The Testes

  • Jill P. Ginsberg
  • Amit Maity
Part of the Pediatric Oncology book series (PEDIATRICO)


Sertoli Cell Leydig Cell Seminiferous Tubule Gonadal Function Testicular Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ahmed SR, Shalet SM, Campbell RH, Deakin DP (1983) Primary gonadal damage following treatment of brain tumors in childhood. J Pediatr 103:562–565PubMedGoogle Scholar
  2. 2.
    Albers-Schonberg HE (1903) Über eine bisher unbekannte Wirkung der Roengenstrahlen auf den Organismus der Tiere. Munch Med Wochenschr 50:1859–1860Google Scholar
  3. 3.
    Andersson AM, Muller J, Skakkeaek NE (1998) Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 83:4451–4458CrossRefPubMedGoogle Scholar
  4. 4.
    Ash P (1980) The influence of radiation on fertility in man. Br J Radiol 53:271–278PubMedGoogle Scholar
  5. 5.
    Aubier F, Flamamant F, Brauner R, Caillaud JM, Chaussain JM, Lemerle J (1989) Male gonadal function after chemotherapy for solid tumors in childhood. J Clin Oncol 7:304–309PubMedGoogle Scholar
  6. 6.
    Bakker B, Massa GG, Oostdijk W, van Weel-Sipman MH, Vossen JM, Wit JM (2000) Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies. Eur J Pediatr 159:31–37CrossRefPubMedGoogle Scholar
  7. 7.
    Ben Arush MW, Solt I, Lightman A, Linn S, Kuten A (2000) Male gonadal function in survivors of childhood Hodgkin and non-Hodgkin lymphoma, Pediatr Hematol Oncol 17: 239–245CrossRefPubMedGoogle Scholar
  8. 8.
    Blatt J, Sherins RJ, Niebrugge D, Bleyer WA, Poplack DG (1985) Leydig cell function in boys following treatment for testicular relapse of acute lymphoblastic leukemia. J Clin Oncol 3:1227–1231PubMedGoogle Scholar
  9. 9.
    Brauner R, Czernichow P, Cramer P, Schaison G, Rappaport R (1983) Leydig-cell function in children after direct testicular irradiation for acute lymphoblastic leukemia. N Engl J Med 309:25–28PubMedGoogle Scholar
  10. 10.
    Buchanan JD, Fairley KF, Barrier JU (1975) Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 2:156–157CrossRefPubMedGoogle Scholar
  11. 11.
    Byrne J, Mulvihill JJ, Myers MH, Connelly RR, Naughton MD, Krauss MR, Steinhorn SC, Hassinger DD, Austin DF, Bragg K (1987) Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 19:1315–1321Google Scholar
  12. 12.
    Castillo LA, Craft AW, Kernahan J, Evans RG, Aynsley-Green A (1990) Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia. Med Pediatr Oncol 18:185–189PubMedGoogle Scholar
  13. 13.
    Centola GM, Keller JW, Henzler M, Rubin P (1994) Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl 15:608–613PubMedGoogle Scholar
  14. 14.
    Chan PT.K, Palermo GD, Veeck LL, Rosenwaks Z, Schlegel PN (2001) Testicular sperm extraction combined with intracytoplasmic sperm injection in the treatment of men with persistent azoospermia post-chemotherapy. Cancer 92:1632–1637CrossRefPubMedGoogle Scholar
  15. 15.
    Charak BS, Gupta R, Mandrekar P, Sheth NA, Banavali SD, Saikia TK, Gopal R, Dinshaw KA, Advani SH (1990) Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin's disease. A long-term follow-up study. Cancer 65:1903–1906PubMedGoogle Scholar
  16. 16.
    Colvin M (1982) The comparative pharmacology of cyclophosphamide and ifosfamide. Semin Oncol 9:2–7PubMedGoogle Scholar
  17. 17.
    Conte FA, Grumbach MM (1990) Pathogenesis, classification, diagnosis and treatment of anomalies of sex. In: Degroot LJ (ed) Endocrinology. Saunders, PhiladelphiaGoogle Scholar
  18. 18.
    Couto-Silva AC, Trivin C, Thibaud E, Esperou H, Michon J, Brauner R (2001) Factors affecting gonadal function after bone marrow transplantation during childhood. Bone Marrow Transplant 28:67–75CrossRefPubMedGoogle Scholar
  19. 19.
    Czeizel A, Erodi E, Toth J (1981) Genetics of undescended testes. J Urol 126:528PubMedGoogle Scholar
  20. 20.
    Da Cunha MF, Meistrich ML, Fuller LM (1984) Recovery of spermatogenesis after treatment for Hodgkin's disease: limiting dose of MOPP chemotherapy. J Clin Oncol 2:571–577PubMedGoogle Scholar
  21. 21.
    Damani MN, Masters V, Meng MV, Burgess C, Turek P, Oates RD (2002) Post-chemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 20:930–936CrossRefPubMedGoogle Scholar
  22. 22.
    de Kretser DM, McFarlane JR (1996) Inhibin in the male. J Androl 17:179–182PubMedGoogle Scholar
  23. 23.
    Fraass BA, Kinsella TJ, Harrington FS, Glatstein E (1985) Peripheral dose to the testes: the design and clinical use of a practical and effective gonadal shield. Int J Radiat Oncol Biol Phys 11:609–615PubMedGoogle Scholar
  24. 24.
    Giwercman A, von der Maase H, Berthelsen JG, Rorth M, Bertelsen A, Skakkebaek NE (1991) Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab 73:596–603PubMedGoogle Scholar
  25. 25.
    Hahn EW, Feingold SM, Nisce L (1976) Aspermia and recovery of spermatogenesis in cancer patients following incidental gonadal irradiation during treatment: a progress report. Radiology 119:223–225PubMedGoogle Scholar
  26. 26.
    Hahn EW, Feingold SM, Simpson L, Batata M (1982) Recovery from aspermia induced by low-dose radiation in seminoma patients. Cancer 50:337–340PubMedGoogle Scholar
  27. 27.
    Hansen PV, Hansen SW (1993) Gonadal function in men with testicular germ cell cancer: the influence of cisplatin-based chemotherapy. Eur Urol 23:153–156PubMedGoogle Scholar
  28. 28.
    Hansen PV, Trykker H, Helkjoer PE, Andersen J (1989) Testicular function in patients with testicular cancer treated with orchiectomy alone or orchiectomy plus cisplatin-based chemotherapy. J Natl Cancer Inst 81:1246–1250PubMedGoogle Scholar
  29. 29.
    Hassel JU, Bramswig JH, Schlegel W, Schellong G (1991) Testicular function after OPA/COMP chemotherapy without procarbazine in boys with Hodgkin's disease. Results in 25 patients of the DAL-HD-85 study. Klin Padiatr 203:268–272PubMedGoogle Scholar
  30. 30.
    Hayes FJ, Hall JE, Boepple PA, Crowley WF (1998) Differential control of gonadotropin secretion in the human: endocrine role of inhibin. J Clin Endocrinol Metab 83:1835–1841CrossRefPubMedGoogle Scholar
  31. 31.
    Heikens J, Behrendt H, Adriaanse R, Berghout A (1996) Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease. Cancer 78:2020–2024CrossRefPubMedGoogle Scholar
  32. 32.
    Heyn R, Raney RB, Jr, Hays DM, Tefft M, Gehan E, Webber B, Maurer HM (1992) Late effects of therapy in patients with paratesticular rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol 10:614–623PubMedGoogle Scholar
  33. 33.
    Howell S, Shalet S (1998) Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am 27:927–943CrossRefPubMedGoogle Scholar
  34. 34.
    Howell SJ, Shalet SM (2001) Testicular function following chemotherapy. Hum Reprod Update 7:363–369CrossRefPubMedGoogle Scholar
  35. 35.
    Howell SJ, Shalet SM (2002) Effect of cancer therapy on pituitary-testicular axis. Int J Androl 25:269–276CrossRefPubMedGoogle Scholar
  36. 36.
    Izard MA (1995) Leydig cell function and radiation: a review of the literature. Radiother Oncol 34:1–8CrossRefPubMedGoogle Scholar
  37. 37.
    Jensen TK, Andersson AM, Hjollund NH (1997) Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab 82:4059–4063CrossRefPubMedGoogle Scholar
  38. 38.
    Johnson DH, Linde R, Hainsworth JD, Vale W, Rivier J, Stein R, Flexner J, van Welch R, Greco FA (1985) Effect of luteinizing hormone releasing hormone agonist given during combination chemotherapy on post-therapy fertility in male patients with lymphoma: preliminary observations. Blood 65:832–836PubMedGoogle Scholar
  39. 39.
    Kenney LB, Laufer MR, Grant FD, Grier H, Diller L (2001) High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer 91:613–621CrossRefPubMedGoogle Scholar
  40. 40.
    Khan F (2003) The physics of radiation therapy, 3rd edn. Lippincott, Willimas and Wilkins, PhiladelphiaGoogle Scholar
  41. 41.
    Kinsella TJ, Trivette G, Rowland J, Sorace R, Miller R, Fraass B, Steinberg SM, Glatstein E, Sherins RJ (1989) Long-term follow-up of testicular function following radiation therapy for early-stage Hodgkin's disease. J Clin Oncol 7:718–724PubMedGoogle Scholar
  42. 42.
    Kreuser ED, Hetzel WD, Heit W, Hoelzer D, Kurrle E, Xiros N, Heimpel H (1988) Reproductive and endocrine gonadal functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia. J Clin Oncol 6:588–595PubMedGoogle Scholar
  43. 43.
    Kulkarni SS, Sastry PS, Saikia TK, Parikh PM, Gopal R, Advani SH (1997) Gonadal function following ABVD therapy for Hodgkin's disease. Am J Clin Oncol 20:354–357CrossRefPubMedGoogle Scholar
  44. 44.
    Lampe H, Horwich A, Norman A, Nicholls J, Dearnaley DP (1997) Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol 15:239–245PubMedGoogle Scholar
  45. 45.
    Leiper AD, Grant DB, Chessells JM (1986) Gonadal function after testicular radiation for acute lymphoblastic leukaemia. Arch Dis Child 61:53–56PubMedGoogle Scholar
  46. 46.
    Leiper AD, Stanhope R, Lau T, Grant DB, Blacklock H, Chessells JM, Plowman PN (1987) The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function. Br J Haematol 67:419–426PubMedGoogle Scholar
  47. 47.
    Livesey EA, Brook CG (1988) Gonadal dysfunction after treatment of intracranial tumours. Arch Dis Child 63:495–500PubMedGoogle Scholar
  48. 48.
    Longhi A, Macchiagodena M, Vitali G, Bacci G (2003) Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. J Pediatr Hematol Oncol 25:292–296CrossRefPubMedGoogle Scholar
  49. 49.
    Mackie EJ, Radford M, Shalet SM (1996) Gonadal function following chemotherapy for childhood Hodgkin's disease. Med Pediatr Oncol 27:74–78CrossRefPubMedGoogle Scholar
  50. 50.
    Marshall WA, Tanner JM (1970) Variation in pattern of pubertal changes in boys. Arch Dis Child:45:13–23PubMedGoogle Scholar
  51. 51.
    Moore KL (1988) The urogenital system. The developing human. Saunders, TorontoGoogle Scholar
  52. 52.
    Morris ID (1996) The testis: endocrine function. In: Hiller SG, Kitchener HC, Neilson JP (eds) Scientific essentials of reproductive medicine. Saunders, London, pp 160–171Google Scholar
  53. 53.
    Muller J, Sonksen J, Sommer P, Schmiegelow M, Petersen PM, Heilman C, Schmiegelow K (2000) Cryopreservation of semen from pubertal boys with cancer. Med Ped Oncol 34:191–194CrossRefGoogle Scholar
  54. 54.
    Muller U, Stahel RA (1993) Gonadal function after MACOPB or VACOP-B with or without dose intensification and ABMT in young patients with aggressive non-Hodgkin's lymphoma. Ann Oncol 4:399–402PubMedGoogle Scholar
  55. 55.
    O'Dell WD (1989) Puberty. In: DeGroot LJ (ed) Endocrinology, 2nd edn. Saunders, PhiladelphiaGoogle Scholar
  56. 56.
    Ogilvy-Stuart AL, Clark DJ, Wallace WH, Gibson BE, Stevens RF, Shalet SM, Donaldson MD (1992) Endocrine deficit after fractionated total body irradiation, Arch Dis Child, 67:1107–10PubMedGoogle Scholar
  57. 57.
    Ortin TT, Shostak CA, Donaldson SS (1990) Gonadal status and reproductive function following treatment for Hodgkin's disease in childhood: the Stanford experience. Int J Radiat Oncol Biol Phys 19:873–880PubMedGoogle Scholar
  58. 58.
    Palermo GD, Cohen J, Alikani M, Adler A, Rosenwaks Z (1995) Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility. Fertil Steril 63: 1231–1240PubMedGoogle Scholar
  59. 59.
    Papadakis V, Vlachopapadopoulou E, van Syckle K, Ganshaw L, Kalmanti M, Tan C, Sklar C (1999) Gonadal function in young patients successfully treated for Hodgkin disease. Med Pediatr Oncol 32:366–372CrossRefPubMedGoogle Scholar
  60. 60.
    Petersen PM, Andersson AM, Rorth M, Daugaard G, Skakkeaek NE (1999) Undetectable inhibin B serum levels in men after testicular irradiation. J Clin Endocrinol Metab 84:213–215CrossRefPubMedGoogle Scholar
  61. 61.
    Petersen PM, Giwercman A, Daugaard G, Rorth M, Petersen JH, Skakkeaek NE, Hansen SW, von der Maase H (2002) Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis. J Clin Oncol 20:1537–1543CrossRefPubMedGoogle Scholar
  62. 62.
    Pfeifer SM, Coutifaris C (1999) Reproductive technologies 1998: options available for the cancer patient. Med Ped Oncol 33:34–40CrossRefGoogle Scholar
  63. 63.
    Pryzant RM, Meistrich ML, Wilson G (1993) Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J Clin Oncol 11:239–247PubMedGoogle Scholar
  64. 64.
    Radford JA, Clark S, Crowther D, Shalet SM (1994) Male fertility after VAPEC-B chemotherapy for Hodgkin's disease and non-Hodgkin's lymphoma. Br J Cancer 69:379–381PubMedGoogle Scholar
  65. 65.
    Regaud C, Blanc J (1906) Extreme sensibilite des spermatogonies a ces rayons. CR Soc Biol Paris 61:163–165Google Scholar
  66. 66.
    Rivkees SA, Crawford JD (1988) The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA 259:2123–2125CrossRefPubMedGoogle Scholar
  67. 67.
    Sandeman TF (1966) The effects of x irradiation on male human fertility. Br J Radiol 39:901–907PubMedGoogle Scholar
  68. 68.
    Sanders JE, Pritchard S, Mahoney P, Amos D, Buckner CD, Witherspoon RP, Deeg HJ, Doney KC, Sullivan KM, Appelbaum FR et al. (1986) Growth and development following marrow transplantation for leukemia. Blood 68:1129–1135PubMedGoogle Scholar
  69. 69.
    Sarafoglou K, Boulad F, Gillio A, Sklar C (1997) Gonadal function after bone marrow transplantation for acute leukemia during childhood. J Pediatr 130:210–216PubMedGoogle Scholar
  70. 70.
    Schilsky RL (1989) Infertility in patients with testicular cancer: testis, tumor, or treatment? J Natl Cancer Inst 81:1204–1205PubMedGoogle Scholar
  71. 71.
    Schmiegelow M, Lassen S, Poulsen HS, Schmiegelow K, Hertz H, Andersson AM, Skakkebaek NE, Muller J (2001) Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab 86:2446–2452CrossRefPubMedGoogle Scholar
  72. 72.
    Shalet SM, Horner A, Ahmed SR, Morris-Jones PH (1985) Leydig cell damage after testicular irradiation for lymphoblastic leukaemia. Med Pediatr Oncol 13:65–68PubMedGoogle Scholar
  73. 73.
    Shalet SM, Tsatsoulis A, Whitehead E, Read G (1989) Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol 120:161–165PubMedGoogle Scholar
  74. 74.
    Shapiro E, Kinsella TJ, Makuch RW, Fraass BA, Glatstein E, Rosenberg SA, Sherins RJ (1985) Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 3:1232–1239PubMedGoogle Scholar
  75. 75.
    Sherins RJ, Olweny CL, Ziegler JL (1978) Gynaecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkins disease. N Engl J Med 299:12–16PubMedGoogle Scholar
  76. 76.
    Sklar C (1999) Reproductive physiology and treatment-related loss of sex hormone production. Med Pediatr Oncol 33:2–8CrossRefPubMedGoogle Scholar
  77. 77.
    Sklar CA, Robison LL, Nesbit ME, Sather HN, Meadows AT, Ortega JA, Kim TH, Hammond GD (1990) Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Children Cancer Study Group. J Clin Oncol 8:1981–1987PubMedGoogle Scholar
  78. 78.
    Smith EP, Boyd J, Frank GR (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056–1061CrossRefPubMedGoogle Scholar
  79. 79.
    Smith KD, Rodgriguez-Rigau LJ (1989) Laboratory evaluation of testicular function. In: Degroot LJ (ed) Endocrinology. Saunders, PhiladelphiaGoogle Scholar
  80. 80.
    Speiser B, Rubin P, Casarett G (1973) Aspermia following lower truncal irradiation in Hodgkin's disease. Cancer 32:692–698PubMedGoogle Scholar
  81. 81.
    Spitz S (1948) The histological effects of nitrogen mustards on human tumors and tissues. Cancer 1:383–398Google Scholar
  82. 82.
    Steinberger E (1989) Structural consideration of the male reproductive system. In: DeGroot LJ (ed) Endocrinology. Saunders, PhiladelphiaGoogle Scholar
  83. 83.
    Styne DM (1982) The testes: disorders of sexual differentiation and puberty. In: Kaplan SA (ed) Clinical pediatric endocrinology. Saunders, PhiladelphiaGoogle Scholar
  84. 84.
    Thomson AB, Campbell AJ, Irvine DC, Anderson RA, Kelnar CJ, Wallace WH (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study. Lancet 360:361–367CrossRefPubMedGoogle Scholar
  85. 85.
    Tsatsoulis A, Shalet SM, Morris ID, de Kretser DM (1990) Immunoactive inhibin as a marker of Sertoli cell function following cytotoxic damage to the human testis. Horm Res 34:254–259PubMedGoogle Scholar
  86. 86.
    Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G (1985) Gonadal toxicity after combination chemotherapy for Hodgkin's disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21:601–605CrossRefPubMedGoogle Scholar
  87. 87.
    Wallace WH, Shalet SM, Lendon M, Morris-Jones PH (1991) Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia, Int J Androl 14:312–319PubMedGoogle Scholar
  88. 88.
    Watson AR, Rance CP, Bain J (1985) Long-term effects of cyclophosphamide on testicular function. Br Med J 291:1457–1460Google Scholar
  89. 89.
    Waxman JH, Ahmed R, Smith D, Wrigley PF, Gregory W, Shalet S, Crowther D, Rees LH, Besser GM, Malpas JS (1987) Failure to preserve fertility in patients with Hodgkin's disease. Cancer Chemother Pharmacol 19:159–162CrossRefPubMedGoogle Scholar
  90. 90.
    Willemse PH, Sleijfer DT, Sluiter WJ, Schraffordt Koops H, Doorenbos H (1983) Altered Leydig cell function in patients with testicular cancer: evidence for bilateral testicular defect. Acta Endocrinol (Copenh) 102:616–624PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Jill P. Ginsberg
  • Amit Maity

There are no affiliations available

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