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Hemolymphoproliferative Diseases and Treatment-Related Disorders

  • Paolo Tortori-Donati
  • Andrea Rossi
  • Roberta Biancheri

Abstract

Pediatric hemolymphoproliferative diseases (HLDs) are a constellation of disorders that prominently include leukemia, lymphoma, and histiocytoses. These conditions are invariably severe, and are burdened by elevated morbidity and mortality in the absence of proper treatment. HLDs are systemic disorders, i.e., they typically affect multiple organs and systems in the human body. While, as a whole, leukemia and lymphomas account for about 40% of all malignancies in children [1], the majority of histiocytoses are not malignant. Intensive treatment regimens have resulted in a significant increase in the number of survivors, but have also disclosed new phases of the natural history of these disorders, among which is involvement of the central nervous system (CNS). CNS disease is not consistent, but when present, it is commonly associated with worsened prognosis. Moreover, current treatment modalities, including systemic therapy (i.e., combination chemotherapy) and specific CNS prophylaxis (i.e., intrathecal chemotherapy with or without cranial irradiation), are potentially neurotoxic.

Keywords

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Disseminate Intravascular Coagulation Posterior Reversible Encephalopathy Syndrome Pituitary Stalk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Paolo Tortori-Donati
    • 1
  • Andrea Rossi
    • 1
  • Roberta Biancheri
    • 1
  1. 1.Department of Pediatric NeuroradiologyG. Gaslini Children’s Research HospitalGenoaItaly

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