Second Malignancies Following Treatment for Childhood Cancer

  • Barbara Anne Hieb
  • Susan K. Ogle
  • Anna T. Meadows
Part of the Pediatric Oncology book series (PEDIATRICO)


Clin Oncol Childhood Cancer Childhood Cancer Survivor Multiple Primary Cancer Nevoid Basal Cell Carcinoma Syndrome 
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  1. 1.
    Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL (2003) New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 21:1352–1358CrossRefPubMedGoogle Scholar
  2. 2.
    Bassal M, Kadan-Lottick NS, Neglia JP, Taylor L, Yasui Y, Friedman DL, Mertens AC, Robison LL, Meadows AT (2004) Risk of rare adult-type carcinomas as a subsequent malignant neoplasm in survivors of childhood cancer: the Childhood Cancer Survivor Study. Paper presented at the ASCO, New Orleans, Louisiana, abstr. 8530Google Scholar
  3. 3.
    Bhatia S, Ramsay NK, Steinbuch M, Dusenbery KE, Shapiro RS, Weisdorf DJ, Robison LL, Miller JS, Neglia JP (1996a) Malignant neoplasms following bone marrow transplantation. Blood 87:3633–3639PubMedGoogle Scholar
  4. 4.
    Bhatia S, Robison LL, Oberlin O, Greenberg M, Bunin G, Fossati-Bellani F, Meadows AT (1996b) Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med 334:745–751CrossRefPubMedGoogle Scholar
  5. 5.
    Bhatia S, Yasui Y, Robison LL, Birch JM, Bogue MK, Diller L, DeLaat C, Fossati-Bellani F, Morgan E, Oberlin O, Reaman G, Ruymann FB, Tersak J, Meadows AT (2003) High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group. J Clin Oncol 21:4386–4394CrossRefPubMedGoogle Scholar
  6. 6.
    Birch JM, Hartley AL, Tricker KJ, Prosser J, Condie A, Kelsey AM, Harris M, Jones PH, Binchy A, Crowther D et al (1994) Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res 54:1298–1304PubMedGoogle Scholar
  7. 7.
    Bishop DT, Kolodner RD (1999) DNA repair disorders and multiple primary cancers. In: Neugut AI, Meadows AT, Robinson E (eds) Multiple primary cancers. Lippincott Williams and Wilkins, Philadelphia, pp 197–212Google Scholar
  8. 8.
    Curtis RE, Boice JD Jr, Stovall M, Bernstein L, Greenberg RS, Flannery JT, Schwartz AG, Weyer P, Moloney WC, Hoover RN (1992) Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N Engl J Med 326:1745–1751PubMedGoogle Scholar
  9. 9.
    Curtis RE, Travis LB, Rowlings PA, Socie G, Kingma DW, Banks PM, Jaffe ES, Sale GE, Horowitz MM, Witherspoon RP, Shriner DA, Weisdorf DJ, Kolb HJ, Sullivan KM, Sobocinski KA, Gale RP, Hoover RN, Fraumeni JF Jr, Deeg HJ (1999) Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood 94:2208–2216PubMedGoogle Scholar
  10. 10.
    Diller L, Medeiros Nancarrow C, Shaffer K, Matulonis U, Mauch P, Neuberg D, Tarbell NJ, Litman H, Garber J (2002) Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol 20:2085–2091CrossRefPubMedGoogle Scholar
  11. 11.
    Dunst J, Ahrens S, Paulussen M, Rube C, Winkelmann W, Zoubek A, Harms D, Jurgens H (1998) Second malignancies after treatment for Ewing's sarcoma: a report of the CESS-studies. Int J Radiat Oncol Biol Phys 42:379–384CrossRefPubMedGoogle Scholar
  12. 12.
    Eng C, Maher ER (1999) Dominant genes and phakomatoses associated with multiple primary cancers. In: Neugut AI, Meadows AT, Robinson E (eds) Multiple primary cancers. Lippincott Williams and Wilkins, Philadelphia, pp 165–195Google Scholar
  13. 13.
    Felix CA (1999) Chemotherapy-related second cancers. In: Neugut AI, Meadows AT, Robinson E (eds) Multiple primary cancers. Lippincott Williams and Wilkins, Philadelphia, Lippincott Williams and Wilkins, Philadelphia, p. 137–164Google Scholar
  14. 14.
    Friedman DL, Meadows AT (1999) Pediatric tumors. p. 235–256Google Scholar
  15. 15.
    Friedman DL, Himelstein B, Shields CL, Shields JA, Needle M, Miller D, Bunin GR, Meadows AT (2000) Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma. J Clin Oncol 18:12–17PubMedGoogle Scholar
  16. 16.
    Friedman DJ, Whitton JA, Yasui Y, Mertens AC, Hammond S, Stovall M, Donaldson SS, Meadows AT, Robison LL, Neglia JP (2004) Second malignant neoplasms in five-year survivors of childhood cancer: an update from the Childhood Cancer Survivor Study. Paper presented at the ASCO, New Orleans, Louisiana, abstr. 8530Google Scholar
  17. 17.
    Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643–646PubMedGoogle Scholar
  18. 18.
    Gross TG, Steinbuch M, DeFor T, Shapiro RS, McGlave P, Ramsay NK, Wagner JE, Filipovich AH (1999) B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome. Bone Marrow Transplant 23:251–258CrossRefPubMedGoogle Scholar
  19. 19.
    Guerin S, Dupuy A, Anderson H, Shamsaldin A, Svahn-Tapper G, Moller T, Quiniou E, Garwicz S, Hawkins M, Avril MF, Oberlin O, Chavaudra J, de Vathaire F (2003) Radiation dose as a risk factor for malignant melanoma following childhood cancer. Eur J Cancer 39:2379–2386CrossRefPubMedGoogle Scholar
  20. 20.
    Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, Viskochil D (1997) The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 278:51–57CrossRefPubMedGoogle Scholar
  21. 21.
    Hawkins MM, Wilson LM, Burton HS, Potok MH, Winter DL, Marsden HB, Stovall MA (1996) Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 88:270–278PubMedGoogle Scholar
  22. 22.
    Hino O, Kobayashi E, Hirayama Y, Kobayashi T, Kubo Y, Tsuchiya H, Kikuchi Y, Mitani H (1995) Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2). Mol Carcinog 14:23–27PubMedGoogle Scholar
  23. 23.
    Inskip PD (1999) Second cancers following radiotherapy. In: Neugut AI, Meadows AT, Robinson E (eds) Multiple primary cancers. Lippincott Williams and Wilkins, Philadelphia, pp 91–136Google Scholar
  24. 24.
    Inskip PD (2001) Thyroid cancer after radiotherapy for childhood cancer. Med Pediatr Oncol 36:568–573CrossRefPubMedGoogle Scholar
  25. 25.
    Jablon S, Kato H (1970) Childhood cancer in relation to prenatal exposure to atomic-bomb radiation. Lancet 2:1000–1003CrossRefPubMedGoogle Scholar
  26. 26.
    Karagas MR, McDonald JA, Greenberg ER, Stukel TA, Weiss JE, Baron JA, Stevens MM (1996) Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy. For The Skin Cancer Prevention Study Group. J Natl Cancer Inst 88:1848–1853PubMedGoogle Scholar
  27. 27.
    Karnes PS (1998) Neurofibromatosis: a common neurocutaneous disorder. Mayo Clin Proc 73:1071–1076PubMedGoogle Scholar
  28. 28.
    Kaste SC, Hudson MM, Jones DJ, Fryrear R, Greenwald CA, Fleming ID, Pratt CB (1998) Breast masses in women treated for childhood cancer: incidence and screening guidelines. Cancer 82:784–792CrossRefPubMedGoogle Scholar
  29. 29.
    Kivela T (1999) Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol 17:1829–1837PubMedGoogle Scholar
  30. 30.
    Knudson AG, Jr. (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820–823PubMedGoogle Scholar
  31. 31.
    Krishnan A, Bhatia S, Slovak ML, Arber DA, Niland JC, Nademanee A, Fung H, Bhatia R, Kashyap A, Molina A, O'Donnell MR, Parker PA, Sniecinski I, Snyder DS, Spielberger R, Stein A, Forman SJ (2000) Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors. Blood 95:1588–1593PubMedGoogle Scholar
  32. 32.
    Kuttesch JF Jr, Wexler LH, Marcus RB, Fairclough D, Weaver-McClure L, White M, Mao L, Delaney TF, Pratt CB, Horowitz ME, Kun LE (1996) Second malignancies after Ewing's sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol 14:2818–2825PubMedGoogle Scholar
  33. 33.
    Le Deley MC, Leblanc T, Shamsaldin A, Raquin MA, Lacour B, Sommelet D, Chompret A, Cayuela JM, Bayle C, Bernheim A, de Vathaire F, Vassal G, Hill C (2003) Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Societe Francaise d'Oncologie Pediatrique. J Clin Oncol 21:1074–1081CrossRefPubMedGoogle Scholar
  34. 34.
    Lefkowitz IB, Obringer AC, Meadows AT (1990) Neurofi-bromatosis and cancer: incidence and management. In: Rubenstein AE, Korf BR (eds) Neurofibromatosis: a handbook for patients, families and health care professionals. Thieme Medical, New York, pp 99–110Google Scholar
  35. 35.
    Li FP, Fraumeni JF J. (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 71:747–752PubMedGoogle Scholar
  36. 36.
    Loning L, Kaatsch P, Riehm H, Schrappe M (1998) Secondary neoplasms subsequent to acute lymphoblastic leukemia in childhood: experience of the BFM study group. Blood 92:679aGoogle Scholar
  37. 37.
    Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA et al (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233–1238PubMedGoogle Scholar
  38. 38.
    Meadows AT, Baum E, Fossati-Bellani F, Green D, Jenkin RD, Marsden B, Nesbit M, Newton W, Oberlin O, Sallan SG et al (1985) Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 3:532–538PubMedGoogle Scholar
  39. 39.
    Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, Smithson WA, Robison LL (2001) Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 19:3163–3172PubMedGoogle Scholar
  40. 40.
    Moolgavkar SH, Knudson AG Jr (1981) Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst 66:1037–1052PubMedGoogle Scholar
  41. 41.
    Neglia JP, Meadows AT, Robison LL, Kim TH, Newton WA, Ruymann FB, Sather HN, Hammond GD (1991) Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 325:1330–1336PubMedGoogle Scholar
  42. 42.
    Neglia JP, Friedman DL, Yasui Y, Mertens AC, Hammond S, Stovall M, Donaldson SS, Meadows AT, Robison LL (2001) Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 93:618–629CrossRefPubMedGoogle Scholar
  43. 43.
    Newton WA Jr, Meadows AT, Shimada H, Bunin GR, Vawter GF (1991) Bone sarcomas as second malignant neoplasms following childhood cancer. Cancer 67:193–201PubMedGoogle Scholar
  44. 44.
    Nichols KE, Heath JA, Friedman D, Biegel JA, Ganguly A, Mauch P, Diller L (2003) TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms. J Clin Oncol 21:4505–4509CrossRefPubMedGoogle Scholar
  45. 45.
    Pedersen-Bjergaard J, Larsen SO (1982) Incidence of acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin's disease. N Engl J Med 307:965–971PubMedGoogle Scholar
  46. 46.
    Pedersen-Bjergaard J, Andersen MK, Christiansen DH (2000) Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood 95:3273–3279PubMedGoogle Scholar
  47. 47.
    Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer Z, Robison LL, Mertens AC (2003) Non-melanoma skin cancer in survivors of childhood and adolescent cancer: a report from the Childhood cancer Survivor Study. Paper presented at the ASCO, New Orleans, Louisiana, abstr. 8530Google Scholar
  48. 48.
    Pui CH, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, Head DR, Behm FG, Mahmoud MH, Sandlund JT et al (1991) Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 325:1682–1687PubMedGoogle Scholar
  49. 49.
    Relling MV, Rubnitz JE, Rivera GK, Boyett JM, Hancock ML, Felix CA, Kun LE, Walter AW, Evans WE, Pui CH (1999) High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 354:34–39CrossRefPubMedGoogle Scholar
  50. 50.
    Ron E, Modan B, Boice JD Jr, Alfandary E, Stovall M, Chetrit A, Katz L (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039PubMedGoogle Scholar
  51. 51.
    Schellong G, Riepenhausen M, Creutzig U, Ritter J, Harbott J, Mann G, Gadner H (1997) Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group. J Clin Oncol 15:2247–2253PubMedGoogle Scholar
  52. 52.
    Shields CL, Meadows AT, Shields JA, Carvalho C, Smith AF (2001) Chemoreduction for retinoblastoma may prevent intracranial neuroblastic malignancy (trilateral retinoblastoma). Arch Ophthalmol 119:1269–1272PubMedGoogle Scholar
  53. 53.
    Sigurdson A, Ronckers CM, Mertens AC et al (2004) Second Primary Thyroid Cancer After First Childhood Malignancy: a report from the Childhood Cancer Survivor Study. Paper presented at the Epidemiologisch Congress, LeidenGoogle Scholar
  54. 54.
    Smith MA, Rubinstein L, Anderson JR, Arthur D, Catalano PJ, Freidlin B, Heyn R, Khayat A, Krailo M, Land VJ, Miser J, Shuster J, Vena D (1999) Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol 17:569–577PubMedGoogle Scholar
  55. 55.
    Socie G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB, Sullivan KM, Rowlings PA, Kingma DW, Banks PM, Travis WD, Witherspoon RP, Sanders J, Jaffe ES, Horowitz MM (2000) New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol 18:348–357PubMedGoogle Scholar
  56. 56.
    Toguchida J, Yamaguchi T, Dayton SH, Beauchamp RL, Herrera GE, Ishizaki K, Yamamuro T, Meyers PA, Little JB, Sasaki MS et al (1992) Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma. N Engl J Med 326:1301–1308PubMedGoogle Scholar
  57. 57.
    Travis LB, Hill DA, Dores GM, Gospodarowicz M, van Leeuwen FE, Holowaty E, Glimelius B, Andersson M, Wiklund T, Lynch CF, Van't Veer MB, Glimelius I, Storm H, Pukkala E, Stovall M, Curtis R, Boice JD Jr, Gilbert E (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 290:465–475CrossRefPubMedGoogle Scholar
  58. 58.
    Tucker MA, D'Angio GJ, Boice JD Jr, Strong LC, Li FP, Stovall M, Stone BJ, Green DM, Lombardi F, Newton W et al (1987) Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 317:588–593PubMedGoogle Scholar
  59. 59.
    Tucker MA, Jones PH, Boice JD Jr, Robison LL, Stone BJ, Stovall M, Jenkin RD, Lubin JH, Baum ES, Siegel SE, Merdons AT, Hoover RN, Kaumeni JF (1991) Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group. Cancer Res 51:2885–2888PubMedGoogle Scholar
  60. 60.
    Van Leeuwen FE, Klokman WJ, Veer MB, Hagenbeek A, Krol AD, Vetter UA, Schaapveld M, van Heerde P, Burgers JM, Somers R, Aleman BM (2000) Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood. J Clin Oncol 18:487–497PubMedGoogle Scholar
  61. 61.
    Walter AW, Hancock ML, Pui CH, Hudson MM, Ochs JS, Rivera GK, Pratt CB, Boyett JM, Kun LE (1998) Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J Clin Oncol 16:3761–3767PubMedGoogle Scholar
  62. 62.
    Wong FL, Boice JD Jr, Abramson DH, Tarone RE, Kleinerman RA, Stovall M, Goldman MB, Seddon JM, Tarbell N, Fraumeni JF Jr, Li FP (1997) Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 278:1262–1267CrossRefPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Barbara Anne Hieb
  • Susan K. Ogle
  • Anna T. Meadows

There are no affiliations available

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