Indomethacin Effects and Side Effects

  • Berndt Urlesberger


Premature Infant Patent Ductus Arteriosus Blood Flow Velocity Cerebral Blood Flow Velocity Intestinal Perfusion 
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  1. 1.
    Heymann MA, Rudolph AM, Silverman NH. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 1976; 295:530–533PubMedCrossRefGoogle Scholar
  2. 2.
    Friedman WF, Hirschklau MJ, Printz MP, et al. Pharmacologic closure of patent ductus arteriosus in premature infants. N Engl J Med 1976; 295:526–529PubMedCrossRefGoogle Scholar
  3. 3.
    Nehgme RA, O’Connor TZ, Lister G, et al. Patent Ductus Arteriosus. In Sinclair and Bracken (Eds.) »Effective Care of the Newborn« Oxford University Press 1992Google Scholar
  4. 4.
    Cooke L, Steer P, Woodgate P. Indomethcin for asymptomatic patent ductus arteriosusin preterm infants. Cochrane Database 2003Google Scholar
  5. 5.
    Fowlie PW, Davis PG. Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database 2002Google Scholar
  6. 6.
    Herrera C, Holberton J, Davis P. Prolonged versus short course of indomethacin for treatment of patent ductus arteriosus in perterm infants. Cochrane Database 2004Google Scholar
  7. 7.
    Seyberth HW, Rascher W, Hackenthal R, et al. Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus. J Pediatr 1983; 103:979PubMedCrossRefGoogle Scholar
  8. 8.
    John EG, Vasan U, Hastreiter AR, et al. Intravenous indomethacin and changes of renal function in premature infants with patent ductus arteriosusGoogle Scholar
  9. 9.
    van Bel F, Guit GL, Schipper J, et al. Indomethacin-induced changes in renal blood flow velocity waveform in premature infants investigated with color Doppler imaging. J Pediatr 1991; 118:621–626PubMedCrossRefGoogle Scholar
  10. 10.
    Speziale MV, Allen RG, Henderson CR, et al. Effects of ibuprofen and indomethacin on the regional circulation in newborn piglets. Biol Neonate 1999; 76:242–252CrossRefPubMedGoogle Scholar
  11. 11.
    Christmann V, Liem KD, Semmekrot BA, et al. Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin. Acta Pediatr 2002; 91:440–446CrossRefGoogle Scholar
  12. 12.
    Leititis JU, Burghard R, Gordjani, et al. Effect of modified fluid therapy on renal function during indomethacin therapy for persistent ductus arteriosus. Acta Pediatr Scand 1987; 76:789–94CrossRefGoogle Scholar
  13. 13.
    Barrington K, Brion LP. Dopamine versus no treatment to prevent renal dysfunction in indomethacin-treated preterm newborn infants. Cochrane Database 2002Google Scholar
  14. 14.
    Brion LP, Campbell DE. Furosemide for prevention of morbidity in indomethacin-treated infants with patent ductus arteriosus. Cochrane Database 2001Google Scholar
  15. 15.
    van Bel F, van de Bor M, Stijnen, et al. Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: duration of ist effect. Pediatrics 1989; 84:802–7PubMedGoogle Scholar
  16. 16.
    Mardoum R, Bejar R, Merritt A, et al. Controlled study of the effects of indomethacin on cerebral blood flow velocities in newborn infants. J Pediatr 1991; 118:112–115PubMedCrossRefGoogle Scholar
  17. 17.
    Pryds O, Greisen G, Johansen KH. Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus. Eur J Pediatr 1988; 147:315–316CrossRefPubMedGoogle Scholar
  18. 18.
    Edwards AD, Wyatt JS, Richardson C, et al. Effects of indomethacin on cerebral haemodynamics in very preterm infants. Lancet 1990; 335:1491–1495PubMedCrossRefGoogle Scholar
  19. 19.
    Therkelsen K, Jensen KA, Freundlich M, et al. Endothelin-1 and cerebral blood flow: influence of hypoxia, hypercapnia and indomethacin on circulating endothelin levels in healthy volunteers. Scand J Clin Lab Invest. 1994; 54:441–51.PubMedCrossRefGoogle Scholar
  20. 20.
    Simko A, Mardoum R, Merritt, et al. Effects on cerebral blood flow velocities of slow and rapid infusion of indomethacin. J Perinatol 1994; 14:29–35PubMedGoogle Scholar
  21. 21.
    Ment LR, Oh W, Ehrenkranz RA, et al. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 1994; 93:543–50PubMedGoogle Scholar
  22. 22.
    van Bel F, van Zoeren D, Schipper J, et al. Effect of indomethacin on superior mesenteric artery flow velocity in preterm infants. J Pediatr 1990; 116:965–70PubMedCrossRefGoogle Scholar
  23. 23.
    Coombs RC, Morgan ME, Durbin GM, et al. Gut blood flow velocities in the newborn: effects of patent ductus arteriosus ant perenteral indomethacin. Arch Dis Child 1990; 65:1067–71PubMedCrossRefGoogle Scholar
  24. 24.
    Grosfeld JL, Chaet M, Molinari F, et al. Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin. Ann surg 1996; 224:350–57CrossRefPubMedGoogle Scholar
  25. 25.
    Fujii Am, Brown E, Mirochnick M, et al. Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol 2002; 22:535–40CrossRefPubMedGoogle Scholar
  26. 26.
    O’Donovan DJ, Baetiong A, Adams K, et al. Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. J Perinatol 2003; 23:286–90PubMedCrossRefGoogle Scholar
  27. 27.
    Yeh TF, Raval D, Lilien LD, et al. Decreased plasma glucose following indomethacin therapy in premature infants with patent ductus arteriosus. Pediatr Pharmacol 1982; 2:171–77Google Scholar
  28. 28.
    Hosono S, Ohono T, Kimoto H, et al. Reduction in blood glucose values following indomethacin therapy for patent ductus arteriosus. Paediatr Int 1999; 41:525–528Google Scholar
  29. 29.
    Wasner HK, Weber S, Partke HJ, et al. Indomethacin treatment causes loss of insulin action in rats: Involvement of prostaglandins in the mechanism of insulin action. Acta Diabetol 1994;31:175–82CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag Heidelberg 2005

Authors and Affiliations

  • Berndt Urlesberger
    • 1
  1. 1.Department of NeonatologyUniversitätsklinik für Kinder- und JugendheilkundeGrazAustria

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