Hemolymphoproliferative Diseases and Treatment-Related Disorders

  • Paolo Tortori-Donati
  • Andrea Rossi
  • Roberta Biancheri


Pediatric hemolymphoproliferative diseases (HLDs) are a constellation of disorders that prominently include leukemia, lymphoma, and histiocytoses. These conditions are invariably severe, and are burdened by elevated morbidity and mortality in the absence of proper treatment. HLDs are systemic disorders, i.e., they typically affect multiple organs and systems in the human body. While, as a whole, leukemia and lymphomas account for about 40% of all malignancies in children [1], the majority of histiocytoses are not malignant. Intensive treatment regimens have resulted in a significant increase in the number of survivors, but have also disclosed new phases of the natural history of these disorders, among which is involvement of the central nervous system (CNS). CNS disease is not consistent, but when present, it is commonly associated with worsened prognosis. Moreover, current treatment modalities, including systemic therapy (i.e., combination chemotherapy) and specific CNS prophylaxis (i.e., intrathecal chemotherapy with or without cranial irradiation), are potentially neurotoxic.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Disseminate Intravascular Coagulation Posterior Reversible Encephalopathy Syndrome Pituitary Stalk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Parker BR. Leukemia and lymphoma in childhood. Radiol Clin North Am 1997; 35:1495–1516.PubMedGoogle Scholar
  2. 2.
    Ginsberg LE, Leeds NE. Neuroradiology of leukemia. AJR Am J Roentgenol 1995; 165:525–534.PubMedGoogle Scholar
  3. 3.
    Linet MS, Devesa SS. Descriptive epidemiology of childhood leukaemia. Br J Cancer 1991; 63:424–429.PubMedGoogle Scholar
  4. 4.
    Smith MA, Ries LAG, Gurney JG, Ross JA. Leukemia. National Cancer Institute Online Publication, 2002. Available online at Accessed January 27, 2002.Google Scholar
  5. 5.
    Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, Edwards BK. SEER Cancer Statistics Review, 1973–1999, National Cancer Institute, Bethesda, MD, 2002. Available online at Accessed January 27, 2002.Google Scholar
  6. 6.
    Chen CY, Zimmerman RA, Faro S, Bilaniuk LT, Chou TY, Molloy PT. Childhood leukemia: central nervous system abnormalities during and after treatment. AJNR Am J Neuroradiol 1996; 17:295–310.PubMedGoogle Scholar
  7. 7.
    Azzarelli V, Roessmann U. Pathogenesis of central nervous system infiltration in acute leukemia. Arch Pathol Lab Med 1997; 101:203–205.Google Scholar
  8. 8.
    Johnston DL. Relapse of childhood acute lymphoblastic leukemia in the lacrimal gland. Med Pediatr Oncol 2003; 40:337–338.CrossRefPubMedGoogle Scholar
  9. 9.
    Shad A, Magrath I. Non-Hodgkin’s lymphoma. Pediatr Clin North Am 1997; 44:863–890.CrossRefPubMedGoogle Scholar
  10. 10.
    Epstein LG, DiCarlo FJ Jr, Joshi VV, Connor EM, Oleske JM, Kay D, Koenigsberger MR, Sharer LR. Primary lymphoma of the central nervous system in children with acquired immunodeficiency syndrome. Pediatrics 1988; 82:355–363.Google Scholar
  11. 11.
    Bataille B, Delwail V, Menet E, Vandermarcq P, Ingrand P, Wager M, Guy G, Lapierre F. Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 2000; 92:261–266.CrossRefPubMedGoogle Scholar
  12. 12.
    Ciftci E, Erden I, Akyar S. MR findings of primary central nervous system lymphoma in a child. A case report. Acta Radiol 1998; 39:727–729.CrossRefPubMedGoogle Scholar
  13. 13.
    Baleydier F, Galambrun C, Manel AM, Guibaud L, Nicolino M, Bertrand Y. Primary lymphoma of the pituitary stalk in an immunocompetent 9-year-old child. Med Pediatr Oncol 2001; 36:392–395.CrossRefPubMedGoogle Scholar
  14. 14.
    Silfen ME, Garvin JH Jr, Hays AP, Starkman HS, Aranoff GS, Levine LS, Feldstein NA, Wong B, Oberfield SE. Primary central nervous system lymphoma in childhood presenting as progressive panhypopituitarism. J Pediatr Hematol Oncol 2001; 23:130–133.CrossRefPubMedGoogle Scholar
  15. 15.
    Han MH, Chang KH, Kim IO, Kim DK, Han MC. Non-Hodgkin lymphoma of the central skull base: MR manifestations. J Comput Assist Tomogr 1993; 17:567–571.CrossRefPubMedGoogle Scholar
  16. 16.
    Kim HJ, Ryu KN, Choi WS, Choi BK, Choi JM, Yoon Y. Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging. Clin Imaging 1999; 23:125–133.CrossRefPubMedGoogle Scholar
  17. 17.
    Writing Group of the Histiocyte Society. Histiocytosis syndromes in children. Lancet 1987; 1:208.Google Scholar
  18. 18.
    Ladisch S, Jaffe ES. The histiocytoses. In: Pizzo PA, Poplack DG (eds) Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott, 1989:491–504.Google Scholar
  19. 19.
    Poe LB, Dubowy RL, Hochhauser L, Collins GH, Crosley CJ, Kanzer MD, Oliphant M, Hodge CJ Jr. Demyelinating and gliotic cerebellar lesions in Langerhans cell histiocytosis. AJNR Am J Neuroradiol 1994; 15:1921–1928.PubMedGoogle Scholar
  20. 20.
    Kepes JJ. Histiocytosis X. In: Vinken PJ, Bruyn GW (eds) Handbook of Clinical Neurology, vol. 38. Amsterdam: North-Holland, 1979:93–117.Google Scholar
  21. 21.
    Maghnie M, Aricò M, Villa A, Genovese E, Beluffi G, Severi F. MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis. AJNR Am J Neuroradiol 1992; 13:1365–1371.PubMedGoogle Scholar
  22. 22.
    Grois NG, Favara BE, Mostbeck GH, Prayer D. Central nervous system disease in Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998; 12:287–305.CrossRefPubMedGoogle Scholar
  23. 23.
    Beltran J, Aparisi F, Bonmati LM, Rosenberg ZS, Present D, Steiner GC. Eosinophilic granuloma: MRI manifestations. Skeletal Radiol 1993; 22:157–161.CrossRefPubMedGoogle Scholar
  24. 24.
    Tortori-Donati P, Danieli D, Meli S, Fondelli MP, Rossi A, Curri D, Garre ML, Gullotta F. Langerhans cell histiocytosis presenting as a lumbosacral intradural-extramedullary mass. Pediatr Radiol 1996; 26:731–733.CrossRefPubMedGoogle Scholar
  25. 25.
    Henter JI, Aricò M, Elinder G, Imashuku S, Janka G. Familial hemophagocytic lymphohistiocytosis. Hematol Oncol Clin N Am 1998; 12:417–433.CrossRefGoogle Scholar
  26. 26.
    Kollias SS, Ball WS Jr, Tzika AA, Harris RE. Familial eryhtrophagocytic lymphohistiocytosis: neuroradiologic evaluation with pathologic correlation. Radiology 1994; 192:743–754.PubMedGoogle Scholar
  27. 27.
    Cirillo S, Caranci F, Briganti F, D’Amico A, Striano S, Elefante R. Erythrophagocytic lymphohistiocytosis: MR findings in 5 cases. Rivista di Neuroradiologia 1999; 12:633–642.Google Scholar
  28. 28.
    Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer. Medicine (Baltimore) 1985; 64:16–35.CrossRefPubMedGoogle Scholar
  29. 29.
    Zinreich SJ, Kennedy DW, Malat J, Curtin HD, Epstein JI, Huff LC, Kumar AJ, Johns ME, Rosenbaum AE. Fungal sinusitis: diagnosis with CT and MR imaging. Radiology 1988; 169:439–444.PubMedGoogle Scholar
  30. 30.
    Vazquez E, Lucaya J, Castellote A, Piqueras J, Sainz P, Olive T, Sanchez-Toledo J, Ortega JJ. Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis. Radiographics 2002; 22:1411–1428.CrossRefPubMedGoogle Scholar
  31. 31.
    DeLone DR, Goldstein RA, Petermann G, Salamat MS, Miles JM, Knechtle SJ, Brown WD. Disseminated aspergillosis involving the brain: distribution and imaging characteristics. AJNR Am J Neuroradiol 1999; 20:1597–1604.PubMedGoogle Scholar
  32. 32.
    Ashdown BC, Tien RD, Felsberg GJ. Aspergillosis of the brain and paranasal sinuses in immunocompromised patients: CT and MR imaging findings. AJR Am J Roentgenol 1994; 162:155–159.PubMedGoogle Scholar
  33. 33.
    Yamada K, Shrier DA, Rubio A, Shan Y, Zoarski GH, Yoshiura T, Iwanaga S, Nishimura T, Numaguchi Y. Imaging findings in intracranial aspergillosis. Acad Radiol 2002; 9:163–171.CrossRefPubMedGoogle Scholar
  34. 34.
    Christophe C, Azzi N, Bouche B, Dan B, Levivier M, Ferster A. Magnetic resonance imaging and angiography in cerebral fungal vasculitis. Neuropediatrics 1999; 30:218–220.CrossRefPubMedGoogle Scholar
  35. 35.
    Lai PH, Lin SM, Pan HB, Yang CF. Disseminated miliary cerebral candidiasis. AJNR Am J Neuroradiol 1997; 18:1303–1306.PubMedGoogle Scholar
  36. 36.
    LeBlang SD, Whiteman ML, Post MJ, Uttamchandani RB, Bell MD, Smirniotopolous JG. CNS Nocardia in AIDS patients: CT and MRI with pathologic correlation. J Comput Assist Tomogr 1995; 19:15–22.CrossRefPubMedGoogle Scholar
  37. 37.
    Miaux Y, Ribaud P, Williams M, Guermazi A, Gluckman E, Brocheriou C, Laval-Jeantet M. MR of cerebral aspergillosis in patients who have had bone marrow transplantation. AJNR Am J Neuroradiol 1995; 16:555–562.PubMedGoogle Scholar
  38. 38.
    Mora J, White M, Dunkel IJ. Listeriosis in pediatric oncology patients. Cancer 1998; 83:817–820.CrossRefPubMedGoogle Scholar
  39. 39.
    Sakai C, Iuchi T, Ishii A, Kumagai K, Takagi T. Bacillus cereus brain abscesses occurring in a severely neutropenic patient: successful treatment with antimicrobial agents, granulocyte colony-stimulating factor and surgical drainage. Intern Med 2001; 40:654–657.CrossRefPubMedGoogle Scholar
  40. 40.
    Singh N, Carrigan DR. Human herpesvirus 6 in transplantation: an emerging pathogen. Ann Intern Med 1996; 124:1065–1071.PubMedGoogle Scholar
  41. 41.
    Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthum subitum. Lancet 1988; 1:1065–1067.CrossRefPubMedGoogle Scholar
  42. 42.
    Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein LG. Neuroinvasion and persistence of human herpesvirus 6 in children. J Infect Dis 1994; 170:1586–1589.PubMedGoogle Scholar
  43. 43.
    Kamei A, Ichinohe S, Onuma R, Hiraga S, Fujiwara T. Acute disseminated demyelination due to primary human herpesvirus-6 infection. Eur J Pediatr 1997; 156:709–712.CrossRefPubMedGoogle Scholar
  44. 44.
    Bosi A, Zazzi M, Amantini A, Cellerini M, Vannucchi AM, De Milito A, Guidi S, Saccardi R, Lombardini L, Laszlo D, Rossi Ferrini P. Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant. Bone Marrow Transplant 1998; 22:285–288.CrossRefPubMedGoogle Scholar
  45. 45.
    Tiacci E, Luppi M, Barozzi P, Gurdo G, Tabilio A, Ballanti S, Torelli G, Aversa F. Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor. Haematologica 2000; 85:94–97.PubMedGoogle Scholar
  46. 46.
    Ball WS Jr, Prenger EC, Ballard ET. Neurotoxicity of radio/ chemotherapy in children: pathologic and MR correlation. AJNR Am J Neuroradiol 1992; 13:761–776.PubMedGoogle Scholar
  47. 47.
    Sheline GE, Wara WM, Smith V. Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 1980; 6:1215–1228.PubMedGoogle Scholar
  48. 48.
    Rastogi H, Bazan III C, Da Costa Leite C, Jinkins JR. The posttherapeutic cranium. In: Jinkins JR (ed) Posttherapeutic Diagnostic Imaging. New York: Lippincott-Raven, 1997:3–36.Google Scholar
  49. 49.
    Dowling C, Bollen AW, Noworolski SM, McDermott MW, Barbaro NM, Day MR, Henry RG, Chang SM, Dillon WP, Nelson SJ, Vigneron DB. Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens. AJNR Am J Neuroradiol 2001; 22:604–612.PubMedGoogle Scholar
  50. 50.
    Kinoshita K, Tada E, Matsumoto K, Asari S, Ohmoto T, Itoh T. Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy. AJNR Am J Neuroradiol 1997; 18:1753–1761.PubMedGoogle Scholar
  51. 51.
    Schlemmer HP, Bachert P, Henze M, Buslei R, Herfarth KK, Debus J, van Kaick G. Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy. Neuroradiology 2002; 44:216–222.CrossRefPubMedGoogle Scholar
  52. 52.
    Suzuki S, Nishio S, Takata K, Morioka T, Fukui M. Radiationinduced brain calcification: paradoxical high signal intensity in T1-weighted MR images. Acta Neurochir (Wien) 2000; 142:801–804.CrossRefGoogle Scholar
  53. 53.
    Larson JJ, Ball WS, Bove KE, Crone KR, Tew JM Jr. Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children. J Neurosurg 1998; 88:51–56.CrossRefPubMedGoogle Scholar
  54. 54.
    Novelli PM, Reigel DH, Langham Gleason P, Yunis E. Multiple cavernous angiomas after high-dose whole-brain radiation therapy. Pediatr Neurosurg 1997; 26:322–325.CrossRefPubMedGoogle Scholar
  55. 55.
    Pozzati E, Giangaspero F, Marliani F, Acciarri N. Occult cerebrovascular malformations after irradiation. Neurosurgery 1996; 39:677–682.CrossRefPubMedGoogle Scholar
  56. 56.
    Detwiler PW, Porter RW, Zabramski JM, Spetzler RF. Radiation-induced cavernous malformation (letter). J Neurosurg 1998; 89:167–168.PubMedGoogle Scholar
  57. 57.
    Christie D, Leiper AD, Chessells JM, Vargha-Khadem F. Intellectual performance after presymptomatic cranial radiotherapy for leukaemia: effects of age and sex. Arch Dis Child 1995; 73:136–140.CrossRefPubMedGoogle Scholar
  58. 58.
    Brown RT, Madan-Swain A, Walco GA, Cherrick I, Ievers CE, Conte PM, Vega R, Bell B, Lauer SJ. Cognitive and academic late effects among children previously treated for acute lymphocytic leukemia receiving chemotherapy as CNS prophylaxis. J Pediatr Psychol 1998; 23:333–340.CrossRefPubMedGoogle Scholar
  59. 59.
    Kramer JH, Norman D, Brant-Zawadzki M, Ablin A, Moore IM. Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis therapy for leukemia. Cancer 1988; 61:928–930.CrossRefPubMedGoogle Scholar
  60. 60.
    Iuvone L, Mariotti P, Colosimo C, Guzzetta F, Ruggiero A, Riccardi R. Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia. Cancer 2002; 95:2562–2570.CrossRefPubMedGoogle Scholar
  61. 61.
    Mike V, Meadows AT, D’Angio GJ. Incidence of second malignant neoplasms in children: results of an international study. Lancet 1982; 2:1326–1331.CrossRefPubMedGoogle Scholar
  62. 62.
    Kimball Dalton VM, Gelber RD, Li F, Donnelly MJ, Tarbell NJ, Sallan SE. Second malignancies in patients treated for childhood acute lymphoblastic leukemia. J Clin Oncol 1998; 16:2848–2853.PubMedGoogle Scholar
  63. 63.
    Colosimo C, Cerase A, Di Lella GM, Riccardi R. Cerebral gliomas occurring as second tumors in children treated with brain irradiation and chemotherapy for malignancy (Abstr). Proceedings of ASNR 2000:283.Google Scholar
  64. 64.
    Li FP, Fraumeni JF Jr, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA, Miller RW. A cancer family syndrome in twenty-four kindreds. Cancer Res 1988; 48:5358–5362.PubMedGoogle Scholar
  65. 65.
    Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990; 250:1233–1238.CrossRefPubMedGoogle Scholar
  66. 66.
    Asato R, Akiyama Y, Ito M, Kubota M, Okumura R, Miki Y, Konishi J, Mikawa H. Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 1992; 70:1997–2004.CrossRefPubMedGoogle Scholar
  67. 67.
    Ebner F, Ranner G, Slavc I, Urban C, Kleinert R, Radner H, Einspieler R, Justich E. MR findings in methotrexateinduced CNS abnormalities. AJNR Am J Neuroradiol 1989; 10:959–964.PubMedGoogle Scholar
  68. 68.
    von der Weid NX, de Crousaz H, Beck D, Deonna T, Miklossy J, Janzer RC. Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia. Med Pediatr Oncol 1991; 19:192–198.CrossRefPubMedGoogle Scholar
  69. 69.
    Stone JA, Castillo M, Mukherji SK. Leukoencephalopathy complicating an Ommaya reservoir and chemotherapy. Neuroradiology 1999; 41:134–136.CrossRefPubMedGoogle Scholar
  70. 70.
    Priest JR, Ramsay NK, Steinherz PG, Tubergen DG, Cairo MS, Sitarz AL, Bishop AJ, White L, Trigg ME, Levitt CJ, Cich JA, Coccia PF. A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia. J Pediatr 1982; 100:984–989.CrossRefPubMedGoogle Scholar
  71. 71.
    Rathi B, Azad RK, Vasudha N, Hissaria P, Sawlani V, Gupta RK. L-asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia. Pediatr Neurosurg 2002; 37:203–205.CrossRefPubMedGoogle Scholar
  72. 72.
    Vaughn DJ, Jarvik JG, Hackney D, Peters S, Stadtmauer EA. High-dose cytarabine neurotoxicity: MR findings during the acute phase. AJNR Am J Neuroradiol 1993; 14:1014–1016.PubMedGoogle Scholar
  73. 73.
    Bentson J, Reza M, Winter J, Wilson G. Steroids and apparent cerebral atrophy on computed tomography scans. J Comput Assist Tomogr 1978; 2:16–23.CrossRefPubMedGoogle Scholar
  74. 74.
    Provenzale JM, Graham ML. Reversible leukoencephalopathy associated with graft-versus-host disease: MR findings. AJNR Am J Neuroradiol 1996; 17:1290–1294.PubMedGoogle Scholar
  75. 75.
    Padovan CS, Yousry TA, Schleuning M, Holler E, Kolb HJ, Straube A. Neurological and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation. Ann Neurol 1998; 43:627–633.CrossRefPubMedGoogle Scholar
  76. 76.
    Ferrara JL, Deeg HJ. Graft-versus-host disease. N Engl J Med 1991; 324:667–674.PubMedCrossRefGoogle Scholar
  77. 77.
    Zimmer WE, Hourihane JM, Wang HZ, Schriber JR. The effect of human leukocyte antigen disparity on cyclosporine neurotoxicity after allogeneic bone marrow transplantation. AJNR Am J Neuroradiol 1998; 19:601–608.PubMedGoogle Scholar
  78. 78.
    Beausang-Linder M, Bill A. Cerebral circulation in acute arterial hypertension-protective effects of sympathetic nervous activity. Acta Physiol Scand 1981; 111:193–199.CrossRefPubMedGoogle Scholar
  79. 79.
    Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334:494–500.CrossRefPubMedGoogle Scholar
  80. 80.
    Coley SC, Porter DA, Calamante F, Chong WK, Connelly A. Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity. AJNR Am J Neuroradiol 1999; 20:1507–1510.PubMedGoogle Scholar
  81. 81.
    Gleeson JG, duPlessis AJ, Barnes PD, Riviello JJ Jr. Cyclosporin A acute encephalopathy and seizure syndrome in childhood: clinical features and risk of seizure recurrence. J Child Neurol 1998; 13:336–344.CrossRefPubMedGoogle Scholar
  82. 82.
    Pavlakis SG, Frank Y, Chusid R. Hypertensive encephalopathy, reversible occipitoparietal encephalopathy, or reversible posterior leukoencephalopathy: three names for an old syndrome. J Child Neurol 1999; 14:277–281.CrossRefPubMedGoogle Scholar
  83. 83.
    Pace MT, Slovis TL, Kelly JK, Abella SD. Cyclosporin A toxicity: MRI appearance of the brain. Pediatr Radiol 1995; 25:180–183.CrossRefPubMedGoogle Scholar
  84. 84.
    Schwartz RB, Bravo SM, Klufas RA, Hsu L, Barnes PD, Robson CD, Antin JH. Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MR findings in 16 cases. AJR Am J Roentgenol 1995; 165:627–631.PubMedGoogle Scholar
  85. 85.
    Truwit CL, Denaro CP, Lake JR, DeMarco T. MR imaging of reversible cyclosporin A-induced neurotoxicity. AJNR Am J Neuroradiol 1991; 12:651–659.PubMedGoogle Scholar
  86. 86.
    Dillon WP, Rowley H. The reversible posterior cerebral edema syndrome. AJNR Am J Neuroradiol 1998; 19:591.PubMedGoogle Scholar
  87. 87.
    Debaere C, Stadnik T, De Maeseneer M, Osteaux M. Diffusion-weighted MRI in cyclosporin A neurotoxicity for the classification of cerebral edema. Eur Radiol 1999; 9:1916–1918.CrossRefPubMedGoogle Scholar
  88. 88.
    Schaefer PW, Buonanno FS, Gonzalez RG, Schwamm LH. Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia. Stroke 1997; 28:1082–1085.PubMedGoogle Scholar
  89. 89.
    Antunes NL, Small TN, George D, Boulad F, Lis E. Posterior leukoencephalopathy syndrome may not be reversible. Pediatr Neurol 1999; 20:241–243.CrossRefPubMedGoogle Scholar
  90. 90.
    Teksam M, Casey SO, Michel E, Truwit CL. Subarachnoid hemorrhage associated with cyclosporine A neurotoxicity in a bone-marrow transplant recipient. Neuroradiology 2001; 43:242–245.CrossRefPubMedGoogle Scholar
  91. 91.
    Padovan CS, Bise K, Hahn J, Sostak P, Holler E, Kolb HJ, Straube A. Angiitis of the central nervous system after allogeneic bone marrow transplantation? Stroke 1999; 30:1651–1656.PubMedGoogle Scholar
  92. 92.
    Rossi A, Biancheri R, Lanino E, Faraci M, Haupt R, Micalizzi C, Tortori-Donati P. Neuroradiology of pediatric hemolymphoproliferative disease. Riv Neuroradiol 2003; 16:221–250.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Paolo Tortori-Donati
    • 1
  • Andrea Rossi
    • 1
  • Roberta Biancheri
    • 1
  1. 1.Department of Pediatric NeuroradiologyG. Gaslini Children’s Research HospitalGenoaItaly

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