Skip to main content

Interstitielle Nephritis

  • Chapter
Therapie innerer Krankheiten
  • 183 Accesses

Zusammenfassung

Die interstitielle Nephritis ist pathohistologisch gut definiert. Im Gegensatz hierzu stehen der äußerst variable klinische Verlauf und die sehr unterschiedliche Ätiologie (Kelly u. Neilson 1996; Klooker u. Brass 1997; Rossert 2001; Schwarz et al. 2000; Takemura et al. 1999). Angaben zur Behandlung bzw. „Behandlungsoptionen“ sind im Schriftum entsprechend zurückhaltend formuliert (Schwarz et al. 2000; Baker 2004).

Die akute interstitielle Nephritis kann eine rapid progressive Glomerulonephritis imitieren (Chang et al. 2001; Giron et al. 2001; Scherberich 1997). Ein Teil der Patienten erreicht die Klinik im akuten oligurischen dialysepflichtigen Nierenversagen (Klooker u. Brass 1997; Kodner 2003). Andere Betroffene leiden an einer „chronischen“ Form, die medikamenteninduziert, postinfektiös oder im Verlauf von Systemerkrankungen entsteht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abo-Zenah H, Katsoudas S, de Takats D, Shortland J, Wild G, Brown CB, El Nahas AM (2002) Early progressive interstitial fibrosis in renal allografts. Clin Nephrol 57:9–18

    CAS  PubMed  Google Scholar 

  • Acker van BAC, Prummel MF, Weber JA, Wersinga WM; Arisz L (1993) Effect of prednisone on renal function in man. Nephron 65:254–259

    PubMed  Google Scholar 

  • Baer P, Scherberich JE, Bereiter-Hahn J, Geiger H (2000) Induction of Rantes, HLA-DR and intercellular adhesion molecule-1 on highly purified distal tubular cells from human kidney. Transplantation 69:2456–2459

    CAS  PubMed  Google Scholar 

  • Baker RJ, Pusey CD (2004) The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant 19:8–11

    PubMed  Google Scholar 

  • Booth A, Harper L, Hammad T et al. (2004) Prospective study of TNF-alpha blockade with Infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol 15:717–721

    Article  CAS  PubMed  Google Scholar 

  • Bossini N, Savoldi S, Franceschini F et al. (2001) Clinical and morphological features of kidney involvement in primary Sjögren’s syndrome. Nephrol Dial Transplant 16:2328–2336

    CAS  PubMed  Google Scholar 

  • Buttgereit F, Hiepe F, Burmester GR (1997) Das therapeutische Potential der Lazaroide (21-Aminosteroide). Dtsch Med Wschr 122:1363–1367

    CAS  PubMed  Google Scholar 

  • Chang C-H, Wang YM, Yang A-H, Chiang A-S (2001) Rapidly progressive interstitial fibrosis associated with chinese herbal medications. Am J Nephrol 21:441–448

    CAS  PubMed  Google Scholar 

  • Cinotti GA, Zuchelli PC (2001) Effect of Lisinopril on the progression of renal insufficiency in mild proteinuric non-diabetic nephropathies. Nephrol Dial Transplant 16:961–966

    CAS  PubMed  Google Scholar 

  • Contreras G, Prado V, Leclercq B et al. (2004) Sequential therapies for proliferative lupus nephritis. N Engl J Med 350:971–980

    Article  CAS  PubMed  Google Scholar 

  • Cordonnier DJ, Pinel N, Barro C et al (1999) Expansion of cortical interstitium is limited by converting enzyme inhibition in type 2 diabetic patients with glomerulosclerosis. J Am Soc Nephrol 10:1253–1263

    CAS  PubMed  Google Scholar 

  • Eddy AA (2004) Proteinuria and interstitial injury. Nephrol Dial Transplant 19:277–281

    PubMed  Google Scholar 

  • Giron FF, Mora FF, Conde-Garcia J, Sanchez MB, Perez MJM, Munoz SC, Martinez JG (2001) Granulomatous interstitial nephritis, hypercalcemia and rapidly progressive kidney failure secondary to Sarcoidosis with exclusive renal involvement. Am J Nephrol 21:514–516

    Google Scholar 

  • Göbel U, Kettritz R, Schneider W, Luft FC (2001) The protean face of renal sarcoidosis. J Am Soc Nephrol 12:616–623

    PubMed  Google Scholar 

  • Jehle PM, Jehle DR (2000) Use of corticosteroids in nephrology-risk and prevention of osteoporosis induction. Nephrol Dial Transplant 15:565–568

    CAS  PubMed  Google Scholar 

  • Kelly CJ, Neilson EC (1996) Tubulointerstitial diseases. In: Brenner B (ed) The kidney, 5th edn. Saunders, Philadelphia, pp 1655–1679

    Google Scholar 

  • Klooker P, Brass H (1997) Akute interstitielle Nephritis. In: Brass H, Philipp T, Schulz W (Hrsg) Manuale Nephrologicum. Dustri-Dr Karl Feistle, Deistenhofen, VIII-3-1, S 1–6

    Google Scholar 

  • Kodner CM, Kudrimoti A (2003) Diagnosis and management of acute interstitial nephritis. Am Fam Physician 67:2527–2534

    PubMed  Google Scholar 

  • Kondo S, Kagami S, Kido H, Strutz F, Müller GA, Kuroda Y (2001) Role of mast cell tryptase in renal interstitial fibrosis. J Am Soc Nephrol 12:1668–1676

    CAS  PubMed  Google Scholar 

  • Lewington AJP, Arici M, Harris KPG, Brunskill NJ, Walls J (2001) Modulation of the renin-angiotensin system in proteinuric renal disease: are there added benefits? Nephrol Dial Transplant 16:885–888

    CAS  PubMed  Google Scholar 

  • Marjkowitz GS, Radhakrishnan J, Kambham N, Valeri AM, Hines WH, DÀgati VDD (2000) Lithium Nephropathy: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol 11:1439–1448

    Google Scholar 

  • Michielsen P, de Schepper P (2001) Trends of analgesic nephropathy in two high-endemic regions with different legislation. J Am Soc Nephrol 12:550–556

    CAS  PubMed  Google Scholar 

  • Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S (2002) Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13:S14–S21

    Article  CAS  PubMed  Google Scholar 

  • Nockher WA, Scherberich JE (1997) Expression and release of the monocyte LPS receptor antigen CD14 are suppressed by glucocorticoids in vivo and in vitro. J Immunol 158:1345–1352

    CAS  PubMed  Google Scholar 

  • Rossert J (2001) Drug-induced acute interstitial nephritis. Kidney Int 60:804

    Article  CAS  PubMed  Google Scholar 

  • Scherberich JE (1997) Nierenbeteiligung bei rheumatoider Arthritis. In: Brass H, Philipp T, Schulz W (Hrsg) Manuale Nephrologicum. Dustri, Deisenhofen, VIII-4-3, S 1–21

    Google Scholar 

  • Scherberich JE (1999) Chronische Pyelonephritis. MMW-Fortschr Med 141:598–602

    Google Scholar 

  • Scherberich JE; Nockher A, Baer PC (1999) Cross-talk between activated tubular epithelia of human kidney and monocytes: a basis for target cell-specific pharmacotherapy? Nephrol Dial Transplant 14(Suppl 4):8–10

    PubMed  Google Scholar 

  • Scherberich JE, Nockher WA (1999) CD14++monocytes, CD14+/16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy. Clin Chem Lab Med 37:209–213

    Article  CAS  PubMed  Google Scholar 

  • Scherberich JE (2003) Proinflammatory blood monocytes; main effect and target cells in systemic and renal disease. Int J Clin Pharmacol Ther 41:459–464

    CAS  PubMed  Google Scholar 

  • Schneider KM (1998) Plasmapheresis and immunoadsorption: different techniques and their current role in medical therapy. Kidney Int 53(Suppl 64):S-61–S-65

    Google Scholar 

  • Schwarz A, Krause PH, Kunzendorf U, Keller F, Distler A (2000) The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis. Clin Nephrol 54:179–190

    CAS  PubMed  Google Scholar 

  • Stoves J, Inglis H, Newstead (2001) A randomized study on oral vs intravenous iron supplementation in patients with progressive renal insufficiency treated with erythropoietin. Nephrol Dial Transplant 16:967–974

    CAS  PubMed  Google Scholar 

  • Strutz F, Heeg M, Kochsiek T, Siemers G, Zeisberg M, Müller GA (2000) Effect of pentoxifylline, pentifylline, and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Nephrol Dial Transplant 15:1535–1546

    CAS  PubMed  Google Scholar 

  • Takemura T et al (1999) Course and outcome of tubulointerstitial nephritis and uveitis syndrome. Am J Kidney Dis 34:1016–1021

    CAS  PubMed  Google Scholar 

  • Ueno M, Kawashima S, Nichi S, Shimada H, Karasawa R, Suzuki Y, Maruyama Y, Arakawa M (1997) Tubulointerstitial lesions in noninsulin dependent diabetes mellitus. Kidney Int 52(Suppl 63), S-191–S-194

    Google Scholar 

  • Wang Y, Rangan GK, Tay Y-C, Wang Y, Harris DCH (1999) Induction of monocyte chemo-attractant protein-1 by albumin is mediated by nuclear factor kB in proximal tubule cells. J Am Soc Nephrol 10:1204–1213

    CAS  PubMed  Google Scholar 

  • Zhou X, Ono H, Ono Y, Frohlich ED (2004) Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR Model. Am J Nephrol 24:242–249

    Article  CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Medizin Verlag

About this chapter

Cite this chapter

Scherberich, J. (2005). Interstitielle Nephritis. In: Steinbeck, G., et al. Therapie innerer Krankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26504-X_31

Download citation

  • DOI: https://doi.org/10.1007/3-540-26504-X_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23750-1

  • Online ISBN: 978-3-540-26504-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics