Advertisement

Complications of Cyclooxygenase Inhibition in Preterm Infants

  • Véronique Gournay

Keywords

Preterm Infant Patent Ductus Arteriosus Cerebral Blood Volume Newborn Piglet Ibuprofen Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 2001;15:2057–2072.CrossRefPubMedGoogle Scholar
  2. 2.
    Edwards AD, Wyatt JS, Richardson C, Potter A, Cope M, Delpy DT, Reynolds EO. Effects of indomethacin on cerebral haemodynamics in very preterm infants. Lancet. 1990;335:1491–5.PubMedGoogle Scholar
  3. 3.
    McCormick DC, Edwards AD, Brown GC, Wyatt JS, Potter A, Cope M, Delpy DT, Reynolds EO. Effect of indomethacin on cerebral oxidized cytochrome oxidase in preterm infants. Pediatr Res. 1993;33:603–8.PubMedGoogle Scholar
  4. 4.
    Leffler CW, Busija DW, Fletcher AM, Beasley DG, Hessler JR, Green RS. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediatr Res. 1985;19:1160–4.PubMedGoogle Scholar
  5. 5.
    Leffler CW, Busija DW, Beasley DG, Fletcher AM. Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: Role of prostanoids. Circ Res. 1986;59:562–7.PubMedGoogle Scholar
  6. 6.
    Chemtob S, Beharry K, Barna T, Varma DR, Aranda JV. Differences in the effects in the newborn piglet of various nonsteroidal antiinflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins. Pediatr Res. 1991;30:106–11.PubMedGoogle Scholar
  7. 7.
    Mosca F, Bray M, Lattanzio M, Fumagalli M, Tosetto C. Comparative evaluation of the effects of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus. J Pediatr. 1997;131:549–54.PubMedGoogle Scholar
  8. 8.
    Pellicer A, Aparicio M, Cabanas F, Valverde E, Quero J, Stiris TA. Effect of the cyclo-oxygenase blocker ibuprofen on cerebral blood volume and cerebral blood flow during normocarbia and hypercarbia in newborn piglets. Acta Paediatr. 1999;88:82–8.PubMedGoogle Scholar
  9. 9.
    Patel J, Roberts I, Azzopardi D, Hamilton P, Edwards AD. Randomized double-blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res. 2000;47:36–42.PubMedGoogle Scholar
  10. 10.
    Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets. Stroke. 1990;21:777–84.PubMedGoogle Scholar
  11. 11.
    Benesova O, Tejkalova H, Kristofikova Z, Husek P, Nedvidkova J, Yamamotova A. Brain maldevelopment and neurobehavioural deviations in adult rats treated neonatally with indomethacin. Eur Neuropsychopharmacol. 2001;11:367–73PubMedGoogle Scholar
  12. 12.
    Couser RJ, Hoekstra RE, Ferrara TB, Wright GB, Cabalka AK, Connett JE. Neurodevelopmental follow-up at 36 months’s corrected age of preterm infants treated with prophylactic indomethacin. Arch Paediatr Adolesc Med 2000;154:598–602.Google Scholar
  13. 13.
    Schmidt B, Davis P, Moddemann D, et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med 2001;344:1966–72.CrossRefPubMedGoogle Scholar
  14. 14.
    Fowlie PW, Davis PG. Prophylactic indomethacin for preterm infants: A systematic review and meta-analysis. Arch Dis Child 2003;88:F464–66.Google Scholar
  15. 15.
    Gournay V, Roze JC, Kuster A et al. Multicenter prospective randomized double blind trial comparing prophylactic ibuprofen versus placebo in very premature infants. Lancet 2004; 364: 1939–44.CrossRefPubMedGoogle Scholar
  16. 16.
    Tod ML, Yoshimura K, Rubin LJ. Indomethacin prevents ventilation-induced decreases in pulmonary vascular resistance of the middle region in fetal lambs. Pediatr Res 1991;29:449–54.PubMedGoogle Scholar
  17. 17.
    Velvis H, Moore P, Heymann MA. Prostaglandin inhibition prevents the fall in pulmonary vascular resistance as a result of rhythmic distension of the lungs in fetal lambs. Pediatr Res 1991;30:62–8.PubMedGoogle Scholar
  18. 18.
    Gournay V, Savagner C, Thiriez G, Kuster A, Roze JC. Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants. Lancet 2002;359:1486–88.CrossRefPubMedGoogle Scholar
  19. 19.
    Schmidt B. Ibuprofen prophylaxis in preterm neonates. Lancet 2002;360:492.PubMedGoogle Scholar
  20. 20.
    Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of a patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2003;(2): CD003481.Google Scholar
  21. 21.
    Jensen BL, Stubbe J, Madsen K, Nielsen FT, Skott O. The renin-angiotensin system system in kidney development: Role of COX-2 and adrenal steroids. Acta Physiol Scand 2004;181:549–59.CrossRefPubMedGoogle Scholar
  22. 22.
    Betkerur MV, Yeh TF, Miller K, Glasser RJ, Pildes RS. Indomethacin and its effect on renal function and urinary kallicrein excretion in premature infants with patent ductus arteriosus. Pediatrics 1981;68:99–102.PubMedGoogle Scholar
  23. 23.
    Pezzati M, Vangi V, Biagiotti R, Bertini G, Cianciulli D, Rubaltelli FF. Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus. J Pediatr 1999;135:733–8.PubMedGoogle Scholar
  24. 24.
    Romagnoli C, De Carolis MP, Papacci P, Polimeni V, Luciano R, Piersigilli F, Delogu AB, Tortorolo G. Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm infants. Clin Pharmacol Ther 2000;67:676–83.CrossRefPubMedGoogle Scholar
  25. 25.
    Van Overmeire B, Smets K, Lecoutere D, Van de Broek H, Weyler J, De Groote K, Langhendries JP. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med 2000;343:674–81.CrossRefPubMedGoogle Scholar
  26. 26.
    Lago P, Bettiol T, Salvadori S, Pitassi I, Vianello A, Chiandetti L, Saia OS. Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: A randomised controlled trial. Eur J Pediatr 2002;161:202–7.CrossRefPubMedGoogle Scholar
  27. 27.
    Chamaa NS, Mosig D, Drukker A, Guignard JP. The renal hemodynamic effects of ibuprofen in the newborn rabbit. Pediatr Res 2000;48:600–5.PubMedGoogle Scholar
  28. 28.
    Van Bel F, Van Zoeren D, Schipper J, Guit GL, Baan J. Effect of indomethacin on superior mesenteric artery blood flow velocity in preterm infants. J Pediatr 1990;116:965–70.PubMedGoogle Scholar
  29. 29.
    Fuji AM, Brown E, Mirochnick M, O’Brien S, Kaufman G. Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol 2002;22:535–40.Google Scholar
  30. 30.
    Rennie JM, Doyle J, Cooke RW. Early administration of indomethacin to preterm infants. Arch Dis Child 1986;61:233–8.PubMedCrossRefGoogle Scholar
  31. 31.
    Tatli MM, Kumral A, Duman N, Demir K, Gurcu O, Ozkan H. Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants. Acta Padiatr 2004;93:999–1001.Google Scholar
  32. 32.
    Aranda JV, Varvarigou A, Beharry K, Bansal R, Bardin C, Modanlou H, Papageorgiou A, Chemtob S. Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant. Acta Pediatr 1997;86:289–93.Google Scholar
  33. 33.
    Cooper-Peel C, Brodersen R, Robertson A. Does ibuprofen affect bilirubin-albumin binding in newborn infant serum? Pharmacol Toxicol 1996;79:297–9.PubMedCrossRefGoogle Scholar
  34. 34.
    Ahlfors CE. Effect of ibuprofen on bilirubin-albumin binding. J Pediatr 2004;144:386–8.PubMedGoogle Scholar
  35. 35.
    Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, Ehrenkranz RA, Carlo WA, Shankaran S, Poole K, Wright LL. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics 2003; 112: 773–9.CrossRefPubMedGoogle Scholar
  36. 36.
    Allegaert K, Cossey V, Langhendries JP, Naulaers G, Vanhole C, Devlieger H, Van Overmeire B. Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life. Biol Neonate 2004; 86: 207–11.CrossRefPubMedGoogle Scholar
  37. 37.
    Hanna N, Graboski S, Laskin DL, Weinberger B. Effects of ibuprofen and hypoxia on neutrophil apoptosis in neonates. Biol Neonate 2004; 86: 235–9.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag Heidelberg 2005

Authors and Affiliations

  • Véronique Gournay
    • 1
  1. 1.Division of Pediatric CardiologyUniversity Hospital of Nantes, Hôpital Mère EnfantNantes Cedex 1France

Personalised recommendations