Hepatitis C Virus Population Dynamics During Infection

  • J.-M. Pawlotsky
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 299)


Hepatitis C virus (HCV) behaves as an evolving viral quasispecies in its continuously changing environment. The study of HCV quasispecies population dynamics in experimental models and infected patients can provide useful information on factors involved in the HCV life cycle and pathogenicity. HCV quasispecies variability also has therapeutic implications, as the continuous generation and selection of fitter or truly resistant variants can allow the virus to escape control by antiviral drugs.


Internal Ribosome Entry Site Viral Quasispecies HVR1 Sequence Quasispecies Variant Quasispecies Distribution 
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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • J.-M. Pawlotsky
    • 1
  1. 1.Service de VirologieHôpital Henri MondorCréteilFrance

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