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Molecular Mechanisms of Poliovirus Variation and Evolution

  • V. I. Agol
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 299)

Abstract

Replication of poliovirus RNA is accomplished by the error-prone viral RNA-dependent RNA polymerase and hence is accompanied by numerous mutations. In addition, genetic errors may be introduced by nonreplicative mechanisms. Resulting variability is manifested by point mutations and genomic rearrangements (e.g., deletions, insertions and recombination). After description of basic mechanisms underlying this variability, the review focuses on regularities of poliovirus evolution (mutation fixation) in tissue cultures, human organisms and populations.

Keywords

Internal Ribosome Entry Site Oral Poliovirus Vaccine Poliovirus Type Sabin Strain Poliovirus Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • V. I. Agol
    • 1
    • 2
  1. 1.M.P. Chumakov Institute of Poliomyelitis and Viral EncephalitidesRussian Academy of Medical SciencesRussia
  2. 2.M.V. Lomonosov Moscow State UniversityMoscowRussia

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