Imaging Techniques for Dynamic Susceptibility Contrast-Enhanced MRI

  • Michael Pedersen
  • Peter van Gelderen
  • Chrit T. W. Moonen
Part of the Medical Radiology book series (MEDRAD)


Contrast Agent Point Spread Function Magn Reson Image Mean Transit Time Spin Echo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aronen HJ, Gazit IE, Louis DN, Buchbinder BR, Pardo FS, Weisskoff RM, Harsh GR, Cosgrove GR, Halpern EF, Hochberg FH (1994) Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 191:41–51PubMedGoogle Scholar
  2. Aumann S, Schoenberg SO, Just A, Briley-Saebo K, Bjørnerud A, Bock M, Brix G (2003) Quantification of renal perfusion using an intravascular contrast agent (part 1): results in a canine model. Magn Reson Med 49:276–287CrossRefPubMedGoogle Scholar
  3. Axel L (1980) Cerebral blood flow determination by rapid-sequence computed tomography. Radiology 137:679–686PubMedGoogle Scholar
  4. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM (1995) MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 34:555–566PubMedGoogle Scholar
  5. Brix G, Semmler W, Port R, Schad LR, Layer G, Lorenz WJ (1991) Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 15:621–628PubMedGoogle Scholar
  6. Carroll TJ, Haughton VM, Rowley HA, Cordes D (2002) Confounding effect of large vessels on MR perfusion images analyzed with independent component analysis. AJNR Am J Neuroradiol 23:1007–1012PubMedGoogle Scholar
  7. D'Arcy JA, Collins DJ, Rowland IJ, Padhani AR, Leach MO (2002) Applications of sliding window reconstruction with cartesian sampling for dynamic contrast enhanced MRI. NMR Biomed 15:174–183CrossRefPubMedGoogle Scholar
  8. Donahue KM, Burstein D, Manning WJ, Gray ML (1994) Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med 32:66–76PubMedGoogle Scholar
  9. Donahue KM, Weisskoff RM, Burstein D (1997) Water diffusion and exchange as they influence contrast enhancement. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. J Magn Reson Imaging 7:102–110PubMedGoogle Scholar
  10. Duyn JH, Yang Y, Frank JA, Mattay VS, Hou L (1996) Functional magnetic resonance neuroimaging data acquisition techniques. Neuroimage 4:S76–S83PubMedGoogle Scholar
  11. Edelman RR, Mattle HP, Atkinson DJ, Hill T, Finn JP, Mayman C, Ronthal M, Hoogewoud HM, Kleefield J (1990) Cerebral blood flow: assessmen with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5T. Radiology 176:211–220PubMedGoogle Scholar
  12. Eichling JO, Raichle ME, Grubb RL Jr, Ter-Pogossian MM (1974) Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey. Circ Res 35:358–364PubMedGoogle Scholar
  13. Farzaneh F, Riedrer SJ, Pelc NJ (1992) Analysis of T2 limitations and off-resonance effects on spatial resolution and artifacts in Echo-Planar imaging. Magn Reson Med 14:123–139Google Scholar
  14. Fenstermacher JD, Blasberg RG, Patlak CS (1981) Methods for Quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 14:217–248CrossRefPubMedGoogle Scholar
  15. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ (1991) MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med 17:336–347PubMedGoogle Scholar
  16. Flacke S, Urbach H, Folkers PJ, Keller E, van den Brink JS, Traber F, Block W, Gieseke J, Schild HH (2000) Ultra-fast three-dimensional MR perfusion imaging of the entire brain in acute stroke assessment. J Magn Reson Imaging 11:250–259PubMedGoogle Scholar
  17. Freeman AJ, Gowland PA, Mansfield P (1998) Optimization of the ultrafast Look-Locker echo-planar imaging T1 mapping sequence. Magn Reson Med 16:765–772Google Scholar
  18. Fritz-Hansen T, Rostrup E, Larsson HB, Søndergaard L, Ring P, Henriksen O (1996) Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging. Magn Reson Med 36:225–231PubMedGoogle Scholar
  19. Golay X, Pruessmann KP, Weiger M, Crelier GR, Folkers PJ, Kollias SS, Boesiger P (2000) PRESTO-SENSE: an ultrafast whole-brain fMRI technique. Magn Reson Med 43:779–786CrossRefPubMedGoogle Scholar
  20. Gowland P, Mansfield P, Bullock P, Stehling M, Worthington B, Firth J (1992) Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging. Magn Reson Med 26:241–258PubMedGoogle Scholar
  21. Guckel FJ, Brix G, Schmiedek P, Piepgras Z, Becker G, Kopke J, Gross H, Georgi M (1996) Cerebraovascular reserve capacity in patients with occlusive cerebrovascular disease: assessment with dynamic susceptibility contrast-enhanced MR imaging and the acetozalomide stimulation test. Radiology 201:405–412PubMedGoogle Scholar
  22. Heiland S, Benner T, Debus J, Rempp K, Reith W, Sartor K (1999) Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood-brain-barrier. Magn Reson Imaging 17:21–27Google Scholar
  23. Henderson E, Sykes J, Drost D, Weinmann HJ, Rutt BK, Lee TY (2000) Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents. J Magn Reson Imaging 12:991–1003CrossRefPubMedGoogle Scholar
  24. Hou L, Yang Y, Mattay VS, Frank JA, Duyn JH (1999) Optimization of fast acquisition methods for whole-brain relative cerebral blood volume (rCBV) mapping with susceptibility contrast agents. J Magn Reson Imaging 9:233–239CrossRefPubMedGoogle Scholar
  25. Kjær L, Ring P, Thomsen C, Henriksen O (1995) Texture analysis in quantitative MR imaging. Tissue characterisation of normal brain and intracranial tumours at 1.5 T. Acta Radiol 36:127–135PubMedGoogle Scholar
  26. Koshimoto Y, Yamada H, Kimura H, Maeda M, Tsuchida C, Kawamura Y, Ishii Y (1999) Quantitative analysis of cerebral microvascular hemodynamics with T2-weighted dynamic MR imaging. J Magn Reson Imaging 9:462–467PubMedGoogle Scholar
  27. Lee JH, Li X, Sammi MK, Springer CS Jr (1999) Using flow relaxography to elucidate flow relaxivity. J Magn Reson 136:102–113CrossRefPubMedGoogle Scholar
  28. Li KL, Zhu XP, Waterton J, Jackson A (2000) Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 12:347–357CrossRefPubMedGoogle Scholar
  29. Lia TQ, Guang Chen Z, Østergaard L, Hindmarsh T, Moseley ME (2000) Quantification of cerebral blood flow by bolus tracking and artery spin tagging methods. Magn Reson Imaging 18:503–512CrossRefPubMedGoogle Scholar
  30. Liu G, Sobering G, Duyn J, Moonen CT (1993) A functional MRI technique combining principles of Echo-Shifting with a train of observations (PRESTO). Magn Reson Med 30:764–768PubMedGoogle Scholar
  31. Lombardi M, Jones RA, Westby J, Kvaerness J, Torheim G, Michelassi C, L'Abbate A, Rinck PA (1997) MRI for the evaluation of regional myocardial perfusion in an experimental animal model. J Magn Reson Imaging 7:987–995PubMedGoogle Scholar
  32. Mayr NA, Yuh WT, Zheng J, Ehrhardt JC, Magnotta VA, Sorosky JI, Pelsang RE, Oberley LW, Hussey DH (1998) Prediction of tumor control in patients with cervical cancer: analysis of combined volume and dynamic enhancement pattern by MR imaging. AJR 170:177–182PubMedGoogle Scholar
  33. McKenzie CA, Pereira RS, Prato FS, Chen Z, Drost DJ (1999) Improved contrast agent bolus tracking using T1 FARM. Magn Reson Med 41:429–435CrossRefPubMedGoogle Scholar
  34. Miyazaki T, Yamashita Y, Tsuchigame T, Yamamoto H, Urata J, Takahashi M (1996) MR cholangiopancreatography using HASTE (half-Fourier acquisition single-shot turbo spin-echo) sequences. AJR 166:1297–1303PubMedGoogle Scholar
  35. Moonen CT, Liu G, van Gelderen P, Sobering G (1992) A fast gradient-recalled MRI technique with increased sensitivity to dynamic susceptibility effects. Magn Reson Med 26:184–189PubMedGoogle Scholar
  36. Moseley ME, Vexler Z, Asgari HS, Mintorovitch J, Derugin N, Rocklage S, Kucharczyk J (1991) Comparison of Gd-and Dy-chelates for T2* contrast-enhanced imaging. Magn Reson Med 22:259–264PubMedGoogle Scholar
  37. Noseworthy MD, Kim JK, Stainsby JA, Stanisz GJ, Wright GA (1999) Tracking oxygen effects on MR signal in blood and skeletal muscle during hyperoxia exposure. J Magn Reson Imaging 9:814–820CrossRefPubMedGoogle Scholar
  38. Oesterle C, Strohschein R, Kohler M, Schnell M, Hennig J (2000) Benefits and pitfalls of keyhole imaging, especially in first-pass perfusion studies. J Magn Reson Imaging 11:312–323CrossRefPubMedGoogle Scholar
  39. Parker GJ, Tofts PS (1999) Pharmacokinetic analysis of neoplasms using contrast-enhanced dynamic magnetic resonance imaging. Top Magn Reson Imaging 10:130–142CrossRefPubMedGoogle Scholar
  40. Pedersen M, Mørkenborg J, Jensen FT, Stødkilde-Jørgensen H, Djurhuus JC, Frøkiær J (2000) In vivo measurements of relaxivities in the rat kidney cortex. J Magn Reson Imaging 12:289–296CrossRefPubMedGoogle Scholar
  41. Perman WH, Gado MH, Larson KB, Perlmutter JS (1992) Simultaneous MR acquisition of arterial and and brain signal-time curves. Magn Reson Med 28:74–83PubMedGoogle Scholar
  42. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962CrossRefPubMedGoogle Scholar
  43. Rempp KA, Brix G, Wenz F, Becker CR, Guckel F, Lorenz WJ (1994) Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology 193:637–641PubMedGoogle Scholar
  44. Roberts TPL, Chuang N, Roberts HC (2000) Neuroimaging: do we really need new contrast agents for MRI? Eur J Radiol 34:166–178CrossRefPubMedGoogle Scholar
  45. Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1990) Contrast agents and cerebral hemodynamics. Magn Reson Med 14:249–265PubMedGoogle Scholar
  46. Schmalbrock P, Hines JV, Lee SM, Ammar GM, Kwok EW (2001) T1 measurements in cell cultures: a new tool for characterizing contrast agents at 1.5T. J Magn Reson Imaging 14:636–648CrossRefPubMedGoogle Scholar
  47. Schreiber WG, Schmitt M, Kalden P, Mohrs OK, Kreitner KF, Thelen M (2002) Dynamic contrast-enhanced myocardial perfusion imaging using saturation-prepared TrueFISP. J Magn Reson Imaging 16:641–652CrossRefPubMedGoogle Scholar
  48. Simonsen CZ, Østergaard L, Smith DF, Vestergaard-Poulsen P, Gyldensted C (2000) Comparison of gradient-and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking. J Magn Reson Imaging 12:411–416CrossRefPubMedGoogle Scholar
  49. Sodickson DK, Manning WJ (1997) Simultaneous acquisition of spatial harmonics (SMASH): ultra-fast with radio-frequency coil arrays. Magn Reson Med 38:591–603PubMedGoogle Scholar
  50. Sorensen AG, Buonanno FS, Gonzalez RG, Schwamm LH, Lev MH, Huang-Hellinger FR, Reese TG, Weisskoff RM, Davis TL, Suwanwela N, Can U, Moreira JA, Copen WA, Look RB, Finklestein SP, Rosen BR, Koroshetz WJ (1996) Hyperacute stroke: evaluation with combined multi-section diffusion weighted and haemodynamically weighted echo planar MR imaging. Radiology 199:391–401PubMedGoogle Scholar
  51. Speck O, Chang L, Itti L, Itti E, Ernst T (1999) Comparison of static and dynamic MRI techniques for the measurement of regional cerebral blood volume. Magn Reson Med 41:1264–1268CrossRefPubMedGoogle Scholar
  52. Speck O, Chang L, DeSilva NM, Ernst T (2000) Perfusion MRI of the human brain with dynamic susceptibility contrast: gradient-echo versus spin-echo techniques. J Magn Reson Imaging 12:381–387CrossRefPubMedGoogle Scholar
  53. St Lawrence KS, Lee TY (1998) An adiabatic approximation to the tissue homogeneity model for water exchange in the brain. I. Theoretical derivation. J Cereb Blood Flow Metab 18:1365–1377CrossRefPubMedGoogle Scholar
  54. Stables LA, Kennan RP, Gore JC (1998) Asymmetric spin-echo imaging of magnetically inhomogeneous systems: theory, experiment, and numerical studies. Magn Reson Med 40:432–442PubMedGoogle Scholar
  55. Strouse PJ, Prince MR, Chenevert TL (1996) Effect of the rate of gadopentetate dimeglumine administration on abdominal vascular and soft-tissue MR imaging enhancement patterns. Radiology 201:809–816PubMedGoogle Scholar
  56. Tian G, Shen JF, Dai G, Sun J, Xiang B, Luo Z, Somorjai R, Deslauriers R (1999) An interleaved T1-T2* imaging sequence for assessing myocardial injury. J Cardiovasc Magn Reson 1:145–151PubMedGoogle Scholar
  57. Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101PubMedGoogle Scholar
  58. Tofts PS, Kermode AG (1991) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med 17:357–367PubMedGoogle Scholar
  59. Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232CrossRefPubMedGoogle Scholar
  60. Van Gelderen P, Grandin C, Petrella JR, Moonen CTW (2000) Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain. Radiology 216:603–608Google Scholar
  61. Van Osch MJ, Vonken EJ, Bakker CJ, Viergever MA (2001) Correcting partial volume artifacts of the arterial input function in quantitative cerebral perfusion MRI. Magn Reson Med 45:477–485CrossRefPubMedGoogle Scholar
  62. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ (1988) Dynamic Imaging with Lanthanide Chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6:164–174Google Scholar
  63. Vonken EJ, van Osch MJ, Bakker CJ, Viergever MA (2000) Measurement of cerebral perfusion with dual-echo multi-slice quantitative dynamic susceptibility contrast MRI. Magn Reson Med 43:820–827CrossRefPubMedGoogle Scholar
  64. Warach S, Dashe JF, Edelman RR (1996) Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: a preliminary analysis. J Cerebral Blood Flow Metabol 16:3–59Google Scholar
  65. Weisskoff RM, Chesler D, Boxerman JL, Rosen BR (1993) Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 29:553–559PubMedGoogle Scholar
  66. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR (1994) Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 31:601–610PubMedGoogle Scholar
  67. Zheng J, Venkatesan R, Haacke EM, Cavagna FM, Finn PJ, Li D (1999) Accuracy of T1 measurements at high temporal resolution: feasibility of dynamic measurement of blood T1 after contrast administration. J Magn Reson Imaging 10:576–581CrossRefPubMedGoogle Scholar
  68. Zhu XP, Li KL, Kamaly-Asl ID, Checkley DR, Tessier JJ, Waterton JC, Jackson A (2000) Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 11:575–585CrossRefPubMedGoogle Scholar
  69. Zur Y, Stokar S, Bendel P (1988) An analysis of fast imaging sequences with steady-state transverse magnetization refocusing. Magn Reson Med 6:175–193PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Michael Pedersen
    • 1
    • 2
  • Peter van Gelderen
    • 3
  • Chrit T. W. Moonen
    • 1
  1. 1.Imagerie Moléculaire et Fonctionnelle: de la Physiologie à la ThérapieERT CNRS/ Universite Victor Segalen Bordeaux 2Bordeaux CedexFrance
  2. 2.MR Research Center, Institute of Experimental Clinical ResearchAarhus University Hospital, SkejbyAarhus NDenmark
  3. 3.Laboratory for Molecular and Functional ImagingNINDS, NIHBethesdaUSA

Personalised recommendations