Skip to main content

Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations

  • Chapter
  • 495 Accesses

Part of the Springer Series in Biophysics book series (BIOPHYSICS,volume 8)

Keywords

  • Chemokine Receptor
  • Fluorescence Resonance Energy Transfer
  • Receptor Dimerization
  • Fluorescence Lifetime Imaging Microscopy
  • Chemokine Signaling

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/3-540-26511-2_6
  • Chapter length: 18 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   219.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-26511-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   279.99
Price excludes VAT (USA)
Hardcover Book
USD   249.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alcami A (2003) Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol 3:36–50

    CrossRef  PubMed  Google Scholar 

  • Ali M, Sayeski PP, Dirksen L, Hayzer D, Marrero M, Bernstein K (1997) Dependence on the motif YIPP for the physical association of JAK2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J Biol Chem 272:23382–23388

    CrossRef  PubMed  Google Scholar 

  • Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, Fukii N, Amagau T, Nagasawa T (2003) A role of CXC chemokine ligand 12/stromal cell-derived dactor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol 170:4649–4655

    PubMed  Google Scholar 

  • Aragay A, Mellado M, Rodriguez-Frade JM, Martin AM, Jimenez-Sainz MC, Martínez-A C, Mayor F Jr (1998) Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc Natl Acad Sci USA 95:2985–2990

    CrossRef  PubMed  Google Scholar 

  • Araki T, Gamper M, Early A, Fukuzawa M, Abe T, Kawata T, Kim E, Firtel RA, Williams JG (1998) Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor. EMBO J 17:4018–4028

    CrossRef  PubMed  Google Scholar 

  • Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392:565–568

    PubMed  Google Scholar 

  • Baggiolini M, Loetscher P (2000) Chemokines in inflammation and immunity. Immunol Today 21:418–420

    CrossRef  PubMed  Google Scholar 

  • Belpario J, Keane M, Arenberg D, Addison C, Ehlert J, Burdick M, Strieter R (2000) CXC chemokines in angiogenesis. J Leuk Biol 68:1–8

    Google Scholar 

  • Benkirane M, Jin D-Y, Chun RF, Koup RA, Jeang KT (1997) Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5D32. J Biol Chem 272:30603–30606

    CrossRef  PubMed  Google Scholar 

  • Berger EA, Murphy PM, Farber JM (1999) Chemokines as HIV-1 coreceptors: roles in viral entry, tropism and disease. Annu Rev Immunol 17:657–700

    CrossRef  PubMed  Google Scholar 

  • Bokoch GM (1995) Chemoattractant signaling and leukocyte activation. Blood 86:1649–1660

    PubMed  Google Scholar 

  • Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111–136

    CrossRef  PubMed  Google Scholar 

  • Bruhl H, Cihak J, Schneider MA, Plachy J, Rupp T, Wenzel I, Shakarami M, Milz S, Ellwart JW, Stangassinger M, Schlondorff D, Mack M (2004) Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells. J Immunol 172:890–898

    PubMed  Google Scholar 

  • Buggy JJ (1998) Binding of α-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. Biochem J 331:211–216

    PubMed  Google Scholar 

  • Carvalho-Pinto C, Garcia MI, Gomez L, Ballesteros A, Zaballos A, Flores JM, Mellado M, Rodriguez-Frade JM, Balomenos D, Martinez-A C (2004) Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice. Eur J Immunol 34:548–557

    CrossRef  PubMed  Google Scholar 

  • Culley F, Fadlon EJ, Kirchem A, Williams TJ, Jose PJ, Pease JE (2003) Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Eur J Immunol 33:1302–1310

    CrossRef  PubMed  Google Scholar 

  • del Pozo MA, Vicente-Manzanares M, Tejedor R, Serrador JM, Sanchez-Madrid F (1999) Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol 29:3609–3620

    CrossRef  PubMed  Google Scholar 

  • Elangovan M, Day RN, Periasamy A (2002) Nanosecond fluorescence resonance energy transfer — fluorescence lifetime imaging microscopy to localize the protein interactions in a single living cell. J Microsc 205:3–14

    CrossRef  PubMed  Google Scholar 

  • Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BRL1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037–1047

    CrossRef  PubMed  Google Scholar 

  • Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF (1996) Phosphorylation by a G-protein-coupled kinase inhibits signalling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol 157:5606–5612

    PubMed  Google Scholar 

  • Fukata M, Nakagawa M, Kaibuchi K (2003) Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol 15:590–597

    CrossRef  PubMed  Google Scholar 

  • Gerard C, Rollins BJ (2001) Chemokines and disease. Nat Immunol 2:108–115

    CrossRef  PubMed  Google Scholar 

  • Godessart N, Kunkle SL (2001) Chemokines in autoimmune diseases. Curr Opin Immunol 13:670–675

    CrossRef  PubMed  Google Scholar 

  • Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509–514

    CrossRef  PubMed  Google Scholar 

  • Hernanz-Falcon P, Rodriguez-Frade JM, Serrano A, Juan D, del Sol A, Soriano SF, Roncal F, Gomez L, Valencia A, Martinez-A C, Mellado M (2004) Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol 5:216–223

    CrossRef  PubMed  Google Scholar 

  • Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049–1053

    CrossRef  PubMed  Google Scholar 

  • Homey B, Müller A, Zlotnik A (2002) Chemokines: agents for the immunotherapy of cancer? Nat Rev Immunol 2:175–184

    CrossRef  PubMed  Google Scholar 

  • Hooper NM (1999) Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae. Mol Membr Biol 16:145–156

    CrossRef  PubMed  Google Scholar 

  • Horuk R (2001) Chemokine receptors. Cytokine Growth Factor Rev 12:313–335

    Google Scholar 

  • Issafras H, Angers S, Bulenger S, Blanpain C, Parmentier M, Labbé-Jullié C, Bouvier M, Marullo S (2002) Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors. J Biol Chem 277:34666–34673

    CrossRef  PubMed  Google Scholar 

  • Jacobelli J, Andres PG, Boisvert J, Krummel MF (2004) New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol 16:345–352

    CrossRef  PubMed  Google Scholar 

  • Jordan BA, Devi LA (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697–700

    CrossRef  PubMed  Google Scholar 

  • Kenworthy AK (2001) Imaging protein—protein interactions using fluorescence resonance energy transfer microscopy. Methods 24:289–296

    CrossRef  PubMed  Google Scholar 

  • Kim SK, Cleary MM, Fox HS, Chantry D, Sarvetnick N (2002) CCR4-bearing T cells participate in autoimmune diabetes. J Clin Invest 110:1675–1686

    CrossRef  PubMed  Google Scholar 

  • Kuang Y, Wu Y, Jiang H, Wu D (1996) Selective G protein coupling by C-C chemokine receptors. J Biol Chem 271:3975–3978

    CrossRef  PubMed  Google Scholar 

  • Kupfer A, Singer SJ (1989) Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu Rev Immunol 7:309–337

    CrossRef  PubMed  Google Scholar 

  • Lee SP, O’Dowd BF, George SR (2003) Homo-and hetero-oligomerization of G protein-coupled receptors. Life Sci 74:173–180

    CrossRef  PubMed  Google Scholar 

  • Liu KD, Gaffen SL, Goldsmith MA (1998) JAK/STAT signalling by cytokine receptors. Curr Opin Immunol 10:271–278

    CrossRef  PubMed  Google Scholar 

  • Locati M, Zhou D, Luini W, Evangelista V, Mantovani A, Sozzani S (1994) Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of calcium influx, synergism with platelet-activating factor and significance for chemotaxis. J Biol Chem 269:4746–4753

    PubMed  Google Scholar 

  • Loetscher P, Seitz M, Baggiolini M, Moser B (1996) Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 184:569–577

    CrossRef  PubMed  Google Scholar 

  • Lukacs NW, Miller AL, Hogaboam CM (2003) Chemokine receptors in asthma: searching for the correct immune targets. J Immunol 171:11–15

    PubMed  Google Scholar 

  • Mackay CR (2001) Chemokines: immunology’s high impact factors. Nat Immunol 2:95–101

    CrossRef  PubMed  Google Scholar 

  • Manes S, Mira E, Gomez-Mouton C, Lacalle RA, Keller P, Labrador JP, Martinez-A C (1999) Membrane raft microdomains mediate front—rear polarity in migrating cells. EMBO J 18:6211–6220

    CrossRef  PubMed  Google Scholar 

  • Manes S, del Real G, Lacalle RA, Lucas P, Gomez-Mouton C, Sanchez-Palomino S, Delgado R, Alcami J, Mira E, Martinez AC (2000) Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep 1:190–196

    CrossRef  PubMed  Google Scholar 

  • McVey M, Ramsay D, Kellet E, Rees S, Wilson S, Pope AJ, Milligan G (2001) Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. J Biol Chem 276:14092–14099

    PubMed  Google Scholar 

  • Mellado M, Rodríguez-Frade JM, Aragay A, del Real G, Martín AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martínez-A C (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161:805–813

    PubMed  Google Scholar 

  • Mellado M, Rodríguez-Frade JM, Mañes S, Martínez-A C (2001a) Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Annu Rev Immunol 19:397–421

    CrossRef  PubMed  Google Scholar 

  • Mellado M, Rodriguez-Frade JM, Vila-Coro AJ, Fernandez S, Martin de Ana A, Jones DR, Toran JL, Martinez AC (2001b) Chemokine receptor homo-or heterodimerization activates distinct signaling pathways. EMBO J 20:2497–2507

    CrossRef  PubMed  Google Scholar 

  • Milligan G, Ramsay D, Pascal G, Carrillo JJ (2003) GPCR dimerization. Life Sci 74:181–188

    CrossRef  PubMed  Google Scholar 

  • Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan M, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verástegui E, Zlotnik A (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50–56

    CrossRef  PubMed  Google Scholar 

  • Papadopoulus EJ, Sassetti C, Saeki H, Yamada N, Kawamura T, Fitzhugh DJ, Saraf MA, Schall TJ, Blauvelt A, Rosen SD, Hwang ST (1999) Fractalkine, a CXCR3 chemokine is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol 29:2551–2559

    CrossRef  PubMed  Google Scholar 

  • Park ES, Kim H, Suh JM, Park SJ, You SH, Chung HK, Lee KW, Kwon OY, Cho BY, Kim YK, Ro HK, Chung J, Shong M (2000) Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway. Mol Endocrinol 14:662–670

    CrossRef  PubMed  Google Scholar 

  • Parks E, Strieter RM, Lukacs NW, Gauldie J, Hitt M, Graham FL, Kunkel SL (1998) Transient gene transfer of IL-2 regulates chemokine expression and disease severity in experimental arthritis. J Immunol 160:4615–4619

    PubMed  Google Scholar 

  • Pelletier S, Duhamel F, Coulombe P, Popoff MR, Meloche S (2003) Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol 23:1316–1333

    CrossRef  PubMed  Google Scholar 

  • Pollok BA, Heim R (1999) Using GFP in FRET-based applications. Trends Cell Biol 9:57–60

    CrossRef  PubMed  Google Scholar 

  • Pouysségur J (2000) An arresting start for MAPK. Science 290:1515–1518

    CrossRef  PubMed  Google Scholar 

  • Proudfoot AEI (2002) Chemokine receptors: multifaceted therapeutic targets. Nat Rev Immunol 2:106–115

    CrossRef  PubMed  Google Scholar 

  • Rajan A, Asensio VC, Campbell IL, Brossnan CF (2000) Experimental autoimmune encephalomyelitis on the SJL mouse: effect of δγ T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J Immunol 164:2120–2130

    PubMed  Google Scholar 

  • Raz E (2003) Primordial germ-cell development: the zebrafish perspective. Nat Rev Genet 4:690–700

    CrossRef  PubMed  Google Scholar 

  • Reddy PS, Corley RB (1998) Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum. Bioessays 20:546–554

    CrossRef  PubMed  Google Scholar 

  • Resh MD (1999) Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochem Biophys Acta 1451:1–16

    CrossRef  PubMed  Google Scholar 

  • Ridley A (2001) Rho family proteins: coordinating cell responses. Trends Cell Biol 11:471–477

    CrossRef  PubMed  Google Scholar 

  • Rodriguez-Frade JM, Llorente M, Mellado M, Alcamí J, Gutierrez-Ramos JC, Zaballos A, del Real G, Martínez-A C (1997) The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection. J Clin Invest 100:1–6

    PubMed  Google Scholar 

  • Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martinez-A C, Mellado M (1999) The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc Natl Acad Sci USA 96:3628–3633

    CrossRef  PubMed  Google Scholar 

  • Rodriguez-Frade JM, Mellado M, Martinez-A C (2001) Chemokine receptor dimerization: two are better than one. Trends Immunol 22:612–617

    CrossRef  PubMed  Google Scholar 

  • Rodriguez-Frade JM, Del Real G, Serrano A, Hernanz-Falcon P, Soriano SF, Vila-Coro AJ, De Ana AM, Lucas P, Prieto I, Martinez-A C, Mellado M (2004) Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. EMBO J 23:66–76

    CrossRef  PubMed  Google Scholar 

  • Rollins B (1997) Chemokines. Blood 90:909–928

    PubMed  Google Scholar 

  • Rossi D, Zlotnik A (2000) The biology of chemokines and their receptors. Annu Rev Immunol 18:217–242

    CrossRef  PubMed  Google Scholar 

  • Sallusto F, Lanzavecchia A, Mackay C (1998) Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19:568–574

    CrossRef  PubMed  Google Scholar 

  • Sanchez-Madrid F, del Pozo MA (1999) Leukocyte polarization in cell migration and immune interactions. EMBO J 18:501–511

    CrossRef  PubMed  Google Scholar 

  • Scheiffele P, Roth MG, Simons K (1997) Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J 16:5501–5508

    CrossRef  PubMed  Google Scholar 

  • Sekar RB, Periasamy A (2003) Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations. J Cell Biol 160:629–633

    CrossRef  PubMed  Google Scholar 

  • Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sanchez-Madrid F (1997) Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization. J Cell Biol 138:1409–1423

    CrossRef  PubMed  Google Scholar 

  • Showkat AM, Sayeski PP, Bernstein KE (2000) Jak2 acts both as STAT1 kinase and as a molecular bridge linking STAT1 to the angiotensin II AT1 receptor. J Biol Chem 275:15586–15593

    CrossRef  PubMed  Google Scholar 

  • Soede RDM, Zeelenberg IS, Wijnands YM, Kamp M, Roos E (2001) Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. J Immunol 166:4293–4301

    PubMed  Google Scholar 

  • Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, Qin S, Rottman J, Sellebjerg F, Strieter RM, Frederiksen JL, Ransohoff RM (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103:807–815

    PubMed  Google Scholar 

  • Soriano SF, Serrano A, Hernanz-Falcon P, Martin de Ana A, Monterrubio M, Martinez-A C, Rodriguez-Frade JM, Mellado M (2003) Chemokines integrate JAK/STAT and G protein pathways during chemotaxis and calcium flux responses. Eur J Immunol 33:1328–1333

    CrossRef  PubMed  Google Scholar 

  • Sorkin A, McClure M, Huang F, Carter R, (2000) Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. Curr Biol 10:1395–1398

    CrossRef  PubMed  Google Scholar 

  • Stein JV, Soriano SF, M’rini C, Nombela-Arrieta C, de Buitrago GG, Rodriguez-Frade JM, Mellado M, Girard JP, Martinez-A C (2003) CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood 101:38–44

    CrossRef  PubMed  Google Scholar 

  • Suzuki S, Chuang LF, Yau P, Doi RH, Chuang RY (2002) Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res 280:192–200

    CrossRef  PubMed  Google Scholar 

  • Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, Rogers TJ (2002) Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci USA 99:10276–10281

    CrossRef  PubMed  Google Scholar 

  • Terrillon S, Bouvier M (2004) Roles of G-protein-coupled receptor dimerization. EMBO Rep 5:30–34

    CrossRef  PubMed  Google Scholar 

  • Trettel F, Di Bartolomeo S, Lauro C, Catalano M, Ciotti MT, Limatola C (2003) Ligand-independent CXCR2 dimerization. J Biol Chem 278:40980–40988

    CrossRef  PubMed  Google Scholar 

  • Ulbrich H, Eriksson EE, Lindbom L (2003) Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease, Trends Pharmacol Sci 24:640–647

    CrossRef  PubMed  Google Scholar 

  • Vila-Coro AJ, Rodriguez-Frade JM, Martin de Ana A, Moreno-Ortiz MC, Martinez-A C, Mellado M (1999) The chemokine SDF-1a triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 13:1699–1710

    PubMed  Google Scholar 

  • Vila-Coro AJ, Mellado M, Martin de Ana A, Lucas P, del Real G, Martinez-A C, Rodriguez-Frade JM (2000) HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization. Proc Natl Acad Sci USA 97:3388–3393

    CrossRef  PubMed  Google Scholar 

  • Ward SG (2004) Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 25:67–74

    CrossRef  PubMed  Google Scholar 

  • Wright N, de Lera TL, Garcia-Moruja C, Lillo R, Garcia-Sanchez F, Caruz A, Teixido J (2003) Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion. Blood 102:1978–1984

    CrossRef  PubMed  Google Scholar 

  • Wulfing C, Davis MM (1998) A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282:2266–2269

    CrossRef  PubMed  Google Scholar 

  • Yang W, Wang D, Richmond A (1999) Role of clathrin-mediated endocytosis in CXCR2 sequestration, resensitization, and signal transduction. J Biol Chem 274:11328–11333

    CrossRef  PubMed  Google Scholar 

  • Yang YF, Mukai T, Gao P, Yamaguchi N, Ono S, Iwaki H, Obika S, Imanishi T, Tsujimura T, Hamaoka T, Fujiwara H (2002) A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses. Eur J Immunol 32:2124–2132

    CrossRef  PubMed  Google Scholar 

  • Zernecke A, Weber KSC, Erwig LP, Kluth DC, Schröppel B, Rees AJ, Weber C (2001) Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis. J Immunol 166:5755–5762

    PubMed  Google Scholar 

  • Zou Y, Kottmann A, Kuroda M, Taniuchi I, Littman D (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595–599

    CrossRef  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rodríguez-Frade, J.M., Serrano, A., Martínez-A, C., Mellado, M. (2005). Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations. In: Damjanovich, S. (eds) Biophysical Aspects of Transmembrane Signaling. Springer Series in Biophysics, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26511-2_6

Download citation