Ocular Complications Due to Cancer Treatment

  • Michael Ober
  • Camille A. Servodidio
  • David Abramson
Part of the Pediatric Oncology book series (PEDIATRICO)


Optic Neuritis Ciliary Body Trabecular Meshwork Nurse Management Ocular Complication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Haik BH, Jereb B, Abramson DH et al. (1983) Ophthalmic radiotherapy. In: Iliff NT (ed) Complications in ophthalmic surgery. Churchill Livingstone, New York, pp 4449–4485Google Scholar
  2. 2.
    Brady LW, Shields J, Augusburger JJ et al (1989) Complications from radiation therapy to the eye. Front Radiat Ther Oncol 23:238–250PubMedGoogle Scholar
  3. 3.
    Ober MD, Beaverson K, Abramson DH Ocular complications. In: Wallace H, Green D (eds) Late effects of childhood cancer. Arnold, LondonGoogle Scholar
  4. 4.
    Al-Tweigeri T, Nabholtz JM, Mackey JR (1996) Ocular toxicity and cancer chemotherapy. A review. Cancer 78:1359–1373CrossRefPubMedGoogle Scholar
  5. 5.
    Sidi Y, Douer D, Pinkhas J (1977) Sicca syndrome in a patient with toxic reaction to busulfan. JAMA 238:1951CrossRefPubMedGoogle Scholar
  6. 6.
    Straus DJ, Mausolf FA, Ellerby RA (1977) Cicatricial ectropian secondary to 5-fluorouracil therapy. Med Pediatr Oncol 3:15–19PubMedGoogle Scholar
  7. 7.
    Esmaeli B, Valero V, Ahmadi A et al (2001) Canalicular stenosis secondary to docetaxel (taxotere). A newly recognized side effect. Ophthalmology 108:994–995CrossRefPubMedGoogle Scholar
  8. 8.
    Miller D, Pecxon JD (1965) Corticosteroid and functions in the anterior segment of the eye. Am J Ophthalmol 59:31PubMedGoogle Scholar
  9. 9.
    Seiff SR, Shorr N, Adams T (1985) Surgical treatment of punctual-canalicular fibrosis from 5-fluorouracil therapy. Cancer 56:2148–2149PubMedGoogle Scholar
  10. 10.
    Donnenfeld ED, Ingraham HJ, Abramson DH (1993) Effects of ionizing radiation on the conjunctiva, cornea, and lens. In: Alberti WE, Sagerman RH (eds) Medical radiology. Radiotherapy of intraocular and orbital tumors. Springer, Berlin Heidelberg New York, pp 261–270Google Scholar
  11. 11.
    Palmer ML, Hyndiuk RA (2000) Toxicology of corticosteroids and other antiinflammatory agents. In: Albert DM, Jakobiec FA (eds) Principals and practice of ophthalmology, 2nd edn. Saunders, Philadelphia, PA, pp 399–416Google Scholar
  12. 12.
    Tseng SC (1986) Topical treatment for severe dry-eye disorders. J Am Acad Dermatol 15:860–866PubMedGoogle Scholar
  13. 13.
    Blondi FC (1958) The late effects of x-radiation on the cornea. Trans Am Ophthalmol Soc 56:413–450Google Scholar
  14. 14.
    Albert DM, Wong VG, Henderson ES (1967) Ocular complications of vincristine therapy. Arch Ophthalmol 78:709–713PubMedGoogle Scholar
  15. 15.
    Kaiser-Kupfer MI, Lippman ME (1978) Tamoxifen retinopathy. Cancer Treat Rep 62:315–320PubMedGoogle Scholar
  16. 16.
    Merriam GR, Focht EF (1957) A clinical study of radiation cataracts and the relationship to dose. Am J Roentgenol 77:759–785Google Scholar
  17. 17.
    Braver DA, Richards RD Good TA (1967) Posterior subcapsular cataracts in steroid treated children. Arch Ophthalmol 77:161PubMedGoogle Scholar
  18. 18.
    Loredo A, Rodriguez RS, Murillo L (1972) Cataracts after short-term corticosteroid treatment. N Engl J Med 286:160PubMedGoogle Scholar
  19. 19.
    Podos SM, Canellos GP (1969) Lens changes in chronic granulocytic leukemia. Possible relationship to chemotherapy. Am J Ophthalmol 68:500–504PubMedGoogle Scholar
  20. 20.
    Gorin MB, Day R, Costantino JP (1998) Long-term tamoxifen citrate use and potential ocular toxicity. Am J Ophthalmol 125:493–501CrossRefPubMedGoogle Scholar
  21. 21.
    Armaly MF (1966) The heritable nature of dexamethasoneinduced ocular hypertension. Arch Ophthalmol 75:32–35PubMedGoogle Scholar
  22. 22.
    Armaly MF (1963) Effect of corticosteroids on intraocular pressure and fluid dynamics. I. Effect of dexamethasone in the normal eye. Arch Ophthalmol 70:482–490PubMedGoogle Scholar
  23. 23.
    Armaly MF (1963) Effect of corticosteroids on intraocular pressure and fluid dynamics. II. The effect of dexamethasone in the glaucomatous eye. Arch Ophthalmol 70:492–499PubMedGoogle Scholar
  24. 24.
    Spaeth GL, Rodriques MM, Weinreb S (1977) Steroid induced glaucoma. A: Persistent elevation of intraocular pressure. B: Histopathological aspects. Trans Am Ophthalmol Soc 75:353–381PubMedGoogle Scholar
  25. 25.
    Margo CE, Murtagh FR (1993) Ocular and orbital toxicity after intra-carotid cisplatin therapy. Am J Ophthalmol 116:508–509PubMedGoogle Scholar
  26. 26.
    Anderson B, Anderson B (1960) Necrotizing uveitis incident to perfusion of intracranial malignancies with nitrogen mustard and related compounds. Trans Am Ophthalmol Soc 58:95–104PubMedGoogle Scholar
  27. 27.
    Brown GC, Shields JA, Sanborn G et al (1982) Radiation retinopathy. Ophthalmology 89:1494–1501PubMedGoogle Scholar
  28. 28.
    Shingleton BJ, Bienfang DC, Albert DM et al (1982) Ocular toxicity associated with high-dose carmustine. Arch Ophthalmol 100:1766–1772PubMedGoogle Scholar
  29. 29.
    Miller DF, Bay JW, Lederman RJ (1985) Ocular and orbital toxicity following intra-carotid injection of BCNU and cisplatin for malignant gliomas. Ophthalmology 92:402–406PubMedGoogle Scholar
  30. 30.
    Ostrow S, Hohn D, Wiernik PH et al (1978) Ophthalmologic toxicity after cis-dichlorodiamine platinum (II) therapy. Cancer Treat Rep 62:1591–1593PubMedGoogle Scholar
  31. 31.
    Margo CE, Murtagh FR (1993) Ocular and orbital toxicity after intra-carotid cisplatin therapy. Am J Ophthalmol 116:508–509PubMedGoogle Scholar
  32. 32.
    Rankin EM, Pitts JE (1993) Ophthalmic toxicity during carboplatin therapy. Ann Oncol 4:337–338PubMedGoogle Scholar
  33. 33.
    Millay, RH, Klein ML, Shults WT (1986) Maculopathy associated with combination chemotherapy and osmotic opening of the blood brain barrier. Am J Ophthalmol 102:626–632PubMedGoogle Scholar
  34. 34.
    Ashford AR, Donev I, Tlwarl RP (1988) Reversible ocular toxicity related to tamoxifen therapy. Cancer 61:33–35PubMedGoogle Scholar
  35. 35.
    Albert DM, Wong VG, Henderson ES (1967) Ocular complications of vincristine therapy. Arch Ophthalmol 78:709–713PubMedGoogle Scholar
  36. 36.
    Shurin SB, Rekate HL, Annable W (1982) Optic atrophy induced by vincristine. Pediatrics 70:288–291PubMedGoogle Scholar
  37. 37.
    Porges Y, Blumen S, Fireman Z et al (1998) Cyclosporine-induced optic neuropathy, ophthalmoplegia, and nystagmus in a patient with Crohn's disease. Am J Ophthalmol 126:607–609CrossRefPubMedGoogle Scholar
  38. 38.
    Chun JH, Leyland-Jones BR, Caryk SM et al (1986) Central nervous system toxicity of fludarabine phosphate. Cancer Treat Rep 70:1225–1228PubMedGoogle Scholar
  39. 39.
    Capri G, Munzone E, Tarenzi E et al (1994) Optic nerve disturbances: a new form of paclitaxel neurotoxicity. J Natl Cancer Inst 86:1099–1101PubMedGoogle Scholar
  40. 40.
    Margileth DA, Poplack DG, Pizzo PA (1977) Blindness during remission in two patients with acute lymphoblastic leukemia. A possible complication of multimodality therapy. Cancer 39:58–61PubMedGoogle Scholar
  41. 41.
    Abramson DH (1988) The diagnosis of retinoblastoma. Bull NY Acad Med 64:283–317Google Scholar
  42. 42.
    Abramson DH, Frank CM (1998) Second non-ocular tumors in survivors of bilateral retinoblastoma: a possible age effect on radiation-related risk. Ophthalmology. 105:573–579; discussion 579–5780CrossRefPubMedGoogle Scholar
  43. 43.
    Lauer AK, Wobig JL, Shults WT et al (1999) Severe ocular and orbital toxicity after intracarotid etoposide phosphate and carboplatin therapy. Am J Ophthalmol 127:230–233CrossRefPubMedGoogle Scholar
  44. 44.
    Van Dalen JT, Sherman MD (1989) Corticosteroid-induced exophthalmos. Doc Ophthalmol 72:273–277CrossRefPubMedGoogle Scholar
  45. 45.
    Bixenman WW, Nicholls JV, Warwick OH (1968) Oculomotor disturbances associated with 5-fluorouracil chemotherapy. Am J Ophthalmol 83:604–608Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Michael Ober
  • Camille A. Servodidio
  • David Abramson

There are no affiliations available

Personalised recommendations