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An Introduction to Dynamic Contrast-Enhanced MRI in Oncology

  • Ingrid S. Gribbestad
  • Kjell I. Gjesdal
  • Gunnar Nilsen
  • Steinar Lundgren
  • Mari H. B. Hjelstuen
  • Alan Jackson
Part of the Medical Radiology book series (MEDRAD)

Keywords

Magn Reson Image Dynamic Magnetic Resonance Image Endothelial Permeability Dynamic Contrast Dynamic Susceptibility Contrast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aronen HJ, Perkio J (2002) Dynamic susceptibility contrast MRI of gliomas. Neuroimaging Clin N Am 12(4):501–523CrossRefPubMedGoogle Scholar
  2. Baba Y, Furusawa M, Murakami R, Yokoyama T, Sakamoto Y, Nishimura R, Yamashita Y, Takahashi M, Ishikawa T (1997) Role of dynamic MRI in the evaluation of head and neck cancers treated with radiation therapy. Int J Radiat Oncol Biol Phys 37:783–787CrossRefPubMedGoogle Scholar
  3. Barbier EL, Lamalle L, Decorps M (2001) Methodology of brain perfusion imaging. J Magn Reson Imaging 13(4):496–520CrossRefPubMedGoogle Scholar
  4. Barentsz JO, Engelbrecht M, Jager GJ, Witjes JA, de LaRosette J, van Der Sanden BP, Huisman HJ, Heerschap A (1999) Fast dynamic gadolinium-enhanced MR imaging of urinary bladder and prostate cancer. J Magn Reson Imaging 10:295–304CrossRefPubMedGoogle Scholar
  5. Bartolozzi C, Lencioni R, Donati F, Cioni D (1999) Abdominal MR: liver and pancreas. Eur Radiol 9:1496–1512PubMedGoogle Scholar
  6. Belli P, Pastore G, Romani M, Terribile D, Canade A, Costantini M (2002) Role of magnetic resonance imaging in the diagnosis of recurrence after breast conserving therapy. Rays 27(4):241–257PubMedGoogle Scholar
  7. Bhujwalla ZM, Artemov D, Glockner J (1999) Tumor angiogenesis, vascularization, and contrast-enhanced magnetic resonance imaging. Top Magn Reson Imaging 10:92–103PubMedGoogle Scholar
  8. Boetes C, Stoutjesdijk M (2001) MR imaging in screening women at increased risk for breast cancer. Magn Reson Imaging Clin N Am 9:357–72, viiPubMedGoogle Scholar
  9. Boetes C, Barentsz JO, Mus RD, van der Sluis RF, van Erning LJ, Hendriks JH, Holland R, Ruys SH (1994) MR characterization of suspicious breast lesions with a gadolinium-enhanced TurboFLASH subtraction technique. Radiology 193:777–781PubMedGoogle Scholar
  10. Brix G, Semmler W, Port R, Schad LR, Layer G, Lorenz WJ (1991) Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 15:621–628PubMedGoogle Scholar
  11. Calamante F, Gadian DG, Connelly A (2000) Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition. Magn Reson Med 44:466–473CrossRefPubMedGoogle Scholar
  12. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249–257PubMedGoogle Scholar
  13. Daniel BL, Yen YF, Glover GH, Ikeda DM, Birdwell RL, Sawyer-Glover AM, Black JW, Plevritis SK, Jeffrey SS, Herfkens RJ (1998) Breast disease: dynamic spiral MR imaging. Radiology 209:499–509PubMedGoogle Scholar
  14. Delorme S, Knopp MV (1998) Non-invasive vascular imaging: assessing tumour vascularity. Eur Radiol 8:517–527CrossRefPubMedGoogle Scholar
  15. Drew PJ, Kerin MJ, Turnbull LW, Imrie M, Carleton PJ, Fox JN, Monson JR (1998) Routine screening for local recurrence following breast-conserving therapy for cancer with dynamic contrast-enhanced magnetic resonance imaging of the breast. Ann Surg Oncol 5(3):265–270PubMedGoogle Scholar
  16. Drew PJ, Chatterjee S, Turnbull LW, Read J, Carleton PJ, Fox JN, Monson JR, Kerin MJ (1999) Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer. Ann Surg Oncol 6:599–603PubMedGoogle Scholar
  17. Drew PJ, Kerin MJ, Mahapatra T, Malone C, Monson JR, Turnbull LW, Fox JN (2001) Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breast. Eur J Surg Oncol 27:617–620CrossRefPubMedGoogle Scholar
  18. Dvorak AM, Kohn S, Morgan ES, Fox P, Nagy JA, Dvorak HF (1996) The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation. J Leukoc Biol 59:100–115PubMedGoogle Scholar
  19. Gilles R, Guinebretière JM, Toussaint C, Spielman M, Rietjens M, Petit JY, Contesso G, Masselot J, Vanel D (1994) Locally advanced breast cancer: contrast-enhanced subtraction MR imaging of response to preoperative chemotherapy. Radiology 191:633–638PubMedGoogle Scholar
  20. Gillies RJ, Bhujwalla ZM, Evelhoch J, Garwood M, Neeman M, Robinson SP, Sotak CH, Van Der Sanden B (2000) Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia 2:139–151CrossRefPubMedGoogle Scholar
  21. Gong QY, Brunt JN, Romaniuk CS, Oakley JP, Tan LT, Roberts N, Whitehouse GH, Jones B (1999) Contrast enhanced dynamic MRI of cervical carcinoma during radiotherapy: early prediction of tumour regression rate. Br J Radiol 72(864):1177–1184PubMedGoogle Scholar
  22. Gribbestad IS, Nilsen G, Fjosne H, Fougner R, Haugen OA, Petersen SB, Rinck PA, Kvinnsland S (1992) Contrast-enhanced magnetic resonance imaging of the breast. Acta Oncol 31(8):833–842PubMedGoogle Scholar
  23. Gribbestad IS, Nilsen G, Fjøsne HE, Kvinnsland S, Haugen OA, Rinck PA (1994) Comparative signal intensity measurements in dynamic gadolinium-enhanced MR mammography. J Magn Reson Imaging 4:477–480PubMedGoogle Scholar
  24. Griswold MA, Jakob PM, Nittka M, Goldfarb JW, Haase A (2000) Partially parallel imaging with localized sensitivities (PILS). Magn Reson Med 44:602–609CrossRefPubMedGoogle Scholar
  25. Gyngell ML (1988) The application of steady-state free precession in rapid 2DFT NMR imaging: FAST and CE-FAST sequences. Magn Reson Imaging 6:415–419CrossRefPubMedGoogle Scholar
  26. Haase A (1990) Snapshot FLASH MRI. Applications to T1, T2, and chemical-shift imaging. Magn Reson Med 13:77–89PubMedGoogle Scholar
  27. Hayes C, Padhani AR, Leach MO (2002) Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 15:154–163CrossRefPubMedGoogle Scholar
  28. Jain RK (1987) Transport of molecules across tumor vasculature. Cancer Metastasis Rev 6:559–593CrossRefPubMedGoogle Scholar
  29. Jain RK (1988) Determinants of tumor blood flow: a review. Cancer Res 48:2641–2658PubMedGoogle Scholar
  30. Jones RA, Haraldseth O, Müller TB, Rinck PA, Oksendal AN (1993) K-space substitution: a novel dynamic imaging technique. Magn Reson Med 29:830–834PubMedGoogle Scholar
  31. Kassner A, Annesley DJ, Zhu XP, Li KL, Kamaly-Asl ID, Watson Y, Jackson A (2000) Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. J Magn Reson Imaging 11(2):103–113CrossRefPubMedGoogle Scholar
  32. Kneeshaw PJ, Turnbull LW, Drew PJ (2003) Current applications and future direction of MR mammography. Br J Cancer 88:4–10PubMedGoogle Scholar
  33. Knopp MV, Weiss E, Sinn HP, Mattern J, Junkermann H, Radeleff J, Magener A, Brix G, Delorme S, Zuna I, van Kaick G (1999) Pathophysiologic basis of contrast enhancement in breast tumors. J Magn Reson Imaging 10:260–266CrossRefPubMedGoogle Scholar
  34. Knopp MV, Giesel FL, Marcos H, von Tengg-Kobligk H, Choyke P (2001) Dynamic contrast-enhanced magnetic resonance imaging in oncology. Top Magn Reson Imaging 12:301–308CrossRefPubMedGoogle Scholar
  35. Kremer S, Grand S, Berger F, Hoffmann D, Pasquier B, Remy C, Benabid AL, Bas JF (2003) Dynamic contrast-enhanced MRI: differentiating melanoma and renal carcinoma metastases from high-grade astrocytomas and other metastases. Neuroradiology 45(1):44–49PubMedGoogle Scholar
  36. Kuhl CK, Schild HH (2000) Dynamic image interpretation of MRI of the breast. J Magn Reson Imaging 12:965–974CrossRefPubMedGoogle Scholar
  37. Kuhl CK, Mielcareck P, Klaschik S, Leutner C, Wardelmann E, Gieseke J, Schild HH (1999) Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions?. Radiology 211:101–110PubMedGoogle Scholar
  38. Kvistad KA, Rydland J, Vainio J, Smethurst HB, Lundgren S, Fjosne HE, Haraldseth O (2000) Breast lesions: evaluation with dynamic contrast-enhanced T1-weighted MR imaging and with T2*-weighted first-pass perfusion MR imaging. Radiology 216(2):545–553PubMedGoogle Scholar
  39. Larsson HB, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB (1990) Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med 16:117–131PubMedGoogle Scholar
  40. Li KL, Zhu XP, Checkley DR, Tessier JJ, Hillier VF, Waterton JC, Jackson A (2003) Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data. Br J Radiol 76:39–50CrossRefPubMedGoogle Scholar
  41. Liu G, Sobering G, Duyn J, Moonen CT (1993) A functional MRI technique combining principles of echo-shifting with a train of observations (PRESTO). Magn Reson Med 30:764–768PubMedGoogle Scholar
  42. Mayr NA, Yuh WT, Arnholt JC, Ehrhardt JC, Sorosky JI, Magnotta VA, Berbaum KS, Zhen W, Paulino AC, Oberley LW, Sood AK, Buatti JM (2000) Pixel analysis of MR perfusion imaging in predicting radiation therapy outcome in cervical cancer. J Magn Reson Imaging 12:1027–1033PubMedGoogle Scholar
  43. Mukhopadhyay D, Tsiokas L, Sukhatme VP (1995) Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 55(24):6161–6165PubMedGoogle Scholar
  44. Oesterle C, Strohschein R, Köhler M, Schnell M, Hennig J (2000) Benefits and pitfalls of keyhole imaging, especially in first-pass perfusion studies. J Magn Reson Imaging 11:312–323CrossRefPubMedGoogle Scholar
  45. Ogura K, Maekawa S, Okubo K, Aoki Y, Okada T, Oda K, Watanabe Y, Tsukayama C, Arai Y (2001) Dynamic endorectal magnetic resonance imaging for local staging and detection of neurovascular bundle involvement of prostate cancer: correlation with histopathologic results. Urology 57:721–726CrossRefPubMedGoogle Scholar
  46. Oppelt A, Graumann R, Fisher H, Hertl W, Schajor W (1986) FISP: a new fast MRI sequence. Electromedica 3:15–18Google Scholar
  47. Padhani AR (1999) Dynamic contrast-enhanced MRI studies in human tumours. Br J Radiol 72(857):427–431PubMedGoogle Scholar
  48. Padhani AR (2002) Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J Magn Reson Imaging 16(4):407–422CrossRefPubMedGoogle Scholar
  49. Padhani AR, Gapinski CJ, Macvicar DA, Parker GJ, Suckling J, Revell PB, Leach MO, Dearnaley DP, Husband JE (2000) Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA. Clin Radiol 55:99–109PubMedGoogle Scholar
  50. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962CrossRefPubMedGoogle Scholar
  51. Rosen BR, Belliveau JW, Buchbinder BR, McKinstry RC, Porkka LM, Kennedy DN, Neuder MS, Fisel CR, Aronen HJ, Kwong KK et al (1991) Contrast agents and cerebral hemodynamics. Magn Reson Med 19:285–292PubMedGoogle Scholar
  52. Ross BD, Chenevert TL, Rehemtulla A (2002) Magnetic resonance imaging in cancer research. Eur J Cancer 38(16):2147–2156CrossRefPubMedGoogle Scholar
  53. Ruddon RW (1987) Cancer Biology.Google Scholar
  54. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983–985PubMedGoogle Scholar
  55. Sobin LH, Fleming ID (1997) TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 80:1803–1804Google Scholar
  56. Sodickson DK, Manning WJ (1997) Simultaneous acquisition of spatial harmonics (SMASH): fast imaging with radiofrequency coil arrays. Magn Reson Med 38:591–603PubMedGoogle Scholar
  57. St Lawrence KS, Lee TY (1998) An Adiabatic Approximation to the Tissue Homogeneity Model for Water Exchange in the Brain: I. Theoretical Derivation. J Cereb Blood Flow Metab 18:1365–1377CrossRefPubMedGoogle Scholar
  58. Taylor JS, Reddick WE (2000) Evolution from empirical dynamic contrast-enhanced magnetic resonance imaging to pharmacokinetic MRI. Adv Drug Deliv Rev 41:91–110CrossRefPubMedGoogle Scholar
  59. Thacker NA, Scott ML, Jackson A (2003) Can dynamic susceptibility contrast magnetic resonance imaging perfusion data be analyzed using a model based on directional flow?. J Magn Reson Imaging 17:241–255CrossRefPubMedGoogle Scholar
  60. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, Gwyther SG (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92(3):205–216PubMedGoogle Scholar
  61. Tofts PS (1996) Optimal detection of blood-brain barrier defects with Gd-DTPA MRI-the influences of delayed imaging and optimised repetition time. Magn Reson Imaging 14(4):373–380PubMedGoogle Scholar
  62. Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101PubMedGoogle Scholar
  63. Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101PubMedGoogle Scholar
  64. Tofts PS, Berkowitz B, Schnall MD (1995) Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model. Magn Reson Med 33:564–568PubMedGoogle Scholar
  65. Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10(3):223–232CrossRefPubMedGoogle Scholar
  66. Tsao J, Boesiger P, Pruessmann KP (2003) k-t BLAST and k-t SENSE: dynamic MRI with high frame rate exploiting spatiotemporal correlations. Magn Reson Med 50(5):1031–1042CrossRefPubMedGoogle Scholar
  67. van Vaals JJ, Brummer ME, Dixon WT, Tuithof HH, Engels H, Nelson RC, Gerety BM, Chezmar JL, den Boer JA (1993) “Keyhole” method for accelerating imaging of contrast agent uptake. J Magn Reson Imaging 3:671–675PubMedGoogle Scholar
  68. Verstraete KL, De Deene Y, Roels H, Dierick A, Uyttendaele D, Kunnen M (1994) Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging-parametric “first-pass” images depict tissue vascularization and perfusion. Radiology 192(3):835–843PubMedGoogle Scholar
  69. Wang HZ, Riederer SJ (1990) A spoiling sequence for suppression of residual transverse magnetization. Magn Reson Med 15:175–191PubMedGoogle Scholar
  70. Weidner N (1996) Intratumoral vascularity as a prognostic factor in cancers of the urogenital tract. Eur J Cancer 32A:2506–2512CrossRefPubMedGoogle Scholar
  71. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR (1994) Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 31:601–610PubMedGoogle Scholar
  72. WHO (1979) Handbook for reporting results of cancer treatment.Google Scholar
  73. Zhu XP, Li KL, Kamaly-Asl ID, Checkley DR, Tessier JJ, Waterton JC, Jackson A (2000) Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 11:575–585CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Ingrid S. Gribbestad
    • 1
    • 2
  • Kjell I. Gjesdal
    • 3
  • Gunnar Nilsen
    • 4
  • Steinar Lundgren
    • 2
  • Mari H. B. Hjelstuen
    • 5
  • Alan Jackson
    • 6
  1. 1.SINTEF Unimed, MR CenterTrondheim
  2. 2.Cancer ClinicSt. Olavs University HospitalTrondheimNorway
  3. 3.Ullevaal University HospitalOsloNorway
  4. 4.Molde HospitalMoldeNorway
  5. 5.Central Hospital of StavangerStavangerNorway
  6. 6.Imaging Science and Biomedical Engineering, The Medical SchoolUniversity of ManchesterManchesterUK

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