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Acquired Inflammatory White Matter Diseases

  • Massimo Gallucci
  • Massimo Caulo
  • Paolo Tortori-Donati

Abstract

During the last decades, several different classifications were proposed to define white matter diseases. However, none proved to be completely satisfactory. Therefore, even now, some entities have clinical significance but no specific pathological, biochemical, or radiological support (i.e., Schilder’s myelinoclastic diffuse sclerosis), and the reverse is true with others. Furthermore, several diseases, although not primitively categorized as inflammatory white matter disorders, present mixed or poorly defined borders; such is the case of X-linked adrenoleukodystrophy, a genetically defined metabolic disorder which presents a constant and often dramatic white matter inflammatory component. White matter inflammation is also constant in some acquired metabolic diseases (i.e., Wernicke’s encephalopathy). Discussion is also progressing on review of single diseases which were apparently already well defined: are Devic’s neuromyelitis optica, Balò’s concentric sclerosis, and Schilder’s myelinoclastic diffuse sclerosis specific entities? Are they variants of multiple sclerosis (MS)? Or else, do they simply represent occasional combinations of some of the signs, symptoms, and findings that are common in pediatric MS?

Keywords

Multiple Sclerosis White Matter Optic Neuritis Demyelinating Disease Magnetization Transfer Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Menkes JH. Textbook of Child Neurology, 5th edn. Baltimore: Williams & Wilkins, 1995.Google Scholar
  2. 2.
    Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 29:338:278–285.CrossRefGoogle Scholar
  3. 3.
    Raine CS. Demyelinating diseases. In: Davis RL, Robertson DM (eds) Textbook of Neuropathology. Baltimore: Williams & Wilkins, 1991:581–593.Google Scholar
  4. 4.
    Van der Knaap MS, Valk J. Magnetic Resonance of Myelin, Myelination, and Myelin disorders, 2nd edn. Berlin: Springer, 1995.Google Scholar
  5. 5.
    Hanefeld F. Multiple sclerosis in childhood. Curr Opin Neurol Neurosurg 1992; 5:359–363.PubMedGoogle Scholar
  6. 6.
    Kurtzke JF, Hyllestedt K. Multiple sclerosis in the Faroe Islands. Neurology 1986; 36:307–328.PubMedGoogle Scholar
  7. 7.
    Adams RD, Victor M. Principles of Neurology, 4th edn. New York: McGraw-Hill, 1989.Google Scholar
  8. 8.
    Gallucci M, Gagliardo O, Splendiani A, Micheli C. Malattie demielinizzanti infantili. Rivista di Neuroradiologia 1999; 12:97–102.Google Scholar
  9. 9.
    Duquette P, Murray TJ, Pleines J. MS in childhood: clinical profile in 125 patients. J Pediatr 1987; 111:359–363.CrossRefPubMedGoogle Scholar
  10. 10.
    Bauer HJ, Hanefeld F Chriten HJ. MS in early childhood. Lancet 1991;336:1190.CrossRefGoogle Scholar
  11. 11.
    Bejar JM, Ziegler DK. Onset of MS in a 24 month old child. Arch Neurol 1984; 41:881–882.PubMedGoogle Scholar
  12. 12.
    Shaw CM, Alword EC Jr. MS beginning in infancy. J Child Neurol 1987; 2:252–256.CrossRefPubMedGoogle Scholar
  13. 13.
    Micheli C, Bozzao A, Bastianello S, Vergoni G, Cenni P, Guttman S, Iannetti P, Tortori-Donati P, Ferretti M, Gallucci M. Multiple sclerosis in the pediatric age and Schilder disease (abstract). Neuroradiology 1996; 38(Suppl 2):S56–S57.Google Scholar
  14. 14.
    Gall JC Jr, Hayles AB, Siekert RG, Keith HM. MS in children; a clinical study of 40 cases with onset in childhood. Pediatrics 1958, 21:703–709.PubMedGoogle Scholar
  15. 15.
    Simone IL, Carrara D, Tortorella C, Liguori M, Lepore V, Pellegrini F, Bellacosa A, Ceccarelli A, Pavone I, Livrea P. Course and prognosis in early-onset MS. Neurology 2002; 59:1922–1928.PubMedGoogle Scholar
  16. 16.
    Riikonen R, Donner M, Ekkila H. Optic neuritis in children and its relationship with MS. A clinical study of 21 children. Dev Med Child Neurol 1988; 30:349–359.PubMedCrossRefGoogle Scholar
  17. 17.
    Optic Neuritis Study Group. The 5-year risk of MS after optic neuritis. Experience of the optic neuritis treatment trial. Neurology 1997; 49:1404–1413.Google Scholar
  18. 18.
    Zelnik N, Gale AD, Shelburne SA Jr. Multiple sclerosis in black children. J Child Neurol 1991;6:53–57.CrossRefPubMedGoogle Scholar
  19. 19.
    McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50:121–127.CrossRefPubMedGoogle Scholar
  20. 20.
    Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH, Comi G, Ader HJ, Losseff N, Valk J. Comparison of MR imaging criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997; 120:2059–2069.CrossRefPubMedGoogle Scholar
  21. 21.
    Tintore M, Rovira A, Martinez MJ, Rio J, Diaz-Villoslada P, Brieva L, Borras C, Grive E, Capellades J, Montalban X. Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis. AJNR Am J Neuroradiol 2000; 21:702–706.PubMedGoogle Scholar
  22. 22.
    Kumar K, Toth C, Jay V. Focal plaque of demyelination mimicking cerebral tumor in a pediatric patient. Pediatr Neurosurg 1998; 29:60–63.CrossRefPubMedGoogle Scholar
  23. 23.
    Golden GS, Woody RC. The role of nuclear magnetic resonance imaging in the diagnosis of MS in childhood. Neurology 1987; 37:689–693.PubMedGoogle Scholar
  24. 24.
    Triulzi F, Scotti G. Differential diagnosis of multiple sclerosis: contribution of magnetic resonance techniques. J Neurol Neurosurg Psychiatry 1998; 64(Suppl 1):S6–14.PubMedGoogle Scholar
  25. 25.
    De Stefano N, Narayanan S, Francis GS, Arnaoutelis R, Tartaglia MC, Antel JP, Matthews PM, Arnold DL. Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol 2001; 58:65–70.CrossRefPubMedGoogle Scholar
  26. 26.
    Arnold DL. Magnetic resonance spectroscopy: imaging axonal damage in MS. J Neuroimmunol 1999; 98:2–6.CrossRefPubMedGoogle Scholar
  27. 27.
    Brex P, Ciccarelli O, O’Riordan J, Sailer M, Thompson A, Miller D. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med 2002; 346:158–164.CrossRefPubMedGoogle Scholar
  28. 28.
    Filippi M, Bozzali M, Rovaris M, Gonen O, Kesavadas C, Ghezzi A, Martinelli V, Grossman RI, Scotti G, Comi G, Falini A. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 2003; 126:433–437.CrossRefPubMedGoogle Scholar
  29. 29.
    Filippi M, Iannucci G, Cercignani M, Assunta Rocca M, Pratesi A, Comi G. A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging. Arch Neurol 2000; 57:1017–1021.CrossRefPubMedGoogle Scholar
  30. 30.
    Schilder PF. Zur Kenntnis der sogenannten diffusen Sklerose (über Encephalitis periaxialis diffusa). Zeitschrift für die gesamte Neurologie und Psychiatrie, 1912, 10 Orig.i: 1–60.Google Scholar
  31. 31.
    Poser CM, Goutieres F et al. Schilder’s myelinoclastic diffuse sclerosis. Pediatrics 1986; 77:107–112.PubMedGoogle Scholar
  32. 32.
    Prineas JW, McDonald WI. Demyelinating diseases. In: Graham DI, Lantos PL (eds.) Greenfield’s Neuropathology, 6th edn. London: Arnold, 1997:813.Google Scholar
  33. 33.
    Poser S, Lüer W, Bruhn H, Frahm J, Brück Y, Felgenhauer K. Acute demyelinating disease. Classification and non-invasive diagnosis. Acta Neurol Scand 1992; 86:579–585.CrossRefPubMedGoogle Scholar
  34. 34.
    Afifi AK, Follet KA, Greenlee J, Scott WE, Moore SA. Optic neuritis: a novel presentation of Schilder’s disease. J Child Neurol 2001; 16:693–696.CrossRefPubMedGoogle Scholar
  35. 35.
    Eblen F, Poremba M, Grodd W, Opitz H, Roggendorf W, Dichgans J. Myelinoclastic diffuse sclerosis (Schilder’s disease): clinic-neuroradiologic correlations. Neurology 1991; 41:589–591.PubMedGoogle Scholar
  36. 36.
    Dresser LP, Tourian AY, Anthony DC. A case of myelinoclastic diffuse sclerosis in an adult. Neurology 1991; 41:316–318.PubMedGoogle Scholar
  37. 37.
    Masdeu JC, Quinto C, Olivera C, Tenner M, Leslie D, Visintainer P. Open ring imaging sign highly specific for atypical brain demyelination. Neurology 2000; 54:1427–1433.PubMedGoogle Scholar
  38. 38.
    Kepes JJ. Large focal tumor-like demyelinating lesions of the brain: intermediate entity between MS and ADEM? A study of 31 patients. Ann Neurol 1993; 33:18–27.CrossRefPubMedGoogle Scholar
  39. 39.
    Leuzzi V, Lyon G, Cilio MR, Pedespan JM, Fontan D, Chateil JF, Vital A. Childhood demyelinating diseases with a prolonged remitting course and their relation to Schilder’s disease: report of two cases. J Neurol Neurosurg Psychiatry 1999; 66:407–408.CrossRefPubMedGoogle Scholar
  40. 40.
    Wingerchuk DM, Hogancamp WF, O’Brien PC, Weinshenker BG. The clinical course of neuromyelitis optica (Devic’s syndrome). Neurology 1999; 53:1107–1114.PubMedGoogle Scholar
  41. 41.
    Mandler RN, Davis LE et al. Devic’s neuromyelitis optica: a clinical-pathological study of 8 patients. Ann Neurol 1993; 34:162–168.CrossRefPubMedGoogle Scholar
  42. 42.
    Tashiro K, Ito K, Maruo Y, Homma S, Yamada T, Fujiki N, Moriwaka F. MR imaging of spinal cord in Devic disease. J Comput Assist Tomogr 1987; 11:516–517.CrossRefPubMedGoogle Scholar
  43. 43.
    Tortori-Donati P, Fondelli MP, Rossi A, Rolando S, Andreussi L, Brisigotti M. La neuromielite ottica. Una ulteriore sfida nella diagnosi differenziale con le neoplasie intramidollari. Rivista di Neuroradiologia 1993; 6:53–59.Google Scholar
  44. 44.
    Jeffery AR, Buncic JR. Pediatric Devic’s neromyelitis optica. J Pediatr Ophthalmol Strabismus 1996; 33:223–229.PubMedGoogle Scholar
  45. 45.
    Gold R, Linington C. Devic’s dysease: bridging the gap between laboratory and clinic (Editorial). Brain 2002, 125:1425–1427.CrossRefPubMedGoogle Scholar
  46. 46.
    Filippi M, Rocca MA, Moiola M, Martinelli V, Ghezzi A, Capra R, Salvi F, Comi G. MRI and magnetization transfer imaging changes in the brain and cervical cord of patients with Devic’s neuromyelitis optica. Neurology 1999, 53:1705–1710.PubMedGoogle Scholar
  47. 47.
    Hainfellner JA, Schmidbauer M, Schmutzhard E, Maier H, Budka H. Devic’s neuromyelitis optica and Schilder’s myelinoclastic diffuse sclerosis. J Neurol Neurosurg Psychiatry 1992; 55:1194–1196.CrossRefPubMedGoogle Scholar
  48. 48.
    Lucchinetti CF, Mandler RN, McGavern D, Bruck W, Gleich G, Ransohoff RM, Trebst C, Weinshenker B, Wingerchuk D, Parisi JE, Lassmann H. A role for humoral mechanism in the pathogenesis of Devic’s neuromyelitis optica. Brain 2002; 125:1450–1461.CrossRefPubMedGoogle Scholar
  49. 49.
    Balò J. Encephalitis periaxialis concentrica. Arch Neurol Psychiatry 1928; 19:242–264.Google Scholar
  50. 50.
    Karaarslan E, Altintas A, Senol U, Yeni N, Dincer A, Bayindir C, Karaagac N, Siva A. Balo’s concentric sclerosis: clinical and radiologic features of five cases. AJNR Am J Neuroradiol 2001; 22:1362–1367.PubMedGoogle Scholar
  51. 51.
    Moore GR, Neumann PE, Suzuki K, Lijtmaer HN, Traugott U, Raine CS. Balo’s concentric sclerosis: new observation on lesion development. Ann Neurol 1985; 17:604–611.CrossRefPubMedGoogle Scholar
  52. 52.
    Bolay H, Karabudak R, Tacal T, Onol B, Selekler K, Saribas O. Balo’s concentric sclerosis: report of two patients with MRI follow-up. J Neuroimaging 1996; 6:98–103.PubMedGoogle Scholar
  53. 53.
    Korte JH, Bom EP, Vos LD, Breuer TJ, Wondergem JH. Balo concentric sclerosis. MR diagnosis. AJNR Am J Neuroradiol 1994; 15:1284–1285.PubMedGoogle Scholar
  54. 54.
    de Seze J, Stojkovic T, Ferriby D, Gauvrit JY, Montagne C, Mounier-Vehier F, Verier A, Pruvo JP, Hache JC, Vermersch P. Devic’s neuromyelitis optica: clinical, laboratory, MRI and outcome profile. J Neurol Sci 2002; 197:57–61.CrossRefPubMedGoogle Scholar
  55. 55.
    Andreula CF, Recchia Luciani ANM, Milella D. Magnetic Resonance Imaging in the diagnosis of acute disseminated encephalomyelitis (ADEM). Int J Neuroradiol 1997; 3:21–34.Google Scholar
  56. 56.
    Kamei A, Ichinohe S, Onuma R, Hiraga S, Fujiwara T. Acute disseminated demyelination due to primary human herpesvirus-6 infection. Eur J Pediatr 1997;156:709–712.CrossRefPubMedGoogle Scholar
  57. 57.
    Dubreuil F, Cabre P, Smadja D, Quist D, Arfi S. Acute disseminated encephalomyelitis preceding cutaneous lupus. Rev Med Interne 1998; 19:128–130.CrossRefPubMedGoogle Scholar
  58. 58.
    Yamada M, Inaba A, Yamawaki M, Ishida K, Yokota T, Uchihara T, Eishi Y, Okeda R. Paraneoplastic encephalomyelo-ganglionitis: cellular binding sites of the antineuronal antibody. Acta Neuropathol 1994; 88:85–92.CrossRefPubMedGoogle Scholar
  59. 59.
    Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain 2000; 123:2407–2422.CrossRefPubMedGoogle Scholar
  60. 60.
    Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis. A long-term follow-up study of 84 pediatric patients. Neurology 2002; 59:1224–1231.PubMedGoogle Scholar
  61. 61.
    Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ. Clinical and neuroradiological features of acute disseminated encephalomyelitis in children. Neurology 2001; 56:1308–1312.PubMedGoogle Scholar
  62. 62.
    Kesselring J, Miller DH, Robb SA, Kendall BE, Moseley IF, Kingsley D, du Boulay EP, McDonald WI. Acute disseminated encephalomyelitis. MRI findings and the distinction from multiple sclerosis. Brain 1990; 113:291–302.CrossRefPubMedGoogle Scholar
  63. 63.
    Gallucci M, Caulo M, Cerone G, Masciocchi C. Acquired inflammatory white matter diseases. Child’s Nerv Syst 2001; 17:202–210.CrossRefGoogle Scholar
  64. 64.
    Catalucci A, Caulo M, Puglielli E, Splendiani A, Masciocchi C, Gallucci M. Different MR features of acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in the pediatric age group. Eur Radiol 2002; 12(suppl 1): B0491 (Abs.)Google Scholar
  65. 65.
    Honkaniemi J, Dastibar P, Kahara V, Haapasalo H. Delayed MR imaging changes in acute disseminated encephalomyelitis. AJNR Am J Neuroadiol 2001; 22:1117–1124.Google Scholar
  66. 66.
    Tsai ML, Hung KL. Multiphasic disseminated encephalomyelitis mimicking multiple sclerosis. Brain Dev 1996; 18:412–414.CrossRefPubMedGoogle Scholar
  67. 67.
    Hasegawa H, Bitoh S, Koshino K, Obashi J, Iwaisako K, Fukushima Y. Acute relapsing disseminated encephalomyelitis (ARDEM) mimicking a temporal lobe tumor. No Shinkei Geka 1994; 22:185–188.PubMedGoogle Scholar
  68. 68.
    Wang HS. Concentric thalamic change on MR of acute necrotising encephalopathy of childhood. Neuroradiology 2003; 45:661–662.CrossRefPubMedGoogle Scholar
  69. 69.
    Inglese M, Salvi F, Iannucci G, Mancardi GL, Mascalchi M, Filippi M. Magnetization transfer ad diffusion tensor MR imaging of acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 2002; 23:267–272.PubMedGoogle Scholar
  70. 70.
    Harada M, Hisaoka S, Mori K, Yoneda K, Noda S, Nishitani H. Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy. J Magn Reson Imaging 2000; 11:559–563.CrossRefPubMedGoogle Scholar
  71. 71.
    Bizzi A, Ulug AM, Crawford TO, Passe T, Bugiani M, Bryan RN, Barker PB. Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 2001; 22:1125–1130.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Massimo Gallucci
    • 1
  • Massimo Caulo
    • 2
  • Paolo Tortori-Donati
    • 3
  1. 1.University of L’AquilaL’AquilaItaly
  2. 2.Department of RadiologyITAB-University of ChietiChietiItaly
  3. 3.Department of Pediatric NeuroradiologyG. Gaslini Children’s Research HospitalGenoaItaly

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