA, Howell B (1993) The when and how of Src regulation. Cell 73:1051–1054

    CrossRef  PubMed  Google Scholar 

  • Costello PS, Turner M, Walters AE, Cunningham CN, Bauer PH, Downward J, Tybulewicz VL (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13:2595–2605

    PubMed  Google Scholar 

  • Crocker PR (2002) Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling. Curr Opin Struct Biol 12:609–615

    CrossRef  PubMed  Google Scholar 

  • Crocker PR, Varki A (2001) Siglecs, sialic acids and innate immunity. Trends Immunol 22:337–342

    CrossRef  PubMed  Google Scholar 

  • Csonga R, Prieschl EE, Jaksche D, Novotny V, Baumruker T (1998) Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells. J Immunol 160:273–283

    PubMed  Google Scholar 

  • Daeron M (1997) Fc receptor biology. Annu Rev Immunol 15:203–234

    CrossRef  PubMed  Google Scholar 

  • Daeron M, Latour S, Malbec O, Espinosa E, Pina P, Pasmans S, Fridman WH (1995) The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 3:635–646

    CrossRef  PubMed  Google Scholar 

  • Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR (2001) Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med 194:227–234

    CrossRef  PubMed  Google Scholar 

  • Davidson D, Cloutier JF, Gregorieff A, Veillette A (1997) Inhibitory tyrosine protein kinase p50(csk) is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells. J Biol Chem 272:23455–23462

    CrossRef  PubMed  Google Scholar 

  • Deaglio S, Morra M, Mallone R, Ausiello CM, Prager E, Garbarino G, Dianzani U, Stockinger H, Malavasi F (1998) Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol 160:395–402

    PubMed  Google Scholar 

  • Dong C, Davis RJ, Flavell RA (2002) MAP kinases in the immune response. Annu Rev Immunol 20:55–72

    CrossRef  PubMed  Google Scholar 

  • Donnadieu E, Jouvin MH, Kinet JP (2000) A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit. Immunity 12:515–523

    CrossRef  PubMed  Google Scholar 

  • Donnadieu E, Jouvin MH, Rana S, Moffatt MF, Mockford EH, Cookson WO, Kinet JP (2003) Competing functions encoded in the allergy-associated F(c)epsilonRIbeta gene. Immunity 18:665–674

    CrossRef  PubMed  Google Scholar 

  • Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000) The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. Cell Signal 12:317–326

    CrossRef  PubMed  Google Scholar 

  • Eiseman E, Bolen JB (1992) Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355:78–80

    CrossRef  PubMed  Google Scholar 

  • Erdei A, Andreev S, Pecht I (1995) Complement peptide C3a inhibits IgE-mediated triggering of rat mucosal mast-cells. Int Immunol 7:1433–1439

    PubMed  Google Scholar 

  • Erdei A, Rong X, Ischenko A, Pecht I (1998) Inhibition of IgE-mediated triggering of mast cells by C3a; association of the complement-peptide with the beta-chain of Fc epsilon RI. Mol Immunol 35:413

    CrossRef  Google Scholar 

  • Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC (2001) Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J Biol Chem 276:4872–4878

    CrossRef  PubMed  Google Scholar 

  • Field KA, Holowka D, Baird B (1995) Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci USA 92:9201–9205

    PubMed  Google Scholar 

  • Field KA, Holowka D, Baird B (1997) Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J Biol Chem 272:4276–4280

    CrossRef  PubMed  Google Scholar 

  • Fleming TJ, Donnadieu E, Song CH, Laethem FV, Galli SJ, Kinet JP (1997) Negative regulation of Fc epsilon RI-mediated degranulation by CD81. J Exp Med 186:1307–1314

    CrossRef  PubMed  Google Scholar 

  • Fong DC, Malbec O, Arock M, Cambier JC, Fridman WH, Daeron M (1996) Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol Lett 54:83–91

    CrossRef  PubMed  Google Scholar 

  • Franklin CC, Sanchez V, Wagner F, Woodgett JR, Kraft AS (1992) Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Proc Natl Acad Sci USA 89:7247–7251

    PubMed  Google Scholar 

  • Fukamachi H, Takei M, Kawakami T (1993) Activation of multiple protein kinases including a MAP kinase upon Fc epsilon RI cross-linking. Int Arch Allergy Immunol 102:15–25

    PubMed  Google Scholar 

  • Furumoto Y, Nunomura S, Terada T, Rivera J, Ra C (2004) The FcepsilonRlbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J Biol Chem 279(47):49177–87

    CrossRef  PubMed  Google Scholar 

  • Galli SJ, Gordon JR, Wershil BK (1991) Cytokine production by mast-cells and basophils. Curr Opin Immunol 3:865–873

    CrossRef  PubMed  Google Scholar 

  • Garman SC, Kinet JP, Jardetzky TS (1998) Crystal structure of the human high-affinity IgE receptor. Cell 95:951–961

    CrossRef  PubMed  Google Scholar 

  • Gergely J, Pecht I, Sarmay G (1999) Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells. Immunol Lett 68:3–15

    CrossRef  PubMed  Google Scholar 

  • Ghannadan M, Hauswirth AW, Schernthaner GH, Muller MR, Klepetko W, Schatzl G, Sperr WR, Buhring HJ, Valent P (2002) Detection of novel CD antigens on the surface of human mast cells and basophils. Int Arch Allergy Immunol 127:299–307

    CrossRef  PubMed  Google Scholar 

  • Gibbs BF, Grabbe J (1999) Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. J Leuk Biol 65:883–890

    Google Scholar 

  • Gibbs BF, Plath KE, Wolff HH, Grabbe J (2002) Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. J Leukoc Biol 72:391–400

    PubMed  Google Scholar 

  • Gonzalez-Espinosa C, Odom S, Olivera A, Hobson JP, Martinez ME, Oliveira-Dos-Santos A, Barra L, Spiegel S, Penninger JM, Rivera J (2003) Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med 197:1453–1465

    CrossRef  PubMed  Google Scholar 

  • Gordon JR, Galli SJ (1991) Release of both preformed and newly synthesized tumor-necrosis-factor-alpha (TNF-alpha)/cachectin by mouse mast-cells stimulated via the Fc-epsilon-RI — a mechanism for the sustained action of mast-cell derived TNF-alpha during IgE-dependent biological responses. J Exp Med 174:103–107

    CrossRef  PubMed  Google Scholar 

  • Gordon JR, Burd PR, Galli SJ (1990) Mast-cells as a source of multifunctional cytokines. Immunol Today 11:458–464

    CrossRef  PubMed  Google Scholar 

  • Gounni AS, Lamkhioued B, Kinet JP, Capron A, Capron M (1994) Expression of the high-affinity receptor for IgE (Fc-epsilon-RI) by human eosinophils. FASEB J 8:A979

    Google Scholar 

  • Graham TE, Pfeiffer JR, Lee RJ, Kusewitt DF, Martinez AM, Foutz T, Wilson BS, Oliver JM (1998) MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranyl-geranylated and farnesylated proteins in Fc epsilonRI-mediated signaling. J Immunol 161:6733–6744

    PubMed  Google Scholar 

  • Gronda M, Arab S, Iafrate B, Suzuki H, Zanke BW (2001) Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Mol Cell Biol 21:6851–6858

    CrossRef  PubMed  Google Scholar 

  • Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG (2001) Essential role for Gab2 in the allergic response. Nature 412:186–190

    CrossRef  PubMed  Google Scholar 

  • Gu HH, Pratt JC, Burakoff SJ, Neel BG (1998) Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell 2:729–740

    CrossRef  PubMed  Google Scholar 

  • Gu MX, Warshawsky I, Majerus PW (1992) Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast Sec14P. Proc Natl Acad Sci USA 89:2980–2984

    PubMed  Google Scholar 

  • Gu XG, Laouar A, Wan JM, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N (2003) The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. J Immunol 170:4095–4101

    PubMed  Google Scholar 

  • Gupta S, Campbell D, Derijard B, Davis RJ (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389–393

    PubMed  Google Scholar 

  • Guthmann MD, Tal M, Pecht I (1995) A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin. Proc Natl Acad Sci USA 92:9397–9401

    PubMed  Google Scholar 

  • Hamaguchi T, Takahashi A, Manaka A, Sato M, Osada H (2001) TU-572, a potent and selective CD45 inhibitor, suppresses IgE-mediated anaphylaxis and murine contact hypersensitivity reactions. Int Arch Allergy Immunol 126:318–324

    CrossRef  PubMed  Google Scholar 

  • Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson GS, Dunn AR, Hibbs ML (2001) Gain-and loss-of-function Lyn mutant mice define a critical inhibitory role of Lyn in the myeloid lineage. Immunity 15:603–615

    CrossRef  PubMed  Google Scholar 

  • Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H (1994) Functional-analysis of Csk in signal-transduction through the B-cell antigen receptor. Mol Cell Biol 14:7306–7313

    PubMed  Google Scholar 

  • Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, Witte ON, Kawakami T (1998a) Involvement of Bruton’s tyrosine kinase in Fc epsilon RI-dependent mast cell degranulation and cytokine production. J Exp Med 187:1235–1247

    CrossRef  PubMed  Google Scholar 

  • Hata D, Kitaura J, Hartman SE, Kawakami Y, Yokota T, Kawakami T (1998b) Bruton’s tyrosine kinase-mediated interleukin-2 gene activation in mast cells — dependence on the c-Jun N-terminal kinase activation pathway. J Biol Chem 273:10979–10987

    CrossRef  PubMed  Google Scholar 

  • Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inui M, Ohyama Y, Hikida M, Ohmori H, Takai T (1997) Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem 272:7320–7327

    CrossRef  PubMed  Google Scholar 

  • Heissmeyer V, Macian F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nature Immunol 5:255–265

    CrossRef  Google Scholar 

  • Helm B, Marsh P, Vercelli D, Padlan E, Gould H, Geha R (1988) The mast cell binding site on human immunoglobulin E. Nature 331:180–183

    CrossRef  PubMed  Google Scholar 

  • Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA (1997) SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. J Biol Chem 272:1363–1367

    CrossRef  PubMed  Google Scholar 

  • Hiraoka S, Furumoto Y, Koseki H, Takagaki Y, Taniguchi M, Okumura K, Ra C (1999) Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. Int Immunol 11:199–207

    CrossRef  PubMed  Google Scholar 

  • Hirasawa N, Sato Y, Fujita Y, Ohuchi K (2000) Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells. Biochim Biophys Acta 1456:45–55

    PubMed  Google Scholar 

  • Ho LH, Uehara T, Chen CC, Kubagawa H, Cooper MD (1999) Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci USA 96:15086–15090

    CrossRef  PubMed  Google Scholar 

  • Honda Z, Suzuki T, Hirose N, Aihara M, Shimizu T, Nada S, Okada M, Ra C, Morita Y, Ito K (1997) Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling. J Biol Chem 272:25753–25760

    CrossRef  PubMed  Google Scholar 

  • Honda Z, Suzuki T, Kono H, Okada M, Yamamoto T, Ra C, Morita Y, Yamamoto K (2000) Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling. Mol Cell Biol 20:1759–1771

    CrossRef  PubMed  Google Scholar 

  • Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, Yamamoto T (1999) Distinctive roles of Fyn and Lyn in IgD-and IgM-mediated signaling. Int Immunol 11:1441–1449

    CrossRef  PubMed  Google Scholar 

  • Hsu C, MacGlashan D (1996) IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells. Immunol Lett 52:129–134

    CrossRef  PubMed  Google Scholar 

  • Hua CT, Gamble JR, Vadas MA, Jackson DE (1998) Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1) — identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. J Biol Chem 273:28332–28340

    CrossRef  PubMed  Google Scholar 

  • Huber M, Helgason CD, Damen JE, Liu L, Humphries RK, Krystal G (1998) The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci USA 95:11330–11335

    CrossRef  PubMed  Google Scholar 

  • Huynh H, Wang XD, Li WH, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T (2003) Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. J Immunol 171:6661–6671

    PubMed  Google Scholar 

  • Ishizuka T, Oshiba A, Sakata N, Terada N, Johnson GL, Gelfand EW (1996) Aggregation of the FcepsilonRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin. J Biol Chem 271:12762–12766

    CrossRef  PubMed  Google Scholar 

  • Ishizuka T, Chayama K, Takeda K, Hamelmann E, Terada N, Keller GM, Johnson GL, Gelfand EW (1999) Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells. J Immunol 162:2087–2094

    PubMed  Google Scholar 

  • Jabril-Cuenod B, Zhang C, Scharenberg AM, Paolini R, Numerof R, Beaven MA, Kinet JP (1996) Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J Biol Chem 271:16268–16272

    CrossRef  PubMed  Google Scholar 

  • Jackson DE (2003) The unfolding tale of PECAM-1. FEBS Lett 540:7–14

    CrossRef  PubMed  Google Scholar 

  • James LC, Tawfik DS (2003) The specificity of cross-reactivity: promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness. Protein Sci 12:2183–2193

    CrossRef  PubMed  Google Scholar 

  • James LC, Roversi P, Tawfik DS (2003) Antibody multispecificity mediated by conformational diversity. Science 299:1362–1367

    CrossRef  PubMed  Google Scholar 

  • Janknecht R, Hunter T (1997) Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem 272:4219–4224

    CrossRef  PubMed  Google Scholar 

  • Jensen WA, Marschner S, Ott VL, Cambier JC (2001) FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. Biochem Soc Trans 29:840–846

    CrossRef  PubMed  Google Scholar 

  • Jiang PH, Lagenaur CF, Narayanan V (1999) Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274:559–562

    CrossRef  PubMed  Google Scholar 

  • Joazeiro CAP, Wing SS, Huang HK, Leverson JD, Hunter T, Liu YC (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309–312

    CrossRef  PubMed  Google Scholar 

  • Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911–1912

    CrossRef  PubMed  Google Scholar 

  • Joseph M, Gounni AS, Kusnierz JP, Vorng H, Sarfati M, Kinet JP, Tonnel AB, Capron A, Capron M (1997) Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors. Eur J Immunol 27:2212–2218

    PubMed  Google Scholar 

  • Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G (2001) Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14:801–811

    CrossRef  PubMed  Google Scholar 

  • Kalesnikoff J, Baur N, Leitges M, Hughes MR, Damen JE, Huber M, Krystal G (2002) SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol 168:4737–4746

    PubMed  Google Scholar 

  • Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF (1996) Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc Natl Acad Sci USA 93:10809–10814

    CrossRef  PubMed  Google Scholar 

  • Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M (2000) Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 404:999–1003

    CrossRef  PubMed  Google Scholar 

  • Kawakami Y, Yao L, Miura T, Tsukada S, Witte ON, Kawakami T (1994) Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking. Mol Cell Biol 14: 5108–5113

    PubMed  Google Scholar 

  • Kawakami Y, Yao L, Han W, Kawakami T (1996) Tec family protein-tyrosine kinases and pleckstrin homology domains in mast cells. Immunol Lett 54:113–7

    CrossRef  PubMed  Google Scholar 

  • Kawakami Y, Miura T, Bissonnette R, Hata D, Khan WN, Kitamura T, Maeda-Yamamoto M, Hartman SE, Yao L, Alt FW, Kawakami T (1997) Bruton’s tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc Natl Acad Sci USA 94:3938–3942

    CrossRef  PubMed  Google Scholar 

  • Kawakami Y, Kitaura J, Hata D, Yao LB, Kawakami T (1999) Functions of Bruton’s tyrosine kinase in mast and B cells. J Leukoc Biol 65:286–290

    PubMed  Google Scholar 

  • Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T (2000a) Regulation of protein kinase Cbetal by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci USA 97:7423–7428

    CrossRef  PubMed  Google Scholar 

  • Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T (2000b) Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol 165:1210–1219

    PubMed  Google Scholar 

  • Keane MM, Riverolezcano OM, Mitchell JA, Robbins KC, Lipkowitz S (1995) Cloning and characterization of Cbl-B — a Sh3 binding-protein with homology to the c-Cbl protooncogene. Oncogene 10:2367–2377

    PubMed  Google Scholar 

  • Keegan AD, Paul WE (1992) Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol Today 13:63–68

    CrossRef  PubMed  Google Scholar 

  • Kharitonenkov A, Chen ZJ, Sures I, Wang HY, Schilling J, Ullrich A (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181–186

    CrossRef  PubMed  Google Scholar 

  • Kihara H, Siraganian RP (1994) Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J Biol Chem 269:22427–22432

    PubMed  Google Scholar 

  • Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D’alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR, Tachimoto H, Schleimer RP, White JR (2000) Identification of SAF-2, a novel Siglec expressed on eosinophils, mast cells, and basophils. J Allergy Clin Immunol 105:1093–1100

    CrossRef  PubMed  Google Scholar 

  • Kimata M, Inagaki N, Kato T, Miura T, Serizawa I, Nagai H (2000) Roles of mitogen-activated protein kinase pathways for mediator release from human cultured mast cells. Biochem Pharmacol 60:589–594

    CrossRef  PubMed  Google Scholar 

  • Kimura T, Sakamoto H, Appella E, Siraganian RP (1997a) The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J Biol Chem 272:13991–13996

    CrossRef  PubMed  Google Scholar 

  • Kimura T, Zhang J, Sagawa K, Sakaguchi K, Appella E, Siraganian RP (1997b) Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. J Immunol 159:4426–4434

    PubMed  Google Scholar 

  • Kinet JP (1999) The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu Rev Immunol 17:931–972

    CrossRef  PubMed  Google Scholar 

  • Kitaura J, Asai K, Maeda-Yamamoto M, Kawakami Y, Kikkawa U, Kawakami T (2000) Akt-dependent cytokine production in mast cells. J Exp Med 192:729–740

    CrossRef  PubMed  Google Scholar 

  • Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T (2003) Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci USA 100:12911–12916

    CrossRef  PubMed  Google Scholar 

  • Kraft S, Katoh N, Novak N, Koch S, Bieber T (2001) Unexpected functions of FcepsilonRI on antigen-presenting cells. Int Arch Allergy Immunol 124:35–37

    CrossRef  PubMed  Google Scholar 

  • Kraft S, Novak N, Katoh N, Bieber T, Rupec RA (2002a) Aggregation of the high-affinity IgE receptor Fc epsilon RI on human monocytes and dendritic cells induces NF-kappa B activation. J Invest Dermatol 118:830–837

    CrossRef  PubMed  Google Scholar 

  • Kraft S, Wessendorf JHM, Haberstok J, Novak N, Wollenberg A, Bieber T (2002b) Enhanced expression and activity of protein-tyrosine kinases establishes a functional signaling pathway only in Fc epsilon RIhigh Langerhans cells from atopic individuals. J Invest Dermatol 119:804–811

    CrossRef  PubMed  Google Scholar 

  • Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz O, Kinet JP (2005) Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 201(3):385–396

    CrossRef  PubMed  Google Scholar 

  • Kubagawa H, Burrows PD, Coopers MD (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci USA 94:5261–5266

    CrossRef  PubMed  Google Scholar 

  • Kubagawa H, Chen CC, Ho LH, Shimada T, Gartland L, Mashburn C, Uehara T, Ravetch JV, Cooper MD (1999) Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. J Exp Med 189:309–317

    CrossRef  PubMed  Google Scholar 

  • Kubo S, Matsuoka K, Taya C, Kitamura F, Takai T, Yonekawa H, Karasuyama H (2001) Drastic up-regulation of Fc epsilon RI on mast cells is induced by IgE binding through stabilization and accumulation of Fc epsilon RI on the cell surface. J Immunol 167:3427–3434

    PubMed  Google Scholar 

  • Kumagai H, Oki T, Tamitsu K, Feng SZ, Ono M, Nakajima H, Bao YC, Kawakami Y, Nagayoshi K, Copeland NG, Gilbert DJ, Jenkins NA, Kawakami T, Kitamura T (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun 307:719–729

    CrossRef  PubMed  Google Scholar 

  • Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, Matsuda Y, Takai T (1998) Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene. J Biol Chem 273:1070–1074

    CrossRef  PubMed  Google Scholar 

  • Kyo S, Sada K, Qu X, Maeno K, Miah SM, Kawauchi-Kamata K, Yamamura H (2003) Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc aepsilon RI-mediated mast cell activation. Genes Cells 8:825–836

    CrossRef  PubMed  Google Scholar 

  • Latour S, Veillette A (2001) Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol 13:299–306

    CrossRef  PubMed  Google Scholar 

  • Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ, Maliszewski C, Lindberg FP, Oldenborg A, Ullrich A, Delespesse G, Sarfati M (2001) Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol 167:2547–2554

    PubMed  Google Scholar 

  • Letourneur F, Klausner RD (1991) T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta-family proteins. Proc Natl Acad Sci USA 88:8905–8909

    PubMed  Google Scholar 

  • Lewis RA, Soter NA, Diamond PT, Austen KF, Oates JA, Roberts LJ (1982) Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol. 129:1627–1631

    PubMed  Google Scholar 

  • Liang SY, Baibakov B, Horuzsko A (2002) HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor. Eur J Immunol 32:2418–2426

    CrossRef  PubMed  Google Scholar 

  • Licht A, Pecht I, Schweitzer-Stenner R (2005) Regulation of mast cells’ secretory response by co-clustering the Type I Fcɛ receptor with the mast cell function-associated antigen. Europ J Immunol 35

    Google Scholar 

  • Lienard H, Bruhns P, Malbec O, Fridman WH, Daeron M (1999) Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation. J Biol Chem 274:32493–32499

    CrossRef  PubMed  Google Scholar 

  • Lin S, Cicala C, Scharenberg AM, Kinet JP (1996) The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals. Cell 85:985–995

    CrossRef  PubMed  Google Scholar 

  • Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S, Bouchard D, Jones J, Sarao R, Kozieradzki I, Ohashi PS, Penninger JM, Dumont DJ (1998) The inositol polyphosphate 5-phosphatase SHIP is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med 188:1333–1342

    CrossRef  PubMed  Google Scholar 

  • Livingstone C, Patel G, Jones N (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 14:1785–1797

    PubMed  Google Scholar 

  • Lock P, Casagranda F, Dunn AR (1999) Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J Biol Chem 274:22775–22784

    CrossRef  PubMed  Google Scholar 

  • Lu TT, Barreuther M, Davis S, Madri JA (1997) Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties. J Biol Chem 272:14442–14446

    CrossRef  PubMed  Google Scholar 

  • Lu-Kuo JM, Joyal D, Chambers J, Xu NN, Austen KF, Katz HR (1998) gp49B1 associates with the SHP-1 tyrosine phosphatase and inhibits activating signal transduction in mouse mast cells. FASEB J 12:A1061

    Google Scholar 

  • Lu-Kuo JM, Joyal DM, Austen KF, Katz HR (1999) gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. J Biol Chem 274:5791–5796

    CrossRef  PubMed  Google Scholar 

  • Maeda A, Kurosaki M, Ono M, Takai T, Kurosaki T (1998) Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. J Exp Med 187:1355–1360

    CrossRef  PubMed  Google Scholar 

  • Maeda A, Scharenberg AM, Tsukada S, Bolen JB, Kinet JP, Kurosaki T (1999) Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene 18:2291–2297

    CrossRef  PubMed  Google Scholar 

  • Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375–13378

    CrossRef  PubMed  Google Scholar 

  • Malaviya R, Abraham SN (2001) Mast cell modulation of immune responses to bacteria. Immunol Rev 179:16–24

    CrossRef  PubMed  Google Scholar 

  • Malbec O, Fong DC, Turner M, Tybulewicz VL, Cambier JC, Fridman WH, Daeron M (1998) Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol 160:1647–1658

    PubMed  Google Scholar 

  • Malbec O, Fridman WH, Daeron M (1999) Negative regulation of c-kit-mediated cell proliferation by Fc gamma RIIB. J Immunol 162:4424–4429

    PubMed  Google Scholar 

  • Manetz TS, Gonzalez-Espinosa C, Arudchandran R, Xirasagar S, Tybulewicz V, Rivera J (2001) Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Mol Cell Biol 21:3763–3774

    CrossRef  PubMed  Google Scholar 

  • Marmor MD, Yarden Y (2004) Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23:2057–2070

    CrossRef  PubMed  Google Scholar 

  • Martelli MP, Boomer J, Bu M, Bierer BE (2001) T cell regulation of p62(dok) (Dok1) association with Crk-L. J Biol Chem 276:45654–45661

    CrossRef  PubMed  Google Scholar 

  • Martin A, Tsui HW, Shulman MJ, Isenman D, Tsui FWL (1999) Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains — implications for the SH2-mediated intramolecular regulation of SHP-1. J Biol Chem 274:21725–21734

    CrossRef  PubMed  Google Scholar 

  • Masuda A, Yoshikai Y, Aiba K, Matsuguchi T (2002) Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways. J Immunol 169:3801–3810

    PubMed  Google Scholar 

  • Matsumoto Y, Wang LL, Yokoyama WM, Aso T (2001) Uterine macrophages express the gp49B inhibitory receptor in midgestation. J Immunol 166:781–786

    PubMed  Google Scholar 

  • Matthews RJ, Bowne DB, Flores E, Thomas ML (1992) Characterization of hematopoietic intracellular protein tyrosine phosphatases — description of a phosphatase containing an Sh2 domain and another enriched in proline-rich, glutamic acid-rich, serine-rich, and threonine-rich sequences. Mol Cell Biol 12:2396–2405

    PubMed  Google Scholar 

  • Maurer D, Rieger A, Kilgus O, Reininger B, Ochiai K, Kinet JP, Stingl G (1993) Human peripheral-blood monocytes express the high-affinity IgE receptor Fc-epsilon-RI. J Immunol 150:A222

    Google Scholar 

  • Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G (1995) The high-affinity IgE receptor (Fc-epsilon-RI) mediates IgE-dependent allergen presentation. J Immunol 154:6285–6290

    PubMed  Google Scholar 

  • Maurer D, Ebner C, Reininger B, Fiebiger E, Fischer GF, Wichlas S, Kinet JP, Stingl G (1996) Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha-and Fc epsilon RI gamma-chains and use this receptor for IgE-mediated allergen presentation. J Invest Dermatol 106:739

    CrossRef  PubMed  Google Scholar 

  • McCormick MJ, Castells MC, Austen KF, Katz HR (1999) The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. Immunogenetics 50:286–294

    CrossRef  PubMed  Google Scholar 

  • Metzger H (1992) The receptor with high affinity for IgE. Immunol Rev 125:37–48

    PubMed  Google Scholar 

  • Miura K, MacGlashan DW (2000) Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils. Blood 96:2199–2205

    PubMed  Google Scholar 

  • Miura K, Schroeder JT, Hubbard WC, MacGlashan DW Jr (1999) Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. J Immunol 162:4198–4206

    PubMed  Google Scholar 

  • Muraille E, Bruhns P, Pesesse X, Daeron M, Erneux C (2000) The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. Immunol Lett 72:7–15

    CrossRef  PubMed  Google Scholar 

  • Murakami K, Sato S, Nagasawa S, Yamashita T (2000) Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase. Int Immunol 12:169–176

    CrossRef  PubMed  Google Scholar 

  • Nada S, Okada M, Macauley A, Cooper JA, Nakagawa H (1991) Cloning of a complementary-DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of P60C-Src. Nature 351:69–72

    CrossRef  PubMed  Google Scholar 

  • Nadler MJ, Matthews SA, Turner H, Kinet JP (2000) Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function. Adv Immunol 76:325–355

    PubMed  Google Scholar 

  • Navarro F, Llano M, Bellon T, Colonna M, Geraghty DE, Lopez-Botet M (1999) The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol 29:277–283

    CrossRef  PubMed  Google Scholar 

  • Nishizumi H, Yamamoto T (1997) Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol 158:2350–2355

    PubMed  Google Scholar 

  • Numahata K, Komagata T, Hirasawa N, Someya K, Xiao YQ, Ohuchi K (2003) Analysis of the mechanism regulating the stability of rat macrophage inflammatory protein-2 mRNA in RBL-2H3 cells. J Cell Biochem 90:976–986

    CrossRef  PubMed  Google Scholar 

  • Nutku E, Aizawa H, Hudson SA, Bochner BS (2003) Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 101:5014–5020

    CrossRef  PubMed  Google Scholar 

  • Ohtake H, Ichikawa N, Okada M, Yamashita T (2002) Cutting edge: transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI. J Immunol 168:2087–2090

    PubMed  Google Scholar 

  • Oka T, Hori M, Tanaka A, Matsuda H, Karaki H, Ozaki H (2004) IgE alone-induced actin assembly modifies calcium signaling and degranulation in RBL-2H3 mast cells. Am J Physiol Cell Physiol 286:C256–C263

    CrossRef  PubMed  Google Scholar 

  • Ono M, Bolland S, Tempst P, Ravetch JV (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 383:263–266

    CrossRef  PubMed  Google Scholar 

  • Ortega SE, Pecht I (1988) A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component. J Immunol 141:4324–4332

    PubMed  Google Scholar 

  • Osborne MA, Zenner G, Lubinus M, Zhang XL, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP (1996) The inositol 5′-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J Biol Chem 271:29271–29278

    CrossRef  PubMed  Google Scholar 

  • Oshima K, Amin ARMR, Suzuki A, Hamaguchi M, Matsuda S (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett 519:1–7

    CrossRef  PubMed  Google Scholar 

  • Ota Y, Samelson LE (1997) The product of the proto-oncogene c-Cbl: a negative regulator of the Syk tyrosine kinase. Science 276:418–420

    CrossRef  PubMed  Google Scholar 

  • Ota Y, Beitz LO, Scharenberg AM, Donovan JA, Kinet JP, Samelson LE (1996) Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J Exp Med 184:1713–1723

    CrossRef  PubMed  Google Scholar 

  • Ott VL, Tamir I, Niki M, Pandolfi PP, Cambier JC (2002) Downstream of kinase, p62(dok), is a mediator of Fc gamma RIIB inhibition of Fc epsilon RI signaling. J Immunol 168:4430–4439

    PubMed  Google Scholar 

  • Ozawa K, Yamada K, Kazanietz MG, Blumberg PM, Beaven MA (1993) Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J Biol Chem 268:2280–2283

    PubMed  Google Scholar 

  • Pandey V, Mihara S, Fensome-Green A, Bolsover S, Cockcroft S (2004) Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca(2+), degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J Immunol 172:4048–4058

    PubMed  Google Scholar 

  • Paolini R, Jouvin MH, Kinet JP (1991) Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin-e immediately after receptor engagement and disengagement. Nature 353:855–858

    CrossRef  PubMed  Google Scholar 

  • Paolini R, Molfetta R, Beitz LO, Zhang J, Scharenberg AM, Piccoli M, Frati L, Siraganian R, Santoni A (2002) Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. J Biol Chem 277:36940–36947

    CrossRef  PubMed  Google Scholar 

  • Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez-Espinosa C, Furumoto Y, Saitoh S, Samelson LE, O’shea JJ, Rivera J (2002) Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3:741–748

    PubMed  Google Scholar 

  • Pesesse X, Deleu S, De SF, Drayer L, Erneux C (1997) Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. Biochem Biophys Res Commun 239:697–700

    CrossRef  PubMed  Google Scholar 

  • Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C (1998) The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. FEBS Lett 437:301–303

    CrossRef  PubMed  Google Scholar 

  • Phillips NE, Parker DC (1984) Cross-linking of B lymphocyte Fc gamma receptors and membrane immunoglobulin inhibits anti-immunoglobulin-induced blastogenesis. J Immunol 132:627–632

    PubMed  Google Scholar 

  • Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA (1995) Cd31/Pecam-1 is a ligand for alpha(v)beta(3) integrin involved in adhesion of leukocytes to endothelium. J Cell Biol 130:451–460

    CrossRef  PubMed  Google Scholar 

  • Pivniouk VI, Martin TR, Lu-Kuo JM, Katz HR, Oettgen HC, Geha RS (1999) SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest 103:1737–1743

    PubMed  Google Scholar 

  • Pratt JC, Igras VE, Maeda H, Baksh S, Gelfand EW, Burakoff SJ, Neel BG, Gu HH (2000) Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling. J Immunol 165:4158–4163

    PubMed  Google Scholar 

  • Pribluda VS, Pribluda C, Metzger H (1994) Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci USA 91:11246–11250

    PubMed  Google Scholar 

  • Prieschl EE, Pendl GG, Harrer NE, Baumruker T (1995) P21(Ras) links Fc-epsilon-RI to NF-AT family member in mast-cells — the Ap3-like factor in this cell-type is an NF-AT family member. J Immunol 155:4963–4970

    PubMed  Google Scholar 

  • Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991) Phosphorylation of c-Jun mediated by MAP kinases. Nature 353:670–674

    CrossRef  PubMed  Google Scholar 

  • Qu X, Sada K, Kyo S, Maeno K, Miah SM, Yamamura H (2004) Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood 103:1779–1786

    CrossRef  PubMed  Google Scholar 

  • Rao N, Dodge I, Band H (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leuk Biol 71:753–763

    Google Scholar 

  • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin SQ, Kato RM, Fluckiger AC, Witte ON, Kinet JP (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822–825

    PubMed  Google Scholar 

  • Razin E, Mencia-Huerta JM, Stevens RL, Lewis RA, Liu FT, Corey E, Austen KF (1983) IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells. J Exp Med 157:189–201

    CrossRef  PubMed  Google Scholar 

  • Razin E, Szallasi Z, Kazanietz MG, Blumberg PM, Rivera J (1994) Protein-kinases C-beta and C-epsilon link the mast-cell high-affinity receptor for IgE to the expression of C-Fos and C-Jun. Proc Natl Acad Sci USA 91:7722–7726

    PubMed  Google Scholar 

  • Reth M (1989) Antigen receptor tail clue. Nature 338:383–384

    CrossRef  PubMed  Google Scholar 

  • Roach TI, White L, Thomas ML, Lowell C, Lagenaur C, Brown EJ (1999) Myeloid src family kinases are required for PIR-B and BIT phosphorylation in primary macrophages. Mol Biol Cell 10:319A

    Google Scholar 

  • Robbins SH, Nguyen KB, Takahashi N, Mikayama T, Biron CA, Brossay L (2002) Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J Immunol 168:2585–2589

    PubMed  Google Scholar 

  • Rojo S, Burshtyn DN, Long EO, Wagtmann N (1997) Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J Immunol 158:9–12

    PubMed  Google Scholar 

  • Rolli V, Gallwitz M, Wossning T, Flemming A, Schamel WWA, Zurn C, Reth M (2002) Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell 10:1057–1069

    CrossRef  PubMed  Google Scholar 

  • Rudge EU, Cutler AJ, Pritchard NR, Smith KGC (2002) Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression. J Exp Med 195:1079–1085

    CrossRef  PubMed  Google Scholar 

  • Sagawa K, Kimura T, Swieter M, Siraganian RP (1997a) The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). J Biol Chem 272:31086–31091

    CrossRef  PubMed  Google Scholar 

  • Sagawa K, Swaim W, Zhang J, Unsworth E, Siraganian RP (1997b) Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). J Biol Chem 272:13412–13418

    CrossRef  PubMed  Google Scholar 

  • Sagi-Eisenberg R, Lieman H, Pecht I (1985) Protein kinase-C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukemia-cells. Nature 313:59–61

    CrossRef  PubMed  Google Scholar 

  • Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL (2003) BTK regulates Ptdlns-4,5-P-2 synthesis: importance for calcium signaling and PI3 K activity. Immunity 19:669–678

    CrossRef  PubMed  Google Scholar 

  • Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity 12:525–535

    CrossRef  PubMed  Google Scholar 

  • Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CIE, Driscoll PC, Waterfield MD, Panayotou G (1996) Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton’s tyrosine kinase. EMBO J 15:6241–6250

    PubMed  Google Scholar 

  • Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ (2002) Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11. Bio Med Central Immunol 3:5

    Google Scholar 

  • Scharenberg AM, Lin S, Cuenod B, Yamamura H, Kinet JP (1995) Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J 14:3385–3394

    PubMed  Google Scholar 

  • Scheid MP, Woodgett JR (2003) Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546:108–112

    CrossRef  PubMed  Google Scholar 

  • Schneider H, Cohen-Dayag A, Pecht I (1992) Tyrosine phosphorylation of phospholipase C gamma 1 couples the Fc epsilon receptor mediated signal to mast cells secretion. Int Immunol 4:447–453

    PubMed  Google Scholar 

  • Schweitzer-Stenner R, Pecht I (2005) Death of a dogma or enforcing the artificial: monomeric IgE binding may initiate mast cell response by inducing its receptor aggregation. J Immunol 174:4461–4464

    PubMed  Google Scholar 

  • Seiffert M, Brugger W, Kanz L, Ullrich A, Buhring HJ (1999) Human SIRP alpha 1 is an extracellular ligand for CD47 and is involved in transendothelial and transepithelial migration of neutrophils. Exp Hematol 27:41

    Google Scholar 

  • Siraganian RP, Urata C, McGivney A (1983) Arachidonic acid release during IgE-and Ca2+-ionophore activation of rat basophilic leukemia cells. Monogr Allergy 18:120–123

    PubMed  Google Scholar 

  • Siraganian RP, Zhang J, Suzuki K, Sada K (2002) Protein tyrosine kinase Syk in mast cell signaling. Mol Immunol 38:1229–1233

    CrossRef  PubMed  Google Scholar 

  • Sloane DE, Tedla N, Awoniyi M, MacGlashan DW, Borges L, Austen KF, Arm JP (2004) Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 104:2832–2839

    CrossRef  PubMed  Google Scholar 

  • Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M (1991) Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354:494–496

    CrossRef  PubMed  Google Scholar 

  • Sohn HW, Gu H, Pierce SK (2003) Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med 197:1511–1524

    CrossRef  PubMed  Google Scholar 

  • Song JS, Haleem-Smith H, Arudchandran R, Gomez J, Scott PM, Mill JF, Tan TH, Rivera J (1999) Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. J Immunol 163:802–810

    PubMed  Google Scholar 

  • Stingl G, Maurer D (1997) IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells. Int Arch Allergy Immunol 113:24–29

    PubMed  Google Scholar 

  • Sun J, Williams J, Yan HC, Amin KM, Albelda SM, DeLisser HM (1996) Platelet endothelial cell adhesion molecule-1 (PECAM-1) hemophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem 271:18561–18570

    CrossRef  PubMed  Google Scholar 

  • Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995) Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP. J Biol Chem 270:21902–21906

    CrossRef  PubMed  Google Scholar 

  • Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379:346–349

    CrossRef  PubMed  Google Scholar 

  • Tamir I, Stolpa JC, Helgason CD, Nakamura K, Bruhns P, Daeron M, Cambier JC (2000) The Ras-GAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity 12:347–358

    CrossRef  PubMed  Google Scholar 

  • Taniguchi T, Kobayashi T, Kondo J, Takahashi K, Nakamura H, Suzuki J, Nagai K, Yamada T, Nakamura S, Yamamura H (1991) Molecular-cloning of a porcine gene Syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem 266:15790–15796

    PubMed  Google Scholar 

  • Tedla NT, Tassinari P, Samplaski M, Austen FK, Borges L, Cosman D, Arm JP (2001) Leukocyte immunoglobulin-like receptors expressed in eosinophils and basophils. FASEB J 15:A701

    Google Scholar 

  • Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind JS (1997) Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem 272:10751–10755

    CrossRef  PubMed  Google Scholar 

  • Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem 278:48474–48484

    CrossRef  PubMed  Google Scholar 

  • Toker A, Newton AC (2000) Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275:8271–8274

    CrossRef  PubMed  Google Scholar 

  • Turner H, Cantrell DA (1997) Distinct Ras effector pathways are involved in Fc epsilon R1 regulation of the transcriptional activity of Elk-1 and NFAT in mast cells. J Exp Med 185:43–53

    CrossRef  PubMed  Google Scholar 

  • Turner H, Kinet JP (1999) Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 402:24–30

    CrossRef  Google Scholar 

  • Uehara T, Blery M, Kang DW, Chen CC, Ho LH, Gartland GL, Liu FT, Vivier E, Cooper MD, Kubagawa H (2001) Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B. J Clin Invest 108:1041–1050

    CrossRef  PubMed  Google Scholar 

  • Valent P, Ashman LK, Hinterberger W, Eckersberger F, Majdic O, Lechner K, Bettelheim P (1989) Mast-cell typing — demonstration of a distinct hematopoietic-cell type and evidence for immunophenotypic relationship to mononuclear phagocytes. Blood 73:1778–1785

    PubMed  Google Scholar 

  • Veillette A, Thibaudeau E, Latour S (1998) High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J Biol Chem 273:22719–22728

    CrossRef  PubMed  Google Scholar 

  • Vernon-Wilson EF, Kee WJ, Willis AC, Barclay AN, Simmons DL, Brown MH (2000) CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRP alpha 1. Eur J Immunol 30:2130–2137

    PubMed  Google Scholar 

  • Voehringer D, Blaser C, Brawand P, Raulet DH, Hanke T, Pircher H (2001) Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol 167:4838–4843

    PubMed  Google Scholar 

  • Voehringer D, Koschella M, Pircher H (2002) Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100:3698–3702

    CrossRef  PubMed  Google Scholar 

  • Vonakis BM, Chen HX, Haleem-Smith H, Metzger H (1997) The SH4 domain of lyn kinase is constitutively associated with the high affinity receptor for IgE (Fc epsilon RI). J Allergy Clin Immunol 99:1653

    Google Scholar 

  • Vonakis BM, Haleem-Smith H, Benjamin P, Metzger H (2001) Interaction between the unphosphorylated receptor with high affinity for IgE and Lyn kinase. J Biol Chem 276:1041–1050

    CrossRef  PubMed  Google Scholar 

  • Wang B, Rieger A, Kilgus O, Ochiai K, Maurer D, Fodinger D, Kinet JP, Stingl G (1992) Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc-epsilon-RI. J Exp Med 175:1353–1365

    CrossRef  PubMed  Google Scholar 

  • Wang JY, Koizumi T, Watanabe T (1996) Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med 184:831–838

    CrossRef  PubMed  Google Scholar 

  • Wang LL, Mehta IK, LeBlanc PA, Yokoyama WM (1997) Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors. J Immunol 158:13–17

    PubMed  Google Scholar 

  • Wang LL, Chu DT, Dokun AO, Yokoyama WM (2000) Inducible expression of the gp49B inhibitory receptor on NK cells. J Immunol 164:5215–5220

    PubMed  Google Scholar 

  • Wang X, Huynh H, Gjorloff-Wingren A, Monosov E, Stridsberg M, Fukuda M, Mustelin T (2002) Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells. J Immunol 168:4612–4619

    PubMed  Google Scholar 

  • Wen R, Jou ST, Chen Y, Hoffmeyer A, Wang D (2002) Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. J Immunol 169:6743–6752

    PubMed  Google Scholar 

  • Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403–407

    PubMed  Google Scholar 

  • Wilson BS, Kapp N, Lee RJ, Pfeiffer JR, Martinez AM, Platt Y, Letourneur F, Oliver JM (1995) Distinct functions of the Fc epsilon R1 gamma and beta subunits in the control of Fc epsilon R1-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells. J Biol Chem 270:4013–4022

    CrossRef  PubMed  Google Scholar 

  • Wodnar-Filipowicz A, Heusser CH, Moroni C (1989) Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339:150–152

    CrossRef  PubMed  Google Scholar 

  • Wong MX, Roberts D, Bartley PA, Jackson DE (2002) Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation. J Immunol 168:6455–6462

    PubMed  Google Scholar 

  • Xie ZH, Zhang J, Siraganian RP (2000) Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells. J Immunol 164:1521–1528

    PubMed  Google Scholar 

  • Xie ZH, Ambudkar I, Siraganian RP (2002) The adapter molecule Gab2 regulates Fc epsilon RImediated signal transduction in mast cells. J Immunol 168:4682–4691

    PubMed  Google Scholar 

  • Xu R, Pecht I (2001) The protein tyrosine kinase syk activity is reduced by clustering the mast cell function-associated antigen. Eur J Immunol 31:1571–1581

    CrossRef  PubMed  Google Scholar 

  • Xu R, Abramson J, Fridkin M, Pecht I (2001) SH2 domain-containing inositol polyphosphate 5′-phosphatase is the main mediator of the inhibitory action of the mast cell function-associated antigen. J Immunol 167:6394–6402

    PubMed  Google Scholar 

  • Yamaguchi M, Lantz CS, Oettgen HC, Katona IM, Fleming T, Miyajima I, Kinet JP, Galli SJ (1997a) IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med 185:663–672

    CrossRef  PubMed  Google Scholar 

  • Yamaguchi M, Lantz CS, Oettgen HC, Katona IM, Fleming T, Yano K, Miyajima I, Kinet JP, Galli SJ (1997b) IgE enhances mouse and human mast cell Fc epsilon RI expression, which in turn enhances IgE-dependent mast cell mediator release. J Allergy Clin Immunol 99:422

    Google Scholar 

  • Yamamoto T, Yumioka T, Sekine Y, Sato N, Minoguchi M, Yoshimura A, Matsuda T (2003) Regulation of Fc epsilon RI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Biochem Biophys Res Comm 306:767–773

    CrossRef  PubMed  Google Scholar 

  • Yamanashi Y, Baltimore D (1997) Identification of the Abl-and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88:205–211

    CrossRef  PubMed  Google Scholar 

  • Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T (2001) Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J Biol Chem 276:45175–45183

    CrossRef  PubMed  Google Scholar 

  • Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846–25856

    PubMed  Google Scholar 

  • Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A (2003) Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med 198:223–233

    CrossRef  PubMed  Google Scholar 

  • Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, Ravetch JV, Takai T (1999) Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med 189:187–194

    CrossRef  PubMed  Google Scholar 

  • Zhang J, Berenstein EH, Evans RL, Siraganian RP (1996) Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J Exp Med 184:71–79

    CrossRef  PubMed  Google Scholar 

  • Zhang C, Baumgartner RA, Yamada K, Beaven MA (1997a) Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases. J Biol Chem 272:13397–13402

    CrossRef  PubMed  Google Scholar 

  • Zhang C, Hirasawa N, Beaven MA (1997b) Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways. J Immunol 158:4968–4975

    PubMed  Google Scholar 

  • Zhang J, Finnegan A, Glant TT (2003a) Cbl-b is a negative regulator of PI3-K and map kinases in T cells. Arthritis Rheum 48:S650

    CrossRef  Google Scholar 

  • Zhang WY, Shao Y, Fang DY, Huang JY, Jeon MS, Liu YC (2003b) Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J Biol Chem 278:23978–23983

    CrossRef  PubMed  Google Scholar 

  • Zhao CM, Yu DH, Shen R, Feng GS (1999) Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem 274:19649–19654

    CrossRef  PubMed  Google Scholar 

  • Zhao RX, Fu XQ, Li QS, Krantz SB, Zhao ZZJ (2003) Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine. J Biol Chem 278:22609–22614

    CrossRef  PubMed  Google Scholar 

  • Zhou JS, Friend DS, Feldweg AM, Daheshia M, Li L, Austen KF, Katz HR (2003) Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. J Exp Med 198:1243–1251

    CrossRef  PubMed  Google Scholar 

  • Zidovetzki R, Rost B, Armstrong DL, Pecht I (2003) Transmembrane domains in the functions of Fc receptors. Biophys Chem 100:555–575

    CrossRef  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Abramson, J., Pecht, I. (2005). Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fcε Receptor. In: Damjanovich, S. (eds) Biophysical Aspects of Transmembrane Signaling. Springer Series in Biophysics, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26511-2_8

Download citation